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World Journal of Gastroenterology 2024年第12期30卷 1727-1738页

作者： Hong peng Si-Yi Lei Wei Fan Yu Dai Yi Zhang Gen Chen Ting-Ting Xiong Tian-Zhao Liu Yue huang Xiao-Feng Wang Jin-Hui Xu Xin-hua Luo Department of Infectious Diseases Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Department of Hepatobiliary Surgery Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

BACKGROUND Sarcopenia may be associated with hepatocellular carcinoma(HCC)following *** traditional single clinical variables are still insufficient to predict *** still lack effective prediction models for recent recurrence(time to recurrence5 cm(HR=2.222,95%CI:1.285-3.842,P<0.05),and hepatitis B virus DNA level≥2000 IU/mL(HR=2.1,95%CI:1.407-3.135,P<0.05)were independent risk factors associated with postoperative recurrence of *** on the sarcopenia to assess the RFS model of hepatectomy with hepatitis B-related liver cancer disease(SAMD)was established combined with other the above risk *** area under the curve of the SAMD model was 0.782(95%CI:0.705-0.858)in the training cohort(sensitivity 81%,specificity 63%)and 0.773(95%CI:0.707-0.838)in the validation ***,a SAMD score≥110 was better to distinguish the high-risk group of postoperative recurrence of *** Sarcopenia is associated with recent recurrence after hepatectomy for hepatitis B-rel

关键词： Alpha-fetoprotein Hepatitis B virus Hepatectomy Hepatocellular carcinoma Nomogram Predictive models Recurrence Recurrence-free survival Risk factors Sarcopenia

Small molecule deoxynyboquinone triggers alkylation and ubiquitination of Keap1 at Cys489 on Kelch domain for Nrf2 activation and inflammatory therapy

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Journal of Pharmaceutical Analysis 2024年第3期14卷 401-415页

作者： Ke-Gang Linghu Tian Zhang Guang-Tao Zhang peng Lv Wen-Jun Zhang Guan-Ding Zhao Shi-Hang Xiong Qiu-Shuo Ma Ming-Ming Zhao Meiwan Chen Yuan-Jia Hu Chang-Sheng Zhang hua Yu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Macao Centre for Research and Development in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SARChina Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaRNAM Center for Marine MicrobiologySouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301China State Key Laboratory of Functions and Applications of Medicinal Plants&School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang550025China

Activation of nuclear factor erythroid 2-related factor 2(Nrf2)by Kelch-like ECH-associated protein 1(Keap1)alkylation plays a central role in anti-inflammatory ***,activators of Nrf2 through alkylation of Keap1-Kelch domain have not been ***(DNQ)is a natural small molecule discovered from marine *** current study was designed to investigate the anti-inflammatory effects and molecular mechanisms of DNQ via alkylation of *** exhibited significant anti-inflammatory properties both in vitro and in *** pharmacophore responsible for the anti-inflammatory properties of DNQ was determined to be theα,β-unsaturated amides moieties by a chemical reaction between DNQ and *** exerted anti-inflammatory effects through activation of Nrf2/ARE ***1 was demonstrated to be the direct target of DNQ and bound with DNQ through conjugate addition reaction involving *** specific alkylation site of DNQ on Keap1 for Nrf2 activation was elucidated with a synthesized probe in conjunction with liquid chromatography-tandem mass *** triggered the ubiquitination and subsequent degradation of Keap1 by alkylation of the cysteine residue 489(Cys489)on Keap1-Kelch domain,ultimately enabling the activation of *** findings revealed that DNQ exhibited potent anti-inflammatory capacity throughα,β-unsaturated amides moieties active group which specifically activated Nrf2 signal pathway via alkylation/ubiquitination of Keap1-Kelch domain,suggesting the potential values of targeting Cys489 on Keap1-Kelch domain by DNQ-like small molecules in inflammatory therapies.

