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effects of Helicobacter pylori and Moluodan on the Wnt/β-catenin signaling pathway in mice with precancerous gastric cancer lesions

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 979-990页

作者： Yi-Mei Wang Zheng-wei Luo Yu-Lin Shu xiu Zhou Lin-Qing Wang Chun-Hong Liang Chao-Qun Wu Chang-Ping Li Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina

BACKGROUND Helicobacter pylori(***)is the primary risk factor for gastric cancer(GC),the Wnt/β-Catenin signaling pathway is closely linked to *** has a high mortality rate and treatment cost,and there are no drugs to prevent the progression of gastric precancerous lesions to ***,it is necessary to find a novel drug that is inexpensive and preventive to against *** To explore the effects of *** and Moluodan on the Wnt/β-Catenin signaling pathway and precancerous lesions of GC(PLGC).MeTHODS Mice were divided into the control,N-methyl-N-nitrosourea(MNU),***+MNU,and Moluodan *** first created an *** infection model in the ***+MNU and Moluodan groups.A PLGC model was created in the remaining three groups except for the control *** was fed to mice in the Moloudan group ad *** general condition of mice were observed during the whole experiment *** tissues of mice were grossly and microscopically *** quantitative real-time PCR(qRT-PCR)and Western blotting analysis,the expression of relevant genes were *** Mice in the ***+MNU group showed the worst performance in general condition,gastric tissue visual and microscopic observation,followed by the MNU group,Moluodan group and the control ***-PCR and Western blotting analysis were used to detect the expression of relevant genes,the results showed that the ***+MNU group had the highest expression,followed by the MNU group,Moluodan group and the control *** *** can activate the Wnt/β-catenin signaling pathway,thereby facilitating the development and progression of *** suppressed the activation of the Wnt/β-catenin signaling pathway,thereby decreasing the progression of PLGC.

关键词： Helicobacter pylori Gastric cancer Wnt/β-catenin signaling pathway Moluodan

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A low-frequency and broadband wave-insulating vibration isolator based on plate-shaped metastructures

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Applied Mathematics and Mechanics(english edition) 2024年第7期45卷 1171-1188页

作者： wei wei Feng GUAN Xin FANG College of Intelligent Science National University of Defense TechnologyChangsha410073China Naval Research Academy Beijing100161China

A metamaterial vibration isolator,termed as wave-insulating isolator,is proposed,which preserves enough load-bearing capability and offers ultra-low and broad bandgaps for greatly enhanced wave *** consists of plate-shaped metacells,whose symmetric and antisymmetric local resonant modes offer several low and broad mode bandgaps although the complete bandgap remains high and *** bandgap mechanisms,vibration isolation properties,effects of key parameters,and robustness to complex conditions are *** experimentally demonstrated,the wave-insulating isolator can improve the vibration insulation in the ranges of[50 Hz,180 Hz]and[260 Hz,400 Hz]by 15 dB and 25 dB,respectively,in contrast to the conventional isolator with the same first resonant frequency.

关键词： metamaterial and metastructure vibration isolation bandgap wave insulation plate

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Millisecond dynamics of colloidal suspension studied by X-ray photon correlation spectroscopy at the Shanghai Synchrotron Radiation Facility

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Nuclear Science and Techniques 2024年第1期35卷 1-9页

作者： Chen-Hui Cui Zi-Mu Zhou Lin-Feng wei Song-Lin Li Feng Tian xiu-Hong Li Zhi Guo Yi-Hui Xu Huai-Dong Jiang Ren-Zhong Tai Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Center for Transformative Science ShanghaiTech UniversityShanghai 201210China

X-ray photon correlation spectroscopy(XPCS)has emerged as a powerful tool for probing the nanoscale dynamics of soft condensed matter and strongly correlated materials owing to its high spatial resolution and penetration *** technique requires high brilliance and beam coherence,which are not directly available at modern synchrotron beamlines in *** facilitate future XPCS experiments,we modified the optical setup of the newly commissioned BL10U1 USAXS beamline at the Shanghai Synchrotron Radiation Facility(SSRF).Subsequently,we performed XPCS measurements on silica suspensions in glycerol,which were opaque owing to their high *** were collected using a high frame rate area detector.A comprehensive analysis was performed,yielding correlation functions and several key dynamic *** the results were consistent with the theory of Brownian motion and demonstrated the feasibility of XPCS at ***,by carefully optimizing the setup and analyzing the algorithms,we achieved a time resolution of 2 ms,which enabled the characterization of millisecond dynamics in opaque systems.

