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Clinical and histopathological alterations of lymphangioleiomyomatosis in 14 Chinese patients

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Chinese Medical Journal 2009年第16期122卷 1895-1900页

作者： LU Shao-hua HOU ying-yong TAN Yun-shan XU Jian-fang ZENG Hai-ying SUJIE A-kesu WANG Xiang-dong BAI Chun-xue Department of Pathology Zhongshan Hospital Fudan University Shanghai 200032 China Department of Respiratory Medicine Zhongshan Hospital Fudan University Shanghai 200032 China

Background Lymphangioleiomyomatosis （LAM） is a rare disease that predominantly affects young females. It is considered as an ＂orphan＂ life-threatening disease of unknown etiology, with uncertain clinical prognosis, and no effective treatment. LAM can arise sporadically or in association with tuberous sclerosis complex （TSC）, an autosomal inherited syndrome characterized by hamartoma-like tumor growth and pathologic features that are distinct from manifestations of pulmonary LAM. The clinical course of LAM is characterized by progressive dyspnea on exertion, recurrent pneumothorax, and chylous fluid collections. Methods Fourteen cases of LAM from Zhongshan Hospital, Fudan University are reviewed, twelve were confirmed by lung biopsy, one by retroperitoneal lymphangioleiomyoma resection, and one by autopsy. Results All 14 patients were women, aged 18 to 69 years （mean 43.3 years, median 46.5 years）. Haemoptysis （57.1%） and chylothorax （35.7%） were more frequent than those described in previous case series. Extrapulmonary findings such as renal angiomyolipoma （AML）, enlarged abdominal lymph nodes, liver AML and retroperitoneal lymphangioleiomyoma were seen in 21.4%, 14.3%, 7.14% and 7.14% in 14 cases respectively, which is remarkably lower than in the previously reported. Abnormal smooth muscle cells （LAM cells） were found to line the airways, bronchioles, lymphatics and blood vessels leading to airflow obstruction and replacement of the lung parenchyma by cysts. There were some surprises in the autopsy case as several LAM cell emboli were found in the veins of mediastinum lymph nodes; LAM cells were found to be disseminated in soft tissues adjacent to the ilium. Conclusions Women with unexplained recurrent pneumothorax, tuberous sclerosis, or a diagnosis of primary spontaneous pneumothorax or emphysema in the setting of limited or absent tobacco use should undergo high-resolution computed tomography （HRCT） scan screening for LAM. Routine abdominal and pelvic imaging e

关键词： lymphangioleiomyomatosis patients lung

Combined serum hepatoma-specific alpha-fetoprotein and circulating alpha-fetoprotein-mRNA in diagnosis of hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 538-544页

作者： Wei Wu, Deng-Fu Yao, Yong-Mei Yuan, Ji-Wei Fan, xiu-Feng Lu, Xiao-hua Li, Li-Wei Qiu, Lei Zong and Xin-hua Wu Research Center of Clinical Molecular Biology, Affiliated Hospital of Nantong University, Nantong 226001, China Research Center of Clinical Molecular Biology Affiliated Hospital of Nantong University Nantong 226001 China.

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, its prognosis is poor, and early detection is of utmost importance. Although alpha-fetoprotein (AFP) is a useful marker for detecting and monitoring HCC development, the false-negative or false-positive rates with AFP alone may be as high as 30%-40% for patients with small HCCs. To enhance the specificity and accuracy of AFP measurements for HCC, we analyzed AFP expression states in livers, detected the hepatoma-specific AFP (HS-AFP) fraction and AFP-mRNA from peripheral blood mononuclear cells, and explored their clinical implications for HCC diagnosis. METHODS: AFP expression and hepatocyte distributions in liver specimens were investigated by an immunohistoche- mical assay. Total RNAs were extracted from circulating blood, synthesized to cDNA through random primers and reverse transcriptase, and fragments of the AFP gene were amplified by a nested-PCR assay. The HS-AFP fraction was separated by lectin-affinity chromatography and its level was detected by radioimmunoassay. RESULTS: The incidence of AFP was 73.3% in HCC tissues and its expression in HCCs with moderate or low differentiation was significantly stronger than that of HCCs with high differentiation (P<0.05). The incidence of AFP gene fragments was 100% in HCCs, and 60% in paracancerous tissues (P<0.01). In the HCC and liver cirrhosis groups, the incidence of HS-AFP was 91.7% and 18% (P<0.01), and of AFP-mRNA was 56.7% and 16% (P<0.01), respectively, and neither was found in ***-AFP or AFP-mRNA was not significantly related to size or number of HCC, but to its differentiation, metastasis, and relapse (P<0.05). CONCLUSIONS: Different AFP expression is present in different parts of HCC tissues. HS-AFP and AFP-mRNA fragments improve sensitivity and specificity, and both are useful markers to diagnose HCC or monitor metastasis and relapse.

