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Network Pharmacology of Xian-Lian-Jie-Du Decoction in Ameliorating Colorectal Cancer

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World Journal of Traditional Chinese Medicine 2024年第1期10卷 83-92页

作者： Ming-Xia Zhao Cheng-Lin Song qin-Chang Zhang Hao-Jie Du Shu-Qiong Zhang Yu-Xian Shen Yang Sun Hai-bo Cheng Wen Lv Department of Pharmacy School of Basic Medical SciencesAnhui Medical UniversityHefeiAnhuiChina Department of Biopharmaceutical Research Institute Anhui Medical UniversityHefeiAnhuiChina Department of Pharmaceutical Analysis State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking UniversityBeijingChina Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor First Clinical CollegeNanjing University of Chinese MedicineNanjingJiangsuChina Deparment of Biotechnology and Pharmaceutical Sciences State Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjingJiangsuChina Deparment of Gynecology Institute of Traditional Chinese Medicine of Zhejiang ProvinceTongde Hospital of Zhejiang ProvinceHangzhouZhejiangChina

Objective:In this study,we screened for therapeutic targets of the Xian-Lian-Jie-Du decoction(XLJDD)for colorectal cancer(CRC)and explored the underlying mechanisms using network pharmacology ***:Genes associated with CRC were collected from the Gene Cards *** names of the active compounds of XLJDD were used as keywords in the“chemical name”in the Traditional Chinese Medicine Systems Pharmacology(TCMSP)database to search the *** protein-protein interaction(PPI)network was constructed using Cytoscape *** Ontology functional enrichment and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses were performed to identify key target ***:A total of 234 XLJDD-related targets and 250 cross-targets between XLJDD and CRC were collected based on the TCMSP and HIT 2.0 databases.A PPI network constructed based on the STRING database revealed interactions for all 250 *** network results revealed TP53,MYC,CCND1,AKT1,CASP3,and STAT3 as core potential *** pathway analysis of the 250 potential XLJDD targets for CRC in the Metascape database was performed using RStudio *** top 12 gene ratio aggregated analysis results were visualized in bubble *** interleukin(IL)-17 signaling pathway had the highest correlation with the tumor necrosis factor(TNF)signaling ***:XLJDD may be effective in ameliorating CRC by controlling inflammatory factors related to the IL-17 and TNF pathways and targeting proto-oncogenes and tumor suppressor genes,including MYC,CCND1,CTNNB1,and TP53.

关键词： Colorectal cancer network pharmacology Xian-Lian-Jie-Du decoction

Spatial-and spin-resolution ARPES and magnetism beamline at SSRF

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Nuclear Science and Techniques 2024年第8期35卷 23-37页

作者： Fang‑Yuan Zhu Jie‑Feng Cao Xiang‑Yu Meng Jun‑qin Li Rui Yu Ya‑Mei Wang Shan Qiao bo Zhao Ming‑Zhu Zhang Zhong‑Kai Liu Mei‑Xiao Wang Yong Wang Ren‑Zhong Tai Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China ShanghaiTech Laboratory for Topological Physics School of Physical Science and TechnologyShanghai Tech UniversityShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China

The BL07U beamline is a new extreme ultraviolet and soft X-ray beamline housed in the Shanghai Synchrotron Radiation Facility. Beamlines are used in nano-resolved angle-resolved photoemission spectroscopy(nano-ARPES), spin-resolved angle-resolved photoemission spectroscopy(spin-ARPES), X-ray magnetic circular dichroism spectroscopy, and X-ray magnetic linear dichroism spectroscopy for certain scientific research. The BL07U beamline, which is based on a pair of elliptical polarized undulators and a variable-included-angle plane-grating monochromator, delivers circularly or linear polarized X-rays within the energy range of 50–2000 eV. The beamline features two branches: One dedicated to nano-ARPES,which has a minimum spot size of only ~ 200 nm, and another branch comprising spin-ARPES, a vector magnetic field, and superconductive magnetic end-station.

