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Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines

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Journal of Genetics and Genomics 2020年第2期47卷 119-121页

作者： Xin Liu xiu-jie wang Key Laboratory of Genetic Network Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing100101China University of Chinese Academy of Sciences Beijing100049China Innovation Academy for Seed Design Chinese Academy of SciencesBeijing100101China

Coronaviruses,members of the family Coronaviridae and sub-family Coronavirinae,are enveloped positive-strand RNA viruses which have spikes of glycoproteins projecting from their viral envelopes,thus exhibit a corona or halo-like appearance(Masters and Perlman,2013;Cui et al..2019).Coronaviruses are the causal path-ogens for a wide spectrum of respiratory and gastrointestinal diseases in both wild and domestic animals,including birds,pigs,rodents,etc(Dhama et al,2014).Previous studies have found that six strains of coronaviruses are capable to infect humans,including four strains circulating yearly to cause common cold,and other two strains which are the source for severe acute respiratory syndrome(SARS)and Middle East respiratory syndrome(MERS-CoV),respectively(Dhama et al,2014;Cui et al..2019).

关键词： respiratory envelope Middle

Rising from Ashes:Non-Coding RNAs Come of Age

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Journal of Genetics and Genomics 2013年第4期40卷 141-142页

作者： Zicai Liang xiu-jie wang Institute of Molecular Medicine Peking University The State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of Sciences

It was recognized that a majority of the whole human genome is transcribed but only about 2% of genome actually encode all the proteins that were supposed, according to the central dogma, executing most of the biological functions of an organism. At an age proteins dominate, over 90% nonprotein coding regions were long regarded as trash, but nevertheless it was puzzling why god would allocate such a big portion of a genome to things without obvious meanings, and such curiosity has heightened when it was shown among various genome sequencing projects that the percentage of non-coding sequences is in almost strict correlation with the complexity of the organisms.

关键词： Rising from Ashes RNA

Bioinformaticians wrestling with the big biomedical data

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Journal of Genetics and Genomics 2017年第5期44卷 223-225页

作者： Yu Xue xiu-jie wang MOE Key Laboratory of Molecular Biophysics College of Life Science and Technology and the Collaborative Innovation Center for Brain ScienceHuazhong University of Science and Technology The State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of Sciences

Database plays a critical role throughout the history of the development of bioinformatics and *** 1980s,a number of databases such as GenBank（NCBI Resource Coordinators,2017）,European Nucleotide Archive（ENA）（Toribio et al,2017）,and DNA Data Bank of Japan（DDBJ）（Mashima et al.,2017）were established and have still acted as major data resources for maintaining nucleotide sequences and other types of biological data until today.

关键词： biomedical Nucleotide bioinformatics today maintaining http throughout metastasis until threaten

A long noncoding RNA involved in rice reproductive development by negatively regulating osa-miR160

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Science Bulletin 2017年第7期62卷 470-475页

作者： Meng wang Hua-Jun Wu Jun Fang Chengcai Chu xiu-jie wang State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of Sciences Northeast Institute of Geography and Agroecology Key Laboratory of Soybean Molecular Design BreedingChinese Academy of Sciences

Long noncoding RNAs （IncRNAs） participate in the regulation of multiple biological processes via diverse manners, one of which is functioning as endogenous target mimics （eTMs） to modulate microRNAs （miRNAs） by competing for their targets. Previously, we have predicted one IncRNA （osa-eTM160） as an endogenous repressor of osa-miR160 and validated the target mimicry ability of osa-eTM160 for ath-miR160 in Arabidopsis thaliana, yet the functions of osa-eTM160 in rice remain obscure. Here, we demonstrated that osa-eTM160 attenuated the repression of osa-miR160 on osa-ARF18 mRNAs during early anther developmental stages through the target mimicry manner, therefore to regulate rice seed setting and seed size. These findings revealed the roles of osa-eTM160 in rice, and indicated that lncRNAs with eTM functions may serve as temporal regulators to modulate the effects of miRNAs at specific developmental stages.

