检索结果-南通市图书馆

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 6-20页

作者： xiu-Yun Zhao De-En xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao Zi-Jian Wang xiu-Liang xu Jiang-Hua Yang Department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(P<0.001).The distribution of pathological types of appendicitis was different between the two groups(P<0.001).The incidence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

春季敏感时期三峡库区典型支流富营养化评价

中国农村水利水电 2016年第11期 48-51,57页

作者：陈秀秀宋林旭纪道斌吕垚刘德富三峡大学水利与环境学院湖北宜昌443002 三峡库区生态环境教育部工程研究中心(三峡大学) 湖北宜昌443002

基于2014年4月对三峡水库库首9条支流水环境监测分析结果,使用改进的综合营养状态指数法对其水体营养化状况进行分析和评价。结果表明：支流水体中的总氮含量范围为0.450-3.208 mg/L;总磷含量范围为0.001-0.329 mg/L;叶绿素浓度范围为0.... 详细信息

基于2014年4月对三峡水库库首9条支流水环境监测分析结果,使用改进的综合营养状态指数法对其水体营养化状况进行分析和评价。结果表明：支流水体中的总氮含量范围为0.450-3.208 mg/L;总磷含量范围为0.001-0.329 mg/L;叶绿素浓度范围为0.737-184.610 mg/m3;透明度范围为0.2-4.5 m;高锰酸盐指数范围为1.032-5.451 mg/L,综合营养指数从库区下游到库区上游有递减趋势。

关键词：三峡库区支流富营养化综合营养状态指数

开展多学科协作以切实提高结节性硬化症诊疗水平

在线全文

学校读者我要写书评

暂无评论

临床误诊误治 2016年第10期29卷 4-7页

作者：王俊吴秀秀徐凯峰中国医学科学院北京协和医学院北京协和医院呼吸科北京100730

结节性硬化症(tuberous sclerosis complex,TSC)是一种涉及多系统、多年龄段人群的遗传性疾病。患者常因不同的临床表现就诊多个专科,很少能够得到多系统、全面的评估,漏误诊现象并不少见。因此,亟须通过多学科协作(multidisciplinary t... 详细信息

结节性硬化症(tuberous sclerosis complex,TSC)是一种涉及多系统、多年龄段人群的遗传性疾病。患者常因不同的临床表现就诊多个专科,很少能够得到多系统、全面的评估,漏误诊现象并不少见。因此,亟须通过多学科协作(multidisciplinary team,MDT)进一步提高我国TSC的诊疗水平。在建立区域性TSC专病门诊和MDT的基础上,应构建全国性TSC协作网络,可以开展临床注册登记、规范化诊疗技术推广及新诊疗技术相关研究,并建立转诊体系和远程会诊系统,以有效提高TSC患者诊治水平,改善患者生活质量,对提高医疗质量、有效利用医疗资源、推动科学研究及科学研究在临床中的转化应用,均有积极意义。

关键词：结节性硬化症多学科协作诊断治疗述评

如何减少结节性硬化症相关淋巴管肌瘤病的误漏诊

在线全文

学校读者我要写书评

暂无评论

临床误诊误治 2016年第10期29卷 1-3页

作者：吴秀秀王俊徐凯峰中国医学科学院北京协和医学院北京协和医院呼吸科北京100730

结节性硬化症(tuberous sclerosis complex,TSC)是一种常染色体显性遗传病,以细胞异常增生和组织发育不良为特征,可引起全身多个系统器官损害,肺部受累主要表现为淋巴管肌瘤病(lymphangioleiomyomatosis,LAM)。TSC相关LAM因临床表现多样... 详细信息

结节性硬化症(tuberous sclerosis complex,TSC)是一种常染色体显性遗传病,以细胞异常增生和组织发育不良为特征,可引起全身多个系统器官损害,肺部受累主要表现为淋巴管肌瘤病(lymphangioleiomyomatosis,LAM)。TSC相关LAM因临床表现多样,专科医师对其认知有限,误漏诊时有发生,以致延误病情,故早期诊断对于疾病的治疗及预后至关重要。对于成年女性TSC患者,需通过胸部高分辨CT和血清血管内皮生长因子-D等筛查与诊断方法确认是否患有LAM。提高相关专科医师对TSC相关LAM的认识,熟知其多种临床表现,详细问诊,仔细查体,认真鉴别诊断,可提高临床诊断率。

