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Development and validation of a new.prognostic model for patients w.th acute-on-chronic liver failure in intensive care unit

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w.rld Journal of Gastroenterology 2024年第20期30卷 2657-2676页

作者： Zong-Yi Zhu xiu-Hong Huang Hui-Qing Jiang Li Liu Department of Gastroenterology The Second Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina Department of Gastroenterology Weixian People's HospitalXingtai 054700Hebei ProvinceChina

BACKGROUND Cirrhotic patients w.th acute-on-chronic liver failure(ACLF)in the intensive care unit(ICU)have a poor but variable *** prognosis evaluation can guide the rational management of patients w.th ***,existing prognostic scores for ACLF in the ICU environment lack sufficient *** To develop a new.prognostic model for patients w.th ACLF in *** Data from 938 ACLF patients in the Medical Information Mart for Intensive Care(MIMIC)database w.re used to develop a new.prognostic model(MIMIC ACLF)for ***,calibration and clinical utility of MIMIC ACLF w.re assessed by area under receiver operating characteristic curve(AUROC),calibration curve and decision curve analysis(DCA),*** ACLF w.s then externally validated in a multiple-center cohort,the Electronic Intensive Care Collaborative Research Database and a single-center cohort from the Second Hospital of Hebei Medical University in *** The MIMIC ACLF score w.s determined using nine variables:ln(age)×2.2+ln(w.ite blood cell count)×0.22-ln(mean arterial pressure)×2.7+respiratory failure×0.6+renal failure×0.51+cerebral failure×0.31+ln(total bilirubin)×0.44+ln(internationalized normal ratio)×0.59+ln(serum potassium)×*** MIMIC cohort,the AUROC(0.81/0.79)for MIMIC ACLF for 28/90-day ACLF mortality w.re significantly greater than those of Chronic Liver Failure Consortium ACLF(0.76/0.74),Model for End-stage Liver Disease(MELD;0.73/0.71)and MELD-Na(0.72/0.70)(all Pw.en actual and predicted 28/90-day survival rates of patients according to MIMIC ACLF score w.s excellent and superior to that of existing *** net benefit of MIMIC ACLF w.s greater than that achieved using existing scores w.thin the 50%threshold *** superior predictive accuracy and clinical utility of MIMIC ACLF w.re validated in the external *** w. developed and validated a new.prognostic model w.th satisfactory accuracy

关键词： Acute-on-chronic liver failure Cirrhosis Risk stratification Prognosis Model Scores

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QBIoT:A Quantum Blockchain Framew.rk for IoT w.th an Improved Proof-of-Authority Consensus Algorithm and a Public-Key Quantum Signature

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Computers, Materials & Continua 2024年第7期80卷 1727-1751页

作者： Ang Liu Qing Zhang Shengw.i Xu Huamin Feng xiu-bo Chen w.n Liu Netw.rk and Information Management Division Beijing Electronic Science and Technology InstituteBeijing100070China Department of Cyberspace Security Beijing Electronic Science and Technology InstituteBeijing100070China Information Security Institute Beijing Electronic Science and Technology InstituteBeijing100070China General Office Beijing Electronic Science and Technology InstituteBeijing100070China Information Security Center State Key Laboratory of Networking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China

The Internet of Things(IoT)is a netw.rk system that connects physical devices through the Internet,allow.ng them to ***,IoT has become an integral part of our lives,offering convenience and smart ***,the grow.ng number of IoT devices has brought about a corresponding increase in cybersecurity threats,such as device vulnerabilities,data privacy concerns,and netw.rk *** blockchain technology w.th IoT has proven to be a promising approach to enhance IoT ***,the emergence of quantum computing poses a significant challenge to the security of traditional classical cryptography used in blockchain,potentially exposing it to quantum *** support the grow.h of the IoT industry,mitigate quantum threats,and safeguard IoT data,this study proposes a robust blockchain solution for IoT that incorporates both classical and post-quantum security ***,w. present the Quantum-Enhanced Blockchain Architecture for IoT(QBIoT)to ensure secure data sharing and integrity ***,w. propose an improved Proof of Authority consensus algorithm called“Proof of Authority w.th Random Election”(PoARE),implemented w.thin QBIoT for leader selection and new.block ***,w. develop a publickey quantum signature protocol for transaction verification in the ***,a comprehensive security analysis of QBIoT demonstrates its resilience against cyber threats from both classical and quantum *** summary,this research introduces an innovative quantum-enhanced blockchain solution to address quantum security concernsw.thin the realmof *** proposedQBIoT framew.rk contributes to the ongoing development of quantum blockchain technology and offers valuable insights for future research on IoT security.

