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Fuel source shift or cost reduction:Context-dependent adaptation strategies in closely related Neodon fuscus and Lasiopodomys brandtii against hypoxia

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Zoological Research 2022年第4期43卷 497-513页

作者： xiu-juan li Cong-Cong Qiao Bo-Jian Chen Meng-Yang li Peng Chen Mao-lin Huang Chun-Xiao Chen Yan liu Han Cheng Meng-Wan Jiang Lu-Ye Shi Zhen-Long Wang School of life Sciences Zhengzhou UniversityZhengzhouHenan 450001China College of Environmental Science and Engineering Tongji UniversityShanghai 200092China Jiaxing-Tongji Environmental Research Institute JiaxingZhejiang 314051China State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of life Science University of Chinese Academy of SciencesKunmingYunnan 650223China School of Artificial Intelligence and Big Data Henan University of TechnologyZhengzhouHenan 450001China

Oxygen is essential for most life forms.Insufficient oxygen supply can disrupt homeostasis and compromise survival,and hypoxia-induced cardiovascular failure is fatal in many animals,including humans.However,certain species have adapted and evolved to cope with hypoxic environments and are therefore good models for studying the regulatory mechanisms underlying responses to hypoxia.Here,we explored the physiological and molecular responses of the cardiovascular system in two closely related hypoxiaadapted species with different life histories,namely,Qinghai voles(Neodon fuscus)and Brandt’s voles(Lasiopodomys brandtii),under hypoxic(10%O_(2) for 48 h)and normoxic(20.9%O_(2) for 48 h)exposure.Kunming mice(Mus musculus)were used for comparison.Qinghai voles live in plateau areas under hypoxic conditions,whereas Brandt’s voles only experience periodic hypoxia.Histological and hematological analyses indicated a strong tolerance to hypoxia in both species,but significant cardiac tissue damage and increased blood circulation resistance in mice exposed to hypoxia.Comparative transcriptome analysis revealed enhanced oxygen transport efficiency as a coping mechanism against hypoxia in both N.fuscus and L.brandtii,but with some differences.Specifically,N.fuscus showed upregulated expression of genes related to accelerated cardiac contraction and angiogenesis,whereas L.brandtii showed significant up-regulation of erythropoiesis-related genes.Synchronized upregulation of hemoglobin synthesis-related genes was observed in both species.In addition,differences in cardiometabolic strategies against hypoxia were observed in the rodents.Notably,M.musculus relied on adenosine triphosphate(ATP)generation via fatty acid oxidation,whereas N.fuscus shifted energy production to glucose oxidation under hypoxic conditions and L.brandtii employed a conservative strategy involving down-regulation of fatty acid and glucose oxidation and a bradycardia phenotype.In conclusion,the cardiovascular systems of N.fuscus and L.brandtii have evolved dif

关键词： Heart Hypoxia Lasiopodomys brandtii Neodon fuscus RNA sequencing

Sodium valproate suppresses abnormal neurogenesis induced by convulsive status epilepticus

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Neural Regeneration Research 2019年第3期14卷 480-484页

作者： Peng Wu Yue Hu xiu-juan li Min Cheng li Jiang Department of Neurology Children's Hospital of Chongqing Medical University Chongqing International Science and Technology Cooperation Center for Child Development and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Key Laboratory of Pediatrics in Chongqing

Status epilepticus has been shown to activate the proliferation of neural stem cells in the hippocampus of the brain, while also causing a large amount of neuronal death, especially in the subgranular zone of the dentate gyrus and the subventricular zone. Simultaneously, proliferating stem cells tend to migrate to areas with obvious damage. Our previous studies have clearly confirmed the effect of sodium valproate on cognitive function in rats with convulsive status epilepticus. However, whether neurogenesis can play a role in the antiepileptic effect of sodium valproate remains unknown. A model of convulsive status epilepticus was established in Wistar rats by intraperitoneal injection of 3 mEq/kg lithium chloride, and intraperitoneal injection of pilocarpine 40 mg/kg after 18–20 hours. Sodium valproate(100, 200, 300, 400, 500, or 600 mg/kg) was intragastrically administered six times every day(4-hour intervals) for 5 days. To determine the best dosage, sodium valproate concentration was measured from the plasma. The effective concentration of sodium valproate in the plasma of the rats that received the 300-mg/kg intervention was 82.26 ± 11.23 μg/mL. Thus, 300 mg/kg was subsequently used as the intervention concentration of sodium valproate. The following changes were seen: Recording excitatory postsynaptic potentials in the CA1 region revealed high-frequency stimulation-induced long-term potentiation. Immunohistochemical staining for BrdU-positive cells in the brain revealed that sodium valproate intervention markedly increased the success rate and the duration of induced long-term potentiation in rats with convulsive status epilepticus. The intervention also reduced the number of newborn neurons in the subgranular area of the hippocampus and subventricular zone and inhibited the migration of newborn neurons to the dentate gyrus. These results indicate that sodium valproate can effectively inhibit the abnormal proliferation and migration of neural stem cells and newborn neurons after convulsive status epileptic

