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Relationship between serum bilirubin levels and optic neuritis

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Chinese Medical Journal 2013年第17期126卷 3307-3310页

作者： DENG Juan LIANG Xue-mei ZHANG xiu-lan LING Shi-qi YANG Ting-ting LI Min PENG Fu-hua Department of Ophthalmology Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China Multiple Sclerosis Center Department of Neurology Third Affiliated Hospital of Sun Yat-sen University Guangzhou Guangdong 510630 China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou Guangdong 510630 China

Background Bilirubin is the end product of heme catabolism and has strong antioxidant properties. Serum bilirubin levels are reported to be reduced in patients with multiple sclerosis （MS） and neuromyelitis optica （NMO）. The pathophysiology of optic neuritis （ON） resembles that of MS; however, the role of endogenous bilirubin in ON is unclear. The aim of this study is to measure serum bilirubin levels in patients with ON, and to investigate the correlation between ON and serum antioxidant status of bilirubin. Methods Serum levels of bilirubin were measured in 42 patients with ON, 50 patients with multiple sclerosis （MS）, 48 patients with neuromyelitis optica （NMO） and 48 healthy control subjects. Results Serum total bilirubin （Tbil）, direct bilirubin （Dbil） and indirect bilirubin （Ibil） levels in patients with ON were significantly lower than those in the healthy controls. However, no statistical significance was found between levels in the ON and MS, ON and NMO, and MS and NMO groups. In patients with ON, serum Tbil, Dbil, and Ibil levels were lower in those with recurrence or those with ON for a longer duration （〉1 year）. Moreover, Tbil, Dbil, and Ibil concentrations were lower in patients with papillitis than in those with retrobulbar type ON, but the differences were not statistically significant. Conclusions Low antioxidant status may exist in patients with ON. But serum levels of Tbil, Dbil, and Ibil did not correlate with clinical presentations, such as recurrence, duration of disease and subtypes of ON. Low antioxidant status already existed in MS or NMO patients before systemic symptoms appeared.

关键词： optic neuritis bilirubin antioxidant

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荧光法研究PTB与白蛋白的结合

光谱学与光谱分析 2007年第10期27卷 2079-2082页

作者：陈艳华卜凤泉胡秀丽刘志强刘忠英刘景英周秋丽吉林大学药学院吉林长春130021 中国科学院长春应用化学研究所新药研发室吉林长春130022

利用药物对蛋白的荧光猝灭作用,用荧光法研究了N-苯酰甲噻唑溴(PTB)与牛血清白蛋白(BSA)及人血清白蛋白(HSA)的相互作用。测定发现BSA溶液的最大激发波长为280nm,HSA溶液的最大激发波长为290nm。分别向溶液中加入PTB后,原有的最大发射... 详细信息

利用药物对蛋白的荧光猝灭作用,用荧光法研究了N-苯酰甲噻唑溴(PTB)与牛血清白蛋白(BSA)及人血清白蛋白(HSA)的相互作用。测定发现BSA溶液的最大激发波长为280nm,HSA溶液的最大激发波长为290nm。分别向溶液中加入PTB后,原有的最大发射波长处的强度明显减弱。说明PTB对BSA和HAS有荧光猝灭作用。PTB与BSA,HSA有中等强度的结合。测得15℃时PTB与BSA,HSA的结合常数分别为3.66×103和3.83×103,结合位点数n分别为1.02和1.16;37℃时PTB与BSA,HSA的结合常数分别为3.58×103和3.35×103,结合位点数分别为0.95和0.87。根据热力学常数确定了PTB与BSA,HSA之间的主要作用力类型均为静电作用力。通过Fster偶级-偶级非辐射能量转移原理,得到BSA,HSA与PTB结合的位置距色氨酸残基的距离分别为7.5和7.9nm。根据白蛋白的结构,可以推测BSA,HSA与PTB结合的位点在ⅡA亚结构域,靠近Try214的区域。

关键词： N-苯酰甲噻唑溴牛血清白蛋白人血清白蛋白荧光光度法

超临界CO_2中甲醇和乙醇无限稀释扩散系数的分子动力学模拟与实验测定

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高等学校化学学报 2007年第3期28卷 518-521页