关键词： Soft X-ray beamline Nano-ARPES Spin-ARPES XMCD/XMLD

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钢轨擦伤形成机理、检测与防治综述

交通运输工程学报 2024年第2期24卷 65-84页

作者：侯博文乔林川高亮秦家栋刘秀波马超智北京交通大学土木建筑工程学院北京100044 北京交通大学轨道工程北京市重点实验室北京100044 北京交通大学轨道交通安全协同创新中心北京100044 中国铁道科学研究院集团有限公司基础设施检测研究所北京100081

针对铁路运营过程中存在的钢轨擦伤问题,从擦伤的深度、裂纹扩展角度、尺寸等方面总结了擦伤的具体形态特征,论述了钢轨擦伤的扩展过程;系统分析了钢轨擦伤的形成机理,从塑性变形和热致相变2个成因角度分析了轮轨接触压力、接触区应力... 详细信息

针对铁路运营过程中存在的钢轨擦伤问题,从擦伤的深度、裂纹扩展角度、尺寸等方面总结了擦伤的具体形态特征,论述了钢轨擦伤的扩展过程;系统分析了钢轨擦伤的形成机理,从塑性变形和热致相变2个成因角度分析了轮轨接触压力、接触区应力应变、接触区温度变化在擦伤形成过程中的作用机制;从机车车辆性能、线路参数、轨道类型等方面明确了影响钢轨擦伤发展的主要因素;调研了基于轴箱加速度等不同方式的钢轨擦伤现场检测方法,对比分析了各种方法在擦伤检测方面的适用性;结合擦伤的形成机理与影响因素,从车辆牵引/制动控制、钢轨打磨等角度分析了擦伤防治的有效措施与策略。研究结果表明:目前对于钢轨擦伤形成机理及发展过程的研究主要采用现场调研、样本试验模拟和数值仿真等手段;由轮轨之间的大蠕滑、滑动状态所引起的钢轨母材极限变形、热致相变是钢轨擦伤形成的主要原因,列车运行状态、线路平纵断面参数和线下基础类型等因素会影响轮轨之间的接触状态,从而诱发擦伤的形成和发展;按照钢轨擦伤的检测方式划分,目前主要可采用轴箱加速度响应法、频响函数法与涡流探测法等,但各类检测方法的精度对于不同程度的擦伤有一定差别;针对钢轨擦伤的防治方面,在擦伤形成之前,控制列车牵引/制动过程中的轮轨黏着超限对于预防擦伤较为有效,在擦伤形成后,根据擦伤的不同程度可通过分级打磨或换轨等方式来降低安全隐患。

关键词：铁道工程钢轨擦伤形成机理影响因素防治措施

Establishment of acquired tracheoesophageal fistula using a modified magnetic compression technique in rabbits and its postmodeling evaluation

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World Journal of Gastrointestinal Surgery 2024年第5期16卷 1385-1394页

作者： Han Meng Fu-Yao Nan Na Kou qin-Yan Hong Ming-Sheng Lv Ju-bo Li Bao-Jie Zhang Hang Zou Lei Li Hong-Wu Wang Respiratory Disease Center Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100029China The First Clinical Medical College Beijing University of Chinese MedicineBeijing 100700China Department of Animal Experimental Center National Center for CardiovascularFuwai HospitalBeijing 100037China

BACKGROUND Previous studies have validated the efficacy of both magnetic compression and surgical techniques in creating rabbit tracheoesophageal fistula(TEF)*** compression achieves a 100%success rate but requires more time,while surgery,though less frequently successful,offers rapid model establishment and technical maturity in larger animal *** To determine the optimal approach for rabbit disease modeling and refine the *** TEF models were created in 12 rabbits using both the modified magnetic compression technique and *** of the time to model establishment,success rate,food and water intake,weight changes,activity levels,bronchoscopy findings,white blood cell counts,and biopsies were *** response to the failures encountered during modified magnetic compression modeling,we increased the sample size to 15 rabbit models and assessed the repeatability and stability of the models,comparing them with the original magnetic compression *** The modified magnetic compression technique achieved a 66.7%success rate,whereas the success rate of the surgery technique was 33.3%.Surviving surgical rabbits might not meet subsequent experimental requirements due to TEF-related *** the modified magnetic compression group,one rabbit died,possibly due to magnet corrosion,and another died from tracheal magnet *** events occurred during the second round of modified magnetic compression modeling,with one rabbit possibly succumbing to aggravated lung *** operation time of the first round of modified magnetic compression was 3.2±0.6 min,which was significantly reduced to 2.1±0.4 min in the second round,compared to both the first round and that of the original *** The modified magnetic compression technique exhibits lower stress responses,a simple procedure,a high success rate,and lower modeling costs,making it a more appropriate choice for constructing TEF models in

