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Identifying relevant factors influencing cancer-related fatigue in patients with diffuse large B-cell lymphoma during chemotherapy

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World Journal of Psychiatry 2024年第7期14卷 1017-1026页

作者： xiu-qiao Hao Xiang-Dan Yang Yue qi Department of Hematology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Diffuse large B-cell lymphoma(DLBCL)is a rapidly growing malignant tumor,and chemotherapy is one of the treatments used to combat *** advancements of science and technology have resulted in more and more patients being able to receive effective treatment,they still face side effects such as fatigue and *** is important to thoroughly investigate the factors that contribute to cancer-related fatigue(CRF)during *** To explore the factors related to CRF,anxiety,depression,and mindfulness levels in patients with DLBCL during *** General information was collected from the electronic medical records of eligible *** quality and mindfulness level scores in patients with DLBCL during chemotherapy were evaluated by the Pittsburgh Sleep Quality Index and Five Facet Mindfulness Questionnaire-Short *** Piper Fatigue Scale was used to evaluate the CRF *** Self-Rating Anxiety Scale and Self-Rating Depression Scale were used to evaluate anxiety and depression *** analysis and multivariate regression analysis were used to investigate the factors related to *** The overall average CRF level in 62 patients with DLBCL during chemotherapy was 5.74±*** 25 patients,the highest rate of mild fatigue was in the cognitive dimension(40.32%),and in 35 patients the highest moderate fatigue rate in the behavioral dimension(56.45%).In the emotional dimension,severe fatigue had the highest rate of occurrence,34 cases or 29.03%.The CRF score was positively correlated with cancer experience(all P<0.01)and negatively correlated with cancer treatment efficacy(all P<0.01).Tumor staging,chemotherapy cycle,self-efficacy level,and anxiety and depression level were related to CRF in patients with DLBCL during *** There was a significant correlation between CRF and perceptual control level in *** staging,chemotherapy cycle,self-efficacy level,and anxiety and depression level

关键词： Diffuse large B-cell lymphoma Chemotherapy Cancer-related fatigue Anxiety Depression Mindfulness

Autocrine IL-8 Contributes to Propionibacterium Acnes-induced Proliferation and Differentiation of HaCaT Cells via AKT/FOXO1/Autophagy

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Current Medical Science 2024年第5期44卷 1058-1065页

作者： xiu-qin YU Jin-zhu MAO Shu-yun YANG Lu WANG Chang-zhi YANG Lei HUANG qi-hong qiAN Ting-ting ZHU Department of Dermatology the First Affiliated Hospital of Soochow UniversitySuzhou215006China Department of Dermatology Baoshan People’s Hospital of Yunnan ProvinceBaoshan678000China

Objective Proprionibacterium acnes(***)-induced inflammatory responses,proliferation and differentiation of keratinocytes contribute to the progression of acne vulgaris(AV).*** was found to enhance the production of interleukin-8(IL-8)by *** study aimed to investigate the role of IL-8 in ***-induced proliferation and differentiation of keratinocytes and the underlying *** The ***-stimulated HaCaT cell(a human keratinocyte cell line)model was *** blotting and immunofluorescence were performed to detect the expression of the IL-8 receptors C-X-C motif chemokine receptor 1(CXCR1)and C-X-C motif chemokine receptor 2(CXCR2)on HaCaT *** counting kit-8(CCK-8)assay,5-ethynyl-20-deoxyuridine(EdU)assay and Western blotting were performed to examine the effects of IL-8/CXCR2 axis on the proliferation and differentiation of HaCaT cells treated with ***,the IL-8 neutralizing antibody,the CXCR2 antagonist(SB225002),or the CXCR1/CXCR2 antagonist(G31P).Western blotting,nuclear and cytoplasmic separation,CCK-8 assay,and EdU assay were employed to determine the downstream pathway of CXCR2 after ***-stimulated HaCaT cells were treated with the CXCR2 antagonist,the protein kinase B(AKT)antagonist(AZD5363),or the constitutively active forkhead box O1(FOXO1)***,autophagy markers were measured in HaCaT cells following the transfection of the FOXO1 mutant or treatment with the autophagy inhibitor 3-methyladenine(3-MA).Results The expression levels of CXCR1 and CXCR2 were significantly increased on the membrane of HaCaT cells following *** *** IL-8/CXCR2 axis predominantly promoted the proliferation and differentiation of ***-induced HaCaT cells by activating AKT/FOXO1/autophagy *** brief,IL-8 bound to its receptor CXCR2 on the membrane of keratinocytes to activate the AKT/FOXO1 ***,phosphorylated FOXO1 facilitated autophagy to promote the proliferation and diffe

关键词： acne vulgaris Proprionibacterium acnes keratinocyte interleukin-8 C-X-C motif chemokine receptor 2 protein kinase B forkhead box O1 autophagy

Formaldehyde degradation by UV/TiO_2/O_3 process using continuous flow mode

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Journal of Environmental Sciences 2007年第9期19卷 1136-1140页

作者： qi hong SUN De-zhi CHI Guo-qing School of Municipal and Environmental Engineering Harbin Institute of Technology Harbin 150090 China.

