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Chinese Chemical Letters 2023年第6期34卷 583-587页

作者： xiali xiong Wei Geng Minna Cao Rong Cao State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy SciencesFuzhou 350002China College of Chemistry Engineering Fuzhou UniversityFuzhou 350108China University of Chinese Academy of Sciences Beijing 100049China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou 350108China

Developing efficient and stable electrocatalyst to hydrogen evolution reaction adaptable for electrolytes with different p H is a big *** this work,a hierarchically structured ternary nanohybrid composed of flower-like Ru nanoparticles,rigid macrocyclic cucurbit[6]uril(CB[6])and carboxylated multiwalled carbon nanotubes(MWCNTs)was successfully prepared by chemical wet *** by the structural merits of flower-like Ru nanoparticles exposed abundant active sites supported by the MWCNTs holding superior mass transport and electrons transfer ability as well as the existence of CB[6],the obtained catalyst exhibited outstanding HER activities with overpotentials of 27,37 and 70 m V at-10 m A/cm^(2) in alkaline,acidic,and neutral electrolytes,*** the same electrocatalytic operation conditions,the HER performance is comparable or superior to commercial Pt/C catalyst(47,27and 49 m V).Besides,chronopotentiometric and accelerated stability test also revealed its extraordinary stability,which could be further employed for electrocatalytic procedure in a broad pH range.

关键词： Ruthenium Cucurbit[n]uril Hierarchical structure Hydrogen evolution reaction pH-universal

Vaginal delivery after 37 days of a convalescent pregnant woman with COVID-19: a case report

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中华围产医学杂志 2020年第4期 280-282页

作者： xiong xiali Pang Qiumei Wei Hong Ma Xiaopeng Zhang Zhihong Gao Xiang Department of Obstetrics and Gynecology Beijing You''an Hospital Capital Medical University Beijing 100069 China

We present a case report of a healthy neonate born by vaginal delivery to a woman who had recovered from COVID-19 after 37 days of discharge. The pregnant woman had fever, cough, and chills at 33+1 gestational weeks and was diagnosed with COVID-19 by coronavirus nucleic acid test one day later. She recovered and was discharged after a series of treatment, and the 2019 novel coronavirus nucleic acid test and pulmonary CT were negative at the 2nd and 4th weeks after being discharged. The patient was admitted in early labor at 38+4 gestational weeks and delivered a healthy newborn vaginally at that day. Both the mother and the baby were in good condition. All the maternal or neonatal specimens taken immediately after birth in the delivery room for 2019 novel coronavirus nucleic acid tests were negative, including the maternal pharynx, rectal and cervical secretions, amniotic fluid, an neonatal pharynx and rectal swabs. The qualitative examination of 2019 novel coronavirus antibodies in the maternal venous blood test showed that both IgG and IgM were positive. While the same test for neonatal cord blood and femoral vein blood showed negative results. No inflammatory reaction was found in the placenta and immunohistochemistry detection of novel coronavirus N protein was negative. The mother and newborn were observed postnatally and treated in the same ward, neither of them had fever, cough or fatigue, and were discharged three days after delivery. The qualitative examination of 2019 novel coronavirus antibodies (IgM and IgG) in the femoral vein blood of the nenonate 27 days old showed negative results.

关键词： Coronavirus infections Pregnancy complications, infectious Parturition

孕晚期新型冠状病毒肺炎确诊后37天阴道分娩一例

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中华围产医学杂志 2020年第5期23卷 339-341页

作者：熊霞鹂庞秋梅魏宏马晓鹏张志红高翔首都医科大学附属北京佑安医院妇幼中心

本文报道1例孕33周+1出现发热、干咳和寒战,次日经咽拭子核酸检测确诊的新型冠状病毒肺炎(COVID-19)孕妇,确诊后37 d阴道分娩一健康新生儿。该孕妇COVID-19治疗出院后2和4周复查病毒核酸及肺部CT均无异常。孕38周+4因先兆临产入院,当日... 详细信息

本文报道1例孕33周+1出现发热、干咳和寒战,次日经咽拭子核酸检测确诊的新型冠状病毒肺炎(COVID-19)孕妇,确诊后37 d阴道分娩一健康新生儿。该孕妇COVID-19治疗出院后2和4周复查病毒核酸及肺部CT均无异常。孕38周+4因先兆临产入院,当日阴道分娩一健康男婴,母儿结局良好。孕妇分娩前咽部、直肠、宫颈分泌物及产时羊水、产后初乳,新生儿咽部、直肠拭子新型冠状病毒核酸检测均阴性；孕妇分娩前血清新型冠状病毒特异性抗体定性检查IgG和IgM均阳性,分娩时新生儿脐带血及股静脉血新型冠状病毒特异性IgG和IgM均阴性；胎盘病理未见炎症反应,免疫组织化学检测新型冠状病毒N蛋白呈阴性。产妇及新生儿于母婴同室病房观察治疗,均无发热、咳嗽、乏力等表现,产后3 d均顺利出院。新生儿生后27 d复查股静脉血新型冠状病毒特异性IgG和IgM均阴性。

