检索结果-南通市图书馆

Association of tumor budding with clinicopathological features and prognostic value in stage III-IV colorectal cancer

引用

World Journal of Gastroenterology 2024年第2期30卷 158-169页

作者： Yue-Hao Luo Zhe-Cheng Yan Jia-Ying Liu Xin-Yi Li Ming Yang Jun Fan Bo Huang Cheng-Gong Ma Xiao-Na Chang xiu nie Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022Hubei ProvinceChina

BACKGROUND Tumor budding(TB)has emerged as a promising independent prognostic biomarker in colorectal cancer(CRC).The prognostic role of TB has been extensively studied and currently affects clinical decision making in patients with stage I and II ***,existing prognostic studies on TB in stage III CRC have been confined to small retrospective cohort ***,this study investigated the correlation among TB categories,clinicopathological features,and prognosis in stage III-IV CRC to further enhance the precision and individualization of treatment through refined prognostic risk *** To analyze the relationship between TB categories and clinicopathological characteristics and assess their prognostic value in stage III-IV CRC to further refine the prognostic risk stratification of stage III-IV *** The clinical data of 547 CRC patients were collected for this retrospective *** at the front edge of the tumor buds was counted according to the 2016 International Tumor Budding Consensus Conference *** Multivariate Cox proportional hazards regression analysis demonstrated that chemotherapy(P=0.004),clinical stage IV(P<0.001),≥4 regional lymph node metastases(P=0.004),left-sided colonic cancer(P=0.040),and Bd 2-3(P=0.002)were independent prognostic factors in patients with stage III-IV ***,the density of tumor infiltrating lymphocytes was higher in Bd 1 than in Bd 2-3,both in the tumor stroma and its invasive *** TB has an independent predictive prognostic value in patients with stage III-IV *** is recommended to complete the TB report of stage III-IV CRC cases in the standardized pathological report to further refine risk stratification.

关键词： Tumor budding Tumor infiltrating lymphocytes Colorectal cancer Survival analysis Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Schistosoma infection,KRAS mutation status,and prognosis of colorectal cancer

引用

Chinese Medical Journal 2024年第2期137卷 235-237页

作者： Xinyi Li Hongli Liu Bo Huang Ming Yang Jun Fan Jiwei Zhang Mixia Weng Zhecheng Yan Li Liu Kailin Cai xiu nie Xiaona Chang Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Hubei Key Laboratory of Precision Radiation Oncology WuhanHubei 430022China Institute of Radiation Oncology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Epidemiology and Biostatistics The Ministry of Education Key Lab of Environment and HealthSchool of Public HealthHuazhong University of Science and TechnologyWuhanHubei 430022China Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430022China

To the Editor:Colorectal cancer(CRC)is a major cause of cancer-related death worldwide,and several pathogens with carcinogenic potential,such as Schistosoma,have been associated with an increased risk of *** a frequently mutated gene in CRC patients,kirsten rat sarcoma viral oncogene homolog(KRAS)helps to determine the selection of CRC ***,we aimed to elucidate the association among Schistosoma infection,KRAS mutation status,and the prognosis of CRC in this study.

关键词： Schistosoma KRAS prognosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Real-world data on ALK rearrangement test in Chinese advanced non-small cell lung cancer(RATICAL):a nationwide multicenter retrospective study

引用

Cancer Communications 2024年第9期44卷 992-1004页

作者： Lin Li Wencai Li ChunyanWu Yanfeng Xi Lei Guo Yuan Ji Lili Jiang Ji Li Jingping Yun Gang Chen Yuan Li Yueping Liu DianbinMu Yuchen Han Leina Sun Qingxin Xia Xiaodong Teng Nanying Che WeiWu Xueshan Qiu Chao Liu Xiaochu Yan Daiqiang Li Zhihong Zhang ZheWang Yujun Li ZhengWang Lingchuan Guo xiu nie Jingshu Geng Jianhua Zhou Jianming Ying Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking UnionMedical CollegeBeijingP.R.China Department of Pathology the First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Pathology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiP.R.China Department of Pathology Cancer Hospital Affiliated to Shanxi Medical UniversityShanxi Province Cancer HospitalShanxi Hospital Affiliated to Cancer HospitalChinese Academy of Medical SciencesTaiyuanShanxiP.R.China Department of Pathology Zhongshan HospitalFudan UniversityShanghaiP.R.China Department of Pathology West China Hospital of Sichuan UniversityChengduSichuanP.R.China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China Department of Pathology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdongP.R.China Department of Pathology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujianP.R.China Department of Pathology Department of OncologyFudan University Cancer CenterShanghaiMedical College of Fudan UniversityShanghaiP.R.China Department of Pathology The Fourth Hospital of Hebei Medical UniversityShijiazhuangHebeiP.R.China Department of Pathology Shandong Cancer HospitalJinanShandongP.R.China Department of Pathology Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghaiP.R.China Department of Pathology Tianjin Medical University Cancer Institute and HospitalTianjinP.R.China Department of Pathology the Affiliated Cancer Hospital of Zhengzhou UniversityHenan Provincial Cancer HospitalZhengzhouHenanP.R.China Department of Pathology the First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Department of Pathology Bei