关键词：结节性硬化症淋巴管肌瘤病误诊漏诊述评

Efficacy,safety and treatment satisfaction of transition to a regimen of insulin degludec/aspart:A pilot study

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2025年第1期16卷 65-73页

作者： Na Yang Lu Lv Shu-Meng Han Li-Yun He Zi-Yi Li Yu-Cheng Yang Fan Ping Ling-Ling xu Wei Li Hua-Bing Zhang Yu-xiu Li Department of Endocrinology Key Laboratory of Endocrinology of National Health CommissionPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Allergy Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic DiseasesNational Clinical Research Center for Dermatologic and Immunologic DiseasesPeking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China

BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient data from the Chinese *** To demonstrate the efficacy,safety,and treatment satisfaction associated with the transition to IDegAsp in type 2 diabetes mellitus(T2DM).METHODS In this 12-week open-label,non-randomized,single-center,pilot study,patients with T2DM receiving thrice-daily insulin or intensive insulin treatment were transitioned to twice-daily injections of insulin *** doses,hemoglobin A1c(HbA1c)levels,fasting blood glucose(FBG),hypoglycemic events,a Diabetes Treatment Satisfaction Questionnaire,and other parameters were assessed at baseline and *** This study included 21 participants.A marked enhancement was observed in the FBG level(P=0.02),daily total insulin dose(P=0.03),and overall diabetes treatment satisfaction(P<0.01)in the participants who switched to *** was a decrease in HbA1c levels(7.6±1.1 vs 7.4±0.9,P=0.31)and the frequency of hypoglycemic events of those who switched to IDegAsp decreased,however,there was no statistically significant *** The present findings suggest that treatment with IDegAsp enhances clinical outcomes,particularly FBG levels,daily cumulative insulin dose,and overall satisfaction with diabetes treatment.

关键词： Insulin degludec/aspart Type 2 diabetes management Basal-bolus insulin therapy Pre-mixed insulin Diabetes treatment satisfaction questionnaire

Equilibrium Strategies in an Unobservable On-off Fluid Queue

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematicae Applicatae Sinica 2022年第2期38卷 324-336页

作者： xiu-li xu Shuo WANG School of Science Yanshan UniversityQinhuangdao 060004China

This paper considers an on-off fluid queue *** on and off states of the system appear alternately,and the sojourn times at these two different states are independent,and each one follows an exponential *** fluid flows into the system buffer with some strategies to wait for the system service under the first-come first-served *** the system can process the fluid in the buffer only when the system is on *** given utility functions such as an expected average social profit,and an individual expected profit,the equilibrium strategies are characterized under both the fully unobservable case and the partially observable case.

关键词： fluid model on-off equilibrium strategies optimal benefit

Potential Effects of the COVID-19 Pandemic on the Developing Brain

在线全文

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2023年第2期39卷 343-347页

作者： Xiang Yu xiu xu State Key Laboratory of Membrane Biology School of Life SciencesPeking-Tsinghua Center for Life Sciencesand Peking University McGovern InstitutePeking UniversityBeijing 100871China Autism Research Center of Peking University Health Science Center Beijing 100191China Chinese Institute for Brain Research Beijing 102206China Department of Child Healthcare Children’s Hospital of Fudan UniversityShanghai 201102China

By now,the COVID-19 pandemic has affected all corners of the world for over two *** years constitutes 4%of the life experience of a 50-year-old,or 50%of the life experience of a ***,in terms of the sheer proportion of... 详细信息

关键词： has she ID

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

用高产菌株制备T_4—DNA连接酶

军事医学 1982年第6期33卷 681-685页

作者：于公义王光荣李秀珍徐秀英军事医学科学院基础医学研究所

DNA连接酶是遗传工程研究工作中必不可少的工具酶,常用的有两类即大肠杆菌DNA连接酶及T4-DNA连接酶。其中T4-DNA连接酶不仅具有连接带有粘末端DNA片段的能力,而且还具有连接平末端DNA片段的能力,因而T4-DNA连接酶比大肠杆菌DNA连接酶的... 详细信息

DNA连接酶是遗传工程研究工作中必不可少的工具酶,常用的有两类即大肠杆菌DNA连接酶及T4-DNA连接酶。其中T4-DNA连接酶不仅具有连接带有粘末端DNA片段的能力,而且还具有连接平末端DNA片段的能力,因而T4-DNA连接酶比大肠杆菌DNA连接酶的用途更大。

关键词：连接酶合成酶 T4 高产菌株 DNA