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Exosomes:the next-generation therapeutic platform for ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1221-1235页

作者： Wenjing Yin Hongyin Ma Yang Qu Jiaxin Ren Yingying sun zhen-Ni Guo Yi Yang Stroke Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina Neuroscience Research Center Department of NeurologyFirst Hospital of Jilin UniversityChangchunJilin ProvinceChina

Current therapeutic strategies for ischemic stroke fall short of the desired objective of neurological functional ***,there is an urgent need to develop new methods for the treatment of this *** are natural cell-derived vesicles that mediate signal transduction between cells under physiological and pathological *** have low immunogenicity,good stability,high delivery efficiency,and the ability to cross the blood–brain *** physiological properties of exosomes have the potential to lead to new breakthroughs in the treatment of ischemic *** rapid development of nanotechnology has advanced the application of engineered exosomes,which can effectively improve targeting ability,enhance therapeutic efficacy,and minimize the dosages *** in technology have also driven clinical translational research on *** this review,we describe the therapeutic effects of exosomes and their positive roles in current treatment strategies for ischemic stroke,including their antiinflammation,anti-apoptosis,autophagy-regulation,angiogenesis,neurogenesis,and glial scar formation reduction ***,it is worth noting that,despite their significant therapeutic potential,there remains a dearth of standardized characterization methods and efficient isolation techniques capable of producing highly purified *** optimization strategies should prioritize the exploration of suitable isolation techniques and the establishment of unified workflows to effectively harness exosomes for diagnostic or therapeutic applications in ischemic ***,our review aims to summarize our understanding of exosome-based treatment prospects in ischemic stroke and foster innovative ideas for the development of exosome-based therapies.

关键词： blood–brain barrier electroacupuncture engineering exercise exosomes ischemic stroke mesenchymal stem cells microglia neuroprotection stents

Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen xiu-Qing Qiao Guo Hui Bojing sun Dongfang Hou Meidi Wang Xueqian Wu Tao Wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Cadmium sulfide

Magnetron sputtered nickel oxide with suppressed interfacial defect states for efficient inverted perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 348-355页

作者： Guoqiang Ma Qin Tan Zhaoning Li Jingwei xiu Jiafeng Wang Tianle Cheng Dong He Qiang sun Xuhang Ma Francesco Lamberti Zhubing He Department of Materials Science and Engineering Institute of Innovative Materials (I2M) Shenzhen Key Laboratory of Full Spectral Solar Electricity Generation (FSSEG)Southern University of Science and Technology (SUSTech) Core Research Facilities Southern University of Science and Technology Department of Chemical Sciences Department of Industrial Engineering University of Padova

Widely used spin-coated nickle oxide （NiOx） based perovskite solar cells often suffer from severe interfacial reactions between the NiOxand adjacent perovskite layers due to surface defect states,which inherently impair device performance in a long-term view,even with surface molecule *** this study,we developed high-quality magnetron-sputtered NiOxthin films through detailed process optimization,and compared systematically sputtered and spin-coated NiOxthin film surfaces from materials to *** sputtered NiOxfilms exhibit improved crystallinity,smoother surfaces,and significantly reduced Ni3+or Ni vacancies compared to their spin-coated ***,the interface between the perovskite and sputtered NiOxfilm shows a substantially reduced density of defect *** solar cells （PSCs） fabricated with our optimally sputtered NiOxfilms achieved a high power conversion efficiency （PCE） of up to 19.93%and demonstrated enhanced stability,maintaining 86.2% efficiency during 500 h of maximum power point tracking under one standard sun ***,with the surface modification using (4-(2,7-dibromo-9,9-dimethylacridin-10（9H）-yl)butyl)p hosphonic acid （DMAcPA）,the device PCE was further promoted to 23.07%,which is the highest value reported for sputtered NiOxbased PSCs so far.