关键词： XPCS SSRF Silica suspension Glycerol Brownian motion Millisecond dynamics

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Human extracellular matrix(eCM)-like collagen and its bioactivity

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Regenerative Biomaterials 2024年第4期3卷 14-26页

作者： Hui Zhou Wenwei Li Lixin Pan Tianci Zhu Teng Zhou e.Xiao Qiang wei State Key Laboratory of Polymer Materials and engineering College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China Hunan Maybio Bio-Pharmaceutical Co. LtdChangsha 410000China

Collagen,the most abundant structural protein in the human extracellular matrix(eCM),provides essential support for tissues and guides tissue *** its widespread use in tissue engineering,there remains uncertainty regarding the optimal selection of collagen ***-derived sources pose challenges such as immunogenicity,while the recombinant system is hindered by diminished *** this study,we hypothesized that human eCM-like collagen(hCol)could offer an alternative for tissue *** this study,a facile platform was provided for generating hCol derived from mesenchymal stem cells with a hierarchical structure and biochemical properties resembling native *** results further demonstrated that hCol could facilitate basal biological behaviors of human adipose-derived stem cells,including viability,proliferation,migration and adipocyte-like ***,it could promote cutaneous wound *** to its high similarity to native collagen and good bioactivity,hCol holds promise as a prospective candidate for in vitro and in vivo applications in tissue engineering.

关键词： extracellular matrix native-like collagen cell-derived matrix hierarchical structure

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天基空间态势感知数据仿真研究进展

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中国光学（中英文） 2024年第3期17卷 501-511页

作者：罗秀娟郝伟中国科学院西安光学精密机械研究所西安710119 中国科学院空间精密测量技术重点实验室西安710119

空间态势感知(Space Situational Awareness,SSA)数据仿真可以为空间监测设备及态势感知算法(包括空间目标检测、跟踪、识别和表征)的开发、测试和验证提供关键性数据支持,在空间态势感知能力建设中发挥重要作用。本文以天基空间态势感... 详细信息

空间态势感知(Space Situational Awareness,SSA)数据仿真可以为空间监测设备及态势感知算法(包括空间目标检测、跟踪、识别和表征)的开发、测试和验证提供关键性数据支持,在空间态势感知能力建设中发挥重要作用。本文以天基空间态势感知光学数据仿真为研究对象,给出了SSA数据仿真的研究目的和主要研究内容,详述了SSA光学成像仿真的典型研究方法与过程。介绍了国内外相关工作的研究现状与工作进展,涵盖双目视觉传感器、激光雷达、红外传感器、可见光望远镜和恒星敏感器等不同光学传感系统的成像建模与仿真工作成果。分析了空间态势感知数据仿真研究的发展趋势,为未来SSA数据仿真研究思路与方法提供参考。

关键词：空间态势感知建模仿真空间目标成像

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Planet wind: Planetary evolution dominated by electromagnetic forces

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Science China earth Sciences 2024年第10期67卷 3331-3336页

作者： Yong wei Key Laboratory of earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

1. Introduction Over the five centuries since Copernicus, the focus of planetary science has transitioned from the visible realm to the invisible. In the more than 60 years following the advent of the space age, our a... 详细信息

关键词： evolution dominated planetary

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The lithology and composition of lunar mantle modified by ilmenite bearing cumulate:A thermodynamic model

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Acta Geochimica 2024年第5期43卷 856-875页