The degradation of formaldehyde gas was studied using UV/TiO2/O3 process under the condition of continuous flow mode. The effects of humidity, initial formaldehyde concentration, residence time and ozone adding amount on degradation of formaldehyde gas were investigated. The experimental results indicated that the combination of ozonation with photocatalytic oxidation on the degradation of formaldehyde showed a synergetic action, e.g,, it could considerably increase decomposing of formaldehyde. The degradation efficiency of formaldehyde was between 73.6% and 79.4% while the initial concentration in the range of 1.84--24 mg/m^3 by O3/TiO2flJV process. The optimal humidity was about 50% in UV/TiO2/O3 processs and degradation of formaldehyde increases from 39.0% to 94.1% when the ozone content increased from 0 to 141 mg/m^3. Furthermore, the kinetics of formaldehyde degradation reaction could be described by Langmuir-Hinshelwood model. The rate constant k of 46.72 mg/（m^***） and Langmuir adsorption coefficient K of 0.0268 m^3/mg were obtained.

关键词： UV/TiO2/O3 process formaldehyde continuous flow mode

Analysis and Simulation of Quantum Radar Cross Section

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Chinese Physics Letters 2014年第3期31卷 62-64页

作者： LIU Kang XIAO Huai-Tie FAN hong-qi Science and Technology on Automatic Target Recognition Laboratory National University of Defense Technology Changsha 410073

We derive a modified analytical expression of a quantum radar cross section （QRCS）. Subsequently, we present a comparison between the QRCS and a classical radar cross section （RCS） and analyze the factors that can affect the intensity of the peak and side lobes. Simulation results on a flat rectangular plate demonstrate that QRCS has a similar structure to that of RCS. The analysis of side-lobe structure can benefit the design of quantum stealth platforms as well as the research on quantum radars.

关键词： RADAR cross sections RESEARCH RADAR -- Research QUANTUM theory COMPUTER simulation PHYSICS research

Immobilization of radioactive fluoride waste in aluminophosphate glass:a molecular dynamics simulation

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Nuclear Science and Techniques 2018年第7期29卷 91-102页

作者： Ling-Wei Gao Xiao-Bin Xia xiu-qing Xu Chang-qi Chen Shanghai Institute of Applied Physics Chinese Academy ofSciencesJiading Campus Shanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

Molecular dynamics(MD) simulations were conducted to investigate the structural and chemical environment of aluminum in aluminophosphate *** glasses have the potential for application in the disposal of radioactive fluoride waste from molten salt reactors(MSR).Due to the risks of studying these materials and the limitations of realistic research conditions,MD simulations were used as an alternative method to study the vitrification of radioactive fluoride *** the past decades,aluminophosphate glasses have been studied and they exhibit certain favorable properties for high-level radioactive waste *** work focuses on the effects of fluorine addition on structural changes in the *** observed that glass with composition P_2O_5–Al_2O_3–Na_2O–CaO exhibited a good performance in immobilizing fluoride at low F concentrations(approximately under25 mol%).Significant changes were observed where PO_3F_2 units replaced PO_3F units in the *** fourcoordinated AlO_4 units were increasingly converted into five-coordinated [AlO_xF_y] with the increasing F *** radionuclide Sr in the simulation had the tendency to form six-coordinated octahedrons in the *** conclude that the structural changes resulting from the fluoridewaste added to aluminophosphate glasses does not adversely affect their chemical stability at relatively low F concentrations,i.e.,under 25 mol%.Hence,the use of phosphate glasses is a potential alternative method of fluoride waste disposal.

