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THE MOVEMENT OF BED-LOAD DISCHARGE NEAR THE SHORE OF SHIJIU HARBOUR

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Chinese Journal of Oceanology and Limnology 1985年第2期3卷 212-223页

作者： Shi Maochong Liu Anguo wang xirui (Shandong College of Oceanology)andZhang Bifang (Ningbo Professional School of Oceanology) 1. Shandong College of Oceanology Shangdong China2. Ningbo professional School of Oceanology Ningbo China

Shijiu Harbour is to be constructed at southern Shandong as an important shipping center with a docking capacity of 100 thousand tonnages of a single *** and tidal currents were frequently observed at three different layers from December 1979 to April 1980. Bed-load discharge was sampled and calculated for different weather conditions. Some of the results are as follows:1. The amount of bed-load discharge is 0.1359 g/cm2/day during the spring tide, 0.09 g/cm2/day during the neap tide, 0.488 g/cm2/day during storm weather, which is four times as high as that during average tides.2. The maximum amount of the sediments that settle to the waterway is less than 46.7768 g/cm2 per year, therefore the waterway will not be blocked by the transported sand and clay even after a storm weather.

关键词： THE MOVEMENT OF BED-LOAD DISCHARGE NEAR THE SHORE OF SHIJIU HARBOUR

Xanthophyll Cycle and Its Relative Enzymes

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Journal of Life Sciences 2012年第9期6卷 980-984页

作者： xirui Xiong Xuefei wang Ming'an Liao College of Horticulture Sichuan Agricultural University Ya 'An City SiChuan 625014 China

Light is a fundamental source of energy but is also potentially harmful to organisms. Plants have evolved a variety of regulatory mechanisms to respond to the naturally varying light conditions. Xanthophyll cycle is now recognized as a key regulator and photoprotective mechanism found ubiquitously in plants. Xanthophyll cycle has multiple functions, such as thermal dissipation, protection against oxidative stress caused by light, modulation of the structure of thylakoid membrane, involving in blue light signal transduction and regulating the synthesis ofABA （Abscisic acid）. VDE （Violaxanth de-epoxidase） and ZE （zeaxanth epoxidase）, are involved in xanthophyll cycle. This paper outlined the functions of xanthophylls cycle and its relative enzymes.

关键词： Xanthophyll cycle function VDE ZE.

Synthesis and biological evaluation of N-Alkylamide derivatives as anti-tumor agents

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Journal of Traditional Chinese Medical Sciences 2020年第4期7卷 393-403页

作者： Kunxiu Jiang Yantao Xing Qinghua Quan Qianqian Sun Jingyun Tian Cen Liu Xingzhuo Song xirui wang Yonggang Liu School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China

Background:N-Alkylamides(NAAs),derived from Anacyclus pyrethrum(L.)DC,have potential anti-tumor *** explore the molecular mechanism and chemo-preventive capacity of NAAs,we synthesized an NAA(H-10)and evaluated whether it could inhibit the proliferation of B16,HepG2,HeLa,and HCT116 cancer cells in 2D ***:To evaluate the antiproliferative activity of H-10 in 2D and 3D culture of BD,HepG2,HeLa,and HCT116 cells,multicellular tumor spheroids were constructed to more accurately reflect the cell tumor *** visualize nuclear changes related to apoptosis,Hoechst 33258 staining and propidium iodide-Annexin V double staining were ***:Compound H-10 strongly inhibited the growth of all tested cell *** 33258 staining and propidium iodide-Annexin V double staining revealed that H-10 did not cause morphological alterations in the nuclei and moderately induced late apoptosis only when treated at 180 *** strongest inhibitory effect was observed in HCT116 *** cytometry analysis indicated that treatment of HCT116 cells with compound H-10 resulted in robust cell growth arrest in G2 phase in 2D and 3D cell culture;in 3D-cultured HCT116 cells,growth arrest occurred in G1 *** with compound H-10 also significantly suppressed angiogenesis of chick chorioallantoic membrane in ***:Treatment with compound H-10 strongly affected clonogenic survival(in the long-term)and migration of HCT116 ***,H-10,a compound of NAAs may be useful for treating cancer because of its anti-neoplastic effect and easy synthesis.

