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Preparation of Ultra-High-Speed Casein Trade Mark Adhesive

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复旦学报（自然科学版） 2005年第5期44卷 891-892页

作者： xiong-zhi wu Yu-Jiao Li Key Laboratory of Nonferrous Materials and New Processing Technology Ministry of EducationDepartment of Material and Chemical Engineering Guilin University of Technology Guilin541004 China

In present trade mark adhesives for beer bottle labeling are mostly prepared based on starch[1] ,polyvinyl formal[2] and their derivants[3-5] ,but they can only be applied to the labeling speed of 20 000 bottle/h and their water proofness are not satisfactory, especially when the water temperature is 0℃ below. The application of metal foil requires that sealing and labeling must be finished at the same time, but different penetrating speed of water in metal foil and paper label causes different drying speed, and also, the labeling speed and need of iced beer are increasing now, so these changes result in more strict requirements for *** this paper the chelating casein adhesive was obtained with casein as main moldings, urea as dispersing agent, starch as auxiliary, and ZnSO4 as cross-linked agent. The effects of dispersing agent, cross-linked agent and starch on the performances of adhesive were investigated.

关键词：酪蛋白粘合剂螯合效应淀粉

Proposal of new classification for postoperative patients with hepatocellular carcinoma based on tumor growth characteristics

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World Journal of Gastroenterology 2013年第33期19卷 5534-5541页

作者： Cui-Hong Zhu Xiao-Hui Liu Rui Cao xiong-zhi wu ZhongShan-Men in-Patient Department Tianjin Medical University Cancer Institute and Hospital

AIM:To propose an appropriate staging system for hepatocellular carcinoma(HCC)***:Here,288 in-patients with HCC were studied and divided into three groups:those with expansive growth,invasive growth(including satellite nodules,nodule fusions and direct tumor invasion of adjacent organs),or disseminative growth(including vascular involvement,regional lymph node metastasis and distant metastasis).A survival analysis was performed using a Kaplan-Meier analysis,and prognostic factors for overall survival were determined by the Cox proportional hazards regression ***:The overall survival(OS)of patients with invasive tumor growth was shorter than that of patients with expansive tumor growth(27.796±3.730and 57.398±4.873 mo,respectively,P<0.001).No significant difference in survival was observed between patients with vascular involvement and patients with regional lymph node metastasis(21.667±4.773 and14.619±2.456 mo,respectively,P=0.801).The OS of patients with distant metastasis(6.417±1.395mo)was shorter than that of the other groups(P<0.001).No significant difference in survival was observed between patients with expansive tumor growth and vascular and/or regional lymph node involvement and patients with invasive tumor growth and no vascular and/or lymph node involvement(25.762±7.024,21.200±7.794 and 39.533±5.840 mo,respectively;P=0.871,0.307 and 0.563,respectively).CONCLUSION:These data led to the proposal of a new staging system:the Expansive-Invasive-Disseminative growth staging classification.

关键词： Hepatocellular carcinoma Lymph node Metastasis Invasive growth Staging system classification

Effects of aqueous extracts of Aconitum carmichaeli,Rhizoma bolbostemmatis,Phytolacca acinosa,Panax notoginseng and Gekko swinhonis Gūenther on Bel-7402 cells

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World Journal of Gastroenterology 2007年第19期13卷 2743-2746页

作者： Zhu-Chen Yan Dan Chen xiong-zhi wu Guang-Ru Xie Yi Ba Zhao Yan Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 China Tianijn Infectious Diseases Hospital Tianjin 300192China

AIM： To investigate the anticancer activity of a chinese medical mixture, WRCP （warming and relieving Cold Phlegm）, on hepatocarcinoma Bel-7402 cells. METHODS： Fingerprints of WRCP, which were composed of aqueous extracts of Aconitum carmichae/i, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng and Gekko swinhonis Gdenther, and aconitine, which could be isolated from Aconitum carmichaeli and have the potential toxicity, were identified by high pressure liquid chromatography. Bel-7402 cells were grown in the presence of WRCP, As203 or all-trans-retinoic acid （ATRA）. Cell proliferation and viability were determined by trypan blue stain. Apoptosis and cell cycle of Bel-7402 cells were detected by flow cytometry. Morphologic and ultrastructural variations were determined under optic and electronic microscopy. The secretion of alpha-fetoprotein and albumin was detected by radioimmunoassay. RESULTS： The average quality of aconitine is 1.15：1： 0.10 μg per 7.5 g extracts. WRCP could suppress the proliferation and viability of Bel-7402 cells. The percentage of apoptosis cells and S phase cells increased on WRCP-treated cells. Treated with WRCP, Bel-7402 cells showed ultrastructural features of differentiation. The alpha-fetoprotein secretion decreased while the albumin secretion increased （P 〈 0.001, P 〈 0.001, respectively） markedly in WRCP-treated cells. CONCLUSION： WRCP can affect the proliferation, differentiation and apoptosis of Bel-7402 cells. It can arrest cells in S phase and has strong cytotoxicity to Bel-7402 cells.