关键词： carcinoma, hepatocellular hepatoma-specific AFP AFP-mRNA affinity chromatography immunohistochemistry RT-PCR

Expression and function of Rac1 in the nucleus accumbens of rats with chronic stress depression

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Journal of Hainan Medical University 2019年第20期25卷 15-19页

作者： Bao-Ling Xiao-hua Hu Zong-Qin Wang Zuo-Hui Gao ying-ying Feng Wuhan Mental Health Center 430022 Wuhan Hubei Province

Objective:To investigate the expression and function of Rac1 in the rat nucleus accumbens (NAc) with chronic stress ***: The expression of Rac1 mRNA in the NAc was observed by establishing a chronic stress (CUMS) rat depression model, and the difference in Rac1 mRNA expression was compared with the untreated model group after chronic antidepressant therapy. To explore the relationship between Rac1 and chronic stress depression;over-express Rac1 in rat nucleus accumbens and perform CUMS modeling to explore the function of Rac1 in chronic stress ***: Rac1 expression was decreased in NAc of CUMS rats and correlated with CUMS-induced depression. Imipramine antidepressant treatment significantly attenuated Rac1 decrease in NAc of CUMS rats;overexpression of Rac1 significantly improved CUMS-induced depression-like behavior in ***:The expression of Rac1 in the NAc of rats with chronic stress depression is reduced, and upregulation of Rac1 could improve the depression-like behavior induced by chronic stress.

关键词： chronic stress depression NAc Rca1

从气候科学到气候经济学:诺贝尔物理学奖获得者Hasselmann的交叉科学研究

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气候变化研究进展 2022年第5期18卷 644-652页

作者：廖华叶慧颖北京理工大学管理与经济学院北京100081 北京理工大学能源与环境政策研究中心北京100081

自然科学家Klaus Hasselmann在气候科学领域做出了杰出贡献。2021年瑞典皇家科学院授予他诺贝尔物理学奖,以表彰他在“地球气候的物理建模、量化变化并可靠预测全球变暖”方面的贡献。气候系统是一类复杂物理系统,随机和无序中蕴含着可... 详细信息

自然科学家Klaus Hasselmann在气候科学领域做出了杰出贡献。2021年瑞典皇家科学院授予他诺贝尔物理学奖,以表彰他在“地球气候的物理建模、量化变化并可靠预测全球变暖”方面的贡献。气候系统是一类复杂物理系统,随机和无序中蕴含着可预测性。

关键词：诺贝尔物理学奖瑞典皇家科学院地球气候物理建模可预测性物理系统自然科学家全球变暖

云南不同地区和生境代表性热带植物区系的物种组成比较

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植物科学学报 2014年第6期32卷 594-601页

作者：刘颖颖朱华中国科学院西双版纳热带植物园云南西双版纳666303 2中国科学院大学北京100049

云南热带植物区系地理成分复杂,生物多样性极其丰富。为了解不同地区和生境热带植物区系的物种组成差异,本文选取云南南部和东南部3个有代表性的热带植物区系——西双版纳龙脑香林植物区系(DFX)、西双版纳石灰岩山植物区系(LFX)和文山... 详细信息