关键词： Deoxynyboquinone Anti-inflammation Target Keap1/Nrf2 Alkylation Ubiquitination

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碳纳米管纤维基热电器件的制备及其性能研究

丝绸 2024年第2期61卷 60-66页

作者：余龙邱华顾鹏江南大学纺织科学与工程学院江苏无锡214122

利用温差发电的柔性热电器件具有可持续、环保和可穿戴的优点,但是多数热电器件需要利用金属电极相互连接,这在一定程度上降低了热电器件的整体性能。本文利用OA和FeCl 3对碳纳米管纤维进行N型和P型掺杂,制备了无需金属电极连接的具有连... 详细信息

利用温差发电的柔性热电器件具有可持续、环保和可穿戴的优点,但是多数热电器件需要利用金属电极相互连接,这在一定程度上降低了热电器件的整体性能。本文利用OA和FeCl 3对碳纳米管纤维进行N型和P型掺杂,制备了无需金属电极连接的具有连续P-N结构的热电纤维,并且利用热电纤维制备了3D热电器件。结果显示,N型和P型碳纳米管纤维基热电纤维分别具有-69.7、62.2μV K的高塞贝克系数和552.9、431.4μW(m·K 2)的高功率因数,3D热电器件能够利用人体与环境之间垂直方向上的温差产生开路电压,并可用作简单的温度传感器。这种3D热电器件具有优异的热电性能,在柔性自供电领域有广泛的应用前景。

关键词：碳纳米管纤维 P-N结构热电纤维热电器件温度传感器

Nb_(2)C MXene薄膜眼部植入体的生物相容性

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Transactions of Nonferrous Metals Society of China 2024年第5期34卷 1618-1633页

作者：马巍彭立陈百华中南大学湘雅二医院眼科长沙410011 湖南省眼科临床研究中心长沙410011 中南大学湘雅医学院附属海口医院眼科海口570311

采用四氟硼酸(HBF4)与氢氟酸(HF)复合酸蚀刻和真空抽滤法制备Nb_(2)C MXene薄膜。利用扫描电子显微镜(SEM)、原子力显微镜(AFM)和X射线光电子能谱(XPS)等方法表征Nb_(2)C MXene的表面结构、性质和组成。通过体内和体外实验评价Nb_(2)C M... 详细信息

采用四氟硼酸(HBF4)与氢氟酸(HF)复合酸蚀刻和真空抽滤法制备Nb_(2)C MXene薄膜。利用扫描电子显微镜(SEM)、原子力显微镜(AFM)和X射线光电子能谱(XPS)等方法表征Nb_(2)C MXene的表面结构、性质和组成。通过体内和体外实验评价Nb_(2)C MXene薄膜的生物相容性。结果表明,Nb_(2)C MXene具有层状、微纳表面结构,表面富集大量羟基。相比于对照组,1mg/mL Nb_(2)C MXene培养的结膜成纤维细胞增殖率达到72.15%(p0.05),其溶血率为0.38%(<5%)。Nb_(2)C MXene薄膜降低兔眼组织的炎症和氧化应激反应,在不诱导纤维化的情况下促进伤口愈合,其微纳表面促进细胞的黏附和增殖,表现出良好的生物相容性。

关键词： Nb_(2)C MXene 生物相容性氧化应激细胞增殖眼科应用

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犯罪论的规范基础及其本土化

南京大学学报（哲学．人文科学．社会科学） 2024年第1期61卷 60-75页

作者：彭文华上海政法学院刑事司法学院上海市201701

1979年刑法颁行后,我国刑法立法走上自主创制之路。刑法学研究形成了移植外来理论、对外来理论加以本土化改造与本土理论并驾齐驱的局面。犯罪及其成立条件由法律规定,原则上不能成为理论改造的对象。实质理性与规范理性不能绝对等同,... 详细信息

1979年刑法颁行后,我国刑法立法走上自主创制之路。刑法学研究形成了移植外来理论、对外来理论加以本土化改造与本土理论并驾齐驱的局面。犯罪及其成立条件由法律规定,原则上不能成为理论改造的对象。实质理性与规范理性不能绝对等同,维护实质理性是刑法理论的独立品格。犯罪定量是我国刑法特有规定,属于犯罪构成要件或要素。我国传统犯罪构成论体系的不足在于,未能将正当事由纳入其中,对犯罪构成要件要素的类型化也不尽合理。在进行体系化定位时,正当事由可纳入犯罪客体中评价。在阶层犯罪论体系本土化时,需要对犯罪定量加以体系定位,并区分有责性和刑事责任。对犯罪构成要件是否排序,主要取决于认知理念和思维模式。客观归责理论源自阶层犯罪论体系,不宜适用于平面犯罪论体系。中止犯的自动性认定应以对行为人无需任何特殊预防之必要为依据,其标准是人格实现由恶向善的实质性转化。对犯罪参与体系采取正犯与共犯体系违背我国刑法规定。

