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Effects of Dan-Shao-Hua-Xian on the expression of collagen type I and III in rats with hepatic fibrosis

Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 558-563页

作者： Xiao-Xia Geng, Qin Yang, Ru-Jia Xie, Xin-Hua Luo, Cheng-xiu li and ming-liang Cheng Guizhou, China Department of Infectious Diseases, Affiliated Hospital of Guiyang Medical College Department of Pathophysiology, Guiyang Medical College Depart- ment of Infectious Diseases, People’ s Hospital of Guizhou Province and Department of Pharmacology, Guiyang Medical College Department of Infectious Diseases Affiliated Hospital of Guiyang Medical College Guizhou 550004 China.

BACKGROUND: Hepatic fibrosis is the common patholo gical change in various chronic liver diseases,and its major cause is the imbalance between the production and degra dation of the extracellular matrix, which is mainly com posed of collagens. Dan-Shao-Hua-Xian ( DSHX) cap sule, a traditional Chinese herbal compound, has shown marked preventive effects on hepatic fibrosis in rats in our previous studies. The present study was designed to further investigate its therapeutic actions on hepatic fibrosis in rats and its possible mechanisms. METHODS: Eighty male Wistar rats were randomly divid- ed into normal control group, hepatic fibrosis group, non DSHX-treated group, low-dose-treated group, and high dose-treated group. The rat models of hepatic fibrosis were established by subcutaneous injecton of CC14 , drinking al- cohol , giving diet of hyperliprosis and hypoprotein for 8 weeks. The two DSHX-treated groups were treated respec- tively with low dose (0.5 g/kg) and high dose (1.0 g/kg) of DSHX capsule p. o. everyday for 8 weeks. At the end of the experiment, liver indexes were calculated in each group in addition to the levels of the serum hyaluronic acid and alanine aminotransferase. Their degree of hepatic fibrosis and urinary excretion of hydroxyproline and expression of collagen , were detected. RESULTS: Comparison of the indexes of the hepatic fibro- sis group and non-DSHX-treated group revealed that the liver indexes, levels of serum hyaluronic acid and alanine aminotransferase, and stage of hepatic fibrosis were all sig- nificantly reduced in the two DSHX treated groups. The urinary excretion of hydroxyproline was increased and the expression of collagen I and HI in liver tissue was lessened. These alterations were more obviously observed in the high-dose-treated group. CONCLUSION: DSHX capsule has certain therapeutic effect on hepatic fibrosis in rats.

关键词： liver fibrosis collagen hyaluronic acid hydroxyproline traditional Chinese herbs

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Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： li-Rong Xiao Chen Chen Shuo Wang Zi-Yin Dai Hideo Kimura Cui Ni Chuan-Xin Hou Xue-Qin Sun Si-Jie Guo Wei Du xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

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Tuning the porosity of {Co12IICo8III（μ3-OH）24（X）}11+ supramolecular frameworks by reaction time for D2/H2 separation

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Science China Chemistry 2025年

作者： Zhuozhou Xie Zhu Zhuo Zi-Ang Nan Qing li xiufang li Zi-xiu Lu linzhe Lü Jin liu Luyao liu Wenjing Wang Wei Wang Daqiang Yuan You-Gui Huang State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi InstitutesChinese Academy of Sciences State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemistry College of Chemistry and Chemical EngineeringXiamen University