作者：石剑张敏华董秀芹天津大学石油化工技术开发中心绿色合成与转化教育部重点实验室天津300072

采用分子动力学模拟(MD)方法对甲醇和乙醇在超临界二氧化碳中的无限稀释扩散系数进行了模拟计算,并应用泰勒分散理论,采用超临界色谱仪对模拟结果进行了实验验证.模拟计算值与实验值较吻合,且变化规律基本一致,表明采用这种新方法可以... 详细信息

采用分子动力学模拟(MD)方法对甲醇和乙醇在超临界二氧化碳中的无限稀释扩散系数进行了模拟计算,并应用泰勒分散理论,采用超临界色谱仪对模拟结果进行了实验验证.模拟计算值与实验值较吻合,且变化规律基本一致,表明采用这种新方法可以准确有效地预测超临界体系的扩散性质,能够方便地应用于工程设计.

关键词：超临界流体无限稀释扩散系数分子动力学模拟

Brightness temperature for 166 radio sources

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Research in Astronomy and Astrophysics 2009年第7期9卷 751-760页

作者： Jun-Hui Fan Yong huang Yu-Hai Yuan Jiang-He Yang Yi Liu Jun Tao ying Gao Tong-Xu hua Rui-Guang Lin Jiang-Shui Zhang Jing-Yi Zhang Yi-Ping Qin Center for Astrophysics Guangzhou University Guangzhou 510006 China Physics Institute Hunan Normal University Changsha 410081 China Center for Astrophysics University of Science and Technology of China Hefei 230026 China Department of Physics and Electronics Science Hunan University of Arts and Science Changde 415000 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China

Using the database of the University of Michigan Radio Astronomy Observatory （UMRAO） at three radio frequencies （4.8, 8 and 14.5 GHz）, we determined the short-term variability timescales for 166 radio sources. The timescales are 0.15d （2007＋777） to 176.17 d （0528-250） with an average timescale of Atobs = 17.1 4- 16.5 d for the whole sample. The timescales are used to calculate the brightness temperatures, TB. The value of log TB is in the range of log TB = 10.47 to 19.06 K. In addition, we also estimated the boosting factor for the sources. The correlation between the polarization and the Doppler factor is also discussed.

关键词： galaxies active - BL Lacertae objects general - galaxies jets

随机需求下基于库存责任期的装配系统准时供货模型

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系统工程理论与实践 2013年第9期33卷 2220-2228页

作者：关旭马士华应丹丰武汉大学经济与管理学院武汉430072 华中科技大学管理学院武汉430074

以装配系统为研究对象,考虑在VMI模式下,当制造商采取设定库存责任期以抵御市场需求时间不确定的风险时,供应商的最优供货时间决策和制造商最优的库存责任期设置.文章分别建立了单供应商对单制造商和多供应商对单制造商的主从博弈准时... 详细信息

以装配系统为研究对象,考虑在VMI模式下,当制造商采取设定库存责任期以抵御市场需求时间不确定的风险时,供应商的最优供货时间决策和制造商最优的库存责任期设置.文章分别建立了单供应商对单制造商和多供应商对单制造商的主从博弈准时供货模型,通过数学证明和遍历算法找到了供应链双方在不同模式下的最优选择.研究结果证明制造商并不应该选择过长的库存责任期,而供应商之间的不同步供货会对供应链整体造成巨大损失.并且通过对比集中与分散决策下的供应链绩效,给出实现系统协同的必要条件.最后通过算例分析进一步证明相关结论.

