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Muricatenol, a Linear Acetogenin from Annona muricata (Annonaceae)

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Chinese Chemical Letters 2000年第3期11卷 239-242页

作者： De Yu LI Jing Guang YU xiu zhen luo Lan SUN Shi Lin YANG (Institute of Medicinal Plant Development. Chinese Academy of Medical Sciences and Peking Union Medical College. Beijing 100094) Chinese Acad Med Sci Inst Med Plant Dev Beijing 100094 Peoples R China Peking Union Med Coll Beijing 100094 Peoples R China

Muricatenol 1, a new acetogenin, has been isolated from the seeds of Annona muricata L.. Compound 1 is a C-37 acetogenin without any THF rings. with four hydroxyls and one double bond in the long aliphatic chain. The hydroxyls of 1 are located at C-4, C-10, C-18 and C-19. respectively. The vicinal diet at C-18/C-19 is threo-configuration, and the double bond at C-14/C-15 is cis-configuration.

关键词： Annona muricata Annonaceae acetogenins muricatenol

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

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World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong Jiang-Shan Huang Fei-Long Guo Jing-Yu Wu Mao-xiu Yuan Jia-Fu Zhu Wen-Wei Lin Sui Chen zhen-Yang Zhang Jiang-Bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management

非小细胞肺癌患者表皮生长因子受体及K-Ras基因突变特征与临床病理特征的关系

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实用医院临床杂志 2017年第4期14卷 67-70页

作者：娄冲陈秀珍罗娟四川省内江市第二人民医院检验科四川内江641000 四川省资中县资州医院检验科四川内江641000 四川省内江市中医院检验科四川内江641000

目的分析非小细胞肺癌患者表皮生长因子受体(EGFR)及K-Ras基因突变情况,分析突变与患者临床病理特征的相关性。方法选取本地区非小细胞肺癌手术标本90例,运用突变扩增阻滞系统(ARMS)-Taqman探针法检测EGFR及K-Ras基因外显子突变状态,并... 详细信息

目的分析非小细胞肺癌患者表皮生长因子受体(EGFR)及K-Ras基因突变情况,分析突变与患者临床病理特征的相关性。方法选取本地区非小细胞肺癌手术标本90例,运用突变扩增阻滞系统(ARMS)-Taqman探针法检测EGFR及K-Ras基因外显子突变状态,并分析基因突变与临床病理特征的相关性。结果 90例非小细胞肺癌患者有39例检测到EGFR突变,包括18例19-del和12例L858R,另有9例存在L858R和T790 M双突变;33例K-Ras突变,主要为12密码子突变;3例患者检测到EGFR和K-Ras同时突变,为无吸烟史晚期肺腺癌患者;不同性别、吸烟史、肿瘤类型等亚组患者中EGFR突变率有差异,二元logistic回归分析结果显示EGFR与性别、年龄、肿瘤类型相关,未发现K-Ras与以上临床病理因素的相关性。结论 EGFR基因突变类型以及是否伴随K-Ras突变对于非小细胞肺癌患者临床用药具有重要的指导意义,K-Ras基因与临床病理特征的相关性尚需进一步研究。

关键词：非小细胞肺癌基因检测 DNA突变分析表皮生长因子受体 K-Ras

Update understanding on diagnosis and histopathological examination of atrophic gastritis:A review

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4080-4091页

作者： xiu-zhen Ma Ni Zhou xiu luo Si-Qi Guo Ping Mai The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Gansu Provincial People's HospitalLanzhou 730000Gansu ProvinceChina Department of Gastroenterology Xi'an International Medical CenterXi’an 710000Shaanxi ProvinceChina The First School of Clinical Medicine Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina

Chronic atrophic gastritis(CAG)is a complex syndrome in which long-term chronic inflammatory stimulation causes gland atrophy in the gastric mucosa,reducing the stomach's ability to secrete gastric juice and pepsin,and interfering with its normal physiological *** pathogenic factors contribute to CAG incidence,the most common being Helicobacter pylori infection and the immune reactions resulting from gastric ***,CAG has a broad spectrum of clinical manifestations,including gastroenterology and extraintestinal symptoms and signs,such as hematology,neurology,and ***,the initial CAG evaluation should involve the examination of clinical and serological indicators,as well as diagnosis confirmation via gastroscopy and histopathology if *** on the severity and scope of atrophy affecting the gastric mucosa,a histologic staging system(Operative Link for Gastritis Assessment or Operative Link on Gastritis intestinal metaplasia)could also be ***,chronic gastritis has a higher risk of progressing to gastric cancer(GC).In this regard,early diagnosis,treatment,and regular testing could reduce the risk of GC in CAG ***,the optimal interval for endoscopic monitoring in CAG patients remains uncertain,and it should ideally be tailored based on individual risk evaluations and shared decision-making *** there have been many reports on CAG,the precise etiology and histopathological features of the disease,as well as the diagnosis of CAG patients,are yet to be fully ***,this review offers a detailed account of CAG,including its key clinical aspects,aiming to enhance the overall understanding of the disease.