关键词： nerve regeneration status epilepticus sodium valproate long-term potentiation neural stem cells neurogenesis migration subgranular zone subventricular zone neural regeneration

Flanibizumab Plus Combined Surgery for Treatment o Neovascular Glaucoma with Vitreous Hemorrhage

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Chinese Medical Journal 2015年第15期128卷 2078-2083页

作者： xiu-juan li Xiao-Peng Yang Qiu-Ming li Yu-Ying Wang Xiao-Bei Lyu Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China Department of Medical Equipment The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China

Background：Neovascular glaucoma （NVG） is a refractory glaucoma.The management of NVG is very difficult,and it is more difficult when combined with vitreous hemorrhage.The aim of this study was to investigate the effects of ranibizumab plus combined surgery for NVG with vitreous hemorrhage.Methods：A total of 26 eyes of 26 NVG patients with vitreous hemorrhage were recruited in this study.The patients aged from 36 to 63 years with a mean age of 51.97 ± 7.60 years.The mean intraocular pressure （IOP） was 46.38 ± 5.75 mmHg （1 mmHg =0.133 kPa） while being treated with the maximum medical therapy.The mean best-corrected visual acuities converted to logarithm of the minimum angle of resolution （logMAR BCVA） was 2.62 ± 0.43.All the patients underwent intravitreal injection of 0.5 mg （0.05 ml） ranibizumab combined with pars plana vitrectomy （PPV）,pars plana lensectomy （PPL） with a preserved anterior capsule,panretinal photocoagulation （PRP）,and trabeculectomy （intravitreal ranibizumab [IVR] ＋ PPV ＋ PPL ＋ PRP ＋ trabeculectomy）.The IOP and logMAR BCVA were the main outcome measures in this study.Results：The follow-up period was 12 months.The mean postoperative IOPs were 26.38 ± 3.75 mmHg,21.36 ± 3.32 mmHg,1 8.57 ± 3.21 mmHg,and 16.68 ± 2.96 mmHg,respectively at 7 days,1 month,3 months,and 12 months after PPV ＋ PPL ＋ PRP ＋ trabeculectomy.At the last follow-up,the mean IOP was significantly lower than the preoperative one （t =6.612,P =0.001）.At 7 days,1 month,3 months,and 12 months after PPV ＋ PPL ＋ PRP ＋ trabeculectomy,the mean logMAR BCVA were 1.30 ± 0.36,1.29 ± 0.37,1.29 ± 0.39,and 1.26 ± 0.29,respectively.At the last follow-up,the mean logMAR BCVA was significantly improved,and the difference was statistically significant compared with preoperative one （t =6.133,P =0.002）.The logMAR BCVA improved in 22 eyes （84.62%）,and remained stable in 4 eyes （15.38%）.The neovascularization in the iris and the angle regressed significantly in all patients 7 days after ranibizumab injection.No serious complications occurred during 12 mon

关键词： Neovascular Glaucoma Panretinal Photocoagulation Pars Plana Vitrectomy Ranibizumab Trabeculectomy

Comparison of scleral buckling using wide-angle viewing systems and indirect ophthalmoscope for rhegmatogenous retinal detachment

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International Journal of Ophthalmology(English edition) 2016年第9期9卷 1310-1314页

作者： xiu-juan li Xiao-Peng Yang Xiao-Bei Lyu Department of Ophthalmology the First Affiliated Hospital of Zhengzhou University Department of Medical Equipment the First Affiliated Hospital of Zhengzhou University

