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中国科技信息 2011年第9期 33-33页

作者：王德胜王雄飞湖南省地质工程勘察院

换填地基处理在浅基础设计中经常用到,但在地基换填后的软弱下卧层验算中的一些细节易使人疏忽,并导致计算结果出现一定的偏差。本文通过软弱下卧层验算工程实例,说明对一些细节的疏忽可能导致截然相反的判定结果。

关键词：换填垫层地基处理软弱下卧层承载力验算

5G+ABCDNETS:A Feasible Digital Framework for New Infrastructure of Smart Campus

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China Communications 2022年第9期19卷 191-198页

作者： Lili Tong xiongfei Ren Chen Zhang Tiemai Huang Faculty of Education Beijing Normal University Beijing 100875China Beijing University of Posts and Telecommunications Beijing 100876China China Mobile Chengdu Industry Research Institute Chengdu 610000China

This paper constructs a feasible framework of new infrastructure of smart campus guided by the industry requirements for the construction of new infrastructure of smart campus and based on the technical cooperation of 5G+*** paper puts forward the deployment parameter table of 5G hybrid private network in the basic network around 3 sub items and 9 construction *** designed the specific deployment links of intelligent laboratory,security supervision and scientific research collaboration supported by 14 key technologies such as heterogeneous computing in ABCDNETS,taking the sub item of“smart scientific research facilities”as an *** research findings of this paper provide preliminary exploration for promoting the implementation of technology in the six construction directions of new infrastructure for education.

关键词： smart campus 5G ABCDNETS new infrastructure for education

AIGC Scenario Analysis and Research on Technology Roadmap of Internet Industry Application

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China Communications 2023年第10期20卷 292-304页

作者： xiongfei Ren Lili Tong Jia Zeng Chen Zhang Beijing University of Posts and Telecommunications Beijing 100876China Faculty of Education Beijing Normal University Beijing 100875China

The explosion of ChatGPT is considered to be a milestone in the normalization of artificial intelligence education *** the technical line,the cross-modal AI generation application based on human feedback system is *** the business model,the scenes to realize interactive functions are constantly *** paper reviews the evolution process of AIGC,closely follows the current situation of the coexistence of business acceleration and technical worries in the application of artificial intelligence education,analyzes the application of AIGC education in 7 subdivided fields,and analyzes the optimization direction of application cases from the perspective of perception-cognition-creation technology maturity *** 3 recommendations and 2 follow-up research directions will promote the scientific application of artificial intelligence education in the AIGC period.

关键词： AIGC artificial intelligence education application large model

迷走神经刺激术治疗超难治性癫痫持续状态2例

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临床神经外科杂志 2024年第3期21卷 262-266页

作者：彭鑫涛孙卫进马凯强王雄飞周健王梦阳王静李天富栾国明关宇光首都医科大学三博脑科医院神经外科北京100093 首都医科大学三博脑科医院神经内科北京100093 北京市临床医学研究癫痫病重点实验室北京脑重大疾病研究院癫痫研究所

目的探究迷走神经刺激术(VNS)治疗超难治性癫痫持续状态(SRSE)的疗效。方法纳入2例分别于2012年2月28日和2020年6月10日在首都医科大学三博脑科医院行VNS的SRSE患者,分析其临床特征及手术疗效。结果2例患者术中情况良好,病例1于刺激器开... 详细信息

目的探究迷走神经刺激术(VNS)治疗超难治性癫痫持续状态(SRSE)的疗效。方法纳入2例分别于2012年2月28日和2020年6月10日在首都医科大学三博脑科医院行VNS的SRSE患者,分析其临床特征及手术疗效。结果2例患者术中情况良好,病例1于刺激器开机1周后癫痫持续状态(SE)消失,术后7年随访提示未再发生SE且癫痫发作频率减少50%;病例2于刺激器开机1个月后SE消失,术后2年随访提示未再发生SE且癫痫发作频率减少80%。结论VNS是治疗SRSE的安全有效手段。

关键词：超难治性癫痫持续状态迷走神经刺激术疗效

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Characterization of an extreme alkaline-stable keratinase from the draft genome of feather-degrading Bacillus ***7 from deep-sea

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Acta Oceanologica Sinica 2019年第2期38卷 87-95页

