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PBX1 attributes as a determinant of connexin 32 downregulation in Helicobacter pylori-related gastric carcinogenesis

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World Journal of Gastroenterology 2017年第29期23卷 5345-5355页

作者： xiao-Ming Liu Can-xia Xu Lin-Fang Zhang Li-Hua Huang Ting-Zi Hu Rong Li xiu-juan xia Lin-Yong Xu Ling Luo xiao-xia Jiang Ming Li Department of Gastroenterology the Third Xiangya Hospital of Central South University Center for Medical Experiments the Third Xiangya Hospital of Central South University Department of Medical Statistics Xiangya School of Public Health Central South University

AIM To clarify the mechanisms of connexin 32 (Cx32) downregulation by potential transcriptional factors (TFs) in Helicobacter pylori (H. pylori)-associated gastric carcinogenesis. METHODS Approximately 25 specimens at each developmental stage of gastric carcinogenesis [non-atrophic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and gastric carcinoma (GC)] with H. pylori infection [H. pylori (+)] and 25 normal gastric mucosa (NGM) without H. pylori infection [H. pylori (-)] were collected. After transcriptional factor array analysis, the Cx32 and PBX1 expression levels of H. pylori-infected tissues from the developmental stages of GC and NGM with no H. pylori infection were measured by real-time polymerase chain reaction (RT-PCR) and Western blot analysis. Regarding H. pylori-infected animal models, the Cx32 and PBX1 mRNA expression levels and correlation between the gastric mucosa from 10 Mongolian gerbils with long-term H. pylori colonization and 10 controls were analyzed. PBX1 and Cx32 mRNA and protein levels were further studied under the H. pylori-infected condition as well as PBX1 overexpression and knockdown conditions in vitro. RESULTS Incremental PBX1 was first detected by TF microarray in H. pylori-related gastric carcinogenesis. The identical trend of PBX1 and Cx32 expression was confirmed in the developmental stages of H. pylori-related clinical specimens. The negative correlation of PBX1 and Cx32 was confirmed in H. pylori-infected Mongolian gerbils. Furthermore, decreased PBX1 expression was detected in the normal gastric epithelial cell line GES-1 with H. pylori infection. Enforced overexpression or RNAi-mediated knockdown of PBX1 contributed to the diminished or restored Cx32 expression in GES-1 and the gastric carcinoma cell line BGC823, respectively. Finally, dual-luciferase reporter assay in HEK293T cells showed that Cx32 promoter activity decreased by 30% after PBX1 vector co-transfection, indicating PBX1 as a transcriptio

关键词： Helicobacter pylori Inflammation-carcinoma chain Connexin 32 PBX1 Carcinogenesis

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Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis

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Chinese Medical Journal 2016年第7期129卷 757-762页

作者： Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-xiano Lu xiu-juan xia You-Kun Lin Yu-Zhen Li Cai-xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie xiu-Ping Han Zhi-Qiang Xie xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang Department of Dermatology Peking University People's Hospital Beijing 100044 China Department of Dermatology The Second Xiangya Hospital of Central South University Changsha Hunan 410011 China Department of Dermatology The First Hospital of China Medical University Shenyang Liaoning 110001 China Department of Dermatology Institute of Dermatology Chinese Academy of Medical Sciences Nanjing Jiangsu 210042 China Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China Department of Dermatology Tianjin Changzheng Hospital Tianjin 300120 China Department of Dermatology The Affiliated Hospital of Inner Mongolia Medical University Hohhot Inner Mongolia 010050 China Department of Dermatology Yantai Yuhuangding Hospital Yantai Shandong 264000 China Department of Dermatology The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi 530021 China Department of Dermatology The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang 150001 China Department of Dermatology The Second Hospital of Dalian Medical University Dalian Liaoning 116023 China Department of Dermatology Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200092 China Department of Dermatology Shanghai Huashan Hospital Shanghai 200040 China Department of Dermatology Xijing Hospital Xi'an Shaanxi 710032 China Department of Dermatology The Third Affiliated Hospital Of Sun Yat-sen University Guangzhou Guangdong 510630 China Department of Dermatology The Second Hospital of Heilongjiang Province Harbin Heilongjiang 150010 China Department of Dermatology Xiangya Hospital of Central South University Changsha Hunan 410008 China Department of Dermatology.Shengjing Hospital of China Medical University Shenyang Liaoning 110004 China Department of Dermatology Peking University Third Hospital Beijing 100191 China Department of Dermatology The First Affili