AIM：To compare the effects of scleral buckling using wide-angle viewing systems（WAVS） with that using indirect ophthalmoscope for the treatment of rhegmatogenous retinal detachment.METHODS：The study was a retrospective analyses of the medical records of 94 eyes（94 patients） with rhegmatogenous retinal detachment.Among them,47 eyes underwent scleral buckling using WAVS with endoiiluminator（Group W）,and 47 eyes underwent scleral buckling using indirect ophthalmoscope（Group I）.Surgical durations,primary success rate,best-corrected visual acuities（BCVA）,delayed subretinal fluid absorptions and surgical complications were compared between the two groups.RESULTS：At baseline,there were no statistical differences between the two groups in patient＇s age（P=0.997）,gender（P=0.853）,symptom duration（P=0.216）,BCVA（P=0.389）,refractive error（P=0.167）,intraocular pressure（P=0.595）,the number of retinal breaks（P=0.832）,the extent of retinal detachment（P =0.246）,subretinal demarcation line（P=0.801）,and macular detachment（P=0.811）.The follow-up period was 12 mo.The surgical durations in Group W（with or without encircling buckling） were significant shorter than those in Group I（P〈0.001 respectively）.The primary success rate was94.27%in Group W,which was similar to that in Group I（92.38%,P=0.931）.The BCVA in Group W was better than that in Group I（P〈0.001） at 1-month follow-up visit.However,there were no significant differences between the two groups at 3-month（P=0.221）,6-month（P =0.674）,and 12-month（P=0.363） follow-up visits respectively.Delayed subretinal fluid absorptions were more common in Group I than in Group W at 1-month（P=0.045） follow-up visit,but there were no significant differences between the two groups at 3-month（P=0.111）,6-month（P =1.000） and 12-month follow-up visits respectively.CONCLUSION：Scleral buckling using WAVS can be an alternative choose for rhegmatogenous retinal detachment

关键词： scleral buckling retinal detachment wide-angle viewing systems

ntravitreal Ranibizumab for Aggressive Posterior Retinopathy of Prematurity

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Chinese Medical Journal 2016年第23期129卷 2879-2881页

作者： xiu-juan li Xiao-Peng Yang Shuang Sun Xiao-Bei Lyu Heng Jia Department of Ophthalmology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China Department of Medical Equipment The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China Department of Ophthalmology Children's Hospital of Zhengzhou Zhengzhou Henan 450052 China

Retinopathy ofprematurity （ROP） is a proliferative disease that affects infants of young gestational age （GA） and low birth weight （BW）. Aggressive posterior ROP （AP-ROP） is a rapidly progressing and severe presentation of ROP. It is characterized as posterior location （zone 1 or posterior zone I1）, Stage 3, and with plus disease （arterial tortuosity and venous dilation）. It can quickly lead to retinal detachment and blindness if not treated in time.

关键词： Aggressive Posterior Retinopathy of Prematurity Intravitreal Injection Ranibizumab

Effects of hepatocyte growth factor on MMP-2 expression in scleral fibroblasts from a guinea pig myopia model

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International Journal of Ophthalmology(English edition) 2014年第2期7卷 239-244页

作者： xiu-juan li Xiao-Peng Yang Guang-Ming Wan Yu-Ying Wang Jin-Song Zhang Department of Ophthalmology the First Affiliated Hospital of Zhengzhou University Department of Medical Equipment the First Affiliated Hospital of Zhengzhou University

AIMTo investigate the effects of hepatocyte growth factor (HGF) on MMP-2 expression in scleral fibroblasts from guinea pig with liM.

关键词： myopia fibroblasts hepatocyte growth factor MMP-2 guinea pig

Posterior scleral reinforcement combined with vitrectomy for myopic foveoschisis

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International Journal of Ophthalmology(English edition) 2016年第2期9卷 258-261页

作者： xiu-juan li Xiao-Peng Yang Qiu-Ming li Yu-Ying Wang Jing Wang Xiao-Bei Lyu Heng Jia Department of Ophthalmology the First Affiliated Hospital of Zhengzhou University Department of Medical Equipment the First Affiliated Hospital of Zhengzhou University

