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Journal of Materials Science & Technology 2023年第19期150卷 96-103页

作者： xirui lv Yiming Lei Zhao Zhang Jie Zhang Jingyang Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

High throughput experimentation is employed to establish a ternary system with the compositional range of 30.8 mol.%-75.7 mol.%SiO_(2),16.6 mol.%-61.7 mol.%Yb_(2)O_(3),and 6.3 mol.%-4.1 moll.%Ho_(2)O_(3) through co-sputtering deposition on one combinatorial material *** their application in advanced SiC_(f)/SiC CMC,the phase composition and mechanical properties of samples with various RE/Si ratios and Yb/Ho ratios are comprehensively *** stability and thermal expansion compatibility between SiC and RE silicates with different compositions are also *** materials for the application of environmental barrier coating and interphase for SiC_(f)/SiC CMC are screened respectively according to the above trends and *** work is a case study to establish a composition-property library for RE_(2)O_(3)-SiO_(2) *** is inspired more complicated multicomponent RE silicates could be prepared and characterized by high throughput experimentation,accelerating the design and screening of promising optimal candidates.

关键词： High throughput experimentation RE silicates Phase stability Mechanical properties

Rare earth monosilicates as oxidation resistant interphase for SiCf/SiC CMC:Investigation of SiC_(f)/Yb_(2)SiO_(5)model composites

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Journal of Advanced Ceramics 2022年第5期11卷 702-711页

作者： xirui lv Mengkun YUE Xue FENG Xiaoyan LI Yumin WANG Jiemin WANG Jie ZHANG Jingyang WANG Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China AML Department of Engineering MechanicsTsinghua UniversityBeijing 100084China Center for Mechanics and Materials Tsinghua UniversityBeijing 100084China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

Model composites consisting of SiC fiber and Yb_(2)SiO_(5)were processed by the spark plasma sintering(SPS)*** mechanical compatibility and chemical stability between Yb_(2)SiO_(5)and SiC fiber were studied to evaluate the potential application of Yb monosilicate as the interphase of silicon carbide fiber reinforced silicon carbide ceramic matrix composite(SiC_(f)/SiC CMC).Two kinds of interfaces,namely mechanical and chemical bonding interfaces,were achieved by adjusting sintering ***_(f)/Yb_(2)SiO_(5)interfaces prepared at 1450 and 1500℃exhibit high interface strength and debond energy,which do not satisfy the crack deflection criteria based on He-Hutchison *** spectrum analyzation indicates that the thermal expansion mismatch between Yb_(2)SiO_(5)and SiC contributes to high compressive thermal stress at interface,and leads to high interfacial *** layer at interface in model composite sintered at 1550℃is related to the diffusion promoted by high temperature and DC electric filed during *** is inspired that the interfacial parameters could be adjusted by introducing Yb_(2)Si_(2)O_(7)-Yb_(2)SiO_(5)interphase with controlled composition to optimize the mechanical fuse mechanism in SiC_(f)/SiC CMC.

关键词： silicon carbide fiber reinforced silicon carbide ceramic matrix composite(SiCf/SiC CMC) interphase rare earth(RE)silicates interfacial parameters

5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2153-2176页

作者： Qing Meng Jianshuang Guo Ke lv Yang Liu Jin Zhang Mingyue Li xirui Cheng Shenghua Chen Xiaoguang Huo Quan Zhang Yue Chen Jing Li State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin 300353China College of Chemistry and Frontiers Science Center for New Organic Matter Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China Accendatech Company Ltd.Tianjin 300193China

Aberrant changes in the gut microbiota are implicated in many diseases,including inflammatory bowel disease(IBD).Gut microbes produce diverse metabolites that can shape the immune system and impact the intestinal barrier integrity,indicating that microbe-mediated modulation may be a promising strategy for preventing and treating *** fecal microbiota transplantation and probiotic supplementation are well-established IBD therapies,novel chemical agents that are safe and exert strong effects on the gut microbiota are urgently ***,we report the total synthesis of heudelotinone and the discovery of 5S-heudelotinone(an enantiomer)as a potent agent against experimental colitis that acts by modulating the gut microbiota.5S-Heudelotinone alters the diversity and composition of the gut microbiota and increases the concentration of short-chain fatty acids(SCFAs);thus,it regulates the intestinal immune system by reducing proinflammatory immune cell numbers,and maintains intestinal mucosal integrity by modulating tight junctions(TJs).Moreover,5S-heudelotinone(2)ameliorates colitis-associated colorectal cancer(CAC)in an azoxymethane(AOM)/dextran sulfate sodium(DSS)-induced in situ carcinoma ***,these findings reveal the potential of a novel natural product,namely,5S-heudelotinone,to control intestinal inflammation and highlight that this product is a safe and effective candidate for the treatment of IBD and CAC.

