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Therapeutic effect of placenta-derived mesenchymal stem cells on hypoxic-ischemic brain damage in rats

World Journal of Pediatrics 2015年第1期11卷 74-82页

作者： Hong-fang Ding Hui Zhang Hui-fang Ding Dong Li xin-Hao Yi xin-Yi Gao Wei-Wei Mou xiu-Li Ju Department of Pediatrics Qilu HospitalShandong UniversityJinan 250012China Department of Pediatrics Shengli Oil Field Central HospitalDongying 257034China Department of Neurology Qingdao Municipal HospitalQingdao 266000China

Background:Oxidative stress is involved in the development of hypoxic-ischemic brain damage(HIBD).In this study,we investigated the therapeutic efcts of placenta-derived mesenchymal stem cells(PD-MSCs)and explored the N F-E2-related factor-2/heme oxygenase-1(Nrf2/HO-1)signaling pathway in treating ***:P7 rats were subjected to hypoxic-ischemic brain injury and randomly divided into four groups(control,HIBD,HIBD+PD-MSCs,and HIBD+fbroblasts).Forty-eight hours after the induction of HIBD,5×10^(5)of PD-MSCs were injected into cerebral tissue in the HIBD+PD-MSCs group,while the same dose of fibroblas ts were injected in the HIBD+fibroblasts *** Water Maze,gross and pathological changes were tested at *** level of malondialdehyde(MDA)was detected in rats'***-PCR and western blot analysis were used to evaluate the changes of Nrf2/***:The HIBD group showed significantly longer escape latency and a lower frequency of original platform crossing in the Morris Water M laze compared with the control *** receiving PD MSCs showed significant improvement of *** pathological changes were evident after HIBD,but ameliorated in the PD-MSCs *** with the control group,HO-1 and Nrf2 were up-regulated at gene and protein levels in the HI brain,beginning at 6 hours and peaking at 48 hours(P<0.05).The expression of HO-1 and Nrf2 in the PD-MSCs treatment group was more pronounced than in the HBD group(P<0.01).PD MSCs also decreased MDA production in the brain ***:These results demonstrate that PD-MSCs have neuroprotective effect during the treatment of HIBD and that the mechanism may be partly due to alleviating oxidative stress.

关键词： hypoxia-ischemia mesenchymal stem cells neonatal rat oxidative stress

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Transcriptional Regulation of Plant Secondary Metabolism

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Journal of Integrative Plant Biology 2012年第10期54卷 703-712页

作者： Chang-Qing Yang xin fang xiu-Ming Wu Ying-Bo Mao Ling-Jian Wang Xiao-Ya Chen National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for BiologicalSciences the Chinese Academy of Sciences Shanghai 200032 China plant Science Research Center. Shanahai Chensh-an Botanical Garden. Shanahai 201602. China

Plant secondary metabolites play critical roles in plant-environment interactions. They are synthesized in different organs or tissues at particular developmental stages, and in response to various environmental stimuli, both biotic and abiotic. Accordingly, corresponding genes are regulated at the transcriptional level by multiple transcription factors. Several families of transcription factors have been identified to participate in controlling the biosynthesis and accumulation of secondary metabolites. These regulators integrate internal （often developmental） and external signals, bind to corresponding cis-elements -- which are often in the promoter regions -- to activate or repress the expression of enzyme-coding genes, and some of them interact with other transcription factors to form a complex. In this review, we summarize recent research in these areas, with an emphasis on newly-identified transcription factors and their functions in metabolism regulation.

关键词： Alkaloid phenylpropanoid secondary metabolism terpenoid transcription factor.

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Proteomic Comparison Between Leaves from a Red-Flesh Mutant and Its Wild-Type in Sweet Orange

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Agricultural Sciences in China 2011年第8期10卷 1206-1212页

作者： PAN Zhi-yong DENG xiu-xin National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070P.R.China

The red-flesh mutant Hong Anliu sweet orange is of high nutritional value due to its lycopene *** previous studies on this mutant fruits suggested that photosynthesis and oxidative stress could promote the formation of mutation ***,leaf rather than fruit is the major part for some important biological processes such as *** this study,we analyzed the proteomic alteration in leaves of the red-flesh mutant Hong Anliu *** wild type （WT）.Ten differentially expressed proteins were identified,of which two were involved in photosynthesis,three in oxidative stress,two in defense,and three in *** high up-regulation of photosynthetic proteins proved the hypothesis that enhanced photosynthesis could provide and transport more substrates into mutant fruits for carotenoid *** to the previous results in fruits,anti-oxidative proteins were highly up-regulated in leaves,suggesting the whole plant of Hong Anliu suffered from enhanced oxidative *** involved in defense and metabolism were also identified,and their possible roles in the mutation were discussed.

