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Oxidation behavior of 4774DD1 Ni-based single-crystal superalloy at 980℃ in air

China Foundry 2024年第2期21卷 116-124页

作者： Yu fang Ya-zhou Li Qiang Yang Qun-gong He xiu-fang Gong Qian Duan Hai-yang Song Fu Wang Qiong-yuan Zhang Hong Zeng State Key Laboratory of Long-Life High Temperature Materials Dongfang Turbine Co.Ltd.Deyang 618000SichuanChina State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China

The oxidation behavior of a novel Ni-based single-crystal 4774DD1 superalloy for industrial gas turbine applications was investigated by the isothermal oxidation at 980℃ and discontinuous oxidation weight gain *** phase constitution and morphology of surface oxides and the characteristics of the crosssection oxide film were analyzed by XRD,SEM and *** show that the oxidation kinetics of the 4774DD1 superalloy follows the cubic law,indicating its weak oxidation resistance at this *** the oxidation time increases,the composition of the oxide film evolves as following:One layer consisting of a bottom Al_(2)O_(3)sublayer and an upper(Al_(2)O_(3)+NiO)mixture sublayer after oxidized for 25 ***,two layers composed of an outermost small NiO discontinuous grain layer and an internal layer for 75 *** internal layer is consisted of the bottom Al_(2)O_(3)sublayer,an intermediate narrow CrTaO_(4)sublayer,and an upper(Al_(2)O_(3)+NiO)mixture *** two layers comprising an outermost relative continuous NiO layer with large grain size and an internal layer as the oxidation time increases to 125 *** internal layer is composed of the upper(Al_(2)O_(3)+NiO)mixture sublayer,an intermediate continuous(CrTaO_(4)+NiWO_(4))mixture sublayer,and a bottom Al_(2)O_(3)***,three layers consisting of an outermost(NiAl2O_(4)+NiCr2O_(4))mixture layer,an intermediate(CrTaO_(4)+NiWO_(4))mixture layer,and a bottom Al_(2)O_(3)layer for 200 h.

关键词： nickel-base single crystal superalloy oxidation kinetics oxide film microstructure mechanism

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DGK5-mediated phosphatidic acid homeostasis interplays with reactive oxygen species in plant immune signaling

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Journal of Integrative Plant Biology 2024年第7期66卷 1263-1265页

作者： Dian Wang Minhang Yuan Yamei Zhuang xiu-fang Xin Guang Qi Crop Research Institute Shandong Academy of Agricultural Sciences/National Engineering Research Center of Wheat and Maize/Shandong Technology Innovation Center of WheatJinan 252100China College of Agronomy Qingdao Agricultural UniversityQingdao 266109China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

Plants have evolved a complex innate immune system that deploys two interconnected receptor layers to detect the invasion of various *** surface-resident pattern recognition receptors(PRRs)perceive pathogen-or microbeassociated molecular patterns(PAMPs/MAMPs),initiating a basal defense response called pattern-triggered immunity(PTI)(Zhou and Zhang,2020).

关键词： pattern homeostasis immunity

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Cone-beam computed tomography noise reduction method based on U-Net with convolutional block attention module in proton therapy

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Nuclear Science and Techniques 2024年第7期35卷 89-100页

作者： Xing-Yue Ruan xiu-fang Li Meng-Ya Guo Mei Chen Ming Lv Rui Li Zhi-Ling Chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai201800China University of Chinese Academy of Sciences Beijing100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China Department of Radiation Oncology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai Key Laboratory of Proton therapy Shanghai201801China

Cone-beam computed tomography(CBCT) is mostly used for position verification during the treatment process. However,severe image artifacts in CBCT hinder its direct use in dose calculation and adaptive radiation therapy re-planning for proton therapy. In this study, an improved U-Net neural network named CBAM-U-Net was proposed for CBCT noise reduction in proton therapy, which is a CBCT denoised U-Net network with convolutional block attention modules. The datasets contained 20 groups of head and neck images. The CT images were registered to CBCT images as ground truth. The original CBCT denoised U-Net network, sCTU-Net, was trained for model performance comparison. The synthetic CT(SCT) images generated by CBAM-U-Net and the original sCTU-Net are called CBAM-SCT and U-Net-SCT images, respectively. The HU accuracies of the CT, CBCT, and SCT images were compared using four metrics: mean absolute error(MAE), root mean square error(RMSE), peak signal-to-noise ratio(PSNR), and structure similarity index measure(SSIM). The mean values of the MAE, RMSE, PSNR, and SSIM of CBAM-SCT images were 23.80 HU, 64.63 HU, 52.27 dB, and 0.9919, respectively,which were superior to those of the U-Net-SCT images. To evaluate dosimetric accuracy, the range accuracy was compared for a single-energy proton beam. The γ-index pass rates of a 4 cm × 4 cm scanned field and simple plan were calculated to compare the effects of the noise reduction capabilities of the original U-Net and CBAM-U-Net on the dose calculation results. CBAM-U-Net reduced noise more effectively than sCTU-Net, particularly in high-density tissues. We proposed a CBAM-U-Net model for CBCT noise reduction in proton therapy. Owing to the excellent noise reduction capabilities of CBAM-U-Net, the proposed model provided relatively explicit information regarding patient tissues. Moreover, it maybe be used in dose calculation and adaptive treatment planning in the future.