关键词： microRNA IncRNA miR160 Target mimic

Current progresses of 3D bioprinting based tissue engineering

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Frontiers of Electrical and Electronic Engineering in China 2017年第2期5卷 136-142页

作者： Zeyu Zhang xiu-jie wang Key Laboratory of Genetic Network Biology Collaborative Innovation Center of Genetics and Development Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

Background： The shortage of available organs for transplantation is the major obstacle hindering the application of regenerative medicine, and has also become the desperate problem faced by more and more patients nowadays. The recent development and application of 3D printing technique in biological research （bioprinting） has revolutionized the tissue engineering methods, and become a promising solution for tissue regeneration. Results： In this review, we summarize the current application of bioprinting in producing tissues and organoids, and discuss the future directions and challenges of 3D bioprinting. Conclusions： Currently, 3D bioprinting is capable to generate patient-specialized bone, cartilage, blood vascular network, hepatic unit and other simple components/tissues, yet pure cell-based functional organs are still desired.

关键词：

Promote Connections of Young Computational Biologists in China

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Genomics, Proteomics & Bioinformatics 2013年第4期11卷 253-256页

作者： Shihua Zhang xiu-jie wang National Center for Mathematics and Interdisciplinary Sciences Academy of Mathematics and Systems ScienceChinese Academy of Sciences Center for Molecular Systems Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences

The first Youth Investigator Forum on Interdisciplinary Re- search of Mathematics, Computer Science and Biological Sci- ence （YMCB） took place on May 18-19, 2013 in Beijing, China. The conference was hosted by the National Center for Mathematics and Interdisciplinary Sciences （NCMIS）, Chi- nese Academy of Sciences （CAS）, and was initiated by Dr. xiu-jie wang （Institute of Genetics and Developmental Biol- ogy, CAS） and Dr. Shihua Zhang （Academy of Mathematics and Systems Science, CAS）. This conference was launched to nurture the next generation of computational biologists in Chi- na. More than 300 people from all over the country attended this conference and 21 talks and 40 posters were presented at this meeting. The topics covered next-generation sequencing data analysis, transcription and mRNA regulation, microR- NA and lncRNA regulation, network biology, cancer genom- ics, epigenetics and personalized medicine. The conference was opened by Prof.

关键词： Promote Connections of Young Computational Biologists in China CTCF gene DNA

Omics tools for the needle out of haystack?

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Journal of Genetics and Genomics 2018年第7期45卷 343-344页

作者： Zhiwei Cao xiu-jie wang Shihua Zhang School of Life Sciences and Technology Tongji University Institute of Genetics and Developmental Biology Chinese Academy of Sciences Academy of Mathematics and Systems Science Chinese Academy of Sciences

With the rapid progress of omics technology, mining the needle of knowledge in the haystack of omics data has become extremely challenging and time-consuming. To meet the rising desire from biomedical communities, bioinformaticians worldwide have developed various tools to facilitate omics data analysis for a wide range of purposes.

关键词： In Omics tools for the needle out of haystack

Endogenous Small RNA Clusters in Plants

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Genomics, Proteomics & Bioinformatics 2014年第2期12卷 64-71页

作者： Yong-Xin Liu Meng wang xiu-jie wang State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of Sciences University of Chinese Academy of Sciences

In plants, small RNAs（sRNAs） usually refer to non-coding RNAs（ncRNAs） with lengths of 20–24 nucleotides. sRNAs are involved in the regulation of many essential processes related to plant development and environmental responses. sRNAs in plants are mainly grouped into microRNAs（miRNAs） and small interfering RNAs（siRNAs）, and the latter can be further classified into trans-acting siRNAs（ta-siRNAs）, repeat-associated siRNAs（ra-siRNAs）, natural anti-sense siRNAs（nat-siRNAs）, etc. Many sRNAs exhibit a clustered distribution pattern in the genome. Here, we summarize the features and functions of cluster-distributed sRNAs, aimed to not only provide a thorough picture of sRNA clusters（SRCs） in plants, but also shed light on the identification of new classes of functional sRNAs.

关键词： Small RNA cluster MicroRNA siRNA Expression pattern

Regulation beyond genome sequences: DNA and histone methylation in embryonic stem cells

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Frontiers in Biology 2010年第1期5卷 41-47页

作者： Wei YANG Qi ZHOU xiu-jie wang State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Graduate University of the Chinese Academy of Sciences Beijing 100101China

Embryonic stem(ES)cells distinct themselves from other cell type populations by their pluripotent *** unique features of ES cells are controlled by both genetic and epigenetic *** have shown that the methylation status of DNA and histones in ES cells is quite different from that of differentiated cells and somatic stem ***,we summarized recent advances in DNA and histone methylation studies of mammalian ES *** methylation status of several key pluripotent regulatory genes is also discussed.

关键词： Embryonic stem(ES)cells epigenetic DNA methylation histone methylation