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多元主体合作开发高职新形态教材分析

扬州教育学院学报 2019年第2期37卷 84-87页

作者：黄瑞曾晨曦李蓓蓓雷秀丽扬州职业大学继续教育学院江苏扬州225009 国家测绘地理信息局北京100830 测绘出版社北京100045

高职新形态教材建设是当前高职教育研究领域中的重要命题。以《卫星定位测量》教材开发为例,具体阐释了新形态教材开发的一些思路和做法:如发挥教育行指委的指导作用,建立行业企业参与保障机制,整合纸质与数字化教学资源,根据用户建议... 详细信息

高职新形态教材建设是当前高职教育研究领域中的重要命题。以《卫星定位测量》教材开发为例,具体阐释了新形态教材开发的一些思路和做法:如发挥教育行指委的指导作用,建立行业企业参与保障机制,整合纸质与数字化教学资源,根据用户建议不断更新内容,拓宽教材出版与发行的渠道。这些新思路有助于开发高质量新形态教材,有助于深化职教课程改革。

关键词：高职教育新形态教材教材建设教学资源开发

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang li Jia xiu-Jun Zhan Charity Ngina Qing-Rui Zhang Xiao-Ge li Qi-Bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

Joint Probabilistic Scheduling and Resource Allocation for Wireless Networked Control Systems

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 258-260页

作者： Meng Zheng lei Zhang Wei liang IEEE the State Key Laboratory of Robotics and the Key Laboratory of Networked Control Systems Shenyang Institute of Automation Chinese Academy of Sciences the University of Chinese Academy of Sciences

Dear Editor,This letter presents a joint probabilistic scheduling and resource allocation method(PSRA) for 5G-based wireless networked control systems(WNCSs). As a control-aware optimization method, PSRA minimizes the linear quadratic Gaussian(LQG) control cost of WNCSs by optimizing the activation probability of subsystems, the number of uplink repetitions, and the durations of uplink and downlink phases. Simulation results show that PSRA achieves smaller LQG control costs than existing works.

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan liao Zhenyu Yin Xintong Ge Dai li Rongrong Zhong Qiang liu Fanglian Chen Ping lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

Effect of Bushen Jianpi formula on survival of patients with moderate and advanced hepatocellular carcinoma:a retrospective study

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Journal of Traditional Chinese Medicine 2020年第4期40卷 683-689页

作者： Wang lei li xiu Zhou Rongyao Shan Yawei Depatment of Hepatology Longhua Hospital affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200030China School of Nursing Shanghai University of Traditional Chinese MedicineShanghai 201203China Depatment of Hepatology Shuguang Hospital affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

OBJECTIVE:To investigate the effect of Bushen Jianpi formula(BSJP)therapy on survival of the patients with moderate and advanced hepatocellular carcinoma(HCC).METHODS:This was a five-year retrospective study,enrolling 209 adult patients with moderate and advanced HCC ***-rank test,Cox regression analysis and Kaplan-Meier analysis was applied to analyze the ***:The outcome of single-factor Kaplan-Meier analysis and Log-rank test showed that stage of Barcelona-clinic liver cancer(BCLC),locoregional therapy and BSJP therapy were three factors that dominantly influenced the survival of moderate and advanced HCC patients(P<0.05).In Cox multiple-factor regression analysis,lower BCLC staging(RR=2.016;P=0.000),locoregional therapy(RR=0.611;P=0.011)and BSJP therapy(RR=0.684;P=0.044)were the independent protective factors affecting survival of patients,and BSJP exerted a more significant effect on patients at BCLC-C stage(RR=0.513;P=0.002).CONCLUSION:BSJP therapy and locoregional therapy both contributed to prolonged survival for moderate and advanced HCC patients.