作者： wei Huang wei Du State Key Laboratory of Ore Deposit Geochemistry Institute of GeochemistryChinese Academy of SciencesGuiyang 550081China University of Chinese Academy of Sciences Beijing 100049China Center for excellence in Comparative Planetology Chinese Academy of SciencesHefei 230026China

Due to their high density,the ilmenite-bearing cumulates(IBC)(with or without KReeP)formed during the late-stage lunar magma ocean solidification are thought to sink into the underlying lunar mantle and trigger lunar mantle *** evidence implied that IBC may descend deep inside the Moon and remain as a partially molten layer at the core-mantle boundary(CMB).However,partial melting may have occurred on the mixed mantle cumulates during the sinking of IBC/KReeP and the silicate melt may be positively buoyant,thus preventing the IBC/KReeP layer from sinking to the ***,we perform thermodynamic simulation on the stability of lunar mantle cumulates at different depths mixed with different amounts of IBC/KReeP from an updated LMO *** modeling results suggest that the sinking of IBC/KReeP will cause at least 5 wt%partial melting in the shallow(~120 km)and a much larger degree of partial melting in the deep lunar mantle(~420 km).Due to the density contrast with the surrounding mantle,IBC/KReeP-bearing melts could potentially decouple under certain *** modified lunar mantle by sinking of IBC/KReeP can better explain the formation of different kinds of lunar basaltic magma than the primary lunar mantle formed through differentiation of lunar magma *** of IBC/KReeP back into the lunar mantle may introduce plagioclase,clinopyroxene,garnet,and incompatible radioactive elements into the deep lunar mantle,which will further affect the thermal and chemical evolution of the lunar interior.

关键词： Ilmenite-bearing cumulate KReeP Partial melting Lunar mantle overturn pMeLTS

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A new class of crystalline X-ray induced photochromic materials assembled from anion-directed folding of a flexible cation

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Chinese Chemical Letters 2024年第8期35卷 554-557页

作者： Hong-Jin Liao Zhu Zhuo Qing Li Yoshihito Shiota Jonathan P.Hill Katsuhiko Ariga Zi-xiu Lu Lu-Yao Liu Zi-Ang Nan wei Wang You-Gui Huang CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Provincial Key Laboratory of NanomaterialsFujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China College of Chemistry and Materials Science Fujian Normal UniversityFuzhou 350007China Xiamen Key Laboratory of Rare earth Photoelectric Functional Materials Xiamen Institute of Rare Earth MaterialsHaixi InstitutesChinese Academy of SciencesXiamen 361021China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China Institute for Materials Chemistry and engineering Kyushu UniversityFukuoka 819-0395Japan World Premier International(WPI)Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)Ibaraki 305-0044Japan

electron-deficient viologens are widely used as ligands or structure-directing agents(SDAs)to synthesize crystalline X-ray induced photochromic ***,a new rational strategy of anion-directed fold-ing a flexible cation(H_(2)imb)^(2+)((H_(2)imb)^(2+)=di-protonated 2,3-bis(imidazolin-2-yl)-2,3-dimethylbutane)has been ***-donating Cl−and(ZnCl4)2−are used to direct folding a flexible electron-deficient(H_(2)imb)^(2+)*** complexes(H_(2)imb)(NO_(3))2(1),(H_(2)imb)Cl2·H_(2)O(2),and(H_(2)imb)ZnCl4(3)have been synthesized in which(H_(2)imb)^(2+)crystallize in an anti-conformation,88.8°-gauche,and 51.8°-gauche,*** contrary to X-ray silent complex 1,X-ray induced photochromism has been achieved in both complex 2 and *** intermolecular charge-transfer mechanism has been elucidated and the anion directed folding of(H_(2)imb)^(2+)has been validated to be critical to yield colored long-lived charge-separated states.

