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Saponin from Tupistra chinensis Bak Inhibits NF-κB Signaling in Sarcoma S-180 Cell Mouse Xenografts

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Current Medical Science 2018年第4期38卷 697-703页

作者： Tai-sheng YE xiu-ping wang Xian-mei ZHANG Man-ling ZHANG Ying-wen ZHANG Department of Traditional Chinese Medicine Zhongnan Hospital Wuhan University Wuhan 430071 China Department of Integrated Traditional Chinese Medicine the Third Hospital of Wuhan Wuhan 430062 China

This study examined the effect of saponins from Tupistra chinensis Bak （STCB） on the growth of sarcoma S-180 cells in vitro and in mouse xenografts as well as the underlying mechanisms. Cell proliferation was assessed by MTT assay. Cell cycle distribution was determined by flow cytometry. Sarcoma S-180 tumor-bearing mice were treated with different doses of STCB with 10 μg/mL 5-fluorouracil （5-Fu） as a positive control. The activity of nuclear factor （NF）-κB was detected by gel mobility shift assay. The mRNA level of NF-κB was determined by real-time quantitative RT-PCR. The results showed that in vitro STCB inhibited the growth of S-180 cells in a concentration-dependent manner, which was accompanied by cell cycle arrest at S-phase. In vivo STCB significantly inhibited the growth of S-180 tumor mouse xenografts in a dose-dependent manner with apparent induction of cell apoptosis. Moreover, STCB inhibited the activity of NF-rd3 p65 and reduced the expression of NF-κB p65 mRNA in mouse xenografts. It was concluded that STCB inhibits the proliferation and cell cycle progression of S- 180 cells by suppressing NF-κB signaling in mouse xenografts. Our findings suggest STCB is a promising agent for the treatment of sarcoma.

关键词： Tupistra chinensis Bak S-180 cells proliferation nuclear factor-κB

Proteomics for early prenatal screening of gestational diabetes mellitus

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World Journal of Clinical Cases 2024年第26期12卷 5850-5853页

作者： Liang Wu xiu-ping wang Yun-Xia Zhu Yan-ping Tan Chun-Ming Li Department of Dermatology The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Dermatology Jiangxi Provincial Maternal and Child Health HospitalNanchang 330000Jiangxi ProvinceChina

In this editorial,we comment on the article by Cao et *** applying isobaric tags for relative and absolute quantification technology coupled with liquid chromatography-tandem mass spectrometry,the researchers observed significant differential expression of 47 proteins when comparing serum samples from pregnant women with gestational diabetes mellitus(GDM)to the healthy *** symptoms may involve abnormalities in inflammatory response,complement system,coagulation cascade activation,and lipid *** binding protein 4 and angiopoietin like 8 are potential early indicators of *** stands out as one of the most prevalent metabolic complications during pregnancy and is linked to severe maternal and fetal outcomes like pre-eclampsia and ***,none of the biomarkers discovered so far have demonstrated effectiveness in predicting *** topic was designed to foster insights into advances in the application of proteomics for early prenatal screening of GDM.

关键词： Gestational diabetes mellitus Proteomics Biomarker Blood Placenta

社会网络在创新领域应用研究的知识图谱——基于CiteSpace的可视化分析

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经济管理 2017年第10期43卷 192-208页

作者：张秀萍王振中央民族大学管理学院北京100081

本文以Web of Science数据库(SCI、SSCI)收录的发表于1991—2016年的1775篇社会网络在创新领域应用的文献为研究样本,运用文献计量法分析了研究论文的发文量年代分布,运用Cite Space软件绘制科学知识图谱,分析了该领域主要国家/研究机... 详细信息

本文以Web of Science数据库(SCI、SSCI)收录的发表于1991—2016年的1775篇社会网络在创新领域应用的文献为研究样本,运用文献计量法分析了研究论文的发文量年代分布,运用Cite Space软件绘制科学知识图谱,分析了该领域主要国家/研究机构的合作情况、核心研究学者及其经典文献、研究热点演进过程、研究前沿及发展趋势。结果显示,社会网络在创新领域应用的研究历经10年增速缓慢的酝酿期后,自2002年发文量持续高速增长;美、德两国在该领域的研究处于领先地位,且形成了以"英国—德国—加拿大—芬兰—美国"为中心的核心研究群体;以Granovetter、Burt为代表的社会经济学家为该领域研究奠定了社会网络的方法论基础和理论框架,随后由以Hansen、Cohen为代表的创新领域学者引入创新研究中;该领域研究热点经历了"社会网络理论构建—企业创新网络研究—基于网络能力的创新网络研究—基于社交媒体的创新扩散研究—基于校企合作的创新扩散研究"五个阶段;当前研究前沿主要聚焦于网络能力、网络边界、意见领袖及公共卫生防治四方面在创新研究中的重要作用。最后,本文构建了创新生成环节、创新驱动环节、创新扩散环节组成的社会网络在创新领域应用的研究框架,以期为深入研究社会网络与创新关系的学者提供借鉴和参考。

