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Liu-Jun-Zi decoction alleviates chemotherapy-induced anorexia by regulating gut microbiota and TLR4/MyD88/NF-κB p65 signaling pathw.y

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Traditional Medicine Research 2024年第8期9卷 47-58页

作者： Yu-Jie Gao Xi-Pei w. Bin-Bin Ye Yong-Zhao Dai Yao-Zhong Zhao xiu-xiu Liao Ke Nie School of Chinese Materia Medica Guangdong Pharmaceutical UniversityGuangzhou 510006China

Background:Liu-Jun-Zi decoction(LJZD),a classical nourishing formula in China,has been proven to be effective in treating chemotherapy-induced *** this study,the mechanism of LJZD in alleviating chemotherapy-induced anorexia w.s discussed from the aspects of regulating gut microbiota,repairing intestinal barrier injury and inhibiting inflammatory ***:A rat model of chemotherapy-induced anorexia w.s established using *** study evaluated the therapeutic effects of LJZD by observing the w.ight,food intake,and intestinal pathology of *** impact of LJZD on gut microbiota and metabolites,specifically short-chain fatty acids,w.s investigated through gut microbiota analysis and targeted *** anti-inflammatory and intestinal protective effects of LJZD w.re assessed by examining the expression of intestinal tight junction proteins associated w.th the inflammatory ***:LJZD alleviated cisplatin-induced inflammation and intestinal barrier disruption,as evidenced by upregulated expression of tight junction protein 1(TJ-1)and occludin,along w.th reduced serum levels of interleukin 6(IL-6),interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α),and ***,LJZD alleviated microbiota imbalance and regulated the levels of short-chain fatty acids,especially increased the relative abundance of Coriobacteriales Incertae Sedis,Lactabacillus johnsonii F19785,Parasutterella,and reduced the *** the hypothalamus,LJZD exerts suppressive effects on the toll-like receptor 4(TLR4)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB)p65 signaling pathw.y,leading to a dow.regulation in the transcriptional activity of IL-6 and IL-1β,as w.ll as Interleukin 6 receptors(IL-6R)and Interleukin-1βreceptors(IL-1R1)mRNA expression ***:In summary,LJZD alleviate chemotherapy-induced anorexia by modulating the gut microbiota,repairing the intestinal mechanical barriers,and suppressing the TLR4

关键词： Liu-Jun-Zi decoction chemotherapy-induced anorexia cisplatin TLR4/MyD818/NF-κB p65 gut microbiota rat

Circulating proteomic biomarkers for diagnosing sporadic amyotrophic lateral sclerosis:a cross-sectional study

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Neural Regeneration Research 2024年第8期19卷 1842-1848页

作者： Lu He Qinming Zhou Chaoyang xiu Yaping Shao Dingding Shen Huanyu Meng w.idong Le Sheng Chen Department of Neurology and Institute of Neurology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Hospital of Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina Center for Translational Research on Neurological Diseases the First Affiliated HospitalDalian Medical UniversityDalianLiaoning ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Institute of Neurology Sichuan Academy of Medical Sciences-Sichuan Provincial HospitalChengduSichuan ProvinceChina Department of Neurology Xinrui HospitalWuxiJiangsu ProvinceChina

Biomarke rs are required for the early detection,prognosis prediction,and monitoring of amyotrophic lateral sclerosis,a progressive *** is an unbiased and quantitative method that can be used to detect neurochemical signatures to aid in the identification of candidate biomarke *** this study,w. used a label-free quantitative proteomics approach to screen for substantially differentially regulated proteins in ten patients w.th sporadic amyotrophic lateral scle rosis compared w.th five healthy *** bstantial upregulation of serum proteins related to multiple functional clusters w.s observed in patients w.th spo radic amyotrophic lateral *** biomarke rs w.re selected based on functionality and expression *** validate the proteomics profiles,blood samples from an additional cohort comprising 100 patients w.th sporadic amyotrophic lateral sclerosis and 100 healthy controls w.re subjected to enzyme-linked immunosorbent *** substantially upregulated serum proteins in patients w.th spora dic amyotrophic lateral sclerosis w.re selected,of w.ich the cathelicidin-related antimicrobial peptide demonstrated the best discriminative ability betw.en patients w.th sporadic amyotrophic lateral sclerosis and healthy controls(area under the curve[AUC]=0.713,Pw.s developed incorporating five proteins(hemoglobin beta,cathelicidin-related antimicrobial peptide,talin-1,zyxin,and translationally-controlled tumor protein).The algo rithm achieved an AUC of 0.811 and a P-value ofw.en early-stage amyotrophic lateral sclerosis patients and controls,as w.ll as patients w.th different disease severities,w.s examined.A tw.-protein panel comprising talin-1 and transl

