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Mechanisms by which fibroblast growth factor 20 improves motor performance in a mouse model of Parkinson’s disease

Neural Regeneration Research 2019年第8期14卷 1438-1444页

作者： Ai-Qin Wang Li-Na Kong Ming-Zhu Meng xiu-he zhao Si Chen Xiao-Tang Wang Qilu Hospital of Shandong University

Genome-wide studies have reported that Parkinson’s disease is associated with abnormal expression of various growth factors. In this study, male C57 BL/6 mice aged 10 weeks were used to establish Parkinson’s disease models using an intraperitoneal injection of 60 mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. 28 days later, 10 or 100 ng fibroblast growth factor 20 was injected intracerebroventricularly. The electrophysiological changes in the mouse hippocampus were recorded using a full-cell patch clamp. Expression of Kv4.2 in the substantia nigra was analyzed using a western blot assay. Serum malondialdehyde levels were analyzed by enzyme-linked immunosorbent assay. The motor coordination of mice was evaluated using the rotarod test. The results showed that fibroblast growth factor 20 decreased A-type potassium current in neurons of the substantia nigra, increased long-term potentiation amplitude in the hippocampus, and downregulated Kv4.2 expression. A high dose of fibroblast growth factor 20 reduced serum malondialdehyde levels and enhanced the motor coordination of mice. These findings confirm that fibroblast growth factor 20 has a therapeutic effect on the toxicity induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and its mechanism of action is associated with the inhibition of A-type K+ currents and Kv4.2 expression. All animal procedures were approved by the Animal Care and Use Committee of Qilu Hospital of Shandong University, China in 2017(approval No. KYLL-2017-0012).

关键词： nerve regeneration Parkinson’s disease 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine fibroblast growth factor 20 A-type potassium current long-term potentiation Kv4.2 oxidative stress malondialdehyde motor performance neural regeneration

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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： xiu-Yun zhao De-En Xu Ming-Lei Wu Ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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Response analyses on the drill-string channel for logging while drilling telemetry

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Petroleum Science 2023年第5期20卷 2796-2808页

作者： Ao-Song zhao Xiao he Hao Chen xiu-Ming Wang State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China Beijing Engineering Research Center of Sea Deep Drilling and Exploration Institute of AcousticsChinese Academy of SciencesBeijing100190China

Downhole acoustic telemetry(DAT),using a long drill string with periodical structures as the channel,is a prospective technology for improving the transmission rate of logging while drilling(LWD)*** studies only focused on the acoustic property of a free drill string and neglected the coupling between pipes and fluid-filled *** addition to the drill-string waves,a series of fluid waves are recorded in the DAT channel,which has not been investigated *** channel characteristics result in lower transmission rates and stability than ***,a more realistic channel model is needed considering the fluid-filled *** this paper,we propose a hybrid modeling method to investigate the response characteristics of the DAT *** combining the axial wavenumbers and excitation functions of mode waves in radially layered LWD structures,the channel model is approximated to the 1-D propagation,which considers transmission,reflection,and interconversion of the drillstring and fluid *** proposed 1-D approximation has been well validated by comparing the 2-D finite-difference *** is revealed that the transmitted and converted fluid waves interfere with the drill-string wave,which characterizes the DAT channel as a particular coherent multi-path *** a fluid-filled borehole surrounds the drill string,the channel responses exhibit considerable delay as well as strong frequency selectivity in amplitude and *** new findings suggest that the complexity of the channel response has been underestimated in the past,and therefore channel measurements on the ground are *** address these channel characteristics,we apply a noncoherent demodulation *** transmission rate for synthetic data reaches 15 bps in a 94.5 m long channel,indicating that the acoustic telemetry is promising to break the low-speed limitation of mud-pulse telemetry.

关键词： Logging while drilling Borehole geophysics Downhole acoustic telemetry Channel modeling Frequency selectivity

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Effects of Bounding Potential on High-Order Harmonic Generation with H2＋

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Chinese Physics Letters 2010年第6期27卷 89-92页

作者： zhao Jing zhao Zeng-xiu Department of Physics National University of Defense Technology Changsha 410073

We present harmonic spectra from hydrogen molecular ions with different ionization energy Ip. By comparing the recombination matrix element from helium ions and hydrogen molecular ions, we verify that the interference effect in high-order harmonic generation originates from the recombination interference. A numerical study on recombination matrix elements in 1D shows that w = Ek ＋ Ip holds only when an exact continuum wavefunction is used, and the positions of extrema in harmonic spectra can be predicted accurately. We demonstrate that the positions of extrema in harmonic spectra are mainly affected by bounding potential dependence of the recombination interference.

