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Combined ATAC-seq,RNA-seq,and GWAS analysis reveals glycogen metabolism regulatory network in Jinjiang oyster(Crassostrea ariakensis)

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Zoological Research 2024年第1期45卷 201-214页

作者： Biao Wu Xi Chen Jie Hu Zhen-Yuan Wang Yan Wang Da-You Xu Hao-Bing Guo Chang-Wei Shao Li-Qing Zhou xiu-jun sun Tao Yu Xiao-Mei Wang Yan-Xin Zheng Guang-Yi Fan Zhi-Hong Liu State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China Laboratory for Marine Fisheries Science and Food Production Processes Laoshan LaboratoryQingdaoShandong 266071China BGI-Qingdao BGI-ShenzhenQingdaoShandong 266426China National Demonstration Center for Experimental Fisheries Science Education Shanghai Ocean UniversityShanghai 201306China Changdao Enhancement and Experiment Station Chinese Academy of Fishery SciencesYantaiShandong 265800China State Key Laboratory of Agricultural Genomics BGI-ShenzhenShenzhenGuangdong 518083China

Glycogen serves as the principal energy reserve for metabolic processes in aquatic shellfish and substantially contributes to the flavor and quality of *** Jinjiang oyster(Crassostrea ariakensis)is an economically and ecologically important species in *** the present study,RNA sequencing(RNA-seq)and assay for transposase-accessible chromatin using sequencing(ATAC-seq)were performed to investigate gene expression and chromatin accessibility variations in oysters with different glycogen *** identified 9483 differentially expressed genes(DEGs)and 7215 genes with significantly differential chromatin accessibility(DCAGs)were obtained,with an overlap of 2600 genes between ***,a significant proportion of these genes were enriched in pathways related to glycogen metabolism,including“Glycogen metabolic process”and“Starch and sucrose metabolism”.In addition,genome-wide association study(GWAS)identified 526 single nucleotide polymorphism(SNP)loci associated with glycogen *** loci corresponded to 241 genes,63 of which were categorized as both DEGs and *** study enriches basic research data and provides insights into the molecular mechanisms underlying the regulation of glycogen metabolism in ***.

关键词： Crassostrea ariakensis Glycogen Transcriptome ATAC GWAS

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Theoretical Analysis and Experiment of Temperature Stability for Fiber-optic Mach-Zehnder Interferometer Filter

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Semiconductor Photonics and Technology 2002年第3期8卷 150-152页

作者： LU Ping, LIU De ming, HUANG De xiu, sun jun qiang (Dept. of Optoelectrn. Eng., Huazhong University of Science and Technology, Wuhan 430074, CHN) Dept. of Optoelectrn. Eng. Huazhong University of Science and Technology Wuhan 430074

Fiber optic Mach Zehnder interferometer(MZI) can be used as wavelength multiplexers and demultiplexers. The △ L and △  directly influence the properties of MZI. To lengthen the △ L can demultiplex much more wavelengths, but when the △ L is longer, the temperature will influence MZI more seriously. A method to solve this problem is proposed, which enables MZI to work stably. The wavelength distance is 0.8 nm, and the extinction ratio is high.

关键词： Mach-Zehnder interferometer Coupler Wavelength multiplexers and demultiplexers

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Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei Wen-Bo Cao Sai-jun Mo Zhi-Yan sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by Yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

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半导体光放大器(SOA)皮秒增益和折射率非线性的数值模拟

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中国激光 2003年第9期30卷 775-778页

作者：洪伟黄德修孙军强刘德明华中科技大学光电子工程系湖北武汉430074

从速率方程出发 ,采用分段模型对半导体光放大器 (SOA)的皮秒增益和折射率非线性进行了数值模拟 ,具体分析了注入光脉冲引起的载流子浓度的变化、输出光脉冲时域波形的畸变、注入光脉冲引起的增益和位相变化 ,以及输出光脉冲上的频率啁啾。