关键词： Atrophic gastritis Helicobacter pylori infection Autoimmune gastritis Diagnosis Operative link for gastritis assessment staging Gastric cancer risk

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小鼠肌浸液细胞团刺激因子的初步分离

军事医学科学院院刊 1984年第3期 293-298页

作者：葛忠良刘秀珍骆传环刘学英军事医学科学院放射医学研究所

应用小鼠肌浸液作为细胞团刺激因子(CSF),培养小鼠骨髓粒系定向祖细胞(CFCC)已获得较好的效果。为了了解肌浸液中有效成分的性质,进一步深入研究粒系细胞增殖与分化机制,我们曾对肌浸液的有效成分进行了初步分离,其结果报告如下。材料... 详细信息

应用小鼠肌浸液作为细胞团刺激因子(CSF),培养小鼠骨髓粒系定向祖细胞(CFCC)已获得较好的效果。为了了解肌浸液中有效成分的性质,进一步深入研究粒系细胞增殖与分化机制,我们曾对肌浸液的有效成分进行了初步分离,其结果报告如下。材料与方法 (一) 小鼠肌浸液的制备无菌条件下取小鼠二侧大腿与背脊肌组织于培养液内,洗去肌组织上的血液,用眼科小剪刀把肌组织剪成2—3毫米大小的小块(不能把组织捣碎)放入另一个内有培养液的大培养皿内浸泡,一般浸泡2小时左右(长一些较好),目的是去掉剪破细胞流出的细胞

关键词：提取物细胞团巨噬细胞 CSF 吞噬细胞小家鼠小鼠浸液

Some questions about landscape modelling

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Journal of Environmental Sciences 2001年第4期13卷 459-465页

作者： Michel Godron LI xiu-zhen CCAS F18410BrinonFrance Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China

The paper discusses mainly about the modelling process and related problems with examples from Chinese and French cases. Five practical problems must be solved for modelling the functioning of any landscape: ( 1) The field data are necessarily taken with a sampling procedure that implies a spatial (and often temporal) scale. (2) Every landscape modelled has to be identified, delimited and characterised before application of the hierarchical theory. (3) The functioning of a landscape involves data of multiple types (climate, soil, vegetation, fauna, buildings, communications, economy, aesthetics, etc.) which must be integrated in a holistic approach. (4) Every landscape is spatially heterogeneous, and the structure of the model must be more or less isomorphic with its heterogeneity. ( 5) The evolution of the landscape must be modelled on a rather long period of time. For all these reasons, it is necessary to build ad hoc models. Object-oriented computing languages may be useful for this purpose.

关键词： landscape modelling scale hierarchy holistic approach application

Seismic running safety of trains and a new type of seismic-isolation railway structure

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Transportation Safety and Environment 2021年第2期3卷 152-165页

作者： xiu luo JR Soken Engineering(Railway Technical Research Institute) 2-8-38 Hikari-choKokubunji-shiTokyo 185-0034Japan

Until now,seismic-isolation structures have not yet been applied in the railway *** reason is that though a seismic-isolation structure can reduce the inertial force to the structure,the energy absorption causes big response displacement on the structure,which adversely effects the running safety of the trains supported by the *** this paper,a methodology for seismic running safety assessment is introduced,and a new type of seismic-isolation foundation is proposed,which can convert the seismic response displacement in the lateral direction of track to the longitudinal direction that has a less adverse effect on the running safety of the *** isolation foundation is composed of FPS(Friction Pendulum System)slider,concave plate and guide ***,through model experiments and 3D numerical simulation,it is verified that the proposed foundation can keep both the effects of the seismic isolation and the running safety of the train during an earthquake.

关键词： seismic running safety of trains spectral intensity seismic-isolation foundation response-direction conversion system

Improving solubility and copy number of taxadiene synthase to enhance the titer of taxadiene in Yarrowia lipolytica

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Synthetic and Systems Biotechnology 2023年第2期8卷 331-338页

作者： Man Xu Wenliang Xie zhen luo Chun-xiu Li Qiang Hua Jian-He Xu State Key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for Biomanufacturing and School of BiotechnologyEast China University of Science and Technology130 Meilong RoadShanghai200237China

Taxadiene is an important precursor for the biosynthesis of highly effective anticancer drug paclitaxel,but its microbial biosynthesis yield is very *** this study,we employed Yarrowia lipolytica as a microbial host to produce ***,a“push–pull”strategy was adopted to increase taxadiene production by 234%.Then taxadiene synthase was fused with five solubilizing tags respectively,leading a maximum increase of 62.3%in taxadiene production when fused with ***,a multi-copy iterative integration method was used to further increase taxadiene titer,achieving the maximum titer of 23.7 mg/L in shake flask culture after three rounds of ***,the taxadiene titer was increased to 101.4 mg/L by optimization of the fed-batch fermentation *** is the first report of taxadiene biosynthesis accomplished in ***,serving as a good example for the sustainable production of taxadiene and other terpenoids in this oleaginous yeast.

关键词： Taxadiene Yarrowia lipolytica “Push–pull”ostrategy Multi-copy integration Fed-batch fermentation

Modified state prediction algorithm based on UKF

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Journal of Systems Engineering and Electronics 2013年第1期24卷 135-140页

作者： zhen luo Huajing Fang Department of Control Science and Engineering Huazhong University of Science and Technology

The state prediction based on the unscented Kalman filter （UKF） for nonlinear stochastic discrete-time systems with linear measurement equation is investigated. Predicting future states by using the information of available measurements is an effective method to solve time delay problems. It not only helps the system operator to perform security analysis, but also allows more time for operator to take better decision in case of emergency. In addition, predictive state can make the system implement real-time monitoring and achieve good robustness. UKF has been popular in state prediction because of its advantages in handling nonlinear systems. However, the accuracy of prediction degrades notably once a filter uses a much longer future prediction. A confidence interval （Ci） is proposed to overcome the problem. The advantages of CI are that it provides the information about states coverage, which is useful for treatment-plan evaluation, and it can be directly used to specify the margin to accommodate prediction errors. Meanwhile, the CI of prediction errors can be used to correct the predictive state, and thereby it improves the prediction accuracy. Simulations are provided to demonstrate the effectiveness of the theoretical results.

关键词： unscented Kalman filter state prediction confidenceinterval Bonferroni interval.