关键词： IoT quantum blockchain public-key quantum signature quantum hash function

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Survival prognostic analysis of laparoscopic D2 radical resection for locally advanced gastric cancer: A multicenter cohort study

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w.rld Journal of Gastrointestinal Surgery 2024年第8期16卷 2451-2460页

作者： xiu-Ming Sun Kui Liu w.n w. Chao Meng Department of Pain Management Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Hepatobiliary Surgery Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND w.th the development of minimally invasive surgical techniques,the use of laparoscopic D2 radical surgery for the treatment of locally advanced gastric cancer(GC)has gradually ***,the effect of this procedure on survival and prognosis remains *** study evaluated the survival and prognosis of patients receiving laparoscopic D2 radical resection for the treatment of locally advanced GC to provide more reliable clinical evidence,guide clinical decision-making,optimize treatment strategies,and improve the survival rate and quality of life of *** A retrospective cohort study w.s *** data from 652 patients w.th locally advanced GC in our hospitals from December 2013 to December 2023 w.re *** w.re 442 males and 210 *** mean age w.s 57±12 *** patients underw.nt a laparoscopic D2 radical operation for distal *** patients w.re follow.d up in the outpatient department and by telephone to determine their tumor recurrence,metastasis,and *** follow.up period ended in December *** distributed data are expressed as the mean±SD,and normally distributed data are expressed as M(Q1,Q3)or M(range).Statistical data are expressed as absolute numbers or percentages;theχ2 test w.s used for comparisons betw.en groups,and the Mann-w.itney U nonparametric test w.s used for comparisons of rank *** life table method w.s used to calculate the survival rate,the Kaplan-Meier method w.s used to construct survival curves,the log rank test w.s used for survival analysis,and the Cox risk regression model w.s used for univariate and multifactor *** The median overall survival(OS)time for the 652 patients w.s 81 months,w.th a 10-year OS rate of 46.1%.Patients w.th TNM stages II and III had 10-year OS rates of 59.6%and 37.5%,respectively,w.ich w.re significantly different(P<0.05).Univariate analysis indicated that factors such as age,maximum tumor diameter,tumor

关键词： Gastric neoplasms Chinese Laparoscopic Gastrointestinal Surgery Study Group Laparoscopic surgery Locally advanced gastric cancer D2 lymph node dissection

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In situ meso-tetra(4-carboxyphenyl)porphyrin ligand substitution in Hf-MOF for enhanced catalytic activity and stability in photoredox reactions

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Rare Metals 2024年第6期43卷 2682-2694页

作者： Jie Hu Hong-Xin Lao xiu-w. Xu w.i-Kang w.ng Le-Le w.ng Qin-Qin Liu School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013China College of Chemistry and Materials Engineering Research Center of Carbon NeutralityAnhui Normal UniversityWuhu 241002China Fujian Provincial Key Laboratory of Ecology-Toxicological Effects and Control for Emerging Contaminants Putian UniversityPutian 351100China

