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Potential applications of single-incision laparoscopic totally preperitoneal hernioplasty

World Journal of Gastrointestinal Surgery 2024年第7期16卷 2202-2210页

作者： Xiao-Jun Wang Ting Fei xiong-hua xiang Quan Wang En-Cheng Zhou Department of Gastrointestinal Surgery The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Ambulatory Surgery Center Xijing HospitalAir Force Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND The totally preperitoneal(TPP)approach is a new concept that was recently *** the TPP approach combined with single-incision laparoscopic hernia repair has its own advantages,there is little evidence reflecting the characteristics and feasibility of either *** To analyze the potential applications of single-incision laparoscopic TPP(SILTPP)inguinal hernia hernioplasty for the treatment of inguinal *** A total of 152 SIL-TPP surgeries were performed at the First Affiliated Hospital of Ningbo University from February 2019 to November 2022.A single-port,named Iconport,and standard laparoscopic instruments were used during the *** data,intraoperative parameters and short-term postoperative outcomes were collected and retrospectively *** The demographic data of 152 patients underwent SIL-TPP were shown in Table *** average age was 49.5 years(range from 21 to 81 years).The average body mass index was 27.7 kg/m^(2)(range from 17.7 kg/m^(2) to 35.6 kg/m^(2)).SIL-TPP were conducted successfully in 147 *** patients were converted to the SILtransabdominal preperitoneal laparoscopic herniorrhaphy at the initial stage of the study due to a lack of *** 2 patients with incisional hernias,an auxiliary operation hole was added during the SIL-TPP procedure,as required for *** mean operative time was 64.5 minutes(range:36.0-110.0 minutes)for unilateral direct and femoral hernias and 81.6 minutes for indirect hernias(range:40.0-150.0 minutes).The mean postoperative hospital stay was 3.4 *** SIL-TPP is feasible and has advantages for inguinal hernia ***-TPP has potential benefits for patients with various abdominal wall ***,doctors should be encouraged to actively apply the TPP approach combined with a single incision in their daily work.

关键词： Totally preperitoneal hernioplasty Iconport Single incision laparoscopic Totally extraperitoneal herniorrhaphy Single incision laparoscopic totally preperitoneal hernioplasty

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Dispatchable Capability of Aggregated Electric Vehicle Charging in Distribution Systems

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Energy Engineering 2025年第1期122卷 129-152页

作者： ShiqianWang Bo Liu Yuanpeng hua Qiuyan Li Binhua Tang Jianshu Zhou Yue xiang Economic and Technology Research Institute State Grid Henan Electric Power CompanyZhengzhou450052China College of Electrical Engineering Sichuan UniversityChengdu610065China

This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable *** methodology involves developing a model for aggregated EV charging at the charging station level,estimating its physical dispatchable capability,determining its economic dispatchable capability under economic incentives,modeling its participation in the grid,and investigating the effects of different scenarios and EV penetration on the aggregated load dispatch and dispatchable *** results indicate that using economic dispatchable capability reduces charging prices by 9.7%compared to physical dispatchable capability and 9.3%compared to disorderly ***,the peak-to-valley difference is reduced by 64.6%when applying economic dispatchable capability with 20%EV penetration and residential base load,compared to disorderly charging.

关键词： Aggregated charging dispatchable capability peak shaving and valley filling the economics of charging demand response

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空间视野下少数民族学生普通话学习困境原因探析

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毕节学院学报（综合版） 2013年第6期31卷 105-111页

作者：熊湘华贵阳学院教育科学院贵州贵阳550005

问卷调查及访谈结果表明少数民族学生学习普通话面临的最大困境是:长期被区隔于标准的普通话言语世界之外,缺乏学习普通话的语言环境和心理环境。造成少数民族学生普通话水平低下的原因是:错过了语言学习的黄金期;缺乏学习普通话的融入... 详细信息

问卷调查及访谈结果表明少数民族学生学习普通话面临的最大困境是:长期被区隔于标准的普通话言语世界之外,缺乏学习普通话的语言环境和心理环境。造成少数民族学生普通话水平低下的原因是:错过了语言学习的黄金期;缺乏学习普通话的融入性动机;学校为他们提供的普通话教育服务缺乏人文关怀;已有文化传统、强势方言使他们游离于学习普通话的环境之外。

关键词：空间视野少数民族学生普通话学习困境原因

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轻声的语音修饰作用

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贵阳师范高等专科学校学报（社会科学版） 2005年第2期 60-62页

作者：熊湘华贵阳学院贵州贵阳550008

轻声音长较短,音强较弱,音色偏暗,音高富于变化,附着在阴阳上去四声之后,能给人以委婉、亲切、温柔的感觉。轻声在语流中与重读音节形成对比,可以起到调节音高音长的作用,造成语句高低起伏、错落有致的节奏,给人轻重相间的听觉美感。在... 详细信息