关键词： Proton therapy Cone-beam CT CBAM-U-Net γ-index

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Neurosyphilis complicated by anti-γ-aminobutyric acid-B receptor encephalitis: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1960-1966页

作者： Ya-xiu fang Xiao-Ming Zhou Dong Zheng Guang-Hui Liu Peng-Bo Gao Xiao-Zhen Huang Zhi-Cheng Chen Hui Zhang Lin Chen Ya-fang Hu Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Neurology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing *** cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been *** report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)*** SUMMARY A young man in his 30s who presented with acute epileptic status was admitted to a local *** was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for *** 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were *** was then transferred to our *** Mini-Mental State Examination(MMSE)crude test results showed only 2 *** magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral ***-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and *** treatment,his mental symptoms were *** impairment was significantly improved,with a MMSE of 8 *** anti-GABABR antibody titer decreased to 1:*** patient received methylprednisolone and penicillin after *** months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:*** This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.

关键词： Anti-γ-aminobutyric acid-B receptor GABABR Neurosyphilis Tissue-based assay Magnetic resonance imaging Mini-mental state examination Case report

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Bile acids inhibit ferroptosis sensitivity through activating farnesoid X receptor in gastric cancer cells

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World Journal of Gastroenterology 2024年第5期30卷 485-498页

作者： Chu-Xuan Liu Ying Gao xiu-fang Xu Xin Jin Yun Zhang Qian Xu Huan-Xin Ding Bing-Jun Li fang-Ke Du Lin-Chuan Li Ming-Wei Zhong Jian-Kang Zhu Guang-Yong Zhang Department of General Surgery Shandong Provincial Qianfoshan HospitalShandong UniversityJinan 250014Shandong ProvinceChina Department of General Surgery Linyi People's HospitalLinyi 276034Shandong ProvinceChina Department of Nursing Huantai TCM HospitalZibo 256400Shandong ProvinceChina Center for Translational medical Research The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina Department of General Surgery The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina

BACKGROUND Gastric cancer(GC)is associated with high mortality *** acids(BAs)reflux is a well-known risk factor for GC,but the specific mechanism remains *** GC development in both humans and animals,BAs serve as signaling molecules that induce metabolic *** confers additional cancer phenotypes,including ferroptosis *** is a novel mode of cell death characterized by lipid peroxidation that contributes universally to malignant ***,it is not fully defined if BAs can influence GC progression by modulating *** To reveal the mechanism of BAs regulation in ferroptosis of GC *** In this study,we treated GC cells with various stimuli and evaluated the effect of BAs on the sensitivity to *** used gain and loss of function assays to examine the impacts of farnesoid X receptor(FXR)and BTB and CNC homology 1(BACH1)overexpression and knockdown to obtain further insights into the molecular mechanism *** Our data suggested that BAs could reverse erastin-induced ferroptosis in GC *** effect correlated with increased glutathione(GSH)concentrations,a reduced GSH to oxidized GSH ratio,and higher GSH peroxidase 4(GPX4)expression ***,we confirmed that BAs exerted these effects by activating FXR,which markedly increased the expression of GSH synthetase and ***,BACH1 was detected as an essential intermediate molecule in the promotion of GSH synthesis by BAs and ***,our results suggested that FXR could significantly promote GC cell proliferation,which may be closely related to its anti-ferroptosis *** This study revealed for the first time that BAs could inhibit ferroptosis sensitivity through the FXR-BACH1-GSHGPX4 axis in GC *** work provided new insights into the mechanism associated with BA-mediated promotion of GC and may help identify potential therapeutic targets for GC patients with BAs reflux.

