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Development and validation of a new prognostic model for patients with acute-on-chronic liver failure in intensive care unit

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World Journal of Gastroenterology 2024年第20期30卷 2657-2676页

作者： Zong-Yi Zhu xiu-Hong Huang Hui-Qing Jiang Li liu Department of Gastroenterology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Gastroenterology Weixian People's HospitalXingtai 054700Hebei ProvinceChina

BACKGROUND Cirrhotic patients with acute-on-chronic liver failure(ACLF)in the intensive care unit(ICU)have a poor but variable *** prognosis evaluation can guide the rational management of patients with ***,existing prognostic scores for ACLF in the ICU environment lack sufficient *** To develop a new prognostic model for patients with ACLF in *** Data from 938 ACLF patients in the Medical Information Mart for Intensive Care(MIMIC)database were used to develop a new prognostic model(MIMIC ACLF)for ***,calibration and clinical utility of MIMIC ACLF were assessed by area under receiver operating characteristic curve(AUROC),calibration curve and decision curve analysis(DCA),*** ACLF was then externally validated in a multiple-center cohort,the Electronic Intensive Care Collaborative Research Database and a single-center cohort from the Second Hospital of Hebei Medical University in *** The MIMIC ACLF score was determined using nine variables:ln(age)×2.2+ln(white blood cell count)×0.22-ln(mean arterial pressure)×2.7+respiratory failure×0.6+renal failure×0.51+cerebral failure×0.31+ln(total bilirubin)×0.44+ln(internationalized normal ratio)×0.59+ln(serum potassium)×*** MIMIC cohort,the AUROC(0.81/0.79)for MIMIC ACLF for 28/90-day ACLF mortality were significantly greater than those of Chronic Liver Failure Consortium ACLF(0.76/0.74),Model for End-stage Liver Disease(MELD;0.73/0.71)and MELD-Na(0.72/0.70)(all P<0.001).The consistency between actual and predicted 28/90-day survival rates of patients according to MIMIC ACLF score was excellent and superior to that of existing *** net benefit of MIMIC ACLF was greater than that achieved using existing scores within the 50%threshold *** superior predictive accuracy and clinical utility of MIMIC ACLF were validated in the external *** We developed and validated a new prognostic model with satisfactory accuracy

关键词： Acute-on-chronic liver failure Cirrhosis Risk stratification Prognosis Model Scores

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Influence of powder oxidation on powder properties and formability in H13 hot-work steels processed by electron beam melting

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Journal of Iron and Steel Research International 2024年第4期31卷 924-932页

作者： Wei liu Yan Wang Li-xiong Han Ying-kang Wei Hui-ping Tang Shi-feng liu School of Metallurgical Engineering Xi'an University of Architecture and TechnologyXi'an 710055ShaanxiChina School of Engineering Zhejiang University City CollegeHangzhou 310015ZhejiangChina

The oxygen content of metal powder is decisive for the recyclability of *** research on the effect of oxygen content on powder properties and material formability has practical significance for economical production with additive manufacturing while preventing the waste of ***,we deliberately oxidized the powder by baking at high temperature to increase the oxygen content in the powder and gave the calculation method of the oxygen content in the powder oxidation *** majority of oxygen element was found in the oxide particles in the powder and the oxide flm on the powder surface,which did affect the flowability of the *** is worth noting that the increase in the oxygen content does not change the phase of H13 steel,but it can promote the molten pool flow and obtain a smoother *** increase in the oxygen content in the powder is not the decisive factor for the formability and defects of the printed *** is the combined effect of the powder deformation,the increase in the oxygen content,and the impurity pollution after repeated use,which leads to the limitation of repeated utilization of the powder.

关键词： Additive manufacturing Electron beam melting H13 steel powder-Powder oxidation

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Survival prognostic analysis of laparoscopic D2 radical resection for locally advanced gastric cancer: A multicenter cohort study