作者： Min Jin Chen Chen xiongfei He Runying Zeng State Key Laboratory Breeding Base of Marine Genetic Resource Third Institute of Oceanography Ministry of Natural Resources South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources

Bacillus sp. JM7, a strain isolated from the deep-sea of the South China Sea, was found to efficiently degrade 79.4% native chicken feather within 30 h. Scanning electron microscopy analysis showed that JM7 strain could gradually degrade feather by modifying the microstructure of feather keratin. A total of 25 protease genes were predicted from the draft genome of JM7 strain, among which a predicted subtilisin-like serine protease(designated as Ker02562) was further characterized for its keratinolytic activity. The recombinant Ker02562 functioned at a wide range of temperatures from 30℃ to 60℃, with an optimum at 40–50℃. Ker02562 was highly active at various pHs ranging from 5.0 to 13.0, with a maximum activity observed at pH 7.0–9.0. Remarkably, recombinant Ker02562 was stable in extreme alkaline environments(pH 10–13), which was much better than most other reported keratinases. Collectively, these favorable properties could make Bacillus sp. JM7 and Ker02562 attractive to be applied in the detergent formulation and feather bioconversion.

关键词： Bacillus deep-sea feather-degradation keratinases feather bioconversion alkaline-stable

Emission-Tunable Nanofluorophores through Self-assembly of Amphiphilic Block Copolymers:toward Application in Cell Imaging

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Chinese Journal of Chemistry 2023年第8期41卷 931-938页

作者： Shensong Zhang Shuang Qi xiongfei He Pan Xu Bo Song College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhouJiangsu215123 China Physical Chemistry I&Research Center of Micro-and Nanochemistry and(Bio)Technology(Cμ) Department of Chemistry and BiologySchool of Science and TechnologyUniversity of SiegenAdolf-Reichwein-Str.257076 SiegenGermany

Comprehensive Summary Nanofluorophores based on aggregation-induced emission(AIE)dyes have recently received considerable attention because of their unique optical properties and *** this work,we report an emission-tunable nanofluorophore constructed by the self-assembly of an amphiphilic block copolymer(denoted by PTN).The diblock copolymer was synthesized by RAFT polymerization.A polyethylene glycol-based trithiocarbonate was employed as the macromolecular chain transfer agent,and a near-infrared emitting tetraphenylethylene derivative with a vinyl terminal group was designed as the *** block copolymers self-assembled in an aqueous solution to form nanospheres,which showed near-infrared emission at approximately 720 nm with a significant Stokes shift of approximately 260 ***,nanofluorophores have excellent biocompatibility,photostability,and pH-independent emission-tunable properties,and were successfully applied to label HeLa cells for fluorescence imaging.

关键词： Block copolymers Nanoparticles Fluorescent probes Aggregation-induced emission Twisted intramolecular charge transfer

Glucose-derived solid acids and their stability enhancement for upgrading biodiesel via esterification

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Chinese Journal of Chemical Engineering 2019年第5期27卷 1067-1072页

作者： Donglei Mao Xingguang Zhang xiongfei Zhang Mingmin Jia Jianfeng Yao College of Chemical Engineering Jiangsu Key Lab for the Chemistry & Utilization of Agricultural and Forest Biomass Nanjing Forestry University

Utilization of biomass-derived materials or chemicals plays a significant role in reducing the dependence of unsustainable resources of petroleum and coal. A series of sulfonated glucose-derived solid acids(SGSAs) were developed in this study through a one-step method. These catalysts were characterized by XRD, FT-IR, SEM,and BET to determine their physiochemical properties, and their acid content was measured by acid–base titration. The catalytic performances of SGSA catalysts were evaluated in two esterification reactions: propionic acid or oleic acid with methanol(a typical reaction to upgrade biodiesel). Conversion of oleic acid and selectivity of methyl oleate can reach as high as 93.3% and 94.7% respectively over SGSA-6, which has the highest -SO3 H density. Moreover, regeneration of spent catalysts by sulfuric acid solution can significantly enhance their stability and reusability.