关键词： Tracheoesophageal fistula Modified magnetic compression technique Post-modeling evaluation Pneumonia Malnutrition

Theoretical characterization of the adsorption configuration of pyrrole on Si(100)surface by x-ray spectroscopy

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Chinese Physics B 2024年第2期33卷 430-435页

作者：李好情明静姜志昂李海波马勇宋秀能 School of Physics and Electronics Shandong Normal UniversityJinan 250358China

The possible configurations of pyrrole absorbed on a Si(100)surface have been investigated by x-ray photoelectron spectroscopy(XPS)and near-edge x-ray absorption fine structure(NEXAFS)*** C-1s XPS and NEXAFS spectra of these adsorption configurations have been calculated by using the density functional theory(DFT)method and fullcore hole(FCH)approximation to investigate the relationship between the adsorption configurations and the *** result shows that the XPS and NEXAFS spectra are structurally dependent on the configurations of pyrrole absorbed on the Si(100)*** with the XPS,the NEXAFS spectra are relatively sensitive to the adsorption configurations and can accurately identify *** NEXAFS decomposition spectra produced by non-equivalent carbon atoms have also been calculated and show that the spectral features vary with the diverse types of carbon atoms and their structural environments.

关键词： pyrrole silicon surface x-ray photoelectron spectroscopy(XPS) near-edge x-ray absorption fine structure(NEXAFS)

准周期激励Duffing系统中奇异非混沌吸引子的判别方法

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力学与实践 2024年第2期46卷 332-341页

作者：秦波张颖上海理工大学机械工程学院上海200093 海军军医大学第三附属医院(上海东方肝胆外科医院)超声介入科上海200438 同济大学医学院上海200092

奇异非混沌动力学是非线性动力学领域中的新课题。本文以准周期激励Duffing振子为例,对其产生的奇异非混沌吸引子(strange nonchaotic attractors,SNAs)进行分析。通过三维庞加莱截面和定量方法如傅里叶变换、李雅普诺夫指数、李雅普诺... 详细信息

奇异非混沌动力学是非线性动力学领域中的新课题。本文以准周期激励Duffing振子为例,对其产生的奇异非混沌吸引子(strange nonchaotic attractors,SNAs)进行分析。通过三维庞加莱截面和定量方法如傅里叶变换、李雅普诺夫指数、李雅普诺夫维数、关联维数和盒维数检测SNAs是否存在。研究结果表明,傅里叶变换无法判断混沌与奇异非混沌行为。而李雅普诺夫指数、李雅普诺夫维数可以作为检测系统混沌与非混沌指标。关联维数和盒维数显著表明系统奇异与非奇异性,从而阐明适用于准周期驱动Duffing振子中存在SNAs的判别方法,并为其他类似系统检测SNAs提供指导。

关键词：奇异非混沌吸引子准周期激励李雅普诺夫指数关联维数 Duffing振子

Effect of aflibercept combined with triamcinolone acetonide on aqueous humor growth factor and inflammatory mediators in diabetic macular edema

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 297-303页

作者： De-Shuang Li Hong-Xia Liao Jing-Lin Zhang bo qin Shenzhen Aier Eye Hospital Aier Eye HospitalJinan UniversityShenzhen 518031Guangdong ProvinceChina Guangzhou Aier Eye Hospital Jinan UniversityGuangzhou 510040Guangdong ProvinceChina