关键词：光电子学半导体光放大器 SOA 增益折射率非线性自相位调制 SPM 频率啁啾

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中国四川蓼科荞麦属一新种——皱叶野荞麦

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植物分类学报 2008年第6期46卷 929-932页

作者：刘建林唐宇夏明忠邵继荣蔡光泽罗强孙俊秀西昌学院农学系四川西昌615013 四川烹饪高等专科学校食品科学系成都610072 四川农业大学生命科学与理学院四川雅安625014

描述了蓼科Polygonaceae一新种——皱叶野荞麦Fagopyrum ***。本种近似于细柄野荞麦***(Hemsl.)Damm.& Diels,但以其叶片表面泡状突起,叶缘皱波状,具不规则波状圆齿、圆齿或小圆齿,聚伞花序密集与之相区别。此外,还报道了该物种的染色... 详细信息

描述了蓼科Polygonaceae一新种——皱叶野荞麦Fagopyrum ***。本种近似于细柄野荞麦***(Hemsl.)Damm.& Diels,但以其叶片表面泡状突起,叶缘皱波状,具不规则波状圆齿、圆齿或小圆齿,聚伞花序密集与之相区别。此外,还报道了该物种的染色体数目,发现它是一个四倍体,染色体数目为2n=4x=32。

关键词：染色体数目荞麦属皱叶野荞麦新种四川中国

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人参皂苷Rg1抑制脂多糖诱导BV-2小胶质细胞增殖

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解剖学报 2016年第5期47卷 614-619页

作者：姚玥伊艾青龙陈媛丽尚群竺张汝江毕秀梅孙俊钟莲梅昆明医科大学生物医学工程研究中心昆明650500 昆明医科大学人体解剖学与组织学胚胎学系昆明650500 昆明医科大学第一附属医院神经内科昆明650032

目的探讨人参皂苷Rg1(Rg1)对脂多糖(LPS)诱导BV-2小胶质细胞中增殖细胞核抗原(PCNA)和细胞周期蛋白D1(cyclin D1)的调控作用及其对活化的BV-2小胶质细胞增殖的调控作用。方法体外培养BV-2小胶质细胞并分为空白对照组、LPS不同时间(1,3,6... 详细信息

目的探讨人参皂苷Rg1(Rg1)对脂多糖(LPS)诱导BV-2小胶质细胞中增殖细胞核抗原(PCNA)和细胞周期蛋白D1(cyclin D1)的调控作用及其对活化的BV-2小胶质细胞增殖的调控作用。方法体外培养BV-2小胶质细胞并分为空白对照组、LPS不同时间(1,3,6,8,12 h)处理组及Rg1不同浓度(10、20和50μmol/L)预处理组。采用Western blotting检测细胞增殖相关因子PCNA蛋白和cyclin D1蛋白的表达变化;RT-PCR检测细胞增殖相关因子PCNA和cyclin D1 mRNA的表达变化;免疫荧光染色法观察细胞内cyclin D1蛋白表达变化。采用流式细胞术检测细胞周期的变化。结果 LPS诱导BV-2小胶质细胞PCNA和cyclin D1mRNA和蛋白表达上调,并呈时间依赖性;不同浓度Rg1预处理下调LPS诱导的BV-2小胶质细胞PCNA和cyclin D1的mRNA和蛋白表达。结论Rg1通过下调LPS诱导的BV-2小胶质细胞PCNA和cyclin D1的表达水平来调控细胞周期进而抑制活化的小胶质细胞的增殖。

关键词：人参皂苷Rg1 脂多糖增殖 BV-2小胶质细胞增殖细胞核抗原细胞周期蛋白D1 流式细胞术

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Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia xiu-jun Zhan Charity Ngina Qing-Rui Zhang Xiao-Ge Li Qi-Bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

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Positive psychological intervention for anxiety, depression and coping in subjects addicted to online games