关键词： N-AlkylamideThree-dimensional cell culture HCT116 Anti-tumor agent

气相色谱-三重四极杆串联质谱法同时测定乳粉中22种邻苯二甲酸酯

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食品工业科技 2022年第5期43卷 280-285页

作者：王金翠王晰锐黑龙江省天润检验检测研究院有限公司黑龙江哈尔滨150009 黑龙江省药品审核查验中心黑龙江哈尔滨150001

建立了气相色谱-三重四极杆串联质谱法测定乳粉中22种邻苯二甲酸酯含量的方法。乳粉样品以水溶解,通过乙腈提取,以氯化钠盐析后,采用气相色谱-三重四极杆串联质谱的多反应监测模式(MRM)进行定量分析。结果表明,采用基质匹配标准曲线,在5... 详细信息

建立了气相色谱-三重四极杆串联质谱法测定乳粉中22种邻苯二甲酸酯含量的方法。乳粉样品以水溶解,通过乙腈提取,以氯化钠盐析后,采用气相色谱-三重四极杆串联质谱的多反应监测模式(MRM)进行定量分析。结果表明,采用基质匹配标准曲线,在5~500 ng/mL范围内,22种邻苯二甲酸酯线性关系良好,相关系数(r)均大于0.99,方法检出限在1.0~5.0μg/kg范围,定量限在3.0~15.0μg/kg范围。在奶粉基质中3个加标水平下邻苯二甲酸酯的平均回收率在82.4%~111.4%之间,平行测定6次相对标准偏差(RSD)为2.4%~9.5%。该方法高效便捷、灵敏度高、稳定性好,适用于乳粉中22种邻苯二甲酸酯检测。

关键词：气相色谱-三重四极杆串联质谱(GC-MS/MS) 邻苯二甲酸酯类乳粉

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住房公积金制度管理绩效实证研究——以成都市为例

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改革与战略 2010年第7期26卷 170-172页

作者：王西枘汪梦四川大学工商管理学院四川成都610065

住房公积金在提高缴存人购房能力和完善我国住房保障体系中发挥了重要作用。但在实际运行中存在着监督不力、公积金使用不充分和使用难等问题。文章基于成都市的实地调查与访谈,运用德尔菲法,构建住房公积金制度管理绩效评价指标认为,... 详细信息

住房公积金在提高缴存人购房能力和完善我国住房保障体系中发挥了重要作用。但在实际运行中存在着监督不力、公积金使用不充分和使用难等问题。文章基于成都市的实地调查与访谈,运用德尔菲法,构建住房公积金制度管理绩效评价指标认为,住房公积金管理中心可以完全承担银行在现有公积金管理模式下的金融职能。

关键词：住房公积金管理绩效金融职能

不同碳源下粪产碱杆菌的生长代谢及碳氮比对其反硝化能力的影响

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化学通报 2014年第4期77卷 370-374页

作者：王希睿余萍鲁安怀中国人民大学附属中学北京100080 北京大学地球与空间科学学院北京100871

近年来,地下水中硝酸盐的污染日益严重,饮用水中高浓度的硝酸盐或亚硝酸盐会对人类健康产生极大的威胁,而作为目前研究较多的异养微生物之一,粪产碱杆菌(Alcaligenes faecalis)不仅能降解苯酚、苯胺等多种有机质[1,2],还具有反硝化能力... 详细信息

近年来,地下水中硝酸盐的污染日益严重,饮用水中高浓度的硝酸盐或亚硝酸盐会对人类健康产生极大的威胁,而作为目前研究较多的异养微生物之一,粪产碱杆菌(Alcaligenes faecalis)不仅能降解苯酚、苯胺等多种有机质[1,2],还具有反硝化能力。碳源种类及碳氮比是影响微生物生长和反硝化的两个重要因素。本文以粪产碱杆菌为实验菌种,选择柠檬酸三钠等5种不同碳源,观察其生长情况,进而在不同碳氮比条件下,以亚硝酸根为底物,研究了粪产碱杆菌的反硝化能力。结果表明,粪产碱杆菌可在乳酸钠、乙酸钠和柠檬酸三钠中快速生长,但在葡萄糖和低浓度甲醇中生长缓慢,即不能利用这两种物质作为其生长的碳源;粪产碱杆菌可以利用亚硝酸根作为其反硝化反应的底物,将其还原为低价态的氮氧化物或者氮气;不同碳氮比条件下,粪产碱杆菌反硝化的反应速率不同。

关键词：粪产碱杆菌反硝化碳源碳氮比

Prognostic Nomogram for pancreatic cancer with lung metastasis:a SEER database-based study

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Journal of Pancreatology 2021年第1期4卷 28-36页

作者： Jiachun Ding Jiaqiang Ren Fan Chen Yangyang Yue Chao Ren xirui wang Qingyong Ma Zheng Wu Zheng wang Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina

Objectives:To establish Nomogram to predict the overall survival(OS)rate of pancreatic cancer patients with lung metastasis by utilizing the database of the Surveillance,Epidemiology,and End Results(SEER)***:We obtained the data of 363 pancreatic cancer patients with lung metastasis who were diagnosed between 2010 and 2016 from the SEER *** patients were randomly divided into training(n=255)and validation(n=108)*** Cox proportional hazards regression model was performed to evaluate the prognostic effects of multiple clinicopathologic factors on *** prognostic factors were combined to build *** predictive performance of Nomogram was evaluated via internal(training cohort data)and external validation(validation cohort data)by calculating index of concordance(C-index)and plotting area under curve(AUC)and calibration *** data from SEER database have been fully de-identified and may be used without further independent ethics committee ***:In the training cohort,the results of Cox proportional hazards regression model showed that,tumor location,surgery,chemotherapy and other organ of metastasis were significantly associated with the survival prognosis(P<.05).These factors were used to establish *** Nomogram showed good accuracy in predicting OS rate,with C-index of 0.727[95%CI was(0.689,0.764)]in internal validation and C-index of 0.738[95%CI was(0.679,0.796)]in external *** calibration curves showed excellent consistency between prediction by Nomogram and actual ***:Novel Nomogram for pancreatic cancer patients with lung metastasis was established to predict OS in our *** has good prognostic *** it could provide the clinicians with more accurate and practical predictive tools which can quickly and accurately assess the patients’survival prognosis individually,and make clinical suggestion for doctors in the follow-up treatment of patients.

关键词： Nomogram Pancreatic cancer SEER Survival analysis

2型糖尿病患者视网膜神经纤维层厚度与同型半胱氨酸相关性研究

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中国糖尿病杂志 2022年第11期30卷 821-824页

作者：聂琳陈敏王喜瑞北京市顺义区空港医院内分泌科 101318

目的探讨T2DM患者视网膜神经纤维层(RNFL)厚度与同型半胱氨酸(HCY)的相关性。方法选取2016年8月至2020年8月于北京顺义空港医院内分泌科诊断为T2DM患者582例1164眼,另选取同期于我院体检及眼科就诊的健康者176例342眼为正常对照(NC)组... 详细信息

目的探讨T2DM患者视网膜神经纤维层(RNFL)厚度与同型半胱氨酸(HCY)的相关性。方法选取2016年8月至2020年8月于北京顺义空港医院内分泌科诊断为T2DM患者582例1164眼,另选取同期于我院体检及眼科就诊的健康者176例342眼为正常对照(NC)组。根据荧光素眼底血管造影(FFA)结果分为DR临床前期组(NDR组)、非增生期DR组(NPDR组)、增生期DR组(PDR组)。应用光学相干断层扫描(OCT)测量受试者视网膜上方、下方、颞侧、鼻侧及全周360°RNFL厚度。结果与NC组比较,其他三组DM病程、FPG、HbA1c升高(P<0.05),NDR组上方平均值(SA)、全周360°RNFL平均厚度(mean360°)降低(P<0.05),NPDR组SA、下方平均值(IA)、鼻侧平均值(NA)、mean360°降低(P<0.05),PDR组SA、IA、NA、颞侧平均值(TA)、mean360°升高(P<0.05)。与NDR组比较,PDR组DM病程、FPG、UAlb、HCY、TG、SA升高(P<0.05),IA、mean360°降低(P<0.05)。与NPDR组比较,PDR组DM病程、FPG、UAlb、HCY、TG、SA、IA、NA、TA、mean360°升高(P<0.05)。Pearson相关分析显示,RNFL厚度与SUA呈正相关(P<0.05),与年龄、DM病程、HCY呈负相关(P<0.05)。多元线性回归分析显示,DM病程是RNFL厚度的影响因素。结论在DR非增生期,随着病变加重,RNFL厚度逐渐变薄,与HCY升高相关,在DR增生期,RNFL厚度增厚,RNFL厚度可早期监测DR。

关键词：糖尿病 2型糖尿病视网膜病变视网膜神经纤维层同型半胱氨酸

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大豆蛋白酶水解物抗氧化活性的研究

中国粮油学报 2010年第11期25卷 37-42页

作者：吴瑕江连洲王鑫王晰锐东北农业大学成栋学院哈尔滨150030 东北农业大学食品学院哈尔滨150030

采用碱性蛋白酶水解大豆蛋白,研究大豆蛋白酶水解物的抗氧化活性。通过测定水解物的亚铁还原能力,对卵磷脂脂质氧化体系的氧化抑制作用,DPPH(二苯代苦味肼基)自由基清除能力,研究大豆多肽抗氧化活性的大小。结果表明,大豆多肽的抗氧化... 详细信息

采用碱性蛋白酶水解大豆蛋白,研究大豆蛋白酶水解物的抗氧化活性。通过测定水解物的亚铁还原能力,对卵磷脂脂质氧化体系的氧化抑制作用,DPPH(二苯代苦味肼基)自由基清除能力,研究大豆多肽抗氧化活性的大小。结果表明,大豆多肽的抗氧化能力与底物浓度、加酶量、水解时间、pH值、温度等有关,水解的最佳工艺条件是底物质量浓度50 mg/mL,pH 8.0,加酶量(E/S)2%,温度60℃,水解时间为5 h。研究表明,碱性蛋白酶制备的大豆蛋白水解物,在卵磷脂脂肪氧化体系中可以降低硫代巴比妥酸值(TBARS),且具有较好的清除DP-PH自由基的能力。

关键词：大豆蛋白抗氧化活性碱性蛋白酶酶水解物