关键词： Solid acids Glucose Esterification Oleic acid Biodiesel

Distributed fiber optic sensing system for vibration monitoring of 3D printed bridges

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Optoelectronics Letters 2025年第1期 28-34页

作者： ZHAO Shuai ZHOU Ran LUO Mingming LIU Jianfei LIU xiongfei ZHOU Tao School of Electronic Information Engineering Hebei University of Technology Tianjin Key Laboratory of Electronic Materials and Devices School of Civil Engineering and Transportation Hebei University of Technology Tianjin Jinhang Institute of Technical Physics

The fiber optic sensing technology provides data support in structural health monitoring of the macro facilities, including design, construction, and maintenance of bridges, tunnels, ports and other infrastructures. In this paper, a distributed vibration sensing system is proved to be responsive to a single touch over a 1.8-m-long equivalent fiber segment, covering a vibration frequency from 5 Hz to 25 kHz. The sensing fiber was arranged as an S type layout on the bridge to recognize the standing state, windblown disturbance, and walking vibration. Moreover, the knocking and climbing events are recognized fiber laying spinning lines and hanging on the fences, respectively. The demonstration shows an accurate positioning and sensitive vibration monitoring applied on the automated three-dimensional(3D) printed bridge, which is applicable to all kinds of 3D printed facilities as intelligent sensory neuro-networks.

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Effects of Low Temperature Stress on the Morphology and hsp70 and hsp90 Gene Expression of Phascolosoma esculenta

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Journal of Ocean University of China 2021年第1期20卷 159-168页

作者： SHEN Weiliang LIU Cheng NI Jie GAO Xinming NI Junjie wang Jianping JIN Shan HOU Congcong WU xiongfei ZHU Junquan Key Laboratory of Applied Marine Biotechnology of Ministry of Education School of Marine SciencesNingbo UniversityNingbo 315211China Ningbo Academy of Oceanology and Fishery Ningbo 315012China

Phascolosoma esculenta is an intertidal organism that has recently attracted attention because of its ability to survive at relatively low ***,the gene regulation in *** in relation to its response to low temperatures is *** explore the low temperature adaptability of ***,this study analyzed the changes in the morphology and hsp70 and hsp90 gene expression of *** exposed to a low temperature *** 5℃,*** stretched and softened,and some individuals moved apart from the *** analysis revealed cuticle breaches,myofiber scattering,disruption of the body wall,and epithelial layer dispersion and muscle fiber rupturing in the ***,the mRNA expression levels of hsp70 and hsp90 increased under acute low temperature stress,suggesting that these genes function in low temperature ***,low temperature stress causes morphological changes and histological damage in ***,and hsp70 and hsp90 potentially function in the low temperature adaptability of *** results provide new insights into the adaptive strategies of *** under low temperature environments.

关键词： Phascolosoma esculenta low temperature morphological alteration hsp70 hsp90

FXYD6： a novel therapeutic target toward hepatocellular carcinoma

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Protein & Cell 2014年第7期5卷 532-543页

作者： Qian Gao xiongfei Chen Hongxia Duan Zhaoqing wang Jing Feng Dongling Yang Lina Song Ningxin Zhou Xiyun Yan Key Laboratory of Protein and Peptide Pharmaceuticals CAS-University of Tokyo Joint Laboratory of Structural Virology and Immunology Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China Medical College of Soochow University Industrial Park Suzhou 215123 China Institute of Hepatobiliary Gastrointestinal Disease General Hospital of PLA Second Artillery Beijing 100088 China

FXYD6, FXYD domain containing ion transport regulator 6, has been reported to affect the activity of Na＋/K＋-ATP- ase and be associated with mental diseases. Here, we demonstrate that FXYD6 is up-regulated in hepatocellular carcinoma （HCC） and enhances the migration and prolif- eration of HCC cells. Up-regulation of FXYD6 not only positively correlates with the increase of Na＋IK＋-ATPase but also coordinates with the activation of its downstream Src-ERK signaling pathway. More importantly, blocking FXYD6 by its functional antibody significantly inhibits the growth potential of the xenografted HCC tumors in mice, indicating that FXYD6 represents a potential therapeutic target toward HCC. Altogether, our results establish a critical role of FXYD6 in HCC progression and suggest that the therapy targeting FXYD6 can benefit the clinical treatment toward HCC patients.

关键词： FXYD6 hepatocellular carcinoma (HCC)tumor progression therapeutic target Na+/K+-ATPase,Src-ERK signaling pathway