关键词： CiteSpace 知识图谱社会网络创新

Progress in recent study of drought,flood and waterlogging damages in China

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Journal of Geographical Sciences 1998年第1期8卷 52-64页

作者： Liao RonghuaShaoyang Teacher’s College, Hunan 422000, CHINAYu Guangming xiu Dongwen Chen ping wang ChaonanDepartment of Geography, Central China Normal University, Wuhan 430070, CHINA

The Drought, Flood and Waterlogging Damage (DFWD) study is related to many subjects such as meteorology and climatology, hydrology, geography, and agricultural science In the aforementioned subjects, substantial work has been done on DFWD study by a lot of researchers from the views of their specialities This paper tries to introduce the recent progress on the field Four main problems are referred to the DFWD study, they are as following: (1) The change sequence in historical period The historical data must be quantatitively processed For this purpose, many schemes were suggested in the past years Studies of the historical DFWD have been emphasized in the last fivehundred years as well as the other time scales (2) The mechanism and trigger event Natural disasters are related to factors disastrous to human activities in the evolution of physical environment, and they can reflect natural features of constitution of the physical environment The factors include the monsoon circulation, the sea tempereature effects, the ENSO, and the others (3) The loss estimation The DFWD is not a pure meteorological damage, and it is also a complex ecological damage The ecological effects, crop influences and other socialenvironment features will be considered on the estimation of DFWD loss (4) The measures of prevention and control Many forecast models are developed, and the measures of prevention and control are suggested, ie, the adoption of measures combining engineering techniques with biological measurres In the past years, advances have been made in those four aspects

关键词： drought flood and waterlogging damage basic study recent progress

Re-evaluating the necessity of routine laboratory monitoring during isotretinoin therapy for acne

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World Journal of Clinical Cases 2024年第28期12卷 6237-6240页

作者： Yun-Xia Zhu Liang Wu Sheng-Cai Zhu xiu-ping wang Deng Zhang Yan-ping Tan Xiao-Liang Ouyang Chun-Ming Li Department of Dermatology The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Dermatology Jiangxi Provincial Maternal and Child Health HospitalNanchang 330000Jiangxi ProvinceChina Department of Plastic Surgery The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

In this letter,we discuss the topic of necessity of routine laboratory monitoring during isotretinoin treatment for *** to Park and colleagues,it is advisable to monitor the levels of triglycerides,alanine aminotransferase,and aspartate aminotransferase every 5 to 6 ***,the levels of total cholesterol and low-density lipoprotein should be checked within the first two months of *** is a commonly prescribed agent mainly used to treat *** its high effectiveness,it necessitates regular monitoring of laboratory parameters due to its side effect ***,there remains a lack of consensus on the appropriate frequency for monitoring these parameters during treatment with *** letter will provide insight into this complex and controversial *** on existing literature,we concluded that the incidence of changes in lipid and liver aminotransferase levels during isotretinoin treatment for acne was low and likely clinically *** generally healthy people,we recommend testing lipid and liver profiles once at baseline and a second time at the peak ***,frequent testing might still be beneficial in certain populations of patients.

关键词： Acne Isotretinoin Laboratory monitoring Liver function Blood lipids

Development of an enzyme immune assay for detecting M2 autoantibodies specific for primary biliary cirrhosis

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Hepatobiliary & Pancreatic Diseases International 2003年第2期2卷 606-610页

作者： Xiao-Hua Jiang Xiao-Yun Fang Ren-Qian Zhong xiu-ping wang Yin Hu Xian-Tao Kong the Department of Laboratory Medicine, 85th Military Hospital, Shanghai 200052, China People’s Liberation Army Clinical Immunology Center, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China Shanghai University of Engineering Science, Shanghai 200335. Department of Laboratory Medicine 85th Military Hospital Shanghai 200052 China. jhlulu@***

OBJECTIVE: To develope a new enzyme immune assay (ELISA) for detection of M2 antibody specific for primary biliary cirrhosis (PBC) by using a triple hybrid clone as antigen, which coexpresses the three immunodominant lipoyl domains of PDC-E2, BCOADC-E2 and OGDC-E2 from human sources. METHODS: After expressing autoantigens of PBC in prokaryote by constructing recombinant expressive plasmid successfully, the fusion protein was purified by affinity chromatography. The sera of 17 PBC patients were examined. As controls, the sera of 167 non-PBC patients and the sera of 1225 normal controls aged under 28 were examined. RESULTS: None of the sera from the non-PBC patients or the normal controls was positive for anti-M2 shown by the new ELISA. However, the positivity rate for anti-M2 in the PBC patients was 100% (17/17), as shown by the new ELISA. CONCLUSION: The detection system with a good sensitivity and specificity may be used as a powerful method for the diagnosis of PBC.