关键词：装配系统库存责任期准时供货供应链协同

Twenty-four-hour ambulatory blood pressure changes in older patients with essential hypertension receiving monotherapy or dual combination antihypertensive drug therapy

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Journal of Geriatric Cardiology 2019年第4期16卷 354-361页

作者： Pei-Pei LU Xu MENG ying ZHANG Yan-Qi LI Shu WANG Li-Sheng LIU Wen WANG Yu-Ling LI Yu-Qing ZHANG Ai-hua HU Xian-Liang ZHOU Li-Hong MA Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Science and Peking Union Medical CollegeBeijingChina Clinical Trial and Research Center Beijing Hypertension League InstituteChinese Hypertension LeagueBeijingChina Xinjiekou Community Health Service Center BeijingChina Department of Traditional Chinese Medicine Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective To evaluate the differences in 24-hour ambulatory blood pressure (BP) in older patients with hypertension treated with the five major classes of antihypertensive drugs,as monotherapy or dual combination therapy,to improve daytime and nighttime BP control. Methods We enrolled 1920 Chinese community-dwelling outpatients aged ≥ 60 years and compared ambulatory BP values and ambulatory BP control (24-hour BP < 130/80 mmHg;daytime mean BP < 135/85 mmHg;and nighttime mean BP < 120/70 mmHg),as well as nighttime BP dip patterns for monotherapy and dual combination therapy groups. Results Patients’ mean age was 71 years,and 59.5% of patients were women. Calcium channel blockers (CCBs) constituted the most common (60.3% of patients) monotherapy,and renin–angiotensin system (RAS) blockers combined with CCBs was the most common (56.5% of patients) dual combination therapy. Monotherapy with beta-blockers (BB) provided the best daytime BP control. The probabilities of having a nighttime dip pattern and nighttime BP control were higher in patients receiving diuretics compared with CCBs (OR = 0.52,P = 0.05 and OR = 0.41,P = 0.007,respectively). Patients receiving RAS/diuretic combination therapy had a higher probability of having controlled nighttime BP compared with those receiving RAS/CCB (OR = 0.45,P = 0.004). Compared with RAS/diuretic therapy,BB/CCB therapy had a higher probability of achieving daytime BP control (OR = 1.27,P = 0.45). Conclusions Antihypertensive monotherapy and dual combination drug therapy provided different ambulatory BP control and nighttime BP dip patterns. BB-based regimens provided lower daytime BP,whereas diuretic-based therapies provided lower nighttime BP,compared with other antihypertensive regimens.

关键词： Aging Ambulatory blood pressure monitoring Antihypertensive drugs Beta-blockers Diuretics

Effect of embryo quality on pregnancy outcomes for women completing biochemical pregnancy in in vitro fertilizationembryo transfer(IVF-ET)

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Journal of Reproduction and Contraception 2015年第3期26卷 135-140页

作者： Jing-yuan WANG xiu-juan QI Xia LIU Ji-hui LIN ying-pin LV ART Center of the Affiliated Hospital of Qingdao University

Objective To analyze the effect of the numbers of transferred good-quality embryos on pregnancy outcomes in in vitro fertilization-embryo transfer （IVF-ET）, supplying a reference for selection of transferred embryos.Methods Five hundreds and one infertile patients who underwent IVF-ET were retrospectively analyzed. All cycles were divided into 3 groups by the number of transferred good-quality embryos （group A： two good-quality embryos, group B： one good-quality embryo, group C： no good-quality embryo）, with no significant difference in general condition such as age, infertility duration and infertility types. The pregnancy outcomes were compared and analyzed among the three groups.Results 1） Live-birth rate was improved with increasing good-quality transferred embryo numbers. Groups A （70.3%） and B （69.8%） had no significant difference （P=0. 409）, whereas it was significantly greater in groups A and B than in group C （57. 7%）（P=0.009, P=0.036）. 2） The loss of single gestational sacs rate, which have no significant difference among 3 groups （P=0.221, P=0.539, P=0.226）, reduced with increasing good-quality transferred embryos numbers. 3） Biochemical pregnancy abortion rate in groups A （10.9%） and B （10.1%） was significantly lower than that in group C （18.3%）（P=0.049, P=0.049）. 4） There was no significant difference among 3 groups in ectopic pregnancy rate （P=0.174, P=0.129, P=0.404）. 5）Multiple-birth rate was improved with increasing good-quality transferred embryos numbers, it was significantly greater in group A （31.6%） than in group C （15.0%）（P=0.020）, while groups B and A had no significant difference （P=0.489, P=0.126）.Conclusion Two good-quality transferred embryos have no significantly difference to 1 good-quality embryo in all pregnancy outcomes. In clinic treatment, we can select 1 good-quality embryo and 1 poor-quality embryo when patients only have few goodquality embryos. Meanwhile, a good-quality embryo can improve live-birth rate and multiple pre