关键词： Supramolecular Photochromic X-ray induced Anion-directed folding electron-deficient viologens

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Interface-induced polymerization strategy for constructing titanium dioxide embedded carbon porous framework with enhanced chemical immobilization towards lithium polysulfides

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Nano Research 2024年第3期17卷 1473-1481页

作者： Yue Ouyang Xiaoxiao Li Jiexin Zhu wei Zong Yuhang Dai Xuan Gao wei Zhang Shengyuan Yang Roohollah Bagherzadeh Feili Lai Yue-e Miao Tianxi Liu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua University2999 North Renmin RoadShanghai 201620China The Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Advanced Fibrous Materials LAB Institute for Advanced Textile Materials and Technologies(ATMT)School of Advanced Materials and ProcessesAmirkabir University of TechnologyTehran 15914Iran Christopher Ingold Laboratory Department of ChemistryUniversity College London20 Gordon StreetLondon WC1H 0AJUK Department of Chemistry KU LeuvenCelestijnenlaan 200FLeuven 3001Belgium

The shuttle effect induced by soluble lithium polysulfides(LiPSs)is known as one of the crucial issues that limit the practical applications of lithium-sulfur(Li-S)***,a titanium dioxide nanoparticle embedded in nitrogen-doped porous carbon nanofiber(TiO_(2)@NCNF)composite is constructed via an interface-induced polymerization strategy to serve as an ideal sulfur *** the protection of the nanofiber walls,the uniformly dispersed TiO_(2) nanocrystalline can act as capturing centers to constantly immobilize LiPSs towards durable sulfur ***,the mesoporous microstructure in the fibrous framework endows the TiO_(2)@NCNF host with strong physical reservation for sulfur and LiPSs,sufficient pathways for electron/ion transfer,and excellent endurance for volume *** expected,the sulfur-loaded TiO_(2)@NCNF composite electrode presents a fabulous rate performance and long cycle lifespan(capacity fading rate of 0.062%per cycle over 500 cycles)at 2.0 ***,the assembled Li-S batteries harvest superb areal capacity and cycling stability even under high sulfur loading and lean electrolyte conditions.

关键词： interface-induced polymerization electrospun porous nanofibers lithium-sulfur(Li-S)batteries high sulfur loading lithium polysulfides(LiPSs)immobilization

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High Magnetic Property and Toxicity of Particulate Matter Generated during Welding and Cutting Processes

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environment & Health 2024年第6期2卷 381-389页

作者： wei Cui Zizhen Ma Yuanzheng Chen Shuya Li Di Wu xiu Chen Yuankai Shao Yuzhe Liu Qing Li Jianmin Chen Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and EngineeringFudan UniversityShanghai 200433China School of environmental and Municipal engineering Qingdao University of TechnologyQingdao 266520China Shanghai Institute of eco-Chongming(SIeC) Shanghai 200062China National engineering Laboratory for Mobile Source emission Control Technology China Automotive Technology&Research Center Co.LtdTianjin 300300China

Magnetic particulate matter(PM)has raised increasing concern due to its abundant presence in ambient air and negative health ***,there is still a lack of comprehensive understanding of their emission sources and *** here report the observation of high magnetic property and toxicity of PM generated during typical welding and cutting ***,formed during high-temperature operation with less oxygen pressure,was revealed to be the major magnetic *** averaged saturation magnetization and magnetic susceptibility values of fine PM(PM_(2.5))from welding processes are 1.4−4.2 times greater than those of PM emitted from other unintended emission sources,including iron and steel plants and brake wear,while they are 2.0−5.7 times greater for the cutting ***,PM_(2.5)from welding and cutting processes are nearly 3.5−4.5 times more neurovirulent and 2.1−7.0 times more likely to induce oxidative stress than those from other magnetic sources in the nerve cells ***,all of these magnetic PM_(2.5)exhibit greater negative health effects than typical atmospheric PM_(2.5)collected in Shanghai urban *** new findings suggest that appropriate occupational protection measures should be implemented for the welding and cutting process to reduce adverse health impacts.

关键词： pollutant emission magnetic property particulate matters magnetite welding and cutting

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