关键词： sweet orange lycopene accumulation proteomic photosynthesis oxidative stress

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Histogram-kernel Error and Its Application for Bin Width Selection in Histograms

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Acta Mathematicae Applicatae Sinica 2012年第3期28卷 607-624页

作者： xiu-xiang Wang Jian-fang Zhang Department of Mathematics Graduate University of Chinese Academy of SciencesBeijing 100049China Coltege of Management Graduate University of Chinese Academy of SciencesBeijing 100190China

Histogram and kernel estimators are usually regarded as the two main classical data-based nonparametric tools to estimate the underlying density functions for some given data sets. In this paper we will integrate them and define a histogram-kernel error based on the integrated square error between histogram and binned kernel density estimator, and then exploit its asymptotic properties. 3ust as indicated in this paper, the histogram-kernel error only depends on the choice of bin width and the data for the given prior kernel densities. The asymptotic optimal bin width is derived by minimizing the mean histogram-kernel error. By comparing with Scott＇s optimal bin width formula for a histogram, a new method is proposed to construct the data-based histogram without knowledge of the underlying density function. Monte Carlo study is used to verify the usefulness of our method for different kinds of density functions and sample sizes.

关键词： Histogram binned kernel density estimator bin width histogram-kernel error integrated square error

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Gossypol: phytoalexin of cotton

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Science China(Life Sciences) 2016年第2期59卷 122-129页

作者： xiu Tian Juxin Ruan Jinquan Huang xin fang Yingbo Mao Lingjian Wang Xiaoya Chen Changqing Yang School of Life Sciences Nanjing University Nanjing 210023 China National Key Laboratory of Plant Molecular Genetics and National Center for Plant Gene Research Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China Plant Science Research Center Shanghai Chenshan Botanical Garden Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai 201602 China

Sesquiterpenoids are a class of 15-carbon secondary metabolites that play diverse roles in plant adaptation to environment. Cotton plants accumulate a large amount of sesquiterpene aldehydes （including gossypol） as phytoalexins against pathogens and herbivores. They are stored in pigment glands of aerial organs and in epidermal layers of roots. Several enzymes of goss- ypol biosynthesis pathway have been characterized, including 3-hydroxy-3-methylglutaryl coenzyme A reductase （HMGR） and farnesyl diphosphate synthase （FPS） that catalyze the formation of the precursor farnesyl diphosphate （FPP）, （＋）-6-cadinene synthase （CDN） which is the first enzyme committed to gossypol biosynthesis, and the downstream enzymes of CYP706B 1 and methyltransferase. Expressions of these genes are tightly regulated during cotton plants development and in- duced by jasmonate and fungi elicitors. The transcription factor GaWRKY1 has been shown to be involved in gossypol path- way regulation. Recent development of new genomic platforms and methods and releases of diploid and tetraploid cotton ge- nome sequences will greatly facilitate the elucidation of gossypol biosynthetic pathway and its regulation.

关键词： cotton secondary metabolism gossypol sesquiterpenoid

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Neural-network-based stochastic linear quadratic optimal tracking control scheme for unknown discrete-time systems using adaptive dynamic programming

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Control Theory and Technology 2021年第3期19卷 315-327页

作者： xin Chen fang Wang School of Automation China University of GeosciencesWuhan430074HubeiChina Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systems Wuhan430074HubeiChina

In this paper,a stochastic linear quadratic optimal tracking scheme is proposed for unknown linear discrete-time(DT)systems based on adaptive dynamic programming(ADP)***,an augmented system composed of the original system and the command generator is constructed and then an augmented stochastic algebraic equation is derived based on the augmented ***,to obtain the optimal control strategy,the stochastic case is converted into the deterministic one by system transformation,and then an ADP algorithm is proposed with convergence *** the purpose of realizing the ADP algorithm,three back propagation neural networks including model network,critic network and action network are devised to guarantee unknown system model,optimal value function and optimal control strategy,***,the obtained optimal control strategy is applied to the original stochastic system,and two simulations are provided to demonstrate the effectiveness of the proposed algorithm.

关键词： Stochastic system Optimal tracking control Adaptive dynamic programming Neural networks

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Finite Groups with Its Power Automorphism Groups Having Small Indices

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Acta Mathematica Sinica,English Series 2009年第7期25卷 1097-1108页

作者： Jun xin WANG xiu Yun GUO Department of Mathematics Shanxi University of Finance and Economics Taiyuan 030006 P.R. China Department of Mathematics Shanghai University Shanghai 200444 P.R.China

In this paper, a finite group G with IAut（G）： P（G）I ^- p or pq is determined, where P（G） is the power automorphism group of G, and p, q are distinct primes. Especially, we prove that a finite group G satisfies ｜Aut（G）： P（G）｜= pq if and only if Aut（G）/P（G） ≌S3. Also, some other classes of finite groups are investigated and classified, which are necessary for the proof of our main results.