关键词： POTENTIAL theory (Physics) SECOND harmonic generation HYDROGEN ions heLIUM ions ION recombination NUMERICAL analysis WAVE functions

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氯沙坦对实验性糖尿病大鼠肾脏功能的保护作用

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中国新药与临床杂志 2002年第9期21卷 547-550页

作者：张荣莲孙辉臣张易民修贺明赵区生郝晓东白求恩国际和平医院中心实验科河北石家庄050082

目的 :探讨氯沙坦对糖尿病肾病肾脏功能的保护作用。方法 :制作糖尿病大鼠模型 ,分成 3组 ,每组 15只 ,糖尿病治疗组给予氯沙坦灌胃 ,糖尿病组和正常对照组均给予等量生理盐水灌胃。分别于实验的wk 1,2 ,4取材 ,测定血糖、血肌酐、尿清... 详细信息

目的 :探讨氯沙坦对糖尿病肾病肾脏功能的保护作用。方法 :制作糖尿病大鼠模型 ,分成 3组 ,每组 15只 ,糖尿病治疗组给予氯沙坦灌胃 ,糖尿病组和正常对照组均给予等量生理盐水灌胃。分别于实验的wk 1,2 ,4取材 ,测定血糖、血肌酐、尿清蛋白、尿肌酐、尿α1 微球蛋白排泄率和血浆内皮素(ET)水平。结果 :糖尿病组大鼠出现血糖升高、肌酐清除率下降、尿清蛋白和尿α1 微球蛋白排泄率升高 ,与正常对照组相比差异有非常显著和显著意义(P <0 .0 1或P <0 .0 5 ) ,血浆ET水平升高 ,wk 2时与正常对照组间差异有非常显著意义 ;肌酐清除率、尿清蛋白和尿α1 微球蛋白排泄率等指标 ,治疗组与糖尿病组比较差异均有显著或非常显著意义。结论 :动物实验证实氯沙坦可减轻糖尿病肾病的肾功能损害 ,改善肾功能。

关键词：氯沙坦大鼠肾脏功能保护作用实验研究糖尿病肾病

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New Cnoidal and Solitary Wave Solutions of Coupled Higher-Order Nonlinear SchrSdinger System in Nonlinear Optics

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Communications in Theoretical Physics 2007年第1期47卷 10-14页

作者： HAN zhao-xiu Collage of Statistics and Computing Science ZhejizLng Gongshagng University HzLngzhou 310018 China

The coupled higher-order nonlinear Schroedinger system is a major subject in nonlinear optics as one of the nonlinear partial differential equation which describes the propagation of optical pulses in optic fibers. By using coupled amplitude-phase formulation, a series of new exact cnoidal and solitary wave solutions with different parameters are obtained, which may have potential application in optical communication.

关键词： coupled higher-order nonlinear SchrSdinger system Jacobi elliptic function solitary wave

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Evaluation of suitability of university ladder classroom environment on humans

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Energy and Built Environment 2024年第4期5卷 615-627页

作者： Xin Liu xiu Geng Kailiang Huang Guohui Feng he zhao Xiaotong Wang Jianing he School of Municipal and Environment Engineering Shenyang Jianzhu UniversityShenyang 100168China Jianke EET Co. Ltd.Beijing 100013China

Evaluation of the suitability of university ladder classroom environment on humans is an effective approach to improve the quality of the indoor environment and protect human ***,there are unresolved issues regarding the suitability of university ladder classroom environment for *** example,the design of en-closure structure and heating ventilation and air conditioning(HVAC)system is unreasonable,and the indoor air quality does not meet the required *** this study,the suitability of university ladder classroom environ-ment on humans was considered the research *** evaluation indices of indoor environment were selected from indoor air quality,indoor thermal and humid environments,light environment,and sound *** the health and comfort of users were taken as the evaluation indices of *** to the results of expert investigations and case measurements,the index weight was determined by the expert-entropy weight method,and a complete evaluation system of indices was *** were two first-level,six second-level,and fourteen third-level indices in the evaluation *** evaluation indices of each level with the largest weight were indoor environment(0.5940),user health(0.2530),and indoor temperature(0.1175)*** comparing the actual learning effect to the evaluation results,the applicability of the evaluation system was *** evaluation system of the suitability of university ladder classroom environment on humans is convenient for operators to identify the weak points between humans and the *** evaluation system is endowed with important theoretical and practical significance to realize the green development of colleges and universities and build an environment-friendly campus.