关键词： Perovskite

Insufficient MIRO1 contributes to declined oocyte quality during reproductive aging

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Science China Life Sciences 2025年

作者： zhen-Nan Pan Hao-Lin Zhang Kun-Huan Zhang Jia-Qian Ju Jing-Cai Liu Shao-Chen sun College of Animal Science and Technology Nanjing Agricultural University Reproductive Medicine Centre The Affiliated Yantai Yuhuangding Hospital of Qingdao University

Mitochondrial Rho-GTPase 1 (MIRO1) is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis. In present study, we reported the crucial roles of MIRO1 in mammalian oocyte meiosis and its potential relationship with aging. We found that MIRO1 expressed in mouse and porcine oocytes, and its expression decreased in aged mice. MIRO1 deficiency caused the failure of meiotic resumption and polar body extrusion in both mouse and porcine oocytes, which could be rescued by exogenous MIRO1supplementation. Mass spectrometry data indicated that MIRO1 associated with several cytoskeleton and cell cycle-related proteins, and MIRO1 regulated motor protein Dynein for microtubule-organizing centers (MTOCs) dynamics at germinal vesicle (GV) stage, which determined meiotic resumption. Furthermore, we found that MIRO1 regulated Aurora A and kinesin family member 11 (KIF11) for meiotic spindle assembly in oocytes. Besides, MIRO1 associated with several mitochondria-related proteins dynamic-related protein 1 (DRP1),Parkin and lysosomal-associated membrane protein 2 (LAMP2) for mitochondrial dynamics and mitophagy during oocyte meiosis. Taken together, our results suggested that MIRO1 played pivotal roles in meiotic resumption, spindle assembly and mitochondrial function in mouse and porcine oocytes, and its insufficiency might contribute to the oocyte maturation defects during aging.

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全要素生产率提升与新旧动能转换——以青岛为例

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青岛科技大学学报（社会科学版） 2018年第2期34卷 25-30页

作者：马秀贞孙习武中共青岛市委党校科研部山东青岛266071 青岛市发改委经济研究院山东青岛266071

利用青岛1981—2016年数据,运用索洛模型对青岛全要素生产率进行测度。测度结果显示,青岛经济持续高速增长的主要动能总体上来自要素投入的增加,经济增长仍以旧动能为主。因此青岛新旧动能转换空间巨大。基于全要素生产率提升视角,新旧... 详细信息

利用青岛1981—2016年数据,运用索洛模型对青岛全要素生产率进行测度。测度结果显示,青岛经济持续高速增长的主要动能总体上来自要素投入的增加,经济增长仍以旧动能为主。因此青岛新旧动能转换空间巨大。基于全要素生产率提升视角,新旧动能转变的方向和路径主要有:要素效率提升与升级,存量调整和增量培育,产业结构优化,市场主体素质与核心竞争力提升,制度变革和科技创新。

关键词：全要素生产率新旧动能转换经济增长青岛

男女儿童青少年精神分裂症患者临床特征的比较

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临床精神医学杂志 2016年第6期26卷 416-418页

作者：王秀珍孙太鹏孙晖杨林刘书伟江苏省淮安市第三人民医院 223001

目的:比较儿童青少年精神分裂症男性与女性患者临床特征的差异。方法:对125例男性(男性组)和133例女性(女性组)儿童青少年精神分裂症患者的年龄、发病年龄、病前诱因、阳性家族史、病程特点、住院天数、简明精神病量表(BPRS)、大体评定... 详细信息

目的:比较儿童青少年精神分裂症男性与女性患者临床特征的差异。方法:对125例男性(男性组)和133例女性(女性组)儿童青少年精神分裂症患者的年龄、发病年龄、病前诱因、阳性家族史、病程特点、住院天数、简明精神病量表(BPRS)、大体评定量表(GAS)及临床疗效总评量表(CGI)评分等临床特征进行比较。结果:男性与女性患者在年龄、发病年龄、病前诱因、阳性家族史、病程特点、住院天数方面比较差异无统计学意义(P均>0.05)。BPRS评分中敌对性、动作迟缓、情感淡漠、缺乏活力因子分男性组高于女性组(t=2.164,t=3.317,t=2.096,t=2.230;P0.05),出院时CGI-EI评分女性组高于男性组(t=2.466)、自知力评分男性组高于女性组(t=2.403),差异有统计学意义(P均<0.05)。结论:男性儿童青少年精神分裂症患者的临床特征以情感淡漠、缺乏活力等阴性症状为主,女性则以幻觉、思维障碍等阳性症状更突出;女性临床疗效优于男性。

关键词：儿童青少年精神分裂症临床特征

Analysis model of internal residence time distribution for fluid flow in a multi-strand continuous casting tundish

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Journal of Iron and Steel Research International 2024年第9期31卷 2186-2195页