关键词： 5S-heudelotinone Total synthesis Inflammatory bowel disease Gut microbiota Short-chain fatty acids Immune system Intestinal barrier Drug discovery

Tunable strength of SiCf/β-Yb_(2)Si_(2)O_(7) interface for different requirements in SiCf/SiC CMC:Inspiration from model composite investigation

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Journal of Materials Science & Technology 2021年第8期67卷 165-173页

作者： xirui lv Mengkun Yue Wenfan Yang Xue Feng Xiaoyan Li Yumin Wang Jiemin Wang Jie Zhang Jingyang Wang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China AML Department of Engineering MechanicsTsinghua UniversityBeijing 100084China Center for Mechanics and Materials Tsinghua UniversityBeijing 100084China Institute of Metal Research Chinese Academy of ScienceShenyang 110016China

Model composites consisting of Si C fiber embedded inβ-Yb_(2)Si_(2)O_(7) matrix were processed by Spark Plasma Sintering method and the feasibility of tunable Si Cf/Yb_(2)Si_(2)O_(7) interface in Si C-based CMCs were *** and strengthened Si Cf/Yb_(2)Si_(2)O_(7) interfaces were achieved by adjusting sintering *** indentation crack test and fiber push out experiments clearly demonstrated the different debonding mechanisms in the *** interfaces sintered at 1200 and 1250℃exhibited crack deflection at interface in indentation *** low debond energy at the interface,which were comparable to those of Py C or BN,satisfied the well-recognized interfacial debond and crack deflection criteria for *** interface was strengthened by atomic bonding in model composite sintered at 1450℃,leading to crack penetrating into Si C fiber and high debond *** strong interface may be promising in Si Cf/Si C CMC to withstand higher combustion temperature,because Yb_(2)Si_(2)O_(7) will provide plastic deformation capacity,which would serve as weak interphase for crack deflection and energy ***,it is possible to design the capability of Si C_(f)/RE_(2)Si_(2)O_(7) interface for different requirements by adjusting interfacial strength or debond energy to reach optimal mechanical fuse mechanism in SiC_(f)/SiC CMC.

关键词： SiCf/SiC composite Interphase Rare earth disilicate Tunable interface

人工智能文化产业创新逻辑及其价值风险与治理路径

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传媒经济与管理研究 2022年第3期 213-230页

作者：杨旦修王茜芮吕冠霖云南财经大学传媒与设计艺术学院

针对人工智能驱动文化产业创新问题,本文探讨了其创新的大数据逻辑与算法逻辑,具体分析了人工智能对美术行业、音乐行业以及短视频产业等的创新表现,解构了人工智能文化产业创新的伦理、人文以及意识形态风险,提出了内容监管、数据规制... 详细信息

针对人工智能驱动文化产业创新问题,本文探讨了其创新的大数据逻辑与算法逻辑,具体分析了人工智能对美术行业、音乐行业以及短视频产业等的创新表现,解构了人工智能文化产业创新的伦理、人文以及意识形态风险,提出了内容监管、数据规制以及算法规制等风险治理路径。

关键词：人工智能文化产业创新价值风险风险治理

以新冠肺炎疫情为切入点开展医学生公共卫生法治教育的探索与实践

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中国卫生法制 2021年第3期29卷 76-79页

作者：吕慕苏熙睿山东医学高等专科学校社科部山东临沂市276002

以新冠肺炎疫情为切入点对医学生开展公共卫生法治教育,有助于增强医学生对公共卫生的重视程度、深化医学生卫生法治观念、提高疫情防治法治化水平。教育内容包括公共卫生法治体系、疫情防控法律措施、疫情相关法治实践、热点案例讨论... 详细信息

以新冠肺炎疫情为切入点对医学生开展公共卫生法治教育,有助于增强医学生对公共卫生的重视程度、深化医学生卫生法治观念、提高疫情防治法治化水平。教育内容包括公共卫生法治体系、疫情防控法律措施、疫情相关法治实践、热点案例讨论解析、存在不足与后续改进。教育途径可采取课程讲授、辅导员引导、新媒体宣传、专家报告等方式。