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2451-2460页

作者： xiu-Ming Sun Kui liu Wen Wu Chao Meng Department of Pain Management Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Hepatobiliary Surgery Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND With the development of minimally invasive surgical techniques,the use of laparoscopic D2 radical surgery for the treatment of locally advanced gastric cancer(GC)has gradually ***,the effect of this procedure on survival and prognosis remains *** study evaluated the survival and prognosis of patients receiving laparoscopic D2 radical resection for the treatment of locally advanced GC to provide more reliable clinical evidence,guide clinical decision-making,optimize treatment strategies,and improve the survival rate and quality of life of *** A retrospective cohort study was *** data from 652 patients with locally advanced GC in our hospitals from December 2013 to December 2023 were *** were 442 males and 210 *** mean age was 57±12 *** patients underwent a laparoscopic D2 radical operation for distal *** patients were followed up in the outpatient department and by telephone to determine their tumor recurrence,metastasis,and *** follow-up period ended in December *** distributed data are expressed as the mean±SD,and normally distributed data are expressed as M(Q1,Q3)or M(range).Statistical data are expressed as absolute numbers or percentages;theχ2 test was used for comparisons between groups,and the Mann-Whitney U nonparametric test was used for comparisons of rank *** life table method was used to calculate the survival rate,the Kaplan-Meier method was used to construct survival curves,the log rank test was used for survival analysis,and the Cox risk regression model was used for univariate and multifactor *** The median overall survival(OS)time for the 652 patients was 81 months,with a 10-year OS rate of 46.1%.Patients with TNM stages II and III had 10-year OS rates of 59.6%and 37.5%,respectively,which were significantly different(P<0.05).Univariate analysis indicated that factors such as age,maximum tumor diameter,tumor

关键词： Gastric neoplasms Chinese Laparoscopic Gastrointestinal Surgery Study Group Laparoscopic surgery Locally advanced gastric cancer D2 lymph node dissection

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Accelerating Asteroidal Period and Pole Inversion from Multiple Lightcurves Using Parallel Differential Evolution and Cellinoid Shape Model

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Research in Astronomy and Astrophysics 2024年第4期24卷 271-286页

作者： Yong-Xiong Zhang Wen-xiu Guo Xiao-ping Lu Hua Zheng Hai-Bin Zhao Jun Tian Wei-Lin Wang School of Engineering Guangzhou College of Technology and BusinessGuangzhou 510850China School of Computer Science and Engineering Macao University of Science and TechnologyTaipaMacao 999078China School of Mathematics and Statistics Shaoguan UniversityShaoguan 512099China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao 999078China Key Laboratory of Planetary Sciences Purple Mountain ObservatoryCASNanjing 210023China

Determining asteroid properties provides valuable physical insights but inverting them from photometric lightcurves remains computationally *** paper presents a new approach that combines a simplified Cellinoid shape model with the Parallel Differential Evolution(PDE)algorithm to accelerate *** PDE algorithm is more efficient than the Differential Evolution algorithm,achieving an extraordinary speedup of 37.983 with 64 workers on multicore *** PDE algorithm accurately derives period and pole values from simulated *** analysis of real asteroid lightcurves validates the method’s reliability:in comparison with results published elsewhere,the PDE algorithm accurately recovers the rotational periods and,given adequate viewing geometries,closely matches the pole *** PDE approach converges to solutions within 20,000 iterations and under one hour,demonstrating its potential for large-scale data *** work provides a promising new tool for unveiling asteroid physical properties by overcoming key computational bottlenecks.

关键词： methods:numerical minor planets asteroids:general techniques:photometric astrom

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Effect of drying cracks on swelling and self-healing of bentonite-sand blocks used as engineered barriers for radioactive waste disposal

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1776-1787页

作者： Yu Tan Guangping Zhou Huyuan Zhang Xiaoya Li ping liu School of Civil Engineering and Mechanics Lanzhou UniversityLanzhou730000China Key Laboratory of Mechanics on Disaster and Environment in Western China (Lanzhou University) Ministry of EducationLanzhou730000China Civil and Environmental Engineering University of Wisconsin-MadisonWI53706USA

Experiments were conducted to evaluate the healing of drying cracks in air-dried bentonite-sand blocks after hydration and swelling in groundwater,providing justifications to simplify the protection of blocks prior to installation in a high-level radioactive waste *** groundwater was prepared to represent the geochemistry of Beishan groundwater,and was used to hydrate the blocks during the swelling pressure and swelling strain measurements,as Beishan is the most promising site for China's *** of the surface cracks was recorded by photography,and healing of the internal cracks was visualized by CT images and hydraulic conductivity of air-dried *** results indicate that the maximum swelling pressure and swelling strain are primarily affected by the geochemistry of Beishan groundwater,but not affected by the drying *** maximum swelling pressure and swelling strain of air-dried blocks are comparable to or even higher than the pressure and strain of fresh *** maximum swelling pressure measured in strong(*** ion strength)Beishan groundwater was 44%of the pressure measured in deionized(DI)water,and the maximum swelling strain was reduced to 23%of the strain measured in DI ***,the remained swelling of the blocks hydrated in strong Beishan groundwater was sufficient to heal the surface and internal drying cracks,as demonstrated by the pictures of surface cracks and CT *** hydraulic conductivity of the air-dried block permeated with strong groundwater was comparable(3.7×higher)to the hydraulic conductivity of the fresh block,indicating the self-healing of drying cracks after hydration and swelling in groundwater.A simplified method of protecting the block with plastic wraps before installation is recommended,since the remained swelling of the block hydrated in Beishan groundwater is sufficient to heal the drying cracks.