关键词： Gastric cancer Ferroptosis Bile acids Chenodeoxycholic acid Farnesoid X receptor Glutathione

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Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors

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World Journal of Diabetes 2024年第1期15卷 53-71页

作者： Min Wang Yang Ou Xiang-Lian Yuan xiu-fang Zhu Ben Niu Zhuang Kang Bing Zhang Anwar Ahmed Guo-Qiang Xing Heng Su School of Chemical Science and Technology Yunnan UniversityKunming 650091Yunnan ProvinceChina Department of Endocrinology The First People’s Hospital of Yunnan ProvinceKunming 650032Yunnan ProvinceChina Clinical Laboratory Nanchong Central Hospital&The Second Clinical Medical College of North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health SciencesBethesdaMD 20814United States The Affiliated Hospital and Second Clinical Medical College North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Research and Development Lotus *** LLCGaithersburgMD 20878United States

BACKGROUND The lack of specific predictors for type-2 diabetes mellitus(T2DM)severely impacts early intervention/prevention *** branched-chain amino acids(BCAAs:Isoleucine,leucine,valine)and aromatic amino acids(AAAs:Tyrosine,tryptophan,phenylalanine)show high sensitivity and specificity in predicting diabetes in animals and predict T2DM 10-19 years before T2DM onset in clinical ***,improvement is needed to support its clinical *** To evaluate the effects of body mass index(BMI)and sex on BCAAs/AAAs in new-onset T2DM individuals with varying body *** Ninety-seven new-onset T2DM patients(<12 mo)differing in BMI[normal weight(NW),n=33,BMI=22.23±1.60;overweight,n=42,BMI=25.9±1.07;obesity(OB),n=22,BMI=31.23±2.31]from the First People’s Hospital of Yunnan Province,Kunming,China,were ***-way and 2-way ANOVAs were conducted to determine the effects of BMI and sex on BCAAs/*** Fasting serum AAAs,BCAAs,glutamate,and alanine were greater and high-density lipoprotein(HDL)was lower(P<0.05,each)in OB-T2DM patients than in NW-T2DM patients,especially in male OB-T2DM ***,histidine,leucine,methionine,and lysine were greater in male patients than in female ***,histidine,alanine,glutamate,lysine,valine,methionine,leucine,isoleucine,tyrosine,phenylalanine,and tryptophan were significantly correlated with abdominal adiposity,body weight and BMI,whereas isoleucine,leucine and phenylalanine were negatively correlated with *** Heterogeneously elevated amino acids,especially BCAAs/AAAs,across new-onset T2DM patients in differing BMI categories revealed a potentially skewed prediction of T2DM *** higher BCAA/AAA levels in obese T2DM patients would support T2DM prediction in obese individuals,whereas the lower levels of BCAAs/AAAs in NW-T2DM individuals may underestimate T2DM risk in NW *** potentially skewed T2DM prediction should be considered when BCAAs/AAAs are to

关键词： Hyperaminoacidemia Branched-chain/aromatic amino acids New-onset type-2 diabetes Predictor Obesity Sex

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A modular approach to efficient thermally activated delayed fluorescence from metal-perturbed intraligand charge-transfer excited state of Au(I) complexes

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Science China Chemistry 2024年

作者： Jian-Gong Yang Xingyu Feng Guohua Xie Nengquan Li Jiayu Li xiu-fang Song Ming-De Li Jingling Zhang Xiaoyong Chang Kai Li Shenzhen Key Laboratory of New Information Display and Storage Materials Guangdong Provincial Key Laboratory of New Energy Materials Service Safety College of Materials Science and Engineering Shenzhen University Hubei Key Laboratory of Biomass Fibers and Eco-dyeing & Finishing Department of Chemistry and Chemical EngineeringWuhan Textile University The Institute of Flexible Electronics (Future Technologies) Xiamen University Key Laboratory for Preparation and Application of Ordered Structural Materials of Guangdong Province Department of ChemistryShantou University Department of Chemistry Southern University of Science and Technology

The efficient harvesting of triplet excitons is crucial to the realization of high-performance organic light-emitting diodes（OLEDs）.Herein,we show that coordination of donor-acceptor （D-A） type molecules to a metal atom in a monodentate fashion can lead to thermally activated delayed fluorescence （TADF） emissions with wide color tunability only through varying the noncoordinating acceptor moiety.A panel of TADF gold（I） complexes with emission maxima (λmax) of 545–645 nm from metal perturbed intraligand charge-transfer （MPICT） excited states have been *** effects of heavy atom-induced spin-orbit coupling （SOC）,steric-induced donor-acceptor twisting and suppressed intramolecular motions lead to high emission efficiencies of 65%?85% in doped films with delayed fluorescence lifetime of as short as 2.0μ*** absorption spectroscopic studies on selected complexes determined the kISCto be 6.5×10～*** calculations confirmed the participation of minor d orbital into the lowest excited state,which led to an SOC value of 5.19 cm-1between the lowest-lying singlet and triplet excited *** yellow to deep red solution-processed OLEDs based on the new gold（I） complexes incorporated with various D-A ligands demonstrated promising *** study validates a modular design for TADF metal complexes,which will broaden the choices of metal centers and allow for facile color tuning via simple ligand synthesis.