关键词： Carcinoma,hepatocellular Survival analysis Retrospective studies Bushen Jianpi formula

Statistical characteristics and classification of ionospheric mid-latitude trough as revealed by the observations of DMSP-F18

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Earth and Planetary Physics 2025年第1期9卷 137-147页

作者： Yi liu JiuHou lei FuQing Huang Su Zhou School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China School of Science Guiyang UniversityGuiyang 550005China

Statistical characteristics and the classification of the topside ionospheric mid-latitude trough are systemically analyzed,using observations from the Defense Meteorological Satellite Program F18(DMSP-F18)*** data was obtained at an altitude of around 860 km in near polar orbit,throughout *** study identified the auroral boundary based on the in-situ electron density and electron spectrum,allowing us to precisely determine the location of the mid-latitude *** differs from most previous works,which only use Total Electron Content(TEC)or in-situ electron *** our study,the troughs exhibited a higher occurrence rate in local winter than in summer,and extended to lower latitudes with increasing geomagnetic *** was found that the ionospheric mid-latitude trough,which is associated with temperature changes or enhanced ion drift,exhibited distinct ***,the ionospheric mid-latitude troughs related to electron temperature(Te)peak were located more equatorward of auroral oval boundary in winter than in *** ionospheric mid-latitude troughs related to Te-maximum were less frequently observed at 60−70°S magnetic latitude and 90−240°E ***,the troughs related to ion temperature(Ti)maximums were observed at relatively higher latitudes,occurring more frequently in *** addition,the troughs related to ion velocity(Vi)maximums could be observed in all *** troughs with the maximum-Ti and maximum-Vi were located closer to the equatorward boundary of the auroral oval at the nightside,and in both *** implies that enhanced ion drift velocity contributes to increased collisional frictional heating and enhanced ion temperatures,resulting in a density depletion within the trough region.

关键词： topside ionosphere mid-latitude trough ionospheric main trough auroral oval boundary temperature maximum

Dative B–N bonds weaven toward two-dimensional purely organic materials for single crystals

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Science China Chemistry 2025年第01期 12-14页

作者： Wei-lei Zhou Siwei Wang Yong Chen College of Chemistry and Materials Science Inner Mongolia Key Laboratory of Chemistry for Nature Products and Synthesis for Functional Molecules Innovation Team of Optical Functional Molecular Devices Inner Mongolia Minzu University College of Chemistry Nankai University

Molecular topology is one of the important topics to study and understand the relationship between molecular structure and properties [1]. Particularly, two-dimensional (2D) materials with extremely high surface area and ultra-thin morphology have attracted considerable attention due to their unexpected properties in materials and chemistry [2,3].

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He li li Sai Wang Shao-Jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

FlexPDA:A Flexible Programming Framework for Deep Learning Accelerators

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Journal of Computer Science & Technology 2022年第5期37卷 1200-1220页

作者： lei liu xiu Ma Hua-xiao liu Guang-li li lei liu College of Computer Science and Technology Jilin UniversityChangchunChina Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education Jilin UniversityChangchunChina State Key Laboratory of Computer Architecture Institute of Computing TechnologyChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina

There are a wide variety of intelligence accelerators with promising performance and energy efficiency,deployed in a broad range of applications such as computer vision and speech ***,programming productivity hinders the deployment of deep learning *** low-level library invoked in the high-level deep learning framework which supports the end-to-end execution with a given model,is designed to reduce the programming burden on the intelligence ***,it is inflexible for developers to build a network model for every deep learning application,which probably brings unnecessary repetitive *** this paper,a flexible and efficient programming framework for deep learning accelerators,FlexPDA,is proposed,which provides more optimization opportunities than the low-level library and realizes quick transplantation of applications to intelligence accelerators for fast *** evaluate FlexPDA by using 10 representative operators selected from deep learning algorithms and an end-to-end *** experimental results validate the effectiveness of FlexPDA,which achieves an end-to-end performance improvement of 1.620x over the low-level library.

关键词： deep learning accelerator programming framework domain-specific language