云南热带植物区系地理成分复杂,生物多样性极其丰富。为了解不同地区和生境热带植物区系的物种组成差异,本文选取云南南部和东南部3个有代表性的热带植物区系——西双版纳龙脑香林植物区系(DFX)、西双版纳石灰岩山植物区系(LFX)和文山古林箐石灰岩山植物区系(LFG)为研究对象,比较不同植物区系的科属数量结构、科内多样性、科属分布区类型及植物区系相似性。研究结果显示:(1)3个热带植物区系均具有较高的物种多样性,但种类组成、科属数量结构及科内多样性差异较大;(2)热带分布的科、属在3个热带植物区系中均占绝对优势;(3)3个热带植物区系的共有物种极少,而专有物种(即在3个植物区系之间相对专有)相对较多,植物区系之间的种级相似性极低。云南不同地区和生境热带植物区系强烈的热带亲缘、物种组成的多样性和复杂性以及较低的植物区系相似性,揭示了地理和生境差异会影响各地热带植物区系的演化与发展。

关键词：热带植物区系地理成分科内多样性区系相似性云南

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对21轮SMS4算法的多差分攻击

密码学报 2016年第6期3卷 584-595页

作者：宋何颖秀高海英解放军信息工程大学郑州450004

SMS4算法一种是用于WAPI的分组密码算法,也是国内官方公布的第一个商用密码算法,该算法公布后即引起国内外密码学界的分析热潮.SMS4算法的分组长度为128比特,密钥长度为128比特,加密算法与密钥扩展算法都采用32轮迭代结构.本文的分析方... 详细信息

SMS4算法一种是用于WAPI的分组密码算法,也是国内官方公布的第一个商用密码算法,该算法公布后即引起国内外密码学界的分析热潮.SMS4算法的分组长度为128比特,密钥长度为128比特,加密算法与密钥扩展算法都采用32轮迭代结构.本文的分析方法是综合利用了2^(28)个17轮的SMS4的差分特征,采用基于最优区分器思想的多差分攻击方法对21轮的SMS4算法进行攻击和分析,针对每个实验密钥,构造出基于多个差分特征的统计量,根据统计量的大小判决实验密钥是否是正确密钥.给出了多差分分析方法的计算复杂度,分析了正确密钥、错误密钥对应统计量的概率分布规律,在此基础上给出了多差分分析方法的成功率和数据复杂度之间的关系.最终得出结论可以2^(104)的数据复杂度,2^(114)的计算复杂度,来恢复出该算法的128比特圈子密钥.用该结果与目前已知的对21轮SMS4算法的差分攻击结果进行对比我们可以看出,攻击的数据复杂度和计算复杂度都有所降低.基于该研究结果,我们可以得出以下结论,在成功率相同的条件下,基于的差分特征越多,需要的数据复杂度和计算复杂度越小.

关键词：分组密码 SMS4算法差分特征多差分攻击复杂度成功率

高效液相色谱法同时测定怀山药中4个山药素化合物

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药物分析杂志 2015年第3期35卷 396-400页

作者：朱金花东莹莹胡卫平曹国栋刘绣华河南大学化学化工学院环境与分析科学研究所开封475004 河南省天然产物与免疫工程重点实验室河南大学化学生物学研究所开封475004

目的：建立HPLC法同时测定怀山药不同部位（块茎、皮、茎叶、零余子）中4个山药素化合物（山药素Ⅰ、Ⅲ、Ⅳ、Ⅴ）的含量。方法：采用Aglient HC-C18（4.6 mm×250 mm,5μm）色谱柱,以甲醇（A）-水（B）为流动相,洗脱梯度（0~20 min,50%... 详细信息

目的：建立HPLC法同时测定怀山药不同部位（块茎、皮、茎叶、零余子）中4个山药素化合物（山药素Ⅰ、Ⅲ、Ⅳ、Ⅴ）的含量。方法：采用Aglient HC-C18（4.6 mm×250 mm,5μm）色谱柱,以甲醇（A）-水（B）为流动相,洗脱梯度（0~20 min,50%A;20~65 min,50%A→65%A）,流速1.0 m L·min-1,检测波长274 nm,柱温30℃,进样量20μL。结果：4个山药素化合物在60 min内得到良好的分离,在给定的浓度范围内,4个山药素化合物呈现良好的线性（r≥0.999 9）、精密度（RSD≤0.93%）、稳定性（RSD≤0.62%）和重复性（RSD≤3.2%）,回收率在91%~102%之间。其中怀山药的零余子和茎叶中均含有4个山药素化合物,山药皮中含有3个山药素化合物（山药素Ⅰ、Ⅲ、Ⅴ）,块茎中含有2个山药素化合物（山药素Ⅰ、Ⅲ）。结论：经方法学验证,本文建立的方法为怀山药质量标准研究、产品质量控制以及山药素类化合物的化感研究打下了基础。