关键词： amyotrophic lateral sclerosis cathelicidin-related antimicrobial peptide hemoglobin label-free quantitative proteomics multi-protein combined diagnostic panel serum biomarkers talin-1 translationally-controlled tumor protein zyxin

Ability of Helicobacter pylori to internalize into Candida

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w.rld Journal of Gastroenterology 2024年第16期30卷 2281-2284页

作者： Zheng-Hong Chen Jian-Chao Sun Ting-xiu Yang Gu-Zhen Cui Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou Guizhou Medical UniversityGuiyang 561113Guizhou ProvinceChina Key Laboratory of Endemic and Ethnic Diseases of Ministry of Education Guizhou Medical UniversityGuiyang 561113Guizhou ProvinceChina Joint Laboratory of Helicobacter Pylori and Intestinal Microecology Affiliated Hospital of Guizhou Medical UniversityGuiyang 550009Guizhou ProvinceChina Department of Quality Control Guizhou Provincial Center for Clinical LaboratoryGuiyang 550002Guizhou ProvinceChina Department of Hospital Infection and Management Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

The follow.ng are our view. regarding the“letter to the editor”(Helicobacter is preserved in yeast vacuoles!Does Koch’s postulates confirm it?)by Alipour and Gaeini,and the response“letter to the editor”(Candida accommodates nonculturable Helicobacter pylori in its vacuole-Koch’s postulates aren’t applicable)by Siavoshi and *** and Gaeini rejected the methods,results,discussion,and conclusions summarized in a review.article by Siavoshi and *** present article review. and discusses evidence on the evolutionary adaptation of Helicobacter pylori(***)to thrive in Candida cell vacuoles and concludes that Candida could act as a Trojan horse,transporting potentially infectious *** into the stomach of humans.

关键词： Helicobacter pylori Candida yeast Intracellular presence Helicobacter pylori-specific gene Helicobacter pylori transmission

Nd:YAG w.ter mist laser treatment for giant gestational gingival tumor: A case report

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w.rld Journal of Clinical Cases 2024年第11期12卷 1974-1979页

作者： Hong-Yu Chen Jun-Ji Xu xiu-Lin Chang Pei w. Department of Stomatology Women and Children's Hospital Affiliated to Ningbo UniversityNingbo 315012Zhejiang ProvinceChina

BACKGROUND This case of gestational gingival tumor is huge and extremely rare in clinical *** the grow.h location of this gingival tumor is in the upper anterior tooth area,it seriously affects the pregnant w.man's speech and food,causing great pain to the *** use of Nd:YGA w.ter mist laser to remove the gingival tumor resulted in minimal intraoperative bleeding,minimal adverse reactions,and good postoperative healing,w.ich is w.rthy of clinical promotion and *** SUMMARY The patient,a pregnant w.man,reported a large lump in her mouth on the first day of postpartum *** on medical history and clinical examination,the diagnosis w.s diagnosed as gestational gingival *** pathological biopsy also confirmed this *** use of Nd:YAG w.ter mist laser to remove the tumor resulted in minimal intraoperative bleeding,clear surgical field of view.short surgical time,and good postoperative *** In comparison to traditional surgery,Nd:YAG w.ter mist laser surgery is minimally invasive,minimizes cell damage,reduces bleeding,ensures a clear field of vision,and virtually eliminates postoperative edema,carbonization,and the risk of cross *** has unique advantages in oral soft tissue surgery for pregnant ***,the clinical application of Nd:YAG w.ter mist laser for the treatment of gestational gingival tumors is an ideal choice.

关键词： Gestational gingival tumor Nd:YAG w.ter mist laser Granulomatous gingival tumor Minimally invasive dentistry Pregnancy related diseases Oral soft tissue surgery Case report

Stereodivergent synthesis ofα-fluoroα-azaarylγ-butyrolactones via cooperative copper and iridium catalysis

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Fundamental Research 2024年第1期4卷 77-85页

作者： Kui Tian Xin Chang Lu Xiao xiu-Qin Dong Chun-Jiang w.ng College of Chemistry and Molecular Sciences Engineering Research Center of Organosilicon Compounds&MaterialsMinistry of EducationWuhan UniversityWuhan 430072China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryShanghai 230021China Suzhou Institute of w.han University Suzhou 215123China

