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Effectiveness and safety of combined nimotuzumab and S-1 chemotherapy with concurrent radiotherapy for locally advanced esophageal cancer in malnourished and elderly patients:A prospective phase Ⅱ study

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Chinese Journal of Cancer Research 2024年第3期36卷 270-281页

作者： Guojie Feng Jiao Li Nuo Yu Ziyu Zheng xiongtao yang Lei Deng Tao Zhang Wenqing Wang Wenyang Liu Jianyang Wang Qinfu Feng Jima Lyu Zefen Xiao Zongmei Zhou Nan Bi Jianjun Qin Xin Wang Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College

Objective: Definitive chemoradiotherapy(dCRT) is the standard treatment for unresectable locally advanced esophageal cancer. However, this treatment is associated with substantial toxicity, and most malnourished or elderly patients are unable to complete this therapy. Therefore, there is a need for a more suitable radiotherapy combination regimen for this population. This study was aimed to evaluate the efficacy and safety of a combination regimen comprising chemotherapy with nimotuzumab and S-1 and concurrent radiotherapy for patients with fragile locally advanced esophageal cancer with a high Nutritional Risk Screening 2002(NRS-2002) score.Methods: Eligible patients with unresectable esophageal carcinoma who had an NRS-2002 score of 2 or higher were enrolled. They were treated with S-1 and nimotuzumab with concurrent radiotherapy, followed by surgery or definitive radiotherapy. The primary endpoint was the locoregional control(LRC) rate.Results: A total of 55 patients who met the study criteria were enrolled. After completion of treatment, surgery was performed in 15 patients and radiotherapy was continued in 40 patients. The median follow-up period was 33.3[95% confidence interval(95% CI), 31.4-35.1)] months. The LRC rate was 77.2%(95% CI, 66.6%-89.4%) at 1 year in the entire population. The overall survival(OS) rate and event-free survival(EFS) rate were 57.5% and 51.5% at 3 years, respectively. Surgery was associated with better LRC [hazard ratio(HR)=0.16; 95% CI,0.04-0.70; P=0.015], OS(HR=0.19; 95% CI, 0.04-0.80; P=0.024), and EFS(HR=0.25; 95% CI, 0.08-0.75;P=0.013). Most adverse events were of grade 1 or 2, and no severe adverse events occurred.Conclusions: For malnourished or elderly patients with locally advanced esophageal cancer, radiotherapy combined with nimotuzumab and S-1 is effective and has a good safety profile.

关键词： Esophageal carcinoma squamous cell carcinoma nutritional risk score nimotuzumab S-1 definitive chemoradiotherapy

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CTCs Detection and Whole-exome Sequencing Might Be Used to Differentiate Benign and Malignant Pulmonary Nodules

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中国肺癌杂志 2023年第6期26卷 449-460页

作者： Changdan XU Xiaohong XU Weipeng SHAO Hongliang SUN Xiaohong LIU Hongxiang FENG Xianbo ZUO Jingyang GAO Guohui WANG xiongtao yang Runchuan GU Shutong GE Shijie WANG Liwei GAO Guangying ZHU Department of Radiation Oncology Peking University China-Japan Friendship School of Clinical MedicineBeijing 100029China Department of Radiation Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Thoracic Surgery China-Japan Friendship HospitalBeijing 100029China Department of Radiology China-Japan Friendship HospitalBeijing 100029China Department of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China Department of Dermatology China-Japan Friendship HospitalBeijing 100029China Department of Pharmacy China-Japan Friendship HospitalBeijing 100029China Department of Radiation Oncology Tianjin First Central HospitalTianjin 300070China Department of Oncology Beijing Changping District HospitalBeijing 102200China Faculty of Medicine Lund University Lund SE-22100Sweden Department of Radiation Oncology China-Japan Friendship HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100029China Department of Radiation Oncology Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China

