检索结果-南通市图书馆

Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

引用

World journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De león Yesica A lópez-Mora Valeria García-zárate Ana Varela-Constantino Sergio U Villegas-De leon xitl.l. j gonz.l.z.l.al.raúl.del.toro-mijares Anna C Rodríguez-zúñiga juan F Barrios-Ruiz Victor Mingura-ledezma Perla R Colunga-Pedraza Olga G Cantú-Rodríguez César H Gutiérrez-Aguirre luz Tarín-Arzaga Elías E gonzález-lópez David Gómez-almaguer Hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico Hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico Hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BACKGROUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic hematopoietic stem cell transplantation(alloHSCT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective cohort study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University Hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NRM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and Cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： Hematopoietic cell transplant Social determinants of health Geography Haploidentical Out-of-pocket Financial toxicity Survival Health services and outcomes Hematopoietic malignancy Aplastic anemia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

AMP-activated kinase in human spermatozoa： identification, intracellular localization, and key function in the reRulation of sperm motility

引用

Asian journal of Andrology 2017年第6期19卷 707-714页

作者： Violeta Calle-Guisado Ana Hurtado de llera David Martin-Hidalgo jose mijares Maria C Gil Ignacio S alvarez Maria j Bragado luis j Garcia-Marin Research Group of Intracellular Signalling and Technology of Reproduction (SINTREP) School of Veterinary Medicine University of Extremadura Caceres Spain Assisted Reproduction Unit at the-Minimally Invasive surgery Center jesos Uson (CCMIjU) Caceres Spain Norba Clinic Caceres Spain Research Group of Reproduction and Embryo Development (REDES) University of Extremadura Badajoz Spain Extremadura Institute of Assisted Reproduction (IEra) Badajoz Spain.

AMP-activated kinase （AMPK）, a protein that regulates energy balance and metabolism, has recently been identified in boar spermatozoa where regulates key functional sperm processes essential for fertilization. This work＇s aims are AMPK identification, intracellular localization, and their role in human spermatozoa function. Semen was obtained from healthy human donors. Sperm AMPK and phospho-Thr172-AMPK were analyzed by Western blotting and indirect immunofluorescence. High- and low-quality sperm populations were separated by a 40%-80% density gradient. Human spermatozoa motility was evaluated by an Integrated Semen Analysis System （ISAS） in the presence or absence of the AMPK inhibitor compound C （CC）. AMPK is localized along the human spermatozoa, at the entire acrosome, midpiece and tail with variable intensity, whereas its active form, phospho-Thr172-AMPK, shows a prominent staining at the acrosome and sperm tail with a weaker staining in the midpiece and the postacrosomal region. Interestingly, spermatozoa bearing an excess residual cytoplasm show strong AMPK staining in this subcellular compartment. Both AMPK and phospho-Thr172-AMPK human spermatozoa contents exhibit important individual variations. Moreover, active AMPK is predominant in the high motility sperm population, where shows a stronger intensity compared with the low motility sperm population. Inhibition of AMPK activity in human spermatozoa by CC treatment leads to a significant reduction in any sperm motility parameter analyzed： percent of motile sperm, sperm velocities, progressivity, and other motility coefficients. This work identifies and points out AMPK as a new molecular mechanism involved in human spermatozoa motility. Further AMPK implications in the clinical efficiency of assisted reproduction and in other reproductive areas need to be studied.

关键词： AMP-activated kinase human spermatozoa immunolocalization sperm motility sperm quality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ensuring Quality of random Numbers from TRNG: Design and Evaluation of Post-Processing Using Genetic algorithm

引用

journal of Computer and Communications 2016年第4期4卷 73-92页

作者： jose j. mijares Chan Parimala Thulasiraman Gabriel Thomas Ruppa Thulasiram Electrical and Computer Engineering Department-Faculty of Engineering University of Manitoba Winnipeg Canada Computer Science Department Faculty of Science University of Manitoba Winnipeg Canada

random numbers generated by pseudo-random and true random number generators (TRNG) are used in a wide variety of important applications. A TRNG relies on a non-deterministic source to sample random numbers. In this paper, we improve the post-processing stage of TRNGs using a heuristic evolutionary algorithm. Our post-processing algorithm decomposes the problem of improving the quality of random numbers into two phases: (i) Exact Histogram Equalization: it modifies the random numbers distribution with a specified output distribution;(ii) Stationarity Enforcement: using genetic algorithms, the output of (ii) is permuted until the random numbers meet wide-sense stationarity. We ensure that the quality of the numbers generated from the genetic algorithm is within a specified level of error defined by the user. We parallelize the genetic algorithm for improved performance. The post-processing is based on the power spectral density of the generated numbers used as a metric. We propose guideline parameters for the evolutionary algorithm to ensure fast convergence, within the first 100 generations, with a standard deviation over the specified quality level of less than 0.45. We also include a TestU01 evaluation over the random numbers generated.

关键词： True random Number Generators Genetic algorithms Auto-Correlation Entropy Power Spectral Density

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Metastatic adenocarcinoma of gingival as the first manifestation of gastric cancer

引用

中国口腔颌面外科杂志 2008年第B5期6卷 205-205页

作者： liuzzi j Rincon N leaflez l Velazquez Y mijares A Head and Neck Department Hospital Oncologico Padre Machado Caracas Venezuela Plastic and Reconstructive Surgery Hospital Oncologico Padre Machado Caracas Venezuela

Purpose: The oral cavity is a rare but occasional target for metastases。Oral metastatic lesions have been described in cancer like lung, breast and kidney carcinoma。Methods: We describe an uncommon case of a gingival mucosa metastasis from gastric carcinoma that was originally diagnosed as a periodontal disease, without other symptoms。Results: Histopathological examination of a biopsy of the lesion revealed a poor differentiated cell carcinoma, and a subsequent biopsy of a gastric tumor showed a gastric carcinoma。The patient underwent chemotherapy but died of renal complications。Conclusion: An occult carcinoma of the stomach may rarely have metastasis to the oral cavity even as a first and exclusive manifestation。

关键词：腺癌诊断方法齿龈胃癌

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：