关键词：疫情公共卫生法治教育

尿苷二磷酸葡醛酸转移酶介导的胆汁酸代谢过程及其内源和外源影响因素研究进展

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中国临床药理学与治疗学 2022年第1期27卷 102-107页

作者：郭胜杰管汐蕊曹文莉梁思成齐晓怡葛广波吕沐瀚西南医科大学附属医院皮肤科四川泸州646000 西南医科大学附属医院消化内科四川泸州646000 上海中医药大学交叉科学研究院上海201203

尿苷二磷酸葡萄糖醛酸转移酶(UDP-glucuronosyltransferases, UGTs)作为人体中一种非常重要的II相代谢酶,不仅参与外源性化合物代谢清除,也在胆汁酸等内源性物质的代谢调控中扮演重要角色。解析尿苷二磷酸葡萄糖醛酸转移酶介导的胆汁酸... 详细信息

尿苷二磷酸葡萄糖醛酸转移酶(UDP-glucuronosyltransferases, UGTs)作为人体中一种非常重要的II相代谢酶,不仅参与外源性化合物代谢清除,也在胆汁酸等内源性物质的代谢调控中扮演重要角色。解析尿苷二磷酸葡萄糖醛酸转移酶介导的胆汁酸代谢过程及其内源和外源影响因素有助于增强对相关疾病的治疗和预防。尿苷二磷酸葡萄糖醛酸转移酶对胆汁酸代谢调控作用受到多种内源性和外源性因素影响。本文将重点探讨核受体、遗传因素、外源化合物及肝脏相关疾病等因素对UGT酶作用的影响,讨论体内潜在的胆汁酸动态平衡干预机制。

关键词：尿苷二磷酸葡萄糖醛酸转移酶胆汁酸影响因素平衡干预

人工智能驱动文化产业创新的价值风险与治理研究

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经济与社会发展 2021年第5期19卷 54-62页

作者：杨旦修王茜芮吕冠霖云南财经大学传媒与设计艺术学院云南昆明650221

人工智能驱动文化产业创新促成了新兴的文化产业形态。文章具体分析人工智能对美术行业、人工智能对音乐行业以及人工智能对短视频产业等的创新表现,剖析人工智能文化产业创新的伦理价值、人文价值以及意识形态风险,提出内容监管、数据... 详细信息

人工智能驱动文化产业创新促成了新兴的文化产业形态。文章具体分析人工智能对美术行业、人工智能对音乐行业以及人工智能对短视频产业等的创新表现,剖析人工智能文化产业创新的伦理价值、人文价值以及意识形态风险,提出内容监管、数据规制以及算法规制等风险治理路径。

关键词：人工智能文化产业创新价值风险风险治理

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敦煌《孝经注》残卷的文献价值

西南交通大学学报（社会科学版） 2020年第4期21卷 44-50页

作者：吕冠南山东大学国际汉学研究中心山东济南250100

在宋前的《孝经》学史中,郑氏注曾发生过深刻的影响。但宋代之后,郑注本亡佚,治《孝经》者已无从探讨其得失。清季皮锡瑞所撰《孝经郑注疏》,是前代郑注研究的典范,但其所疏文本来自辑佚,故并非郑注原本。所幸敦煌藏经洞出土了唐写本郑... 详细信息

在宋前的《孝经》学史中,郑氏注曾发生过深刻的影响。但宋代之后,郑注本亡佚,治《孝经》者已无从探讨其得失。清季皮锡瑞所撰《孝经郑注疏》,是前代郑注研究的典范,但其所疏文本来自辑佚,故并非郑注原本。所幸敦煌藏经洞出土了唐写本郑氏《孝经注》残卷九种,既为重新认识郑注本提供了重要的文献基础,也可以用之检验以皮锡瑞《孝经郑注疏》为代表的前代郑注本研究的得失。通过对比研究,可发现敦煌《孝经注》残卷在还原郑注的错简、辨析误辑的郑注和验证前贤对注文的校勘这三个方面均有重要的文献价值。同时,传世文献又能反哺敦煌本《孝经注》,为其进一步完善提供文献材料。

关键词：《孝经》学史《孝经注》今文《孝经》郑氏注敦煌写本《孝经郑注疏》