Though there are numerous intrinsic merits of metal-organic framew.rks(MOFs),low.charge separation efficiency has imposed heavy restrictions on their photocatalytic ***,in situ porphyrin ligand substitution,as a strategy for improving the charge separation efficiency and increasing the amounts of active sites,has been designed and realized in a Hf-biphenyl dicarboxylic acid(BPDC)***,a size and geometry matched meso-tetra(4-carboxyphenyl)porphyrin(TCPP)ligand w.s selected and doped into Hf-BPDC MOF by forming coordinating bonds w.th Hf centers,forming dualligand Hf-BPDC-TCPP *** resultant Hf-BPDC-TCPP MOF show.d significantly improved activity and chemical stability in the photocatalytic H_(2)generation(261μmol·g^(-1)·h^(-1))and tetracycline(TC)degradation reactions(95.8%),w.ich w.s 48 and 1.47 folds higher than that of the Hf-BPDC *** and electrochemical studies revealed that the introduction of porphyrin ligand could generate a stronger internal electric field for boosting the charge separation and transfer,increase the specific surface area for providing more active sites,and narrow.the band gap to enhance the visible light *** in situ ligand substitution method provides a promising approach to build a tunable platform for constructing high-performance MOF photocatalysts.

关键词： Ligand substitution Metal organic framew.rks Meso-tetra(4-carboxyphenyl)porphyrin Hydrogen evolution reaction Tetracycline degradation

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DGK5-mediated phosphatidic acid homeostasis interplays w.th reactive oxygen species in plant immune signaling

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Journal of Integrative Plant Biology 2024年第7期66卷 1263-1265页

作者： Dian w.ng Minhang Yuan Yamei Zhuang xiu-Fang Xin Guang Qi Crop Research Institute Shandong Academy of Agricultural Sciences/National Engineering Research Center of Wheat and Maize/Shandong Technology Innovation Center of WheatJinan 252100China College of Agronomy Qingdao Agricultural UniversityQingdao 266109China National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesInstitute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China

Plants have evolved a complex innate immune system that deploys tw. interconnected receptor layers to detect the invasion of various *** surface-resident pattern recognition receptors(PRRs)perceive pathogen-or microbeassociated molecular patterns(PAMPs/MAMPs),initiating a basal defense response called pattern-triggered immunity(PTI)(Zhou and Zhang,2020).

关键词： pattern homeostasis immunity

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Cone-beam computed tomography noise reduction method based on U-Net w.th convolutional block attention module in proton therapy

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Nuclear Science and Techniques 2024年第7期35卷 89-100页

作者： Xing-Yue Ruan xiu-Fang Li Meng-Ya Guo Mei Chen Ming Lv Rui Li Zhi-Ling Chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai201800China University of Chinese Academy of Sciences Beijing100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China Department of Radiation Oncology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai Key Laboratory of Proton therapy Shanghai201801China

Cone-beam computed tomography(CBCT) is mostly used for position verification during the treatment process. How.ver,severe image artifacts in CBCT hinder its direct use in dose calculation and adaptive radiation therapy re-planning for proton therapy. In this study, an improved U-Net neural netw.rk named CBAM-U-Net w.s proposed for CBCT noise reduction in proton therapy, w.ich is a CBCT denoised U-Net netw.rk w.th convolutional block attention modules. The datasets contained 20 groups of head and neck images. The CT images w.re registered to CBCT images as ground truth. The original CBCT denoised U-Net netw.rk, sCTU-Net, w.s trained for model performance comparison. The synthetic CT(SCT) images generated by CBAM-U-Net and the original sCTU-Net are called CBAM-SCT and U-Net-SCT images, respectively. The HU accuracies of the CT, CBCT, and SCT images w.re compared using four metrics: mean absolute error(MAE), root mean square error(RMSE), peak signal-to-noise ratio(PSNR), and structure similarity index measure(SSIM). The mean values of the MAE, RMSE, PSNR, and SSIM of CBAM-SCT images w.re 23.80 HU, 64.63 HU, 52.27 dB, and 0.9919, respectively,w.ich w.re superior to those of the U-Net-SCT images. To evaluate dosimetric accuracy, the range accuracy w.s compared for a single-energy proton beam. The γ-index pass rates of a 4 cm × 4 cm scanned field and simple plan w.re calculated to compare the effects of the noise reduction capabilities of the original U-Net and CBAM-U-Net on the dose calculation results. CBAM-U-Net reduced noise more effectively than sCTU-Net, particularly in high-density tissues. w. proposed a CBAM-U-Net model for CBCT noise reduction in proton therapy. Ow.ng to the excellent noise reduction capabilities of CBAM-U-Net, the proposed model provided relatively explicit information regarding patient tissues. Moreover, it maybe be used in dose calculation and adaptive treatment planning in the future.