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结合空间和运动特征的行为识别算法

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计算机工程与设计 2024年第7期45卷 2157-2165页

作者：冀振前冯秀芳太原理工大学软件学院山西太原030024

针对视频行为识别方法中运动特征不足导致识别精度低的问题,提出一种结合空间和运动特征的行为识别算法。通过空间和运动两路卷积提取特征。空间卷积采用Res2Net作为主干网络并添加注意力模块;运动卷积细粒度地分为局部和全局特征,构造... 详细信息

针对视频行为识别方法中运动特征不足导致识别精度低的问题,提出一种结合空间和运动特征的行为识别算法。通过空间和运动两路卷积提取特征。空间卷积采用Res2Net作为主干网络并添加注意力模块;运动卷积细粒度地分为局部和全局特征,构造自适应通道序列重构模块提取局部特征,采用逐帧特征信息作差后聚合的方法提取全局特征。将运动和空间特征信息融合后,经过全连接层输出类别。该模型在UCF101和HMDB51数据集上准确率达到95.6%和70.7%,与传统算法相比,识别精度得到一定提升,验证了该算法的有效性。

关键词：行为识别卷积神经网络深度学习残差网络计算机视觉运动特征空间特征

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MEC-Net:基于运动捕捉和通道注意力的行为识别方法

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计算机工程与设计 2024年第6期45卷 1805-1811页

作者：郭志鑫冯秀芳太原理工大学软件学院山西晋中030600

针对视频行为识别过程中面临的特征信息利用不充分、计算量过大的问题,提出一种基于运动捕捉和通道注意力的行为识别模型。模型利用卷积和池化层提高关键特征的利用率,利用空间通道注意力模块在通道维度利用自适应学习参数聚合信息,降... 详细信息

针对视频行为识别过程中面临的特征信息利用不充分、计算量过大的问题,提出一种基于运动捕捉和通道注意力的行为识别模型。模型利用卷积和池化层提高关键特征的利用率,利用空间通道注意力模块在通道维度利用自适应学习参数聚合信息,降低背景冗余信息的影响,引入时空注意力机制融合特征信息获得分类结果。所提模型在公开数据集UCF101、Kinetics-400以及HMDB51上分别获得了94.5%、80.2%和61.9%的精确度,对比其它模型具有更加精准的识别结果以及更少的计算量,验证了模型的有效性。

关键词：行为识别视频混合模型注意力机制时空特征自适应通道

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酒庄废水冬灌对葡萄园土壤理化性质和细菌群落结构的影响

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土壤通报 2024年第4期55卷 1071-1079页

作者：常洁李秀芳郑兰香宁夏大学地理科学与规划学院银川750021 徐州工业职业技术学院江苏徐州221140 宁夏大学生态环境学院银川750021 宁夏回族自治区黄河水联网数字治水重点实验室银川750021

【目的】明确酒庄废水灌溉改善葡萄园土壤理化性质和细菌群落的效果。【方法】在贺兰山东麓的葡萄园开展酒庄废水冬灌试验,设置废水占比分别为0、25%、50%、75%和100%五种处理,每个处理单次灌水量10.8 m3。于11月冬灌,次年4月葡萄展藤... 详细信息

【目的】明确酒庄废水灌溉改善葡萄园土壤理化性质和细菌群落的效果。【方法】在贺兰山东麓的葡萄园开展酒庄废水冬灌试验,设置废水占比分别为0、25%、50%、75%和100%五种处理,每个处理单次灌水量10.8 m3。于11月冬灌,次年4月葡萄展藤后采样,测定0~20、20~40、40~60、60~80、80~100 cm土壤的理化性质,并通过高通量测序技术分析表层土壤细菌的群落组成。【结果】采用酒庄废水冬灌后0~100 cm各土层的有机碳含量增加,全氮、全磷和速效磷含量在0~60 cm土层有所增加,氨氮含量在表层呈增加趋势,且土壤钠吸附比(SAR)增加。废水冬灌能够提高土壤细菌的丰富度和多样性。在门水平上,废水冬灌后放线菌门(Actinobacteria)和酸杆菌门(Acidobacteria)的丰度明显降低,而变形菌门(Protebacteria)、厚壁菌门(Firmicutes)和绿弯菌门(Chloroflexi)的相对丰度却明显增加。在属水平上,废水冬灌后节杆菌属(Arthrobacter)的相对丰度逐渐降低,而假单胞菌属(Pseudomonas)和束毛球菌属(Trichococcus)的相对丰度明显增高。土壤全磷、全氮和有机碳是影响葡萄园土壤微生物群落组成的主要环境因子。【结论】在贺兰山东麓葡萄酒产区,合理控制酒庄废水冬灌能够提高水资源利用率,改善土壤肥力水平,提高土壤细菌群落多样性,但要关注土壤盐分离子积累风险。

关键词：酒庄废水冬灌理化性质细菌群落结构

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