Background:Anaplastic lymphoma kinase(ALK)test in advanced non-small cell lung cancer(NSCLC)can help physicians provide target therapies for patients harboring ALK gene *** study aimed to investigate the real-world test patterns and positive rates of ALK gene rearrangements in advanced ***:In this real-world study(ChiCTR2000030266),patientswith advanced NSCLC who underwent an ALK rearrangement test in 30 medical centers in China between October 1,2018 and December 31,2019 were retrospectively *** training was conducted before the study was *** controls were performed at participating centers using immunohistochemistry(IHC)-*** positive ALK gene rearrangement rate and consistency rate were *** associated clinicopathological characteristics of ALK gene rearrangement were investigated as ***:The overall ALK gene rearrangement rate was 6.7%in 23,689 patients with advanced NSCLC and 8.2%in 17,436 patients with advanced lung *** quality control analysis of IHC-VENTANA-D5F3 revealed an intrahospital consistency rate of 98.2%(879/895)and an inter-hospital consistency rate of 99.2%(646/651).IHC-VENTANA-D5F3 was used in 53.6%,real-time polymerase chain reaction(RT-PCR)in 25.4%,next-generation sequencing(NGS)in 18.3%,and fluorescence in-situ hybridization(FISH)in 15.9%in the adenocarcinoma *** specimens tested with multiple methods,the consistency rates confirmed by IHC-VENTANA-D5F3 were 98.0%(822/839)for FISH,98.7%(1,222/1,238)forNGS,and 91.3%(146/160)for *** overall ALK gene rearrangement rateswere higher in females,patients of≤35 years old,never smokers,tumor cellularity of>50,and metastatic specimens used for testing in the total NSCLC population and adenocarcinoma subgroup(all P<0.05).Conclusions:This study highlights the real-world variability and challenges of ALK test in advanced NSCLC,demonstrating a predominant use of IHCVENTANA-D5F3 with high co

关键词： anaplastic lymphoma kinase diagnosis gene fusion non-small cell lung cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

广州南沙某项目深基坑组合支护结构有限元分析

引用

广州建筑 2024年第5期52卷 27-30页

作者：聂秀娟邵泉广州市第二建筑工程有限公司广州510045 广州市建筑集团有限公司广州510030

广州南沙某项目的深基坑采用了新型的砼芯类刚性大直径三重管(搅拌)旋喷桩+二道混凝土内支撑的组合支护结构体系。为探究该新型结构体系中钢筋混凝土加劲桩、大直径三重管(搅拌)旋喷桩及压顶板在不同工况条件下的相互作用效果,运用三维... 详细信息

广州南沙某项目的深基坑采用了新型的砼芯类刚性大直径三重管(搅拌)旋喷桩+二道混凝土内支撑的组合支护结构体系。为探究该新型结构体系中钢筋混凝土加劲桩、大直径三重管(搅拌)旋喷桩及压顶板在不同工况条件下的相互作用效果,运用三维有限元分析方法,对支护体系的稳定性(主要包括位移、内力)进行数值模拟仿真分析,为保障施工安全提供数据支持。

关键词：有限元深基坑组合支护

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于BIM的锚杆静压桩地基加固施工方法在改扩建工程中的应用研究

引用

广州建筑 2024年第4期52卷 9-12页

作者：聂秀娟邵泉广州市第二建筑工程有限公司广州510045 广州市建筑股份有限公司广州510030

近年来,随着新型城镇化建设工作的快速推进,大量的老旧建筑需要进行改扩建,改扩建工程迎来新的发展机遇。锚杆静压桩由于受施工场地限制较小、施工振动小等优点被广泛应用于改扩建工程的旧有地基加固处理。本文针对某改扩建工程原有地... 详细信息