Background and objective Low-density computed tomography(LDCT)improved early lung cancer diagnosis but introduces an excess of false-positive pulmonary nodules data.Hence,accurate diagnosis of early-stage lung cancer remains challenging.The purpose of the study was to assess the feasibility of using circulating tumour cells(CTCs)to differentiate malignant from benign pulmonary nodules.Materials and methods 122 patients with suspected malignant pulmonary nodules detected on chest CT in preparation for surgery were prospectively recruited.Peripheral blood samples were collected before surgery,and CTCs were identified upon isolation by size of epithelial tumour cells and morphological analysis.Laser capture microdissection,MALBAC amplification,and whole-exome sequencing were performed on 8 samples.The diagnostic efficacy of CTCs counting,and the genomic variation profile of benign and malignant CTCs samples were analysed.Results Using 2.5 cells/5 m L as the cut-off value,the area under the receiver operating characteristic curve was of 0.651(95%confidence interval:0.538-0.764),with a sensitivity and specificity of 0.526 and 0.800,respectively,and positive and negative predictive values of 91.1%and 30.3%,respectively.Distinct sequence variations differences in DNA damage repair-related and driver genes were observed in benign and malignant samples.TP53 mutations were identified in CTCs of four malignant cases;in particular,g.7578115T>C,g.7578645C>T,and g.7579472G>C were exclusively detected in all four malignant samples.Conclusion CTCs play an ancillary role in the diagnosis of pulmonary nodules.TP53 mutations in CTCs might be used to identify benign and malignant pulmonary nodules.

关键词： Chest computed tomography Circulating tumour cells Lung nodule TP53 Whole-exome sequencing

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基于图神经网络的会话推荐方法综述

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数据分析与知识发现 2024年第2期8卷 1-16页

作者：张雄涛祝娜郭玉慧北京科技大学经济管理学院北京100083 西南大学国家治理学院重庆400715 中国人民大学信息学院北京100872

【目的】聚焦图神经网络技术,对会话推荐方法进行述评。【文献范围】分别以“Session-Based Recommendation”“Graph Neural Network”“会话推荐”“图神经网络”为检索词,在Web of Science、中国知网等数据库中筛选出82篇国内外文献... 详细信息

【目的】聚焦图神经网络技术,对会话推荐方法进行述评。【文献范围】分别以“Session-Based Recommendation”“Graph Neural Network”“会话推荐”“图神经网络”为检索词,在Web of Science、中国知网等数据库中筛选出82篇国内外文献。【方法】从框架、评价和趋势三个视角,对基于图神经网络的会话推荐方法进行归纳与对比,总结现有评价资源,讨论未来研究趋势。【结果】图神经网络是当前实现会话推荐系统的主流技术,基于图神经网络的会话推荐方法主要围绕“会话图构建”、“会话图学习”和“会话兴趣表示”三个核心问题展开。【局限】本文仅评述主流研究,并未将所有研究逐一列出。未从可解释性、鲁棒性、多样性和公平性等方面深入研究。【结论】图神经网络是会话推荐系统的主流实现技术,未来可结合会话推荐的特定场景,通过发展图神经网络技术进一步改进现有研究不足。

关键词：图神经网络会话推荐序列推荐推荐系统深度学习

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Epoxy resin nanocomposites reinforced with ionized liquid stabilized carbon nanotubes

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International Journal of Smart and Nano Materials 2011年第3期2卷 176-193页

作者： Zhe Wang xiongtao yang Qiang Wang H.Thomas Hahn Sang-gi Lee Kun-Hong Lee Zhanhu Guo Mechanical&Aerospace Engineering Department University of California Los AngelesLos AngelesCA 90095USA Integrated Composites Lab Dan F.Smith Department of Chemical EngineeringLamar UniversityBeaumontTX 77710USA Institute of Chemical and Engineering Sciences(ICES) A-STARApplied Catalysis1Pesek RoadJurong Island627833 Singapore Department of Chemistry and Nano Science Ewha Womans UniversitySeoul 120-750Korea Department of Chemical Engineering Pohang University of Science and TechnologyPohang 790-784Korea

Epoxy resin nanocomposites reinforced with three different ionic liquid functionalized carbon nanotubes(f-CNTs)were fabricated by an in situ polymerization method.The influence of the anions on the curing process was studied through differential scanning calorimetry(DSC)and normalized Fourier transform infrared(FTIR)spectroscopy.The composition of the nanocomposites was analyzed by X-ray photoelectron spectroscopy.Two different mechanisms are proposed to explain the curing process of the neat epoxy and its composites.The electric conductivity and mechanical properties of the nanocomposites are also reported.The tensile strength was increased dramatically due to the insertion of f-CNTs.Scanning electron microsopy fracture surface analysis indicates a strong interfacial bonding between the carbon nanotubes and the polymer matrix.