关键词： Beishan groundwater chemistry Bentonite buffer Drying cracks High-level radioactive waste(HLW) Self-healing Swelling

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Small holes,big impact:Stomata in plant–pathogen–climate epic trifecta

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Molecular Plant 2024年第1期17卷 26-49页

作者： Shuguo Hou Olivier Rodrigues Zunyong liu Libo Shan ping He Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agriculture Sciences in WeifangWeifangShandong 261325China School of Municipal&Environmental Engineering Shandong Jianzhu UniversityJinanShandong 250101China Unitéde Recherche Physiologie Pathologie et Génétique VégétalesUniversitéde Toulouse Midi-PyrénéesINP-PURPAN31076 ToulouseFrance Department of Molecular Cellularand Developmental BiologyUniversity of MichiganAnn ArborMI 48109USA

The regulation of stomatal aperture opening and closure represents an evolutionary battle between plants and pathogens,characterized by adaptive strategies that influence both plant resistance and pathogen *** ongoing climate change introduces further complexity,affecting pathogen invasion and host *** review delves into recent advances on our understanding of the mechanisms governing immunity-related stomatal movement and patterning with an emphasis on the regulation of stomatal opening and closure dynamics by pathogen patterns and host *** addition,the review explores how climate changes impact plant–pathogen interactions by modulating stomatal *** light of the pressing challenges associated with food security and the unpredictable nature of climate changes,future research in this field,which includes the investigation of spatiotemporal regulation and engineering of stomatal immunity,emerges as a promising avenue for enhancing crop resilience and contributing to climate control strategies.

关键词： stomatal movement stomatal patterning plant resistance pathogen virulence apoplastic immunity and climate change

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Miniaturized and highly sensitive fiber-optic Fabry–Perot sensor for mHz infrasound detection

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Photonics Research 2024年第5期12卷 969-978页

作者： PEIJIE WANG YUFENG PAN JIANGSHAN ZHANG JIE ZHAI DEMING liu ping LU Wuhan National Laboratory for Optoelectronics(WNLO)and National Engineering Research Center of Next Generation Internet Access System School of Optical and Electronic InformationHuazhong University of Science and TechnologyWuhan 430074China Optics Valley Laboratory Wuhan 430074China Department of Electronics and Information Engineering Huazhong University of Science and TechnologyWuhan 430074China

Infrasound detection is important in natural disasters monitoring,military defense,underwater acoustic detection,and other ***-optic Fabry–Perot(FP)acoustic sensors have the advantages of small structure size,long-distance detection,immunity to electromagnetic interference,and so *** size of an FP sensor depends on the transducer diaphragm size and the back cavity ***,a small transducer diaphragm size means a low ***,a small back cavity volume will increase the low cut-off frequency of the ***,it is difficult for fiber-optic FP infrasound sensors to simultaneously achieve miniaturization,high sensitivity,and extremely low detectable *** this work,we proposed and demonstrated a miniaturized and highly sensitive fiber-optic FP sensor for m Hz infrasound detection by exploiting a Cr-Ag-Au composite acoustic-optic transducer diaphragm and a MEMS technique-based spiral micro-flow *** use of the spiral micro-flow hole as the connecting hole greatly reduced the volume of the sensor and decreased the low-frequency limit,while the back cavity volume was not *** with the Cr-Ag-Au composite diaphragm,a detection sensitivity of-123.19 dB re 1 rad∕μPa at 5 Hz and a minimum detectable pressure(MDP)of1.2 mPa∕Hz^(1∕2)at 5 Hz were *** low detectable frequency can reach 0.01 Hz and the flat response range was 0.01–2500 Hz with a sensitivity fluctuation of±1.5 d ***,the size of the designed sensor was only 12 mm×Φ12.7 *** excellent characteristics make the sensor have great practical application prospects.