近年来,随着新型城镇化建设工作的快速推进,大量的老旧建筑需要进行改扩建,改扩建工程迎来新的发展机遇。锚杆静压桩由于受施工场地限制较小、施工振动小等优点被广泛应用于改扩建工程的旧有地基加固处理。本文针对某改扩建工程原有地基承载力不足、需要进行地基加固处理这一实际情况,通过理论分析、方案论证,最终确定使用锚杆静压桩进行地基加固并进行了工艺创新,具体包括:运用BIM技术进行地基加固施工工序模拟及细部节点模拟实现构配件的标准化生产,设计使用了一种凹凸咬合型连接钢板用于方桩接桩提高桩抵抗拉裂、抗弯剪的能力,采用钢模板外包气珠薄膜增强体系结构的内部粘结等。本技术解决了锚杆静压桩施工易断桩、整体性不易保证等问题,提高了桩基施工质量,保证了施工安全,为类似项目提供了借鉴和参考。

关键词：锚杆静压桩 BIM 地基加固改扩建

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gastric carcinoma with osteoclast-like giant cells:a case report and review of the literature

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第3期10卷 237-241页

作者： Li-duan ZHENG xiu-ping YANG Hua-xiong PAN xiu nie Jun HE Qing LV Qiang-song TONG Department of PathologyUnion Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Surgery Union Hospital of Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Gastric carcinoma with osteoclast-like giant cells （OGCs） is an extremely rare tumor. So far, only six cases have been reported in the literature. Here we report an additional case of this tumor in a Chinese 78-year-old man presented with abdominal pain, vomiting, and hematemesis. Physical examination and gastroscopy revealed a tumor in the gastric antrum. The biopsy and pathological findings indicated a gastric adenocarcinoma with OGCs, which were present in both the tumor and the metastatic lymph nodes. Further immunohistochemical staining indicated that OGCs were reactive with CD68, CD45, and vimentin protein, but not with pancytokeratin, carcinoembryonic antigen, or epithelial membrane antigen, suggesting the monocytic/histiocytic derivation of these OGCs. In situ hybridization for Epstein-Burr virus showed no nuclear positivity in either adenocarcinoma or OGCs. Postoperative follow-up showed that the patient had survived for at least 6 months without recurrence. Further investigation is warranted to clearly define the prognostic significance of OGCs in gastric carcinoma.

关键词： Gastric carcinoma Adenocarcinoma Osteoclast-like giant cell (OGC)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ventana-D5F3免疫组化和NGS检测肺腺癌ALK阳性比较

引用

诊断病理学杂志 2024年第6期31卷 574-576页

作者：张继伟李钦丽聂秀常晓娜华中科技大学同济医学院附属协和医院病理科武汉430022 武汉市东西湖区人民医院检验科武汉430040

Ventana-D5F3免疫组化(IHC)和二代测序技术(NGS)在ALK阳性检测上具有较高的一致性,在临床应用中可以采用IHC进行肺腺癌ALK阳性患者的筛查,而NGS精准检测可以作为有效的补充。在检测方法选择时,需要考虑样本类型、肿瘤细胞比例、检测靶... 详细信息

Ventana-D5F3免疫组化(IHC)和二代测序技术(NGS)在ALK阳性检测上具有较高的一致性,在临床应用中可以采用IHC进行肺腺癌ALK阳性患者的筛查,而NGS精准检测可以作为有效的补充。在检测方法选择时,需要考虑样本类型、肿瘤细胞比例、检测靶标对检测方法的限制。

关键词：肺腺癌驱动基因间变性淋巴瘤激酶(ALK) Ventana-D5F3 免疫组化二代测序

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phylogenetic patterns of shrub communities along the longitudinal and latitudinal gradients on the northeastern Qinghai–Tibetan Plateau

引用

Journal of Mountain Science 2020年第5期17卷 1106-1114页

作者： XIAO Yuan-ming YANG Lu-cun nie xiu-qing LI Chang-bin XIONG Feng ZHOU Guo-ying Northwest Institute of Plateau Biology Chinese Academy of SciencesXining 810008China Key Laboratory of Tibetan Medicine Research Chinese Academy of SciencesXining 810008China Qinghai Key Laboratory of Qinghai-Tibet Plateau Biological Resources Xining 810008China University of Chinese Academy of Sciences Beijing 100049China

Biodiversity distribution patterns are a basic and long-standing but crucial aspect of ecology *** patterns form the primary source of data used to develop biodiversity protection practices,especially in mountain *** comprise one of the main types of vegetation on the Qinghai–Tibetan Plateau,where they serve vital ecological *** this study,we used a community phylogenetic approach to examine the distribution patterns of shrub communities along the longitudinal and latitudinal gradients on the northeastern Qinghai–Tibetan *** observed significant latitudinal trends in both the phylogenetic diversity(PD)and net relatedness index(NRI)values of shrub communities,such that the former decreased and the latter increased with increasing ***,no significant PD,NRI and nearest taxon index(NTI)distribution patterns were observed along a longitudinal gradient.A further analysis revealed that the combination of temperature-related and precipitation-related climate variables most strongly affected the PD,NRI and NTI values of shrub communities,indicating that the latitudinal patterns in the PD,NRI and NTI of a shrub community may be determined mainly by interactions with these climate factors.