关键词： epoxy resin nanocomposite carbon nanotube ionic liquid functionalization

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TRIP13通过同源重组通路提高肺腺癌细胞的放射抗性

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中国肺癌杂志 2024年第1期27卷 1-12页

作者：葛舒童谷润川杨雄涛许长丹王诗杰朱广迎北京大学中日友好临床医学院放射肿瘤科北京100029 中日友好临床研究所北京100029 北京市昌平区医院肿瘤科北京102202 中国医学科学院北京协和医学院中日友好医院放射肿瘤科北京100029

背景与目的放疗是非小细胞肺癌(non-small cell lung cancer,NSCLC)最常用的治疗手段之一。然而,一部分肿瘤细胞对放射线的不敏感是放疗疗效差、患者预后不良的重要原因之一,探究放射抵抗背后的深层机制是解决这一临床难题的关键。本研... 详细信息

背景与目的放疗是非小细胞肺癌(non-small cell lung cancer,NSCLC)最常用的治疗手段之一。然而,一部分肿瘤细胞对放射线的不敏感是放疗疗效差、患者预后不良的重要原因之一,探究放射抵抗背后的深层机制是解决这一临床难题的关键。本研究旨在寻找与肺腺癌(lungadenocarcinoma,LUAD)放射抵抗相关的分子,初步经数据库筛选锁定甲状腺素受体结合因子13(thyroid hormone receptor interactor 13,TRIP13)为主要研究对象,并探索TRIP13是否与LUAD的放射抵抗有关及具体机制,以期为临床接受放疗的LUAD患者的联合治疗提供理论依据和潜在靶点。方法选取基因表达综合数据库(Gene Expression Omnibus,GEO)中的GSE18842、GSE19188和GSE33532共3个数据集,借助R 4.1.3软件分别筛选3个数据集中差异表达的基因(|logFC|>1.5,P<0.05),之后使用Venn diagram找出在3个数据集中共有的差异表达基因。随后,借助STRING在线工具和Cytoscape软件,对筛选出来的差异基因进行蛋白质相互作用分析和模块分析,借助Kaplan-Meier Plotter数据库对各基因进行生存预后分析,并确定TRIP13基因作为后续主要研究分子。随后,采用亚致死性剂量照射法对人LUAD细胞系H292进行多次X射线照射,以构建具有放射抗性的细胞系H292DR。采用细胞计数试剂盒-8(cell counting kit-8,CCK-8)实验和克隆形成实验验证H292DR细胞的放射抗性能力。Western blot检测H292细胞和H292DR细胞中TRIP13蛋白的表达水平。使用小干扰RNA(small interfering RNA,siRNA)沉默H292DR细胞中TRIP 13蛋白的表达并进行Western blot检测。观察TRIP13沉默后H292DR细胞的克隆形成能力和迁移能力,随后检测共济失调-毛细血管扩张突变(ataxia telangiectasia mutated,ATM)蛋白等与同源重组密切相关的蛋白的表达水平变化。结果经多个GEO数据集筛选、外部数据集的验证以及生存分析发现,TRIP13在LUAD中高表达,并与接受过放疗的LUAD患者的不良预后有关;并且,TRIP13基因富集分析(gene set enrichment analysis,GSEA)的结果提示,TRIP13可能通过促进放疗后的同源重组修复而与LUAD放射抵抗有密切关联。经实验检测发现,TRIP13的表达在H292DR中上调,而沉默TRIP13后能够增加H292DR细胞对放射线的敏感性。结论TRIP13与接受放疗后的LUAD患者的预后不良有关,可能是通过促进同源重组修复途径来介导LUAD细胞对放射线的抵抗。