关键词： Severe cold region Suitability of environment on humans Natural ventilation Expert-entropy weight method Evaluation system

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Fractionation and solubility of cadmium in paddy soils amended with porous hydrated calcium silicate

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Journal of Environmental Sciences 2007年第3期19卷 343-347页

作者： zhao xiu-lan Saigusa Masaihiko College of Natural Resources and Environmental Sciences Southwest University Chongqing 400716 China Experimental Farm Graduate School of Agricultural Sciences Tohoku University Naruko Miyagi 989-6711 Japan

Previous studies have shown that porous hydrated calcium silicate （PS） is very effective in decreasing cadmium （Cd） content in brown rice. However, it is unclear whether the PS influences cadmium transformation in soil. The present study examined the effect of PS on pH, cadmium transformation and cadmium solubility in Andosol and Alluvial soil, and also compared its effects with CaCO3, acidic porous hydrated calcium silicate （APS） and silica gel. Soil cadmium was operationally fractionationed into exchangeable （Exch）, bound to carbonates （Carb）, bound to iron and manganese oxides （FeMnOx）, bound to organic matters （OM） and residual （Res） fraction. Application of PS and CaCO3 at hig rates enhanced soil pH, while APS and silica gel did not obviously change soil pH. PS and CaCO3 also increased the FeMnOx-Cd in Andosol and Carb-Cd in Alluvial soil, thus reducing the Exch-Cd in the tested soils. However, PS was less effective than CaCO3 at the same application rate. Cadmium fractions in the two soils were not changed by the treatments of APS and silica gel. There were no obvious differences in the solubility of cadmium in soils treated with PS, APS, silica gel and CaCO3 except Andosol treated 2.0% CaCO3 at the same pH of soil-CaC12 suspensions. These findings suggested that the decrease of cadmium availability in soil was mainly attributed to the increase of soil pH caused by PS.

关键词： porous hydrated calcium silicate solubility soil cadmium

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Weak absorption test and defect analysis of optical coatings

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光学精密工程 2005年第4期13卷 430-434页

作者： he Hong-bo LI Xia FAN Shu-hai zhao Yuan-an SHAO Jian-da FAN Zheng-xiu Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Shanghai 201800 China

Surface thermal lensing technique was developed into a high-sensitive apparatus for weak absorption test and defect analysis of optical coatings. A continuous-wave 1 064 nm Nd:YAG laser and a he-Ne laser were employed as pump source and probe source, respectively. Low noise photoelectrical components and a lock-in amplifier were used for photo-thermal deformation signal detection. In order to improve sensitivity, the apparatus configuration was optimized by choosing appropriate parameters, including pump beam spot size, chopper frequency, detection distance, waist radius and position of probe beam. Coating samples were mounted on a x-y stage. Different procedures, such as single spot, linear scan and 2-dimension area scan, could be performed manually or automatically. Various optical coatings were prepared by both electron beam evaporation and ion beam sputtering deposition. High sensitivity was obtained and low to 1×10 -7 weak absorption was tested in low-loss coating samples. For the sensitivity extreme of the system, 1×10 -8 absorption was reason out to be measured by surface thermal lensing technique. Very small standard deviation was achieved for the reproducibility evaluation. Moreover, a spatial resolution of 25 micron was proved according to the area scan which traced out the profile of photo-thermal defects inside optical coatings. The system was employed in the analyses of optical absorption, absorption uniformity and defect characterization, and revealed the relationship between laser-induced damage and absorption of optical coatings.

关键词：光学涂覆技术吸收能力稳定性激光技术

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Tunable VO_(2) cavity enables multispectral manipulation from visible to microwave frequencies

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Light(Science & Applications) 2024年第3期13卷 510-518页

作者： Hang Wei Jinxin Gu Tao zhao Zhiyuan Yan he-xiu Xu Shuliang Dou Cheng-Wei Qiu Yao Li Center for Composite Materials and Structure Harbin Institute of TechnologyHarbin 150001China National University of Singapore Department of Electrical&Computer EngineeringSingapore 117583Singapore School of Chemical Engineering and Technology Harbin Institute of TechnologyHarbin 150001China Suzhou Laboratory Suzhou 215123China

Optical materials capable of dynamically manipulating electromagnetic waves are an emerging field in memories,optical modulators,and thermal ***,their multispectral design preliminarily attracts much attention,aiming to enhance their efficiency and integration of ***,the multispectral manipulation based on these materials is challenging due to their ubiquitous wavelength dependence restricting their capacity to narrow *** this article,we cascade multiple tunable optical cavities with selective-transparent layers,enabling a universal approach to overcoming wavelength dependence and establishing a multispectral platform with highly integrated *** on it,we demonstrate the multispectral(ranging from 400 nm to 3 cm),fast response speed(0.9 s),and reversible manipulation based on a typical phase change material,vanadium *** platform involves tandem VO_(2)-based Fabry–Pérot(F-P)cavities enabling the customization of optical responses at target bands *** can achieve broadband color-changing capacity in the visible region(a shift of~60 nm in resonant wavelength)and is capable of freely switching between three typical optical models(transmittance,reflectance,and absorptance)in the infrared to microwave regions with drastic amplitude tunability exceeding *** work represents a state-of-art advance in multispectral optics and material science,providing a critical approach for expanding the multispectral manipulation ability of optical systems.

关键词： spectral microwave visible

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