关键词：犯罪论规范理性实质理性犯罪构成要件犯罪形态

TRPM2 Mediates Hepatic Ischemia–Reperfusion Injury via Ca^(2+) -Induced Mitochondrial Lipid Peroxidation through Increasing ALOX12 Expression

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Research 2024年第1期2023卷 351-368页

作者： Cheng Zhong Jing Yang Yiyin Zhang Xiaoxiao Fan Yang Fan Ning hua Duguang Li Shengxi Jin Yirun Li peng Chen Yongle Chen Xiaobo Cai Yi Zhang Linhua Jiang Wei Yang Peilin Yu Hui Lin Department of General Surgery Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouP.R.China Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhou 310000P.R.China Department of Physiology and Pathophysiology and Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province Xinxiang Medical University453003 XinxiangHenanP.R.China School of Biomedical Sciences Faculty of Biological SciencesUniversity of LeedsLS29JT LeedsUK Department of Toxicology and Department of Medical Oncology of Second Affiliated Hospital Zhejiang University School of MedicineHangzhouP.R.China Zhejiang Engineering Research Center of Cognitive Healthcare Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310020P.R.China College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhou 310058P.R.China

Hepatic ischemia–reperfusion(IR)injury is a serious clinical problem that complicates liver resection and *** recent advances in understanding of the pathophysiology of hepatic IR injury,effective interventions and therapeutics are still ***,we examined the role of transient receptor potential melastatin 2(TRPM2),a Ca^(2+)-permeable,non-selective cation channel,in mediating hepatic IR *** data showed that TRPM2 deficiency attenuated IR-induced liver dysfunction,inflammation,and cell death in ***,RNA sequencing analysis indicated that TRPM2-induced IR injury occurs via ferroptosis-related ***,as a ferroptosis inducer,(1S,3R)-RSL3 treatment induced mitochondrial dysfunction in hepatocytes and a TRPM2 inhibitor suppressed ***,TRPM2-mediated calcium influx caused mitochondrial calcium accumulation via the mitochondrial Ca^(2+)-selective uniporter and increased the expression level of arachidonate 12-lipoxygenase(ALOX12),which results in mitochondrial lipid peroxidation during hepatic IR ***,hepatic IR injury-induced ferroptosis was obviously relieved by a TRPM2 inhibitor or calcium depletion,both in vitro and in ***,these findings demonstrate a crucial role for TRPM2-mediated ferroptosis in hepatic IR injury via increased Ca^(2+)-induced ALOX12 expression,indicating that pharmacological inhibition of TRPM2 may provide an effective therapeutic strategy for hepatic IR injury-related diseases,such as during liver resection and transplantation.

关键词： TRPM2 Lipid Hepatic

催眠无痛暗示法在产妇无痛分娩中对分娩进程及母儿的影响

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护理管理杂志 2017年第7期17卷 496-497页

作者：张秀华彭勇祝艳吴琴南充市中心人民医院妇产科 637000

目的探讨催眠无痛暗示法在产妇无痛分娩中对分娩进程及母儿的影响。方法选择住院产妇200例,分为对照组和观察组各100例,对照组按常规分娩护理,观察组在对照组基础上给予催眠无痛暗示法护理,由助产士在产妇分娩的过程中分别实施嗅觉暗示... 详细信息

目的探讨催眠无痛暗示法在产妇无痛分娩中对分娩进程及母儿的影响。方法选择住院产妇200例,分为对照组和观察组各100例,对照组按常规分娩护理,观察组在对照组基础上给予催眠无痛暗示法护理,由助产士在产妇分娩的过程中分别实施嗅觉暗示法、语言暗示加听觉刺激或皮肤刺激等干预措施。结果观察组产妇第1、2、3产程疼痛评分降低且产程时间缩短(P<0.01);剖宫产率、新生儿窒息率、胎儿窘迫发生率下降,产后出血量减少(P<0.01)。结论在产妇分娩过程中应用催眠无痛暗示法可以提高产妇分娩舒适度,并且具有较高的安全性。