Background： Atopic dermatitis （AD） is an inflammatory skin disease characterized by chronic recurrent dermatitis with profound itching. Most patients have personal and/or family history of atopic diseases. Several criteria have been proposed for the diagnosis of AD. Although the clinical features of childhood AD have been widely studied, there has been less large-scale study on adult/adolescent AD. The aim of this study was to investigate the clinical features of adult/adolescent patients with chronic symmetrical eczemaJAD and to propose Chinese diagnostic criteria for adult/adolescent AD. Methods： A hospital-based study was performed. Forty-two dermatological centers participated in this study. Adult and adolescent patients （12 years and over） with chronic symmetrical eczema or AD were included in this study. Questionnaires were completed by both patients and-investigators. The valid questionnaires were analyzed using EpiData 3.1 and SPSS 17.0 software. Results： A total of 2662 valid questionnaires were collected （1369 male and 1293 female）. Of all 2662 patients, 2062 （77.5%） patients had the disease after 12 years old, while only 600 （22.5%） patients had the disease before 12 years old, suggesting late-onset eczema/AD is common. Two thousand one hundred and thirty-nine （80.4%） patients had the disease for more than 6 months. One thousand one hundred and forty-four （43.0%） patients had a personal and/or family history of atopic diseases. One thousand five hundred and forty-eight （58.2%） patients had an elevated total serum IgE and/or eosinophilia and/or positive allergen-specific IgE. Based on these clinical and laboratory features, we proposed Chinese criteria for adult/adolescent AD. Of all 2662 patients, 60.3% were satisfied with our criteria, while only 48.2% satisfied with Hanifin Rajka criteria and 32.7% satisfied with Williams criteria, suggesting a good sensitivity of our criteria in adult/adolescent AD patients. Conclusion： Late-onset of eczema or AD is co

关键词： Adolescents and Adults Atopic Dermatitis Clinical Features Diagnostic Criteria Eczema

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“学生中心”模拟课堂的教学设计

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兵团教育学院学报 2025年第1期35卷 65-71页

作者：郑秀霞莆田市荔城区教师进修学校福建莆田351100

传统模拟课堂,因教师教学设计时局限于教师本位和教学本位,产生了教学单向灌输、目标脱离学情、导入价值有限、问题层次失衡等系列问题。缘此,“学生中心”模拟课堂践行“学生本位”的教学思想,聚焦学习需求和发展,呈现“新四中心”的特... 详细信息

传统模拟课堂,因教师教学设计时局限于教师本位和教学本位,产生了教学单向灌输、目标脱离学情、导入价值有限、问题层次失衡等系列问题。缘此,“学生中心”模拟课堂践行“学生本位”的教学思想,聚焦学习需求和发展,呈现“新四中心”的特征,真实展示出课堂“教”行为、“学”生成和“评”实施等预设。研究以福建省第五届教师教学技能大赛初中综合实践活动片断教学为例,阐述“学生中心”模拟课堂的教学设计策略,为一线教育工作者提供教学上的实用参考。

关键词：学生中心模拟课堂教学设计综合实践活动学习本位

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Carbon and Nitrogen Contents in Typical Plants and Soil Profiles in Yanqi Basin of Northwest China

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Journal of Integrative Agriculture 2014年第3期13卷 648-656页

作者： ZHANG juan WANG xiu-jun WANG Jia-ping WANG Wei-xia State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences University of Chinese Academy of Sciences Earth System Science Interdisciplinary Center University of Maryland College ParkMD 20740 USA