关键词：肺肿瘤放射抵抗 TRIP13蛋白同源重组

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基于语篇解析和图注意力网络的对话情绪识别

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电信科学 2024年第5期40卷 100-111页

作者：郝秀兰魏少华曹乾张雄涛湖州师范学院浙江省现代农业资源智慧管理与应用研究重点实验室浙江湖州313002 中国建设银行股份有限公司湖州分行浙江湖州313001

对话情绪识别研究主要聚焦于融合对话上下文和说话者建模的相互关系。当前研究通常忽略对话内部存在的依存关系,导致对话的上下文联系不够紧密,说话者之间的关系也缺乏逻辑。因此,提出了一种基于语篇解析和图注意力网络(discourse parsi... 详细信息

对话情绪识别研究主要聚焦于融合对话上下文和说话者建模的相互关系。当前研究通常忽略对话内部存在的依存关系,导致对话的上下文联系不够紧密,说话者之间的关系也缺乏逻辑。因此,提出了一种基于语篇解析和图注意力网络(discourse parsing and graph attention network,DPGAT)的对话情绪识别模型,将对话内部的依存关系融入语境建模过程中,使语境信息更具有依赖性和全局性。首先,通过语篇解析获取对话内部的话语依存关系,构建语篇依存关系图和说话者关系图。随后,通过多头注意力机制将不同类型的说话者关系图进行内部融合。此外,在图注意力网络的基础上,结合依存关系进行循环学习,以达到上下文信息和说话人信息的有效融合,实现对话语境信息的外部融合。最终,通过分析内、外部融合的结果还原完整对话语境,并对说话者的情绪进行分析。通过在英文数据集MELD、EmoryNLP、DailyDialog和中文数据集M3ED上进行评估验证,F1分数分别为66.23%、40.03%、59.28%、52.77%,与主流的模型相比,所提模型具有较好的适用性,可在不同的语言场景中使用。

关键词：对话情绪识别语篇解析图注意力网络

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Dual-Color Lasing Lines from EMPs in Diluted MagneticSemiconductor CdS:NiI Structure

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Research 2019年第1期2019卷 400-414页

作者： Muhammad Arshad Kamran Bingsuo Zou Kang Zhang xiongtao yang Fujian Ge Lijie Shi Thamer Alharbi Department of Physics College of ScienceMajmaah UniversityAl-Majmaah 11952Saudi Arabia Key Lab of Featured Metal Resources Utilization and Advanced Materials Development Nano and Energy Research CenterSchool of PhysicsGuangxi UniversityNanning 530004China Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic Systems Beijing Institute of TechnologyBeijing 100081China

Have one ever seen a semiconductor that can issue two-color lasing lines? The diluted magnetic semiconductor (DMS) can do this.Here, we have observed dual lasing lines of 530 nm and 789 nm from a DMS structure of CdS:NiI, in which the excitonic magneticpolaron (EMP) and localized excitonic magnetic polaron (LEMP) are excitations out of ferromagnetic (NiS)x nanocluster and NiI2nanoclusters within CdS lattice;both of them could lead to the collective EMP state at high excitation and therein produce coherentemission lines simultaneously. This occurrence is due to the superposition of EMP near CdS bandedge and the combination of thecharge-transfer band of (NiI)n cluster with the LEMP within CdS lattice by overcoming the strong electron correlation of NiI clusterin a DMS structure, evidenced also by ab initio calculation. This finding opens a way to understand the collective behaviour of spincoupled excitons in DMS and to find novel applications in the spin-related quantum technology.