关键词： Phylogenetic diversity Phylogenetic community structure Shrub communities Qinghai–Tibetan Plateau Net Relatedness Index Nearest Taxon Index

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aboveground biomass of the alpine shrub ecosystems in Three-River Source Region of the Tibetan Plateau

引用

Journal of Mountain Science 2018年第2期15卷 357-363页

作者： nie xiu-qing YANG Lu-cun XIONG Feng LI Chang-bin LI FAN ZHOU Guo-ying Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology Chinese Academy of Science Xining 810008 China Qinghai Key Laboratory of Qing-Tibet Plateau Biological Resources Xining 81008 China University of Chinese Academy of Sciences Beijing 100049 China Institute of Qinghai Meteorological Science Research Xining 810001 China

Though aboveground biomass(AGB) has an important contribution to the global carbon cycle,the information about storage and climatic effects of AGB is scare in Three-River Source Region(TRSR)shrub ecosystems. This study investigated AGB storage and its climatic controls in the TRSR alpine shrub ecosystems using data collected from 23 sites on the Tibetan Plateau from 2011 to 2013. We estimated the AGB storage(both shrub layer biomass and grass layer biomass) in the alpine shrubs as 37.49 Tg, with an average density of 1447.31 g m^(-2). Biomass was primarily accumulated in the shrub layer, which accounted for 92% of AGB, while the grass layer accounted for only 8%. AGB significantly increased with the mean annual temperature(P < 0.05). The effects of the mean annual precipitation on AGB were not significant. These results suggest that temperature,rather than precipitation, has significantly effects on of aboveground vegetation growth in the TRSR alpine shrub ecosystems. The actual and potential increase in AGB density was different due to global warming varies among different regions of the TRSR. We conclude that long-term monitoring of dynamic changes is necessary to improve the accuracy estimations of potential AGB carbon sequestration across the TRSR alpine shrub ecosystems.

关键词： Alpine shrub ecosystem Abovegroundbiomass Temperature Precipitation Sanjiangyuan Three-River Source Region

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Remission of hepatotoxicity in chronic pulmonary aspergillosis patients after lowering trough concentration of voriconazole

引用

World Journal of Clinical Cases 2020年第20期8卷 4700-4707页

作者： Guo-Jie Teng Xiang-Rong Bai Lin Zhang Hong-Jun Liu xiu-Hong nie Department of Pulmonary and Critical Care Medicine Xuanwu Hospital Capital Medical UniversityBeijing 100053China Pharmacy Department Xuanwu Hospital Capital Medical UniversityBeijing 100053China Department of Evidence-based Medicine Xuanwu Hospital Capital Medical UniversityBeijingChinaBeijing 100053China

BACKGROUND Chronic pulmonary aspergillosis(CPA)is a rare syndrome that is often accompanied by gradual lung tissue *** is usually employed as the first-line agent for CPA ***,some patients can develop hepatotoxicity and often were forced to stop voriconazole *** To record the improving trend of liver function and the therapeutic effects in patients after lowering the trough concentration of *** This study retrospectively analyzed 12 adult CPA patients who developed hepatotoxicity during the voriconazole *** these patients,the oral dose was reduced to 3/4 or 1/2 of the standard dose(4 mg/kg,twice daily),and the lower limit of voriconazole trough concentration was maintained more than 0.5μg/m *** trend of remission of liver toxicity after drug reduction in 12 patients was *** the same period,25 patients who received standard doses served as the control *** from the two groups were collected and analyzed for different parameters such as demographic characteristics,underlying pulmonary disorders,laboratory tests,and therapeutic *** differences between the two groups were statistically *** Hepatotoxicity occurred in 12 patients within 28-65 d after oral voriconazole *** was mainly manifested by the significantly increased level of gamma-glutamyltransferase and a slight increase of alanine aminotransferase and aspartate *** oral dose of voriconazole was reduced to approximately 3 mg/kg in seven patients and approximately 2 mg/kg in five *** average trough concentrations for the 12 patients before and after voriconazole oral dose reduction were 3.17±1.47μg/m L(1.5-6.0μg/m L)and 1.70±0.78μg/m L(0.6-3.3μg/m L),respectively(P=0.02).After lowering the trough concentrations,the hepatotoxicity was alleviated in all the ***,gamma-glutamyltransferase levels declined *** 4 mo of treatment,7 of the 12 pat

关键词： Voriconazole Hepatotoxicity Chronic pulmonary aspergillosis CYP2C19 genotypes Reduction Trough concentration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：