关键词： Hepatocarcinoma Chinese herb Proliferation Differentiation Apoptosis L--~totoxicity

Cancer field： A new concept

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TMR Cancer 2018年第1期1卷 15-21页

作者： xiong-zhi wu Tianjin Medical University Cancer Institute and Hospital Tianjin 300070 China

The proceeding of cancer development seems to be driven by the complex interaction among cells, stroma and adjacent tissue. Here we advocate a new conception, cancer field, to describe the development of cancer, a complex adaptive system. Cancer field may be divided into center of tumor, periphery of tumor and adjacent tissue. The balance of inhibitors and inducers, including the interaction among cancer cells, niche and adjacent tissue, governs the switch of development of cancer field, which mimic embryonic development, a dynamic process of self-organization. The radial component of intra-tumor heterogeneity raises the field change effects in cancer field. Research strategy may be changed from single cancer cell to cancer field, from malignant transform to cancer development biology.

关键词： Cancer field Self-organization Carcinogenesis Heterogeneity Niche

The role of Si-Jun-Zi decoction in the management of gastric precancerous lesions and its mechanism

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Traditional Medicine Research 2018年第6期3卷 258-259页

作者： xiong-zhi wu TMR

Gastric cancer remains one of the most common and aggressive malignant tumors *** occurence of gastric cancer experiences a cascade of multistep gastric carcinogenesis,starting from inflammation,metaplasia,and ultimately to dysplasia and *** with gastric precancerous lesions,mainly including intestinal metaplasia and dysplasia,are more prone to suffer from gastric adenocarcinoma[1].Therefore,early prevention and treatment regarding gastric precancerous lesions is an important way to reduce the risk of occurence of gastric cancer.

关键词： Gastric cancer tumors worldwide

A review of the treatment for insomnia in patients with cancers

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Life Research 2020年第1期3卷 33-38页

作者： Shuang Liu xiong-zhi wu Tianjin Medical University TianjinChina Tianjin Medical University Cancer Institute and Hospital TianjinChina

Sleep disturbance is considered a prominent problem in cancer patients with a detrimental effect on health outcomes,which accompanies a decline in reduces the quality of life,functional status,and even accelerates progressive of ***,in order to develop new ways to improve the sleeping situations and the quality of life in cancer patients,it is necessary to understand the status of sleep quality in cancer patients and seek more measures of sleep quality evaluation from different cultural *** review summarized the common methods used to improve sleep quality and relieve the pain of cancer *** addition,the status of sleep disturbance in patients with cancer is described.

关键词： Cancer Sleep Insomnia Treatment

Biomechanics mechanism of the anti-tumor effects of sulfated polysaccharide and sulfated glycopeptide

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Tumor Microenvironment Research 2020年第1期2卷 1-6页

作者： xiong-zhi wu Jin-Feng Liu Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300171China

There are also a variety of cytokines in the tumor microenvironment,which are involved in the change in the hardness of the tumor,thereby affecting the invasion and metastasis of tumor *** traditional Chinese medicines,drugs of softening and dissipating firm knot contains different kinds of sulfated polysaccharide and sulfated *** inhibiting the function of cancer-associated fibroblasts,they reduce interstitial fibrosis,thereby reducing the hardness of the tumor and exerting an anti-tumor effect.

关键词： Tumor Metastasis Biomechanics Extracelluar matrix Sulfated polysaccharide Sulfated glycopeptide

Tumor： Life Retrogression？

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TMR Theory and Hypothesis 2018年第1期1卷 2-8页

作者： xiong-zhi wu Hao-Ran Zhang Tianjin Medical University Cancer Institute and Hospital Tianjin China.Correspondence to: Xiong-Zhi Wu Tianjin Medical University Cancer Institute and Hospital Tianjin China

Cancer emerged in human history for centuries. It seems that while human beings are evolving, tumors are always on their heels. In order to explain and study the mechanism of tumor progression, we proposed a new hypothesis that the tumor is a retrogression of life evolution, in other word, a resurgence of some past fragments in human development history. Our inference was based on the fact that tumors are not foreign diseases, but use of human inherent developmental genes to achieve self-improvement. Characteristics and biological behavior of tumor cells are similar to human normal stem cell to some degree. Thus, studying the process of human evolution could speculate and analyze the occurrence and development of tumors. The latest research showed that many cancer treatment were also taking advantages of those features about retrogression. Continuous in-depth analysis about tumor environmental characteristics and internal law of human evolution may produce new approaches to promote cancer prevention and treatment. Our hypothesis, for the first time, proposed that taking advantage of the evolution laws to reverse the tumor progression as a path of life retrogression is better than exterminating them completely as outside enemies. Some new studies on tumor induced differentiation had also demonstrated the clinical significance of our hypothesis

关键词： Tumor Life retrogression Development memory Evolution

Anti-tumor mechanism of Angelica and its compound preparations

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TMR Cancer 2019年第2期2卷 193-199页

作者： Xin-Xiao Lu xiong-zhi wu Tianjin Medical University Cancer Institute and Hospital Tianjin 300070 China

Angelica is a holy medicine for gynecology, clinically used for blood deficiency and chlorosis, dizziness and palpitation, irregular menstruation, dysmenorrhea, abdominal pain, rheumatism, hemorrhoids, constipation. In recent years, with the discovery of polysaccharides enhancing the immune function and anti-tumor effects of the body, Angelica has attracted more and more attention from researchers at home and abroad.

关键词： Angelica Compound preparations The anti-tumor effect