关键词： liver cirrhosis biliary autoantibodies :antoantigen immunoassay diagnosis

C1q肿瘤坏死因子相关蛋白3在心血管疾病中的研究进展

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中国动脉硬化杂志 2016年第10期24卷 1059-1063页

作者：娄秀萍冯帅王玉凡边云飞山西医科大学第二医院心内科心血管疾病诊疗与临床药理山西重点实验室山西省太原市030001

C1q肿瘤坏死因子相关蛋白3是新近发现的C1q肿瘤坏死因子相关蛋白家族中的一员。近年来发现它在糖脂代谢、动脉粥样硬化、肥胖、高血压、促进缺血心肌新生血管形成等心血管疾病方面发挥作用。文章将对C1q肿瘤坏死因子相关蛋白3在心血管... 详细信息

C1q肿瘤坏死因子相关蛋白3是新近发现的C1q肿瘤坏死因子相关蛋白家族中的一员。近年来发现它在糖脂代谢、动脉粥样硬化、肥胖、高血压、促进缺血心肌新生血管形成等心血管疾病方面发挥作用。文章将对C1q肿瘤坏死因子相关蛋白3在心血管疾病方面的研究进展做一综述。

关键词： C1q肿瘤坏死因子相关蛋白3 高血压动脉粥样硬化糖脂代谢

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银杏叶黄酮活性炭脱色工艺的研究

食品研究与开发 2017年第8期38卷 85-88页

作者：金华钟方丽李秀萍王建刚吉林化工学院分析测试中心吉林吉林132022 吉林化工学院化学与制药工程学院吉林吉林130022 中国石油吉林石化公司研究院吉林吉林132021

为了优化活性炭对银杏叶黄酮脱色的工艺条件,通过单因素实验考察脱色时间、p H值、脱色温度以及活性炭用量对脱色率和黄酮保留率的影响。在单因素基础上,采用四因素三水平正交试验分析各因素与脱色率及黄酮保留率的关系。结果表明:活性... 详细信息

为了优化活性炭对银杏叶黄酮脱色的工艺条件,通过单因素实验考察脱色时间、p H值、脱色温度以及活性炭用量对脱色率和黄酮保留率的影响。在单因素基础上,采用四因素三水平正交试验分析各因素与脱色率及黄酮保留率的关系。结果表明:活性炭脱色最佳条件为脱色时间60 min、p H 6.0、脱色温度80℃、活性炭用量2.0%,在该条件下活性炭脱色率达55.07%,银杏叶黄酮保留率为87.52%,相对误差分别为0.94%及0.19%。脱色使银杏叶黄酮提取液获得良好色泽。

关键词：正交试验银杏叶黄酮活性炭脱色

小潮气量机械通气治疗对小儿重症肺炎血气学指标的影响

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海南医学 2017年第16期28卷 2639-2641页

作者：杨琳东王秀萍王娟延安市人民医院儿科陕西延安716000

目的探讨小潮气量机械通气治疗对小儿重症肺炎血气学指标变化的影响。方法回顾性研究2010年2月至2016年12月在本院应用呼吸机辅助通气治疗的小儿重症肺炎患儿76例,根据潮气量的不同分为小潮气量组42例和常规潮气量组34例,潮气量分别为6~... 详细信息

目的探讨小潮气量机械通气治疗对小儿重症肺炎血气学指标变化的影响。方法回顾性研究2010年2月至2016年12月在本院应用呼吸机辅助通气治疗的小儿重症肺炎患儿76例,根据潮气量的不同分为小潮气量组42例和常规潮气量组34例,潮气量分别为6~8 m L/kg和10~12 m L/kg。检测上机前和上机6 h、12 h、24 h后两组患儿血气指标变化情况。结果机械通气治疗后,在不同时间点检测,两组患儿动脉血氧分压(PaO_2)、pH值、氧合指数(P/F)均有升高,小潮气量组较明显,差异具有统计学意义(P<0.05);两组患儿的动脉血二氧化碳分压(PaCO_2)均下降,但小潮气量组较为显著,两组PaCO_2数据间的差异具有统计学意义(P<0.05);小潮气量组平均通气时间为(5.31±2.52)d,常规潮气量组平均通气时间为(7.14±1.90)d,小潮气量组通气时间低于常规潮气量组,差异具有统计学意义(P<0.05);小潮气量组死亡1例,死亡原因为呼吸衰竭,常规潮气量组死亡4例,同样死于呼吸衰竭,两组死亡率比较(2.63%vs 10.52%)差异具有统计学意义(P<0.05)。结论小潮气量机械通气可显著提高小儿重症肺炎患儿PaO_2、pH值、P/F,降低PaCO_2,缩短上机时间,减少肺损伤。

关键词：小潮气量机械通气肺炎血气分析