关键词： Proton therapy Cone-beam CT CBAM-U-Net γ-index

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Tunable VO_(2) cavity enables multispectral manipulation from visible to microw.ve frequencies

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Light(Science & Applications) 2024年第3期13卷 510-518页

作者： Hang w.i Jinxin Gu Tao Zhao Zhiyuan Yan He-xiu Xu Shuliang Dou Cheng-w.i Qiu Yao Li Center for Composite Materials and Structure Harbin Institute of TechnologyHarbin 150001China National University of Singapore Department of Electrical&Computer EngineeringSingapore 117583Singapore School of Chemical Engineering and Technology Harbin Institute of TechnologyHarbin 150001China Suzhou Laboratory Suzhou 215123China

Optical materials capable of dynamically manipulating electromagnetic w.ves are an emerging field in memories,optical modulators,and thermal ***,their multispectral design preliminarily attracts much attention,aiming to enhance their efficiency and integration of ***,the multispectral manipulation based on these materials is challenging due to their ubiquitous w.velength dependence restricting their capacity to narrow.*** this article,w. cascade multiple tunable optical cavities w.th selective-transparent layers,enabling a universal approach to overcoming w.velength dependence and establishing a multispectral platform w.th highly integrated *** on it,w. demonstrate the multispectral(ranging from 400 nm to 3 cm),fast response speed(0.9 s),and reversible manipulation based on a typical phase change material,vanadium *** platform involves tandem VO_(2)-based Fabry–Pérot(F-P)cavities enabling the customization of optical responses at target bands *** can achieve broadband color-changing capacity in the visible region(a shift of~60 nm in resonant w.velength)and is capable of freely sw.tching betw.en three typical optical models(transmittance,reflectance,and absorptance)in the infrared to microw.ve regions w.th drastic amplitude tunability exceeding *** w.rk represents a state-of-art advance in multispectral optics and material science,providing a critical approach for expanding the multispectral manipulation ability of optical systems.

关键词： spectral microw.ve visible

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Dynamic Analysis of A Deepw.ter Drilling Riser w.th A New.Hang-off System

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China Ocean Engineering 2024年第1期38卷 29-41页

作者： LI Yan-w.i LIU xiu-quan w.NG Jin-long CHEN Guo-ming CHANG Yuan-jiang SHENG Lei-xiang Centre for Offshore Engineering and Safety Technology China University of PetroleumQingdao 266580China National Engineering Laboratory of Offshore Geophysical and Exploration Equipment China University of PetroleumQingdao 266580China China CNOOC Research Institute Co. Ltd.Beijing 100028China

The safety of risers in hang-off states is a vital challenge in offshore oil and gas engineering.A new.hang-off system installed on top of risers is proposed for improving the security of *** approach leads to a challenging problem:coupling the dynamics of risers w.th a new.hang-off system combined w.th multiple structures and complex *** accurately analyze the dynamic responses of the coupled system,a coupled dynamic model is established based on the Euler-Bernoulli beam-column theory and penalty function method.A comprehensive analysis method is proposed for coupled dynamic analysis by combining the finite element method and the New.arkβ*** analysis program is also developed in MATLAB for dynamic *** simulation results show.that the dynamic performances of the risers at the top part are significantly improved by the new.hang-off system,especially the novel design,w.ich includes the centralizer and articulation *** bending moment and lateral deformation of the risers at the top part decrease,w.ile the hang-off joint experiences a great bending moment at the bottom of the lateral restraint area w.ich requires particular attention in design and *** platform navigation speed range under the safety limits of risers expands w.th the new.hang-off system in use.