作者： Qiang Yue Yue Li Zi-ming Wang Ben-chen sun xiu-zhen Wang School of Metallurgical Engineering Anhui University of TechnologyMa’anshan243002AnhuiChina School of Mechanical Engineering Anhui University of TechnologyMa’anshan243002AnhuiChina

The external residence time distribution(RTD)curve is extensively used to characterise fluid flow within the single-strand continuous casting *** volume fraction determination typically relies on the external RTD curve to reveal macroscopic fluid flow *** on the external RTD to effectively assess dead volume fractions and other fluid characteristics under conditions of internal non-uniform flow,an internal RTD was *** a smooth pipe under laminar flow conditions,the dead region occupies 25%of the total volume,which is defined as the space between the pipe wall and a radius of 0.866 R0(where R0 is the radius of pipe).Under turbulent flow conditions,the dead region only occupies 0.38%of the reactor’s internal volume,spanning from the pipe wall to a radius of 0.00189 *** results obtained using the external RTD method are consistent with the theoretical *** trials involving water were conducted to examine the flow of molten steel within a five-strand ***,an analysis approach employing internal RTD was employed to evaluate fluid mixing within a multi-flow continuous casting *** the internal RTD method,the analysis revealed that the whole dead zone volume fraction of the intermediate package decreased from 26.9%to 18.9%after the addition of the flow control *** dead volume fraction can be accurately depicted by utilising the internal mean RTD *** association between the internal RTD function and the external average RTD can be effectively employed to scrutinise the response curve of the tracer within a system exhibiting uneven flow distribution.

关键词： Tundish Internal residence time distribution Dead volume Critical velocity Mathematical modelling

Some questions about landscape modelling

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Journal of Environmental Sciences 2001年第4期13卷 459-465页

作者： Michel Godron LI xiu-zhen CCAS F18410BrinonFrance Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China

The paper discusses mainly about the modelling process and related problems with examples from Chinese and French cases. Five practical problems must be solved for modelling the functioning of any landscape: ( 1) The field data are necessarily taken with a sampling procedure that implies a spatial (and often temporal) scale. (2) Every landscape modelled has to be identified, delimited and characterised before application of the hierarchical theory. (3) The functioning of a landscape involves data of multiple types (climate, soil, vegetation, fauna, buildings, communications, economy, aesthetics, etc.) which must be integrated in a holistic approach. (4) Every landscape is spatially heterogeneous, and the structure of the model must be more or less isomorphic with its heterogeneity. ( 5) The evolution of the landscape must be modelled on a rather long period of time. For all these reasons, it is necessary to build ad hoc models. Object-oriented computing languages may be useful for this purpose.

关键词： landscape modelling scale hierarchy holistic approach application

Quantum Remote State Preparation Based on Quantum Network Coding

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Computers, Materials & Continua 2022年第10期73卷 119-132页

作者： zhen-zhen Li Zi-Chen Li Yi-Ru sun Haseeb Ahmad Gang Xu xiu-Bo Chen School of Information Engineering Beijing Institute of Graphic CommunicationBeijing102600China School of Computer Science and Information Engineering Zhejiang Gongshang UniversityHangzhou310018China Information Security Center State key Laboratory of Networking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China Department of Computer Science National Textile UniversityFaisalabad37610Pakistan School of Information Science and Technology North China University of TechnologyBeijing100144China Advanced Cryptography and System Security Key Laboratory of Sichuan Province China

As an innovative theory and technology,quantum network coding has become the research hotspot in quantum network *** this paper,a quantum remote state preparation scheme based on quantum network coding is *** with the general quantum remote state preparation schemes,our proposed scheme brings an arbitrary unknown quantum state finally prepared remotely through the quantum network,by designing the appropriate encoding and decoding steps for quantum network *** is worth mentioning,from the network model,this scheme is built on the quantum k-pair network which is the expansion of the typical bottleneck network—butterfly ***,it can be treated as an efficient quantum network preparation scheme due to the characteristics of network coding,and it also makes the proposed scheme more applicable to the large-scale quantum *** addition,the fact of an arbitrary unknown quantum state remotely prepared means that the senders do not need to know the desired quantum ***,the security of the proposed scheme is ***,this scheme can always achieve the success probability of 1 and 1-max flow of value ***,the communication efficiency of the proposed scheme is ***,the proposed scheme turns out to be practicable,secure and efficient,which helps to effectively enrich the theory of quantum remote state preparation.

关键词： Quantum remote state preparation quantum network coding quantum k-pair network