AIM： To investigate the effects of posterior scleral reinforcement （PSR） combined with vitrectomy for myopic foveoschisis. ~ METHODS： Thirty-nine highly myopic eyes of 39 patients with myopic foveoschisis underwent PSR combined with vitrectomy. Best corrected visual acuity （BCVA）, refraction error, and the foveal thickness by optical coherence tomography （OCT） were recorded before and after the surgery, and complications were noted. RESULTS： The follow-up period was 12mo, and the main focus was on the results of the 12-month follow-up visit. The mean preoperative BCVA was 0.96±0.43 IogMAR. At the final follow-up visit, the mean BCVA was 0.46± 0.28 IogMAR, which significantly improved compared with the preoperative one （P =0.003）. The BCVA improved in 33 eyes （84.62%）, and unchanged in 6 eyes （15.38%）. At the end of follow-up, the mean refractive error was -15.13 ±2.55 D, and the improvement was significantly compared with the preoperative one （-17.53±4.51 D）（P= 0.002）. Twelve months after surgery, OCT showed complete resolution of the myopic foveoschisis and a reattachment of the fovea in 37 eyes （94.87%） and partial resolution in the remained two eyes （5.13%）. The foveal thickness was obviously reduced at 12-month follow-up visit （196.45±36.35um） compared with the preoperative one （389,32±75.56um）（P=0.002）. There were no serious complications during the 12mo follow-up period. CONCLUSION： PSR combined with vitrectomy is a safe and effective procedure for myopic foveoschisis with both visual and anatomic improvement.

关键词： high myopia myopic foveoschisis posteriorscleral reinforcement vitrectomy

Posterior scleral reinforcement for the treatment of pathological myopia

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International Journal of Ophthalmology(English edition) 2016年第4期9卷 580-584页

作者： xiu-juan li Xiao-Peng Yang Qiu-Ming li Yu-Ying Wang Yuan Wang Xiao-Bei Lyu Heng Jia Department of Ophthalmology the First Affiliated Hospital of Zhengzhou University Department of Medical Equipment the First Affiliated Hospital of Zhengzhou University Department of Ophthalmology Zhengzhou Central Hospital Affiliated to Zhengzhou University

AIM： To investigate the effects of posterior scleral reinforcement（PSR） in the treatment of pathological myopia.·METHODS： The study included 52 eyes in 43 patients with pathological myopia who underwent PSR（PSR group）, and 52 eyes in 36 age- and myopia-matched patients who did not undergo such treatment as control group. Axial length, refraction error, best corrected visual acuity（BCVA）, and macular scans by optical coherence tomography（OCT） were recorded at baseline, 6mo, 1, 3and 5y after the surgery, and the complications were noted.·RESULTS： There were no statistical differences in axial length, refractive error, or BCVA between the PSR group and the control group at baseline. At the end of the follow-up, the mean axial length was 29.79 ±1.26 mm in the PSR group, which was significantly shorter than that in the control group（30.78±1.30 mm）（P 〈0.01）, and the mean refractive error was-16.86 ±2.53 D in the PSR group, which was significantly lower than that in the control group（-19.18 ±2.12 D）（P 〈0.01）. A statistically significant difference in BCVA was found between the PSR group（0.51 ±0.25 log MAR） and the control group（0.62±0.26 log MAR） at the postoperative 5-year follow-up（P 〈0.01）. There were no serious complications during the 5-year follow-up period.·CONCLUSION： PSR can prevent axial elongation and myopia progression in eyes with pathological myopia.

关键词： pathological myopia posterior scleral reinforcement axial length

CRYSTAL AND MOLECULAR STRUCTURE OF THE COMPLEX OF METHOXYCARBONYLETHYLTIN TRICHLORIDE WITH SAliCYliDENE-M-TOLUIDINE

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Chinese Chemical Letters 1995年第1期6卷 87-90页

作者： Fang Xin FU xiu juan li Hua De PAN Yan XING Yong Hua liN Department of Chemistry.Northeast Normal University.Changchun 130024 Changchun Applied Chemistry Institute Academy Sinica.Changchun 130022

The synthesis and properties of the title complex CH3OCOCH2CH2SnCl3. 2-HOC6H4CH+= NC6H4-3-CH3 are described. It crystallizes from benzene' in the monoclinic space group P2/n with Unit cell dimensions a= 10. 326 (3) .b=6. 815(8). c=12. 931 (6) A,β=111. 52(3)°, V=2088. 7(1),A3, Z=4, F(000)= 1040, μ= 16. 31cm-1. Dc =1. 67g/cm3 final R factor is 0. 037 for 3177 observed reflections, I≥3σ(I。). The tin atom in the structure of tile complex exists in a dis tored octahedral geomelry defined by three CI atoms, the C and O atoms of a chelating methoxycarbonylethyl group as well as an O atom derived from the Schiff base ligand.

关键词： ?