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World Journal of Clinical Cases 2021年第14期9卷 3287-3293页

作者： xiu-jun Gao Ji-jun sun Mei Xiang Department of Psychiatry Hangzhou Seventh People’s HospitalHangzhou 310013Zhejiang ProvinceChina Department of Elderly Psychiatry Hangzhou Seventh People’s HospitalHangzhou 310013Zhejiang ProvinceChina

BACKGROUND Addiction to online games is not *** patients usually refuse to take medications and present with affective symptoms such as anxiety,depression and negative coping *** intervention based on positive psychology is a promising treatment for such *** To evaluate the effect of positive psychological intervention on anxiety,depression and coping in people addicted to online *** This self-controlled study included 89 people addicted to online games,who received treatment at Hangzhou Seventh People’s Hospital,Hangzhou,China in *** Hamilton Anxiety Scale,Hamilton Depression Scale and Trait Coping Style Questionnaire were administered to evaluate the anxiety,depression and coping style among these *** intervention based on positive psychology was provided for 6 wk followed by another *** results were compared against those from the previous *** After 6 wk of psychological intervention,89 people achieved a significant improvement in the Hamilton Anxiety Scale and Hamilton Depression Scale-24 *** score for positive coping style in Trait Coping Style Questionnaire was significantly improved,while that of the negative coping style decreased significantly(P<0.05).CONCLUSION Psychological intervention based on positive psychology alleviated affective symptoms,such as anxiety and depression,in subjects addicted to online *** intervention corrected negative coping style,thereby improving mental health.

关键词： Online game addiction Positive psychology Anxiety Depression Coping style Psychological intervention

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Ab initio Study of Anharmonic Force Field and Spectroscopic Constants for Germanium Dichloride

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Chinese Journal of Chemical Physics 2016年第6期29卷 657-662,I0001页

作者： Wei-xiu Pang Yun-bin sun Jian-jun Zhao Yi Lu KeyLaboratoryofMagnetismandMaEneticMaterialsatUniversitiesofInnerMongoliaAutonomousRegion DepartmentofPhysicsBaotouNormalUniversityBaotou014030China

Ab initio study of the equilibrium structure, spectroscopy constants, and anharmonic force field for several isotopomers of germanium dichloride （70GeCl2, 72GECl2, and 76GeCl2） have been carried out at the MP2 and CCSD（T） levels of theory using cc-pVTZ basis set. The cal- culated geometries, rotational constants, vibration-rotation interaction constants, harmonic frequencies, anharmonic constants, quartic and sextic centrifugal distortion constants, cubic and quartic force constants are compared with experimental data. For small mass differences of the Ge isotopes, the isotopic effects for germanium dichloride are much weaker. The agreements are satisfactory for these two methods, but the deviations of CCSD（T） results are slightly larger than that of MP2, because of CCSD（T）＇s inadequate treatment of electron correlation in hypervalent Cl atom.

关键词： Anharmonic force field Spectroscopic constants Germanium dichloride

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Highly enantioselective cyclopropanation of trisubstituted olefins

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Science China Chemistry 2018年第5期61卷 526-530页

作者： jun Li Long Zheng Hao Chen Lijia Wang xiu-Li sun jun Zhu Yong Tang The State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences Shanghai 200032 China Collaborative Innovation Center of Chemical Science and Engineering Tianjin 300072 China

A highly efficient asymmetric cyclopropanation of trisubstituted olefins with methyl diazoacetate has been developed in terms of an elaborate modified chiral bisoxazoline/copper complex as a catalyst. A broad scope of substrates is compatible with this catalyst system, including various trisubstituted olefins bearing different aryl-, fused aryl-and alkyl-substituents, providing an easy access to optically active 1,1-dimethyl cyclopropanes in good yields with excellent diastereo-and enantio-selectivity.

关键词： cyclopropanation enantioselective bisoxazoline copper diazoacetate

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