关键词： deepw.ter drilling riser new.hang-off system dynamic analysis finite element method penalty function method

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A homopolymolybdate-supported plate-like 2D cobalt netw.rk constructed from a new.pyrazole-amide-pyridyl ligand: highly electrochemical activity in both capacitive performance and the detection of Cr(Ⅵ)

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Tungsten 2024年第2期6卷 422-427页

作者： xiu-Li w.ng Yong-Zhen Chen Zhi-Han Chang Yu-Chun Lin Jing-Yi Ma College of Chemistry and Materials Engineering Bohai UniversityJinzhou 121013China Professional Technology Innovation Center of Liaoning Province for Conversion Materials of Solar Cell Jinzhou 121013China

By employing a new.semi-rigid pyrazole-amide-derived bis(pyridyl)ligand[N,N'-bis(4-picolylamine)-1-hydropyrazole(4-dpap)],a new.homopolymolybdate-based tw.-dimensional(2D)plate-like complex[Co(4-dpap)(H_(2)O)(β-Mo_(8)O_(2)6)1/2](1)has been prepared under solvothermal condition and structurally ***β-Mo_(8)anions are fi xed betw.en the 2D metal–organic netw.rks[Co(4-dpap)(H_(2)O)]n 2n+via hydrogen-bonding *** 1 possesses satisfactory specifi c capacitance of 1512.4 F·g^(−1)(current density:1 A·g^(−1))and good cycling stability(90.8%after 1000 cycles).Moreover,1 represents a promising amperometric sensor for measurement of Cr(Ⅵ)w.th low.detection limit(0.042μmol·L^(−1))and high *** insertion ofβ-Mo_(8)anions betw.en the unique 2D metal−organic netw.rks improves the active area of polyoxometalates,w.ich further promotes electrochemical performance.

关键词： Homopolymolybdate Metal–organic netw.rk Pyrazole-amide-derived bis(pyridyl)ligand Supercapacitor Electrochemical sensor

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Flexible mille-feuille structure electromagnetic interference shielding film w.th excellent thermal conductivity and Joule heating

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Nano Research 2024年第5期17卷 4544-4554页

作者： Dingw.n Yin Huijuan xiu Simin w.ng Yanfei Pan Na Li Rui Cheng Shaoyan Huang Sha Fan Jinbao Li College of Bioresources Chemical&Materials Engineering Shaanxi University of Science&TechnologyXi'an 710021China National Demonstration Center for Experimental Light Chemistry Engineering Education Shaanxi Provincial Key Laboratory of Papermaking Technology and Specialty Paper DevelopmentXi'an 710021China College of Material Science and Art Design Inner Mongolia Agricultural UniversityHohhot 010018China

The intelligent electronic devices have urgent demands for electromagnetic interference(EMI)shielding films w.th excellent heat dissipation ***,it is challenging to obtain excellent EMI shielding and thermal conductivity performances ***,inspired by mille-feuille structure,the multifunctional EMI shielding films developed by a layer-by-layer self-assembly and hot-pressing *** ingenious introduction of silver nanoparticles(AgNPs)w.th large specific surface area and highly conductive into the netw.rk formed by TEMPO-oxidized cellulose nanofibrils(TOCNFs)w.th large aspect ratio to form the TOCNFs/*** the graphene nanoplates(GNPs)w.th high conductivity loss distributed alternately w.th TOCNFs/AgNPs to construct mille-feuille structure,w.ich had highly efficient conductive netw.rk,complete thermally conduction pathw.y and rich heterogeneous ***,the designed films presented high electrical conductivity of 8520 S/cm,superb EMI effectiveness(SE)of 98.05 dB,and excellent thermal conductivity of 18.82 w.(m·K).Furthermore,the films possessed outstanding Joule heating performances w.th low.voltages,including high heating temperature(100℃),fast response time(w.th fascinating thermal conductivity and Joule heating performances have substantial application in flexible electronics,electromagnetic w.ves shielding and thermal management.

关键词： TEMPO-oxidized cellulose nanofibrils/silver nanoparticles(TOCNFs/AgNPs) mille-feuille structure electromagnetic interference shielding thermal conductivity Joule heating

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