Carbon and nitrogen are the most important elements in the terrestrial ecosystem. Studying carbon and nitrogen distributions in plant and soil is important for our understanding of the ecosystem dynamics and carbon cycle on arid lands. A study was conducted in a typical arid area, the Yanqi Basin, Northwest China. Carbon and nitrogen distributions in plant tissues and soil profiles were determined at 21 sites with typical native plants and crops. Our results indicated that carbon content was similar between crops and native plants, and the average carbon contents in aboveground （42.4%） and belowground （42.8%） tissues were almost the same. Average nitrogen contents in crops were nearly the same （~0.7%） in aboveground and belowground tissues whereas mean nitrogen content was approximately 100% higher in aboveground （2.2%） than in belowground （1.2%） tissues for native species. Soil organic carbon （SOC） and total nitrogen （TN） in cropland （9.4 and 0.9 g kg^-1） were significantly higher than those in native land （6.2 and 0.7 g kg^-1）. Multiple regression analyses indicated that carbon content in belowground tissue and nitrogen content in aboveground tissue were key factors connecting plant and soil in native land. However, there was no significant relationship for carbon or nitrogen between soil and crop, which might reflect human disturbance, such as plowing and applications of various organic materials.

关键词： carbon nitrogen native land cropland arid land

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A 2-D NUMERICAL IRREGULAR WAVE TANK AND ITS VERIFICATION

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Journal of Hydrodynamics 2005年第2期17卷 222-227页

作者： LIBen-xia YUXi-ping YUYu-xiu DepartmentofHydrauhcEngineering TsinghuaUniversityBeijing100084China StateKeyLaboratoryofCoastalandOffshoreEngineering DalianUniversityofTechnologyDalian116024China

A two-dimensional numerical irregular wave tank based on the potential wave theory was developed. A source term was used inside the domain to generate waves, and outgoing waves were dissipated by sponge layers and transmitted by radiation boundary. The σ-coordinate transformation was introduced to map the time-dependent irregular physical domain to a fixed regular computational domain, and thus the free surface and bottom boundary conditions could be implemented precisely. The model was verified by simulating the nonlinear regular and irregular wave propagation on constant-depth water, as well as regular waves reflected from a vertical wall, and satisfactory agreement between numerical results and analytical solutions was obtained. The present numerical model is proved to be an effective tool for a long-duration simulation of coastal wave dynamics where the wave reflection is significant.

关键词： irregular waves numerical wave tank source wave-generating method σ-coordinate transformation potential wave theory

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Predicting CircRNA-Disease Associations Based on Improved Weighted Biased Meta-Structure

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Journal of Computer Science & Technology 2021年第2期36卷 288-298页

作者： xiu-juan Lei Chen Bian Yi Pan School of Computer Science Shaanxi Normal UniversityXi'an 710119China School of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Computer Science Georgia State UniversityAtlantaGA 30302U.S.A

Circular RNAs(circRNAs)are RNAs with a special closed loop structure,which play important roles in tumors and other *** to the time consumption of biological experiments,computational methods for predicting associations between circRNAs and diseases become a better *** the limited number of verified circRNA-disease associations into account,we propose a method named CDWBMS,which integrates a small number of verified circRNA-disease associations with a plenty of circRNA information to discover the novel circRNA-disease *** adopts an improved weighted biased meta-structure search algorithm on a heterogeneous network to predict associations between circRNAs and *** terms of leave-one-out-cross-validation(LOOCV),10-fold cross-validation and 5-fold cross-validation,CDWBMS yields the area under the receiver operating characteristic curve(AUC)values of 0.9216,0.9172 and 0.9005,***,case studies show that CDWBMS can predict unknow circRNA-disease *** conclusion,CDWBMS is an effective method for exploring disease-related circRNAs.