关键词：怀山药连作障碍山药素化感物质不同部位比较山药块茎山药皮山药茎叶山药零余子高效液相色谱法

Controlling malignant pericardial effusion by intrapericardial administration of recombinant mutant human tumor necrosis factor in patients with carcinoma

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The Chinese-German Journal of Clinical Oncology 2007年第5期6卷 442-443页

作者： Kaijian Lei hua Luo Yuming lia Shengqun ying Department of Oncology The No. 2 People＇s Hospital of Yibin Yibin 644000 China

Objective: To evaluate the therapeutic efficacy of injecting recombinant mutant human tumor necrosis factor (rmhTNF) into pericardial cavity of carcinoma patients with malignant pericardial effusion. Methods: In 20 cases of malignant pericardial effusion, the intrapericardial catheter was inserted into pericardial cavity, and then rmhTNF of 1.5 × 107 U was infused. The infusion was repeated every 5-7 days with the total 4-6 times. If the effusion disappeared, rmhTNF was then used 2 more times and then the intrapericardial catheter was pulled out. Results: Of 20 patients, 14 were complete response (CR), 4 were partial response (PR) and 2 no change (NC). The disappearance of effusion in 6 cases lasted for more than 6 months. Conclusion: Injecting rmhTNF into pericardial cavity may be a better way to control malignant pericardial effusion and has mild side effects.

关键词： pericardial effusion recombinant mutant human tumor necrosis factor (rmhTNF) intrapericardial catheter

Concurrent chemoradiotherapy using gemcitabine and nedaplatin in recurrent or locally advanced head and neck squamous cell carcinoma

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World Journal of Clinical Cases 2022年第11期10卷 3414-3425页

作者： Rui-Xue Huo ying-ying Jin Yong-Xue Zhuo Xiao-Tong Ji Yu Cui Xiao-Jing Wu Yi-Jia Wang Long Zhang Wen-hua Zhang Yu-Mei Cai Cheng-Cheng Zheng Rui-Xue Cui Qian-Ye Wang Zhen Sun Feng-Wei Wang Department of Oncology Tianjin Union Medical CenterTianjin 300000China School of Medicine Nankai UniversityTianjin 300000China Laboratory of Oncologic Molecular Medicine Tianjin Union Medical CenterTianjin 300000China

BACKGROUND Patients with recurrent or locally advanced head and neck squamous cell carcinoma(HNSCC)typically have limited treatment options and poor *** To evaluate the efficacy and safety of two drugs with potent radio-sensitization properties including gemcitabine and nedaplatin as concurrent chemoradiotherapy regimens in treating *** This single-arm prospective study enrolled patients with HNSCC to receive gemcitabine on days 1 and 8 and nedaplatin on days 1 to 3 for 21 *** radiation therapy with a conventional fraction was delivered 5 days per *** response rate(ORR),disease control rate,and toxicity were observed as primary *** survival(OS)and progression free survival were recorded and analyzed as secondary *** A total of 24 patients with HNSCC were *** the median 22.4-mo follow-up,both ORR and disease control rate were 100%.The one-year OS was 75%,and one-year progression-free survival(PFS)was 66.7%(median PFS was 15.1 mo).Recurrent HNSCC patients had a poorer prognosis than the treatment-naïve patients,and patients who achieved complete response had better survival than those in the PR group(all P<0.05).The most common grade 1-4(100%)or grade 3-4 toxicities(75%)were hematological,and the most common grade 3-4 non-hematological toxicity was mucositis in 17(71%)*** Gemcitabine plus nedaplatin with concurrent chemoradiotherapy is a therapeutic option for HNSCC with predictable *** the high adverse event rate,the optimized dose and schedule must be further explored.

关键词： Chemoradiotherapy Gemcitabine Nedaplatin Head and neck cancer Recurrent Locally advanced