关键词： sound fiber cavity

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Single-Ni-atoms on nitrogenated humic acid based porous carbon for CO_(2) electroreduction

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Frontiers of Chemical Science and Engineering 2024年第5期18卷 37-47页

作者： Delei Yu Ying Chen Yao Chen Xiangchun liu Xianwen Wei ping Cui Anhui Key Laboratory of Coal Clean Conversion&Utilization School of Chemistry and Chemical EngineeringAnhui University of TechnologyMa’anshan 243002Chin

tWe proposed a facile synthesis of single-Ni-atom catalysts on low-cost porous carbon using a calcina-tion method at the temperatures of 850-1000°C,which were used for CO_(2) electrochemical reduction to *** porous carbon was prepared by carbonizing cheap and abundant humic *** structural characterizations of the as-synthesized catalysts and their electrocatalytic performances were *** results showed that the single-Ni-atom catalyst activated at 950°C showed an optimum catalytic performance,and it reached a CO Faradaic efficiency of 91.9% with a CO partial current density of 6.9 mAcm^(-2)at-0.9 V *** hydrogen electrode(RHE).Additionally,the CO Faradaic efficiency and current density of the optimum catalyst changed slightly after 8 h of continuous operation,suggesting that it possessed an excellent *** structure-activity relations indicate that the variation in the CO_(2) electroche-mical reduction performance for the as-synthesized catalysts is ascribed to the combined effects of the increase in the content of pyrrolic N,the evaporation of Ni and N,the decrease in pore volume,and the change in graphitization degree.

关键词： CO_(2) electroreduction single-Ni-atom cataly-sts humic acid based porous carbon

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In situ meso-tetra(4-carboxyphenyl)porphyrin ligand substitution in Hf-MOF for enhanced catalytic activity and stability in photoredox reactions

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Rare Metals 2024年第6期43卷 2682-2694页

作者： Jie Hu Hong-Xin Lao xiu-Wu Xu Wei-Kang Wang Le-Le Wang Qin-Qin liu School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China College of Chemistry and Materials Engineering Research Center of Carbon NeutralityAnhui Normal UniversityWuhu 241002China Fujian Provincial Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants Putian UniversityPutian 351100China

Though there are numerous intrinsic merits of metal-organic frameworks(MOFs),low charge separation efficiency has imposed heavy restrictions on their photocatalytic ***,in situ porphyrin ligand substitution,as a strategy for improving the charge separation efficiency and increasing the amounts of active sites,has been designed and realized in a Hf-biphenyl dicarboxylic acid(BPDC)***,a size and geometry matched meso-tetra(4-carboxyphenyl)porphyrin(TCPP)ligand was selected and doped into Hf-BPDC MOF by forming coordinating bonds with Hf centers,forming dualligand Hf-BPDC-TCPP *** resultant Hf-BPDC-TCPP MOF showed significantly improved activity and chemical stability in the photocatalytic H_(2)generation(261μmol·g^(-1)·h^(-1))and tetracycline(TC)degradation reactions(95.8%),which was 48 and 1.47 folds higher than that of the Hf-BPDC *** and electrochemical studies revealed that the introduction of porphyrin ligand could generate a stronger internal electric field for boosting the charge separation and transfer,increase the specific surface area for providing more active sites,and narrow the band gap to enhance the visible light *** in situ ligand substitution method provides a promising approach to build a tunable platform for constructing high-performance MOF photocatalysts.

关键词： Ligand substitution Metal organic frameworks Meso-tetra(4-carboxyphenyl)porphyrin Hydrogen evolution reaction Tetracycline degradation

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Anisotropic shearing mechanism of Kangding slate:Experimental investigation and numerical analysis

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1487-1504页

作者： ping liu Quansheng liu Penghai Deng Yucong Pan Yiming Lei Chenglei Du Xianqi Xie The Key Laboratory of Geotechnical and Structural Engineering Safety of Hubei Province School of Civil EngineeringWuhan UniversityWuhan430072China State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan430072China

The shear mechanical behavior is regarded as an essential factor affecting the stability of the surrounding rocks in underground *** shear strength and failure mechanisms of layered rock are significantly affected by the foliation *** shear tests were conducted on cubic slate samples with foliation angles of 0°,30°,45°,60°,and 90°.The effect of foliation angles on failure patterns,acoustic emission(AE)characteristics,and shear strength parameters was *** on AE characteristics,the slate failure process could be divided into four stages:quiet period,step-like increasing period,dramatic increasing period,and remission period.A new empirical expression of cohesion for layered rock was proposed,which was compared with linear and sinusoidal cohesion expressions based on the results made by this paper and previous *** comparative analysis demonstrated that the new expression has better prediction ability than other *** proposed empirical equation was used for direct shear simulations with the combined finite-discrete element method(FDEM),and it was found to align well with the experimental *** both computational efficiency and accuracy,it was recommended to use a shear rate of 0.01 m/s for FDEM to carry out direct shear *** balance the relationship between the number of elements and the simulation results in the direct shear simulations,the recommended element size is 1 mm.

关键词： Anisotropy Empirical expression of cohesion foliation angles Combined finite-discrete element method(FDEM) Shear rate Element size

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