轻声音长较短,音强较弱,音色偏暗,音高富于变化,附着在阴阳上去四声之后,能给人以委婉、亲切、温柔的感觉。轻声在语流中与重读音节形成对比,可以起到调节音高音长的作用,造成语句高低起伏、错落有致的节奏,给人轻重相间的听觉美感。在口语应用中还可以通过改变轻声的读音的方式,来表达语义,满足语用的需要,实现交际目的。

关键词：轻声语音修饰节拍节奏超常变异普通话

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强化观察能力提高作文水平

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贵州教育学院学报 2001年第1期17卷 83-85页

作者：熊湘华贵阳师专贵州贵阳550008

中学生畏惧作文 ,这是因为生活阅历浅 ,写作素材贫乏所致。要改变这种现状。

关键词：作文教学观察能力兴趣中学作文方法

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“X客”族词研究

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贵阳学院学报（社会科学版） 2013年第3期8卷 66-69页

作者：熊湘华贵阳学院教育科学学院贵州贵阳550005

汉语中的"X客"族词主体是类后缀式指人的词,其中的"客"指"……的人"。这一现象形成的主要原因是人们认知心理的影响。"客"的高频使用最终使其意义抽象化,而形成"……的人"的认知模型,进而构建出一个"X客"的词语模,这一词语模具有较强的... 详细信息

汉语中的"X客"族词主体是类后缀式指人的词,其中的"客"指"……的人"。这一现象形成的主要原因是人们认知心理的影响。"客"的高频使用最终使其意义抽象化,而形成"……的人"的认知模型,进而构建出一个"X客"的词语模,这一词语模具有较强的类推构词能力,只要符合"……的人"这一认知模型的表达,都可以构成"X客"族词。

关键词： “X客”族词来源分类意义分类认知

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语言态度与情感对语言学习和使用的影响——对贵阳学院师范生语言使用状况的调查

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贵阳学院学报（社会科学版） 2008年第4期3卷 50-53页

作者：熊湘华贵州大学人文学院贵州贵阳550025

普通话是教师的职业语言。贵阳学院的师范生生活在普通话和方言并存的双语交际社团内,他们的语言态度与语言情感制约着他们对普通话的学习和使用。要提高师范生的普通话水平就必须营造一个良好的语言习得环境;扫除方言区师范生学习普通... 详细信息

普通话是教师的职业语言。贵阳学院的师范生生活在普通话和方言并存的双语交际社团内,他们的语言态度与语言情感制约着他们对普通话的学习和使用。要提高师范生的普通话水平就必须营造一个良好的语言习得环境;扫除方言区师范生学习普通话的心理障碍,帮助和引导学生对普通话学习产生归附动机;针对发音部位、发音方法以及语音结构形成的相对固定的模式,对症下药,进行强化练习以形成新的语音模式。

关键词：普通话师范生语言态度语言情感贵阳话

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南海西沙海域西琛1井生物礁的性质及岩石学特征

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地质通报 2008年第11期27卷 1933-1938页

作者：魏喜贾承造孟卫工熊湘华中国石油勘探开发研究院博士后流动站北京100083 中国石油辽河油田公司博士后工作站辽宁盘锦124010 中国石油杭州地质研究院浙江杭州310023

西沙海域西琛1井生物礁主要是由红藻门壳状珊瑚藻、有节珊瑚藻和绿藻门仙掌藻等钙藻组成的植物礁,其次为珊瑚礁。礁相类型主要有礁核相和礁后泻湖相。岩石矿物成分单一,以碳酸盐矿物为主,包括低镁方解石和铁白云石;结构组分有生物骨架... 详细信息

西沙海域西琛1井生物礁主要是由红藻门壳状珊瑚藻、有节珊瑚藻和绿藻门仙掌藻等钙藻组成的植物礁,其次为珊瑚礁。礁相类型主要有礁核相和礁后泻湖相。岩石矿物成分单一,以碳酸盐矿物为主,包括低镁方解石和铁白云石;结构组分有生物骨架、粒屑、泥晶和亮晶;结构类型有生物格架、生物障积、生物节片、生物捆扎和生物粘结结构。岩石类型包括骨架石灰岩/白云岩、粘结石灰岩/白云岩、粒屑石灰岩/白云岩。储集空间类型有粒间孔、生物体腔孔、藻架孔等原生孔隙和铸模孔、裂缝、颗粒内溶蚀孔、藻类溶孔、扩大的粒间溶孔等次生孔隙。孔隙组合类型以粒间孔+溶孔+晶间孔最为发育,储集性能较好。

关键词：西沙海域生物礁性质储层岩石学特征新近纪以来

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Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting xiang xiangxin Xing Xuyun hua Yuwen Zhang Xin Xue Jiajia Wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： Chen xiong Hong Ling Yingdan huang Hanzhi Dong Bangxiang Xie Qian Hao xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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