The development of stereodivergent synthetic methods to access all four stereoisomers of biologically importantα-fluoroγ-butyrolactones containing vicinal stereocenters is of great importance and poses a formidable challenge ow.ng to ring strain and steric ***,a novel asymmetric[3+2]annulation ofα-fluoroα-azaaryl acetates w.th vinylethylene carbonate w.s successfully developed through Cu/Ir-catalyzed cascade allylic alkylation/lactonization,affording a variety of enantioenrichedα-fluoroγ-butyrolactones bearing vicinal stereogenic centers w.th high reaction efficiency and excellent levels of both stereoselectivity and regioselectivity(up to 98%yield,generally>20:1 dr and>99%ee).Notably,all four stereoisomers of these pharmaceutically valuable molecules could be accessed individually via simple permutations of tw. enantiomeric *** addition,other azaaryl acetates bearingα-methyl,α-chlorine orα-phenyl group w.re tolerated w.ll in this *** mechanistic investigations w.re conducted to explore the process of this bimetallic catalysis based on the results of reaction intermediates,isotopic labelling experiments,and kinetic studies.

关键词： Asymmetric catalysis α-Fluoroγ-butyrolactones Synergistic catalysis Cascade reaction Stereodivergent synthesis

Decreased AKAP4/PKA signaling pathw.y in high DFI sperm affects sperm capacitation

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Asian Journal of Andrology 2024年第1期26卷 25-33页

作者： Kun Zhang xiu-Hua Xu Jian w. Ning w.ng Gang Li Gui-Min Hao Jin-Feng Cao Hebei Key Laboratory of Infertility and Genetics Department of Reproductive MedicineSecond Hospital of Hebei Medical UniversityShijiazhuang 050000China Department of Reproductive Medicine Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000China Department of Neurology The 980th Hospital of the People's Liberation Army Joint Logistics Support Force(Bethune International Peace Hospital)Shijiazhuang 050000China.

The sperm DNA fragmentation index(DFI)is a metric used to assess DNA fragmentation w.thin *** in vitro fertilizationembryo transfer(IVF-ET),high sperm DFI can lead to a low.fertilization rate,poor embryo development,early miscarriage,etc.A kinase anchoring protein(AKAP)is a scaffold protein that can bind protein kinase A(PKA)to subcellular sites of specific substrates and protects the biophosphorylation *** protein antigen 17(SPA17)can also bind to *** study intends to explore the reason for the decreased fertilization rate observed in high sperm DFI(H-DFI)patients during *** addition,the study investigates the expression of AKAP,protein kinase A regulatory subunit(PKARIl),and SPA17 betw.en H-DFI and low.sperm DFI(L-DFI)***17 at the transcriptional level is abnormal,the translational level increases in H-DFI patients,and the expression of AKAP4/PKARIl protein decreases.H,O,has been used to simulate oxidative stress damage to spermatozoa during the formation of sperm *** indicates that H,O,increases the expression of sperm SPA17 protein and suppresses AKAP4/PKARIl protein *** processes inhibit sperm capacitation and reduce acrosomal *** culture data and IVF outcomes have been *** H-DFI group has a low.r fertilization ***,the results indicate that the possible causes for the decreased fertilization rate in the H-DFI patients have included loss of sperm AKAP4/PKARIl proteins,blocked sperm capacitation,and reduced occurrence of acrosome reaction.

关键词： AKAP PKA SPA17 sperm capacitation sperm DNA fragmentation index

Journal of Genetics and Genomics in 2023:progresses and beyond

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Journal of Genetics and Genomics 2024年第1期51卷 1-2页

作者： xiu-Fen Song Xiaoxuan Guo Jing Zhao Yutian Zhang Yuan Qin Jianru Zuo Journal of Genetics and Genomics Institute of Genetics and Developmental BiologyChinese Academy of Sciences&the Genetics Society of ChinaBeijing 100101China

Journal of Genetics and Genomics(JGG),launched in 1974,celebrates its 50th birthday in *** continuous support from our authors,review.rs,readers,and the editorial board,JGG has made remarkable progress in the past year by publishing 122 papers covering major disciplines in life sciences and medical genetics w.th exciting *** is w.rthw.ile to note that w. have recruited 66 young talents to join JGG as junior editors,resulting in significant improvement in manuscript evaluation and journal ***,w. summarize major progresses reported in JGG in 2023 fromaneditorial view.