关键词：动力学模拟放射性核种废物管理氟化物玻璃化分子化学稳定性现实主义

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

The effects of BCGs on the statistics of large-separation lensed quasars by clusters

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Research in Astronomy and Astrophysics 2011年第9期11卷 1003-1018页

作者： hong qi Da-Ming Chen National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

We study the statistics of large-separation multiply-imaged quasars lensed by clusters of galaxies. In particular, we examine how the observed brightest cluster galaxies （BCGs） affect the predicted numbers of wide-separation lenses. We model the lens as an NFW-profiled dark matter halo with a truncated singular isothermal sphere to represent the BCG in its center. We mainly make predictions for the Sloan Digital Sky Survey Quasar Lens Search （SQLS） sample from the Data Release 5 （DRS） in two standard ACDM cosmological models： a model with matter density ΩM = 0.3 and δ8 = 0.9, as is usually adopted in the literature （ACDM1）, and a model suggested by the WMAP seven-year （WMAPT） data with ΩM = 0.266 and δ8 = 0.801. We also study the lensing properties for the WMAP3 cosmology in order to compare with the previous work. We find that BCGs in the centers of clusters significantly enhance the lensing efficiency by a factor of 2 - 3 compared with that of NFW-profiled pure dark matter halos. In addition, the dependence of mass ratios of BCGs to their host halos on the host halo masses reduces the lensing rate by - 20% from assuming a constant ratio as in previous studies, but considering the evolution of this ratio with redshift out to z - 1 would reduce it by - 3%. Moreover, we predict that the numbers of lensed quasars with image separations larger than 10″ in the statistical sample of SQLS from DR5 are 1.22 and 0.47, respectively for ACDM1 and WMAP7 and 0.73 and 0.33 for separations between 10″ and 20″, which are consistent with the only observed cluster lens with such a large separation in the complete SQLS sample.

关键词： cosmological parameters -- cosmology: theory -- galaxies: clusters -- gravitational lensing -- dark matter

Hantavirus Infection during Pregnancy

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Virologica Sinica 2021年第3期36卷 345-353页

作者： Deng-Hui Lu hong Jiang Jian-qi Lian The Center of Diagnosis and Treatment of Infectious Diseases The Second Affiliated HospitalAir Force Medical UniversityXi'an 710038China

Hantavirus infection is a global health challenge,causing widespread public *** recent years,cases of hantavirus infection in pregnant women have been reported in many *** infected pregnant women and their fetuses appear to have more severe clinical symptoms and worse clinical ***,to study the prevalence of hantavirus infection in pregnant women,this study will focus on the epidemiological distribution of the virus,different virus species penetrating the placental barrier,and factors affecting the incidence and clinical outcome of the infection in pregnant women and their *** addition,this review will also discuss the diagnostic tools and treatments for pregnant patients and provide an overview of the relevant future research.

关键词： Hantavirus Pregnancy Hantaan virus(HTNV) HPS HFRS

Influences of petroleum on accumulation of copper and cadmium in the polychaete Nereis diversicolor

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Journal of Environmental Sciences 2006年第1期18卷 109-114页

作者： SUN Fu-hong ZHOU qi-xing ZHANG qian-ru Key Laboratory of Terrestrial Ecological Process Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 China Graduate School of the Chinese Academy of Sciences Beijing 100039 China College of Environmental Sciences and Engineering Nankai University Tianjin 300071 China

Using the exposure simulation experiment, the action of petroleum affecting the accumulation of the trace metals including copper （Cu） and cadmium （Cd） in littoral polychaete Nereis diversicolor collected from the Shuangtaizi Estuary in Liaoning Province, China was examined. The results showed that there was a markedly non-linear relationship between the accumulation of Cu in worms and the experimental concentration of Cu in exposure solutions when the concentration of petroleum remained at 0, 100, and 220 μl/L, respectively. However, significantly non-linear relationship for worms exposed to Cd was observed only when the concentration of added petroleum was 0 and 220 μl/L. The accumulation of Cu in worms did not differ significantly among the three different levels of petroleum concentrations combined with various concentrations of Cu. So was the accumulation of Cd in worms （p〉0.05）. However, the addition of petroleum in exposure solutions brought about an increase in the accumulation of Cu in Nereis diversicolor, in comparison with single Cu pollution. On the other hand, when the concentration of added petroleum remained at 100 μl/L, the accumulation of Cd in worms was lower than that in worms exposed to various concentrations of only cadmium. However, the worms exposed to Cd and petroleum 220 μl/L did not show obvious and identical increase in the accumulation of Cd, compared with single Cd exposure. The accumulation of both Cu and Cd in worms did not increase significantly with the increases in concentrations of Cu or Cd in exposure solutions combined with petroleum （0, 100, and 220μl/L） under the experimental conditions. Although Nereis diversicolor is exposed to very high Cu and Cd in exposure solutions, accumulation and detoxification mechanisms are sufficient to cope with the extra metal influx in order to survive.

关键词： Nereis diversicolor copper cadmium petroleum combined pollution