关键词： circular RNA(circRNA) circRNA-disease association meta-structure heterogeneous network

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Synthesis and Anti-inflammatory Action of (η-C_5H_5)_2Ti(Sal)_2 and (η-C_5H_5)_2Ti(Clo)_2

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Chemical Research in Chinese Universities 2006年第1期22卷 6-10页

作者： LI xiu-juan ZENG Zheng-zhi College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 P. R. China

Two new complexes （Cp）2Ti （Sal）2 and（Cp）2Ti（Clo）2 （Cp=Cyclopentadienyl η^5-C5H5 ）, have been synthesized in anhydrous THF by the reaction of HSal（o-hydroxybenzoic acid, salicylate acid） or HClo[N-（ m-chloro-phenyl） anthranili acid, acidum clofenamicum] with （Cp）2TiCl2 and characterized by means of elemental analyses, IR, H NMR, ^13C NMR, UV and molar conductivity. In complex （Cp）2Ti（Sal）2 or（Cp）2Ti（Clo）2, the oxygen atom of the carboxyl group coordinates to Ti（Ⅳ） in a monodentate manner. The inhibitory action of the complexes on mouse ear tumefaction caused by croton oil and rat foot granulation growth caused by cotton balls is higher than that of the corresponding ligands HSal, HClo and [ （Cp）2TiCl2 ], whereas their toxicity is lower than those of the free ligands.

关键词： Salicylate acid N-(m-Chlorophenyl) anthranilic acid Cyclopentadienyltitanium complexes Anti-in-flammatory

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Abnormal specific heat at low temperatures and transport properties in Mg-Cu-Ag-Gd bulk metallic glass

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Journal of Rare Earths 2023年第2期41卷 277-282页

作者： Qiang Zheng xiu Su Lingyun Li juan Du Institute of Materials School of Materials Science and EngineeringShanghai UniversityShanghai 200072China

We report the pronounced low-temperature specific-heat Cpanomalies in the Mg_(59.5)Cu_(22.9)Ag_(6.6)Gd_(11)bulk metallic glass(BMG).The extrapolated electron’s temperature coefficientγ0Kis up to 681.8 mJ/(molGd·K^(2))at 0 K,which is a heavy-fermion-like *** low temperature specific heat indicates an enhancement of the conduction-electron effective mass m*below 7.5 K,suggesting that the Mg_(59.5)Cu_(22.9)Ag_(6.6)Gd_(11)BMG is not free-electron-like *** excess specific heat in the Mg-based BMG is interpreted with tunneling states and spin glass state(magnetism)which are determined by subtracting electrons’and phonons’contribution to the specific heat below 12 *** Boson peak(BP)temperature is located at 27 K,which is much higher than the reported values of other ***,a BP height of 0.047 mJ/(mol·K^(4))is obtained due to reduced free volume during copper mold casting with a slow cooling *** electrical resistivity was also investigated between 2 and 300 K,which has a negative temperature coefficient of resistivity(TCR)below 35 K(Kondo temperature,TK)and a positive value of 3.9×10^(-4)/K above 35 *** is a minimum at about 35 K for the electrical resistivity,which can be explained by the Kondo *** the resistivity above 35 K,it can be explained by the FaberZiman model due to the T-dependence change of structure factor.

关键词： Specific heat Boson peak Electrical resistivity Bulk metallic glass(BMG) Spin glass behavior Rare earths

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钢渣活性激发的研究现状与发展

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上海大学学报（自然科学版） 2004年第1期10卷 91-95页

作者：许远辉陆文雄王秀娟邵霞上海大学环境与化学工程学院上海200072

详细介绍了钢渣活性激发的各种方法以及其激发的机理,并对今后钢渣活性激发的发展趋势作了预测.

关键词：钢渣活性激发机理

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On Initial Data of the Monopole Equation

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Acta Mathematica Sinica,English Series 2009年第12期25卷 2127-2132页

作者： Hong Yu WANG xiu juan ZHU School of Mathematical Sciences Yangzhou University Yangzhou 225002 P. R. China

The space-time monopole equation is the reduction of anti-self-dual Yang-Mills equations in R2,2 to R2,1. This equation is a non-linear wave equation, and can be encoded in a Lax pair. An equivalent Lax pair is used by Dai and Terng to construct monopoles with continuous scattering data, and then the equation can be linearized by the scattering data, allowing one to use the inverse scattering method to solve the Cauchy problem with rapidly decaying small initial data. In this paper, we use the terminology of holomorphic bundle and transversality of certain maps, parametrized by initial data, to give more initial data, with which we can use scattering method to solve the Cauchy problem of the monopole equation up to gauge transformation.

关键词： continuous scattering holomorphically trivial bundle transversality

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