关键词： IVF-ET good-quality embryo IVF outcome multiple pregnancies

Preclinical evaluation of ZL006-05,a new antistroke drug with fast-onset antidepressant and anxiolytic effects

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Stroke & Vascular Neurology 2023年第6期8卷 463-474页

作者： Haiyin Wu Zhenquan huang Xuan Wang Mingyu Chen Wei Chen Yao hua Jian Ren Luyao Shen Yixuan Song ying Zhou Chunxia Luo Yuhui Lin Yilong Wang Lei Chang Fei Li Dongya Zhu Department of Pharmacology School of PharmacyNanjing Medical UniversityNanjingJiangsuChina Department of Medicinal Chemistry School of PharmacyNanjing Medical UniversityNanjingChina NeuroDawn Pharmaceutical Co. LtdNanjingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina

Background Poststroke depression and anxiety,independent predictor of poor functional outcomes,are common in the acute phase of *** to now,there is no fast-onset antidepressive and anxiolytic agents suitable for the management of acute ***006-05,a dual-target analgesic we developed,dissociates nitric oxide synthase from postsynaptic density-95 while potentiatesα2-containingγ-aminobutyric acid type A *** study aims to determine whether ZL006-05 can be used as an antistroke agent with fast-onset antidepressant and anxiolytic *** Photothrombotic stroke and transient middle cerebral artery occlusion were induced in rats and *** size was measured by TTC(2,3,5-Triphenyltetrazolium chloride)staining or Nissl *** defects were assessed by four-point scale neurological score or modified Neurological Severity ***-walking,cylinder and modified adhesive removal tasks were conducted to assess sensorimotor *** learning was assessed using Morris water maze *** and anxiety were induced by unpredictable chronic mild *** behaviours were assessed by tail suspension,forced swim and sucrose preference *** behaviours were assessed by novelty-suppressed feeding and elevated plus maze ***,toxicokinetics and long-term toxicity studies were performed in *** Administration of ZL006-05 in the acute phase of stroke attenuated transient and permanent ischaemic injury and ameliorated long-term functional impairments significantly,with a treatment window of 12 hours after ischemia,and reduced plasminogen activato-induced haemorrhagic ***006-05 produced fast-onset antidepressant and anxiolytic effects with onset latency of 1 hour in the normal and CMS mice,had antidepressant and anxiolytic effects in stroke ***006-05 crossed the blood-brain barrier and distributed into the brain rapidly,and had a high safety profile in toxicokinetics and

关键词： elevated transient kinetics

Effect of high-dose ulinastatin on the cardiopulmonary bypass-induced inflammatory response in patients undergoing open-heart surgery

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Chinese Medical Journal 2020年第12期133卷 1476-1478页

作者： Yu Liu ying-Lin Wang Shao-hua Zou Peng-Fei Sun Quan Zhao Department of Drug Dispensing The Affiliated Hospital of Qingdao UniversityQingdaoShandong 266500China Department of Clinical Pharmacy Yuhuangding Hospital of Qingdao UniversityYantaiShandong 264000China

Ulinastatin(UTI),a broad-spectrum elastase inhibitor,can stabilize lysosomal membranes and inhibit the activation and release of various inflammatory cytokines caused by cardiopulmonary bypass(CPB).[1,2]UTI has recently been considered to be an effective anti-inflammatory agent and has been widely used in clinical settings,[3-5]but the optimal dose has not been ***,we conducted a prospective,randomized,controlled trial involving 60 patients undergoing cardiac surgeries with CPB and investigated the serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and interleukin-8(IL-8),at different time points in order to evaluate the antiinflammatory efficacy of high-dose UTI and explore the optimum dose.

关键词： bypass inflammatory patients