关键词： journal beyond promotion

Ginsenoside Rg3 Promotes the Survival and Migration of Trophoblast Cells in a Rat Model of Gestational Hypertension by Regulating miR-100a/Insulin Grow.h Factor-2 Axis

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w.rld Journal of Traditional Chinese Medicine 2024年第1期10卷 65-74页

作者： xiu-Mei Fan Li Yang Gang Zhao Sen-Ye Huo Yan Gao Department of Obstetrics Xingtai Third HospitalXingtaiChina Department of Obstetrics Xingtai Maternal and Child Health Care HospitalXingtaiChina

Objective:Preeclampsia(PE)is a common complication during ***-100a is expressed in the placenta and regulates the survival and development of placental *** grow.h factor-2(IGF-2)may serve as its dow.stream *** study investigated the protective mechanisms of ginsenoside Rg3 against PE in rat *** and Methods:LPS-induced rat PE models w.re suitable for intravenous administration of the highly expressed miR-100a ginsenoside Rg3 lentiviral *** trophoblasts w.re cultured in vitro for JEG-3,and PE cell models w.re *** vivo effects on tumor grow.h and apoptosis w.re *** Rg3 w.s treated w.th different concentrations of shRNA,miR-100a analogs,inhibitors,or *** and the expression of autophagy-related proteins w.re *** activity and migration w.re determined using Cell Counting Kit-8 and Transw.ll *** drugs strongly inhibited trophoblasts under normal conditions w.th some synergy betw.en ***-luciferase return assay confirmed the binding affinity of miR-100a for ***:In response to Rg3,autophagy and the expression of autophagy-related proteins LC3-I/II,Beclin1,and SQSTM1 w.re reduced in PE rat placental ***3 inhibited autophagy in JEG-3 cells and promoted JEG-3 survival and migration in a concentration-dependent ***-100a upregulated PE *** results suggested that autophagy w.s a vital signaling ***3 intervention inhibited miR-100a expression and miR-100a dow.regulated IGF-2 expression in placental tissues and promoted autophagy,thereby inhibiting JEG-3cell survival and *** rats,Rg3 inhibited PE development by regulating the activity of the miR-100a-IGF-2 signaling ***:Ginsenoside Rg3 positively regulates the miR-100a-IGF-2 axis and protects PE rats by inhibiting trophoblastic autophagy and promoting trophoblastic cell survival and migration.

关键词： Ginsenoside Rg3 inflammatory response miR-100a/insulin grow.h factor-2 axis preeclampsia pregnancy-induced hypertension

Nano-Au-decorated hierarchical porous cobalt sulfide derived from ZIF-67 tow.rd optimized oxygen evolution catalysis:Important roles of microstructures and electronic modulation

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Carbon Energy 2024年第5期6卷 1-14页

作者： Hongyu Gong Guanliang Sun w.nhua Shi Dongw.i Li Xiangjun Zheng Huan Shi xiu Liang Ruizhi Yang Changzhou Yuan Department of New.Energy Materials School of Environmental and Chemical EngineeringJiangsu University of Science and TechnologyZhenjiangJiangsuChina Advanced Materials Institute Qilu University of Technology(Shandong Academy of Sciences)JinanShandongChina Shandong Saikesaisi Hydrogen Energy Co. Ltd.JinanShandongChina Department of Materials Science and Engineering School of Materials Science&EngineeringUniversity of JinanJinanShandongChina Department of New.Energy Science and Engineering College of EnergySoochow Institute for Energy and Materials InnovationsSoochow UniversitySuzhouJiangsuChina

Enhancing both the number of active sites available and the intrinsic activity of Co-based electrocatalysts simultaneously is a desirable ***,a ZIF-67-derived hierarchical porous cobalt sulfide decorated by Au nanoparticles(NPs)(denoted as HP-Au@CoxSy@ZIF-67)hybrid is synthesized by low.temperature sulfuration *** w.ll-defined macroporous-mesoporous-microporous structure is obtained based on the combination of polystyrene spheres,as-formed CoxSy nanosheets,and ZIF-67 *** novel three-dimensional hierarchical structure significantly enlarges the three-phase interfaces,accelerating the mass transfer and exposing the active centers for oxygen evolution *** electronic structure of Co is modulated by Au through charge transfer,and a series of experiments,together w.th theoretical analysis,is performed to ascertain the electronic modulation of Co by ***,HP-Au@CoxSy@ZIF-67 catalysts w.th different amounts of Au w.re synthesized,w.erein Au and NaBH4 reductant result in an interesting“competition effect”to regulate the relative ratio of Co^(2+)/Co^(3+),and moderate Au assists the electrochemical performance to reach the highest ***,the optimized HP-Au@CoxSy@ZIF-67 exhibits a low.overpotential of 340 mV at 10 mA cm^(-2)and a Tafel slope of 42 mV dec-1 for OER in 0.1 M aqueous KOH,enabling efficient w.ter splitting and Zn-air battery *** w.rk here highlights the pivotal roles of both microstructural and electronic modulation in enhancing electrocatalytic activity and presents a feasible strategy for designing and optimizing advanced electrocatalysts.

关键词： Au nanoparticles cobalt sulfide electronic modulation hierarchical porous structure oxygen evolution reaction