关键词： power automorphism group norm action

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采用小波变换的空间外差干涉图误差分析方法

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光谱学与光谱分析 2025年第1期45卷 8-14页

作者：王方原李晓静叶松李树王新强桂林电子科技大学光电工程学院广西桂林541004 广西光电信息处理重点实验室广西桂林541004

空间外差光谱技术(SHS)是一种应用于微弱物质探测、行星勘探以及大气遥感等领域的超光谱分析技术。受实验环境复杂及被测目标信号微弱等因素的影响,空间外差光谱仪的测量结果易出现干涉条纹倾斜、干涉图有斑点噪声等情况,从而最终影响... 详细信息

空间外差光谱技术(SHS)是一种应用于微弱物质探测、行星勘探以及大气遥感等领域的超光谱分析技术。受实验环境复杂及被测目标信号微弱等因素的影响,空间外差光谱仪的测量结果易出现干涉条纹倾斜、干涉图有斑点噪声等情况,从而最终影响测量光谱的精度。为了尝试解决这些问题,提出了基于小波变换的干涉图误差分析方法,对干涉图的斑点噪声水平和条纹倾斜误差进行有效的评价,从而为后续误差校正提供理论基础。首先对无误差的钾灯仿真干涉图加入不同标准差的高斯噪声,利用小波分解提取复小波系数,采用三种噪声估计法对干涉图数据进行计算,结果表明空域相关小波变换法噪声估计结果与真实值偏差最小,而Donoho估计法在修正截距后与真实值具有更好的吻合度。随后采用Db2小波对噪声水平不同的仿真钾灯干涉图进行一层小波分解并提取水平、对角及垂直三个方向的细节系数,采用Donoho估计法对干涉图进行二维噪声分析,有效表征了三幅干涉图各方向上的噪声水平特征。最后对仿真连续光干涉图进行小波分解并提取系数分析,研究了干涉条纹倾斜角度与小波分解系数的关系。研究结果表明,三个方向的小波细节系数估值变化分别在分解到不同层数时具有相似的变化规律:小波细节系数估值与条纹倾斜方向和小波细节系数的所属方向的夹角成反比,条纹倾斜方向与该小波细节系数的方向夹角越小,估值越大,反之则越小,且水平方向分解到第一层、对角方向分解到第二层、垂直方向分解到第三层符合变化规律。该研究是利用小波分解进行空间外差光谱误差分析的有益尝试,也为后续干涉图条纹倾斜误差的校正提供了一种新途径。

关键词：空间外差光谱技术噪声标准差估计干涉图小波变换

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NUMERICAL MODELING FOR POSITIVE AND INVERSE PROBLEMS OF 3-D SEEPAGE IN DOUBLE FRACTURED MEDIA

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Journal of Hydrodynamics 2005年第2期17卷 186-193页

作者： ZHOUZhi-fang GUOGeng-xin_] CollegeofCivilEngineering HohaiUniversityNanjing210098China

Three-dimensional seepage in double fractured media was modeled in this paper. The determination of hydraulic conductivity tensor of rock mass is a vital problem for the sea water intrusion or sea water encroachment and seepage of fissured medium. According to the geological and hydrogeological conditions for the 2nd-stage construction of the Three Gorges Project (TGP), the physical and mathematical models for the groundwater movement through the 3D double fractured media of rock mass during construction were established in this paper. Based on discontinuity-control inverse theory, some related parameters of double fractured media were inversed with flux being the known quantity and calibration of water table the objective function. Synchronously, the seepage field of the construction region was systematically analyzed and simulated, the results of which exhibit that the double fractured media model of fracture water can comprehensively and correctly describe the geological and hydrogeological conditions in the construction region.

关键词： Three Gorges Project (TGP) double fractured media model inverse analysis specific storativity transference coefficient

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Moving horizon based wavelet de-noising method of dual-observed geomagnetic signal for nonlinear high spin projectile roll positioning

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Defence Technology（防务技术） 2020年第2期16卷 417-424页

作者： Ting-ting Yin fang-xiu Jia Xiao-ming Wang ZNDY of Ministerial Key Laboratory Nanjing University of Science and TechnologyNanjing210094China

Phase-frequency characte ristics of approximate sinusoidal geomagnetic signals can be used fo r projectile roll positioning and other high-precision trajectory correction *** sinusoidal geomagnetic signal deforms in the exposed and magnetically contaminated *** order to preciously recognize the roll information and effectively separate the noise component from the original geomagnetic sequence,based on the error source analysis,we propose a moving horizon based wavelet de-noising method for the dual-observed geomagnetic signal filtering where the captured rough roll frequency value provides reasonable wavelet decomposition and reconstruction level selection basis for sampled sequence;a moving horizon window guarantees real-time performance and non-cumulative calculation *** complete geomagnetic data in full ballistic range and three intercepted paragraphs are used for performance *** positioning performance of the moving horizon wavelet de-noising method is compared with the band-pass *** results show that both noise reduction techniques improve the positioning accuracy while the wavelet de-noising method is always better than the band-pass *** results suggest that the proposed moving horizon based wavelet de-noising method of the dual-observed geomagnetic signal is more applicable for various launch conditions with better positioning performance.

关键词： High-spin projectile roll positioning Dual-observed geomagnetic signal Wavelet de-noising Discrete wavelet transform

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