关键词： collective lasing excitation

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低摩阻水泥浆在长庆气田桃2区块长水平段固井中的应用

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石油化工应用 2024年第3期43卷 44-47页

作者：付雄涛罗延庆杨晓龙刘云中国石油集团川庆钻探工程有限公司长庆固井公司陕西西安710018 中国石油长庆油田苏里格气田开发分公司内蒙古鄂尔多斯017300 西安长立油气工程技术服务有限公司陕西西安710065

普通的减轻材料配制的低密度水泥浆体系存在耐压能力差等缺陷,经井底高压后实际密度有所增加,减轻效果变差。对苏里格区域水平段固井分析,发现常用的轻珠体系施工摩阻明显要高于粉煤灰体系。经评价筛选,调配出以次纳米硅为主要减轻材料... 详细信息

普通的减轻材料配制的低密度水泥浆体系存在耐压能力差等缺陷,经井底高压后实际密度有所增加,减轻效果变差。对苏里格区域水平段固井分析,发现常用的轻珠体系施工摩阻明显要高于粉煤灰体系。经评价筛选,调配出以次纳米硅为主要减轻材料,密度1.40 g/cm^(3)的低摩阻水泥浆体系,该体系经高压后密度增加值≤0.04 g/cm^(3),体系稳定,范宁摩阻系数小。在长庆气田桃2-H井3931 m的长水平段固井中使用,有效控制施工起压值18 MPa,在裸眼段增加的情况下,实际施工压力下降5~6 MPa,理论摩阻压力和实际接近,固井质量合格,为长水平段固井施工提供参考基础。

关键词：低摩阻长水平段低密度水泥浆体系次纳米硅

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空心玻璃微珠在老井侧钻井中的应用

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石油化工应用 2024年第4期43卷 80-82,87页

作者：付雄涛罗延庆蔡维利杨晓龙杨永庆中国石油集团川庆钻探工程有限公司长庆固井公司陕西西安710018 中国石油集团长庆油田苏里格气田开发分公司内蒙古鄂尔多斯017300

随着油气田的开发,老井开窗侧钻井逐渐增多,该类井具有环空间隙窄、水泥石性能要求高等特点。部分井开窗点高、裸眼段较长,目前广泛使用的1.18~1.55g/cm^(3)普通低密度水泥浆体系无法兼顾一次上返固井要求及后期开发的强度要求。经室内... 详细信息

随着油气田的开发,老井开窗侧钻井逐渐增多,该类井具有环空间隙窄、水泥石性能要求高等特点。部分井开窗点高、裸眼段较长,目前广泛使用的1.18~1.55g/cm^(3)普通低密度水泥浆体系无法兼顾一次上返固井要求及后期开发的强度要求。经室内优选出空心玻璃微珠作为减轻材料配制出1.15g/cm^(3)的低密度水泥浆体系,该体系具有流动性好、稳定性高、抗压强度高等优点,能够兼顾固井工艺要求与强度要求,现场应用2口井,固井质量良好,在天然气开窗侧钻井中具有良好的应用前景。

关键词：玻璃微珠老井侧钻低密度水泥固井

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Structural health monitoring and material safety with multispectral technique: A review

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Journal of Safety Science and Resilience 2022年第1期3卷 48-60页

作者： Xiaoqing Huang Pei Wang Song Zhang xiongtao Zhao Yupeng Zhang Department of Engineering Physics Tsinghua UniversityBeijing100084China Institute for Aero Engine Tsinghua UniversityBeijing100084China Innoviation and Research Institute of Hiwing Technology Academy Beijing100084China

Structural health monitoring is the technique which evaluate and analyze materials in the production and service process.In this paper,the basic principles and characteristics of terahertz,infrared,visible-multispectral and X-ray nondestructive testing technologies with different penetration rates,spectral energy,detection accuracy and system complexity are reviewed.Based on the types and causes of defects in aerospace materials,the correspond-ing testing techniques and nondestructive testing technology for different defects are also summarized.Finally,the image processing technology of each detection technology is analyzed.In practice,it is usually necessary to select one or more test methods according to the material properties and damage types.The differences in imaging techniques and processing algorithms are the major obstacles to joint multispectral detection.Although there have been preliminary studies on the methods of combining and associating image data under different spectra,further research is needed on how to integrate more spectra for new,more complex applications.

关键词： Structural health monitoring Composite materials Multispectral

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