Systematicly tuning the porosities of porous materials is crucial for targeted gas mixture separation,yet it remains a longstanding *** a common strategy,altering the phenylene ring count in the organic building units has been exploited to adjust pore apertures in metal organic frameworks （MOFs） and covalent organic frameworks （COFs）,resulting in only a stepwise pore size variation of approximately 2.8?.Unlike MOFs and COFs,the porosities for supramolecular assembly frameworks are highly dependent on the packings of the molecular building units in the *** above strategy cannot be applied to supramolecular assembly frameworks and other strategies are required to adjust pore apertures in supramolecular frameworks,especially to achieve porous materials with the optimal pore size for D2/H2separation （～3?）.Here,we successfully modulate the porosity of supramolecular frameworks of[CoII1+12CoIII8L12（μ3-OH）24（X）]1clusters （L=mono-deprotonated 1-iminoisoindole-3-amine,X=ClO?4or Cl?） by controlling the duration of self-assembly *** simply adjusting the reaction time,we obtain three[CoII12CoIII8L12（μ3-OH）24（X）]11+supramolecular frameworks:[CoII12CoIII8（μ3-OH）24（ClO4）L12)]·（Cl）4·（HCO2）7（1）,[CoII12CoIII8L12（μ3-OH）24（Cl）]·（ClOI4）4·（Cl）6·（HCO2）·（H2O）10（2）,and[CoI12CoIII8L12（μ3-OH）24（Cl）]·（Cl）11·（H2O）12（3）.The different stacking patterns of the[CoII12CoIII8L12（μ3-OH）24（X）]11+clusters in these frameworks lead to significantly varied stabilities and *** 1 exhibits permanent porosity with interconnected channels and maintains stability under harsh *** contrast,compound 2 is nearly nonporous,and compound 3 becomes unstable upon *** pores of compound 1 show higher affinity to D2than H2,and the pore aperture diameter of compound 1 （～3.06?） meets the optimal porosity for D2/***,compound 1 demonstrates moderate D2/H2separation at 77 K (retention time:～7 min/g for D2/H2/Ne （10/10/80 vol%） in a flow of 5 mL

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某企业喷漆车间防毒设施改造前后防护效果评价

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中国卫生工程学 2018年第5期17卷 673-675页

作者：缪明霞高秀明张晓丽佳木斯市疾病预防控制中心黑龙江佳木斯154007

目的对某企业喷漆车间整改前后苯系物的浓度进行调查比对,评价职业病危害防护设施的效果。方法通过职业卫生现场调查,职业卫生检测,采用检查表法、类比法对某企业存在的职业病危害进行综合分析。结果此次工程改造前后车间工人接触的苯... 详细信息

目的对某企业喷漆车间整改前后苯系物的浓度进行调查比对,评价职业病危害防护设施的效果。方法通过职业卫生现场调查,职业卫生检测,采用检查表法、类比法对某企业存在的职业病危害进行综合分析。结果此次工程改造前后车间工人接触的苯系物超标率分别为65%和0%,改造后车间工人接触苯系物的浓度均低于职业接触限值。结论此次工程整改防毒设施达到预期控制效果。

关键词：喷漆车间防护设施比对

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改性聚酯和常规聚酯热性能的研究

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苏州大学学报（工科版） 2004年第6期24卷 23-24,28页

作者：徐秀雯李明苏州大学材料工程学院江苏苏州215021

比较了常规聚酯(PET)和改性聚酯(CDPET)的热性能,分析了不同温度和时间的特性粘度[η]和分子量M变化规律,结果表明,常规聚酯的热性能优于改性聚酯。

关键词：常规聚酯改性聚酯特性粘度分子量

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天蚕素B串联体在紫花苜蓿中的表达

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中国草地学报 2016年第6期38卷 1-7页

作者：刘秀明李晓璇王晶晶杜淑环姚娜孟璐璐李海燕吉林农业大学生物反应器与药物开发教育部工程研究中心吉林长春130118 吉林农业大学生命科学学院吉林长春130118 吉林省科学技术厅吉林长春130118

根据植物偏好性密码子进行改造获得了天蚕素B基因,又通过同尾酶连接获得2个和3个天蚕素B基因的串联体,分别构建植物表达载体,并采用农杆菌介导的方法转化紫花苜蓿。对转基因植物进行分子生物学检测,结果表明CB、CB2、CB3三个基因成功整... 详细信息

根据植物偏好性密码子进行改造获得了天蚕素B基因,又通过同尾酶连接获得2个和3个天蚕素B基因的串联体,分别构建植物表达载体,并采用农杆菌介导的方法转化紫花苜蓿。对转基因植物进行分子生物学检测,结果表明CB、CB2、CB3三个基因成功整合到了苜蓿基因组中,转基因植物总蛋白活性检测表明转CB、CB2、CB3基因的蛋白均有一定的抑菌活性,但串联CB3基因的抑菌活性最强。