AIM:To investigate the efficacy of aflibercept combined with sub-tenon injection of triamcinolone acetonide(TA)in treating diabetic macular edema(DME)and to examine changes in growth factors and inflammatory mediator levels in aqueous humor after ***:Totally 67 DME patients(67 eyes)and 30 cataract patients(32 eyes)were enrolled as the DME group and the control group,*** DME group was divided into the aflibercept group(34 cases)and the aflibercept combined with TA group(combined group,33 cases).The aqueous humor of both groups was collected during the study *** aqueous levels of vascular endothelial growth factor(VEGF),monocyte chemoattractant protein-1(MCP-1),interleukin-6(IL-6),interleukin-8(IL-8),and interleukin-1β(IL-1β)were detected using a microsphere suspension array technology(Luminex 200TM).Aqueous cytokines,best-corrected visual acuity(BCVA),central macular thickness(CMT),and complications before and after treatment were compared between the aflibercept group and combined ***:The concentrations of VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor were significantly higher in the DME group than those of the control group(all P0.05).CONCLUSION:The cytokines VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor of DME patients are significantly *** and aflibercept combined with TA have good efficacy in DME patients,can effectively reduce CMT,improve the patient’s vision,and have high *** combined with TA can quickly downregulate the aqueous humor cytokines and help to relieve macular edema ***,the long-term eff

关键词： diabetic macular edema aqueous humor cytokines aflibercept triamcinolone acetonide

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深海海底山引起的混响杂波联合预报方法

哈尔滨工程大学学报 2024年第3期45卷 466-473页

作者：杨华秦继兴莫东鹏高博中国科学院声学研究所声场声信息国家重点实验室北京100190 中国科学院大学物理学院北京100190 中国人民解放军92578部队北京100161 中国海洋大学信息海洋技术学院山东青岛266100

针对深海复杂海域的主动探测混响杂波干扰的联合工程预报问题,本文基于三维射线-简正波理论建立了深海海底山引起的混响杂波联合预报方法,将海底山当作一类具有强散射特征的体积散射源,提出了对海底山的体积散射函数在水平和垂直维度上... 详细信息

针对深海复杂海域的主动探测混响杂波干扰的联合工程预报问题,本文基于三维射线-简正波理论建立了深海海底山引起的混响杂波联合预报方法,将海底山当作一类具有强散射特征的体积散射源,提出了对海底山的体积散射函数在水平和垂直维度上进行网格划分的数值积分方法。研究了不同水平方位,不同地形条件下的海底混响和海底山杂波强度特征。实现了小起伏水平海底和海底山地形的深海海底混响和海底山杂波的统一预报。研究结果表明:海底山的体积散射源经过水平和垂直维度的划分后,可以和水平海底的小尺度散射过程形成有效耦合,而海底山杂波的时间尺度和包络强度分别受海底山的水平宽度和垂直高度影响。通过海上实验数据比对,验证了本文所提预报方法的准确性。

关键词：深海混响海底山杂波混响杂波模型射线理论主动声呐体积散射混响预报

高灵敏度内置电容式控制棒棒位传感器静态特性研究

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核动力工程 2024年第1期45卷 194-200页

作者：李彦霖秦本科薄涵亮清华大学核能与新能源技术研究院北京100084

内置电容式控制棒棒位传感器可应用于控制棒水力驱动系统。针对四螺旋电极电容式控制棒棒位传感器,本文对双电容值方法测量控制棒棒位的静态特性进行了研究。通过开展传感器的原理性实验,建立了传感器的计算模型,并进行了数值模拟结果... 详细信息

内置电容式控制棒棒位传感器可应用于控制棒水力驱动系统。针对四螺旋电极电容式控制棒棒位传感器,本文对双电容值方法测量控制棒棒位的静态特性进行了研究。通过开展传感器的原理性实验,建立了传感器的计算模型,并进行了数值模拟结果的实验验证。假定被测杆整体偏心,利用数值模拟方法建立了两组电容值与控制棒棒位的函数关系式,并对该函数关系式进行了误差分析,分析了该关系式对被测杆不同偏转方向和倾斜状态的适用性。研究结果表明,利用双电容值的棒位测量方法,对控制棒棒位的最大测量误差小于±6 mm,传感器灵敏度在0.05 pF/mm量级,能够满足控制棒棒位的实际测量需求。

关键词：控制棒水力驱动系统控制棒棒位电容式传感器