关键词：催眠无痛暗示法无痛分娩分娩进程母婴结局

NH_(4)^(+)浓度对N80钢在饱和CO_(2)的3%NaCl溶液中腐蚀行为的影响

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中国腐蚀与防护学报 2024年第3期44卷 745-754页

作者：解辉于超花靖蒋秀化学品安全全国重点实验室青岛266100 中石化安全工程研究院有限公司青岛266110 应急管理部化学品登记中心青岛266100

利用失重法和电化学方法研究了N80钢在不同NH_(4)^(+)浓度下饱和CO_(2)的3%NaCl溶液中的腐蚀行为,通过SEM、3D轮廓仪、XRD和XPS对腐蚀形貌和腐蚀产物进行表征,阐释了腐蚀机理。结果表明,NH_(4)^(+)浓度对N80钢的腐蚀速率产生促进和抑制... 详细信息

利用失重法和电化学方法研究了N80钢在不同NH_(4)^(+)浓度下饱和CO_(2)的3%NaCl溶液中的腐蚀行为,通过SEM、3D轮廓仪、XRD和XPS对腐蚀形貌和腐蚀产物进行表征,阐释了腐蚀机理。结果表明,NH_(4)^(+)浓度对N80钢的腐蚀速率产生促进和抑制双重效果。当NH_(4)^(+)浓度为0~500 mg/L时,N80钢的均匀腐蚀速率随NH_(4)^(+)浓度增加而增加;当NH_(4)^(+)浓度增加至1000~2000 mg/L时,N80钢的均匀腐蚀速率随NH_(4)^(+)浓度增加而降低,且点蚀速率随NH_(4)^(+)浓度的变化规律与均匀腐蚀基本相同;当NH_(4)^(+)浓度为500 mg/L时,均匀腐蚀速率和小孔腐蚀速率最大。当NH_(4)^(+)浓度≤500 mg/L时,NH_(4)^(+)和Cl^(-)在金属表面发生了竞争吸附;当NH_(4)^(+)浓度大于500 mg/L时,NH_(4)^(+)在金属表面发生吸附对腐蚀起抑制作用。

关键词： N80 钢饱和CO_(2)环境 NH_(4)^(+) 腐蚀 NH_(4)^(+) 吸附

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan huang Yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma peng-peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Leukopenia-a rare complication secondary to invasive liver abscess syndrome in a patient with diabetes mellitus:A case report

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World Journal of Gastrointestinal Surgery 2024年第10期16卷 3343-3349页

作者： Chun-Yan Niu Bang-Tao Yao hua-Yi Tao Xin-Gui peng Qing-hua Zhang Yue Chen Lu Liu Department of Gastroenterology Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 211200Jiangsu ProvinceChina Department of Ophthalmology Nanjing Lishui People’s HospitalNanjing 211200Jiangsu ProvinceChina Department of Medical Imaging Nanjing Lishui People’s HospitalZhongda Hospital Lishui BranchSoutheast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Thrombocytopenia is a common complication of invasive liver abscess syndrome(ILAS)by Klebsiella pneumoniae(***)infection,which indicates severe infection and a poor ***,the presence of leukopenia is *** are rare reports on leukopenia and its clinical significance for ILAS,and there is currently no recognized treatment *** and broad-spectrum antimi-crobial therapy may be an effective therapy for treating ILAS and improving its *** SUMMARY A 55-year-old male patient who developed fever,chills,and abdominal distension without an obvious cause presented to the hospital for *** tests revealed thrombocytopenia,leukopenia,and multiple organ *** examinations revealed an abscess in the right lobe of the liver and thromboph-lebitis,and *** was detected in the blood *** the patient was diabetic and had multi-system involvement,he was diagnosed with ILAS accom-panied by leukopenia and *** antibiotic treatment and sys-temic supportive therapy,the symptoms disappeared,and the patient’s condition almost completely *** Leukopenia is a rare complication of ILAS,which serves as an indicator of adverse prognostic outcomes and the severity of infection.

关键词： Invasive liver abscess syndrome Klebsiella pneumoniae Leukopenia Thrombocytopenia Treatment Prognosis Case report