关键词：天蚕素B 抗菌肽紫花苜蓿串联表达抑菌活性

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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang li Jia xiu-Jun Zhan Charity Ngina Qing-Rui Zhang Xiao-Ge li Qi-Bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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Microstructure, mechanical and biodegradable properties of a Mg–2Zn–1Gd–0.5Zr alloy with different solution treatments

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Rare Metals 2019年第6期38卷 532-542页

作者： Jun-xiu Chen ming Gao li-li Tan Ke Yang Institute of Metal Research Chinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

Solution treatment is a useful way to improve the degradation resistance of Mg *** this work,effects of solution treatment temperature on mechanical and biodegradable properties of an extruded Mg–2Zn–1Gd–0.5Zr alloy were *** analysis,tensile test, three-point bending test, immersion test and electrochemical test were *** results showed that increasing solution temperature decreases the mechanical properties of the ***, three-point bending test revealed that the solution-treated alloy at 510 ℃ could maintain 95% of its maximum bending force(Fmax) during the 28-day immersion *** treatment at 510 ℃ for 5 h, all the second phases were dissolved into the alloy, the galvanic corrosion was inhibited, and the alloy exhibited good corrosion resistance with a corrosion rate of 0.35 mm·year-1 in Hank’s solution.

关键词： Mg alloy Solution treatment Microstructure Mechanical property Biodegradable property

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裸燕麦(Avena nuda)的核型研究

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内蒙古农牧学院学报 1988年第2期 23-27页

作者：武生辉李秀娴李明哲内蒙古农牧学院农学系

裸燕麦(莜麦)Avena nuda在植物分类学上属于禾本科早熟禾亚科燕麦族燕麦属。莜麦在我区栽培历史悠久,是重要的粮食作物之一。近年来发现莜麦的籽粒中含有亚硝酸等成份,可做为治疗心血管类疾病的药用食品。因此,莜麦的栽培地位又有所提... 详细信息

裸燕麦(莜麦)Avena nuda在植物分类学上属于禾本科早熟禾亚科燕麦族燕麦属。莜麦在我区栽培历史悠久,是重要的粮食作物之一。近年来发现莜麦的籽粒中含有亚硝酸等成份,可做为治疗心血管类疾病的药用食品。因此,莜麦的栽培地位又有所提高。我国农业部已把莜麦的研究列为国家协作项目之一。但是对莜麦染色体的研究,国内外还很少有人做,在我区尚未见到有人报导过。染色体的研究对于分类和育种实践都有密切关系。除此之外,为了探讨燕麦属的演化趋向以及有关起源等问题提供细胞学依据,我们对Avena nuda蒙燕7312莜麦进行了核型分析。确认莜麦蒙燕7312的核型为:2n=6X=42=22m+20sm(SAT)。

关键词：裸燕麦六倍体核型分析核型模式图核型公式

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Study on the Purification of OPV Produced on Vero Cells with Q-Sepharose F.F.

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Wuhan University Journal of Natural Sciences 1999年第2期4卷 118-122页

作者： liAO Guo yang 1,JIANG Shu de 1,ZHENG Cong yi 2 ,WANG ming xiu 1,li Ping zhong 1 1.Instiute of Medical Biology, Chinese Academy of Medical Science & Peking Union of Medical College, Kunming 650107, China 2.College of life Sciences, Wuh

Q Sepharose Fast Flow(Q Sepharose F.F.) was adopted to purify the suspensions of type Ⅰ,Ⅱ,Ⅲ oral poliovaccine (OPV), which is prepared from Vero cells. After clarification and concentration by ultrafiltration,the recovery of virus infected titre may attain above 85%.Using column chromatography on Q Sepharose F.F. to purify the concentrated virus suspensions,the purified viruses attain 100% recovery of virus infectivity. Dot membrane hybrization was used to detect DNA with the probe of Vero cell genome DNA which was labeled with α P 32 dATP,the contents of residual substrate DNA was less than 100 Pg/dose. The process of downstream had no significant influence on some biological characters of purified viruses,such as virus morphology ,tumorigenicity, rct/40 character and capsid *** downstream reseach indicates that Q Sepharose F.F. is an ideal chromatography material for purifying OPV prepared from Vero cells.

关键词： OPV vero cells substrate DNA purification Q Sepharose F.F.

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