关键词：冠状病毒感染妊娠并发症,感染性分娩

妊娠期肝内胆汁淤积症对HBV感染孕妇妊娠不良结局的影响

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临床肝胆病杂志 2022年第8期38卷 1763-1767页

作者：熊霞鹂朱云霞魏宏赵志强孟君邹怀宾段钟平首都医科大学附属北京佑安医院产科北京100069 首都医科大学附属北京佑安医院疑难肝病及人工肝中心北京100069

目的探讨妊娠期肝内胆汁淤积症(ICP)对HBV感染孕妇不良妊娠结局的影响。方法回顾性选取2018年3月—2021年3月首都医科大学附属北京佑安医院收治的232例慢性HBV感染孕妇。按照孕期是否存在ICP,分为单纯HBV感染组(n=100)和HBV+ICP组(n=13... 详细信息

目的探讨妊娠期肝内胆汁淤积症(ICP)对HBV感染孕妇不良妊娠结局的影响。方法回顾性选取2018年3月—2021年3月首都医科大学附属北京佑安医院收治的232例慢性HBV感染孕妇。按照孕期是否存在ICP,分为单纯HBV感染组(n=100)和HBV+ICP组(n=132);根据ICP严重程度将HBV+ICP组进一步分为HBV+轻度ICP组(n=86)和HBV+重度ICP组(n=46)。比较各组妊娠期母体并发症发生率情况,如早产、胎膜早破、妊娠期糖尿病、妊娠期高血压疾病、产后出血(PPH)发生率情况;以及分别比较各组胎儿/新生儿不良结局情况,如胎死宫内、新生儿窒息、羊水Ⅲ度污染(AFⅢ)、新生儿呼吸窘迫综合征、小于胎龄儿(SGA)、转入新生儿重症监护病房、肺炎以及HBV母婴传播(MTCT)发生情况。计量资料多组间比较采用单因素方差分析;计数资料组间比较采用χ^(2)检验、连续校正χ^(2)检验或Fisher精确概率法。结果HBV+ICP组孕妇在孕晚期母体并发症方面,早产、PPH发生率较单纯HBV感染组增加,差异均有统计学意义(χ^(2)值分别为4.169、5.448,P值分别为0.041、0.020);HBV+ICP组孕妇所分娩新生儿在不良妊娠结局方面,新生儿窒息、AFⅢ及SGA发生率较单纯HBV感染组均增加,差异有统计学意义(χ^(2)值分别为5.448、16.567、11.053,P值分别为0.020、<0.001、0.002)。HBV+重度ICP组孕妇所分娩新生儿在不良妊娠结局方面,AFⅢ及SGA发生率较HBV+轻度ICP组增加,差异均有统计学意义(χ^(2)值分别为4.200、4.511,P值分别为0.040、0.034)。结论HBV感染合并ICP孕妇母体及新生儿不良妊娠结局的发生率相较于单纯HBV感染明显升高,且ICP程度越重,新生儿分娩不良结局发生率越高,但ICP对HBV-MTCT未见影响。

关键词：乙型肝炎病毒胆汁淤积,肝内妊娠

富马酸替诺福韦二吡呋酯对HBV感染孕妇肾功能和胎儿生长发育的安全性研究

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实用肝脏病杂志 2022年第4期25卷 484-487页

作者：熊霞鹂魏宏朱云霞段钟平首都医科大学附属北京佑安医院肝病产科北京市100069 首都医科大学附属北京佑安医院肝病内科北京市100069

目的评估HBV感染孕期应用富马酸替诺福韦二吡呋酯(TDF)抗病毒治疗对肾功能及对胎儿生长发育的影响。方法2018年7月1日~2019年6月30日首都医科大学附属北京佑安医院分娩的HBV感染孕妇120例,孕期全程口服TDF治疗40例(A组),孕中晚期口服TD... 详细信息

目的评估HBV感染孕期应用富马酸替诺福韦二吡呋酯(TDF)抗病毒治疗对肾功能及对胎儿生长发育的影响。方法2018年7月1日~2019年6月30日首都医科大学附属北京佑安医院分娩的HBV感染孕妇120例,孕期全程口服TDF治疗40例(A组),孕中晚期口服TDF治疗40例(B组),未抗病毒治疗40例(C组)。检测血清磷(P)、肾小球滤过率(GFR)、肌酐(sCr)、肌酸激酶(CK)、尿蛋白(uPRO),记录新生儿出生时头围、身长、体质量和不良事件。结果在孕36周时,A组血P、GFR、sCr、CK和uPRO分别为(1.2±0.1)mmol/L、(120.9±7.9)mL/(min·1.73 m^(2))、(52.1±7.9)μmol/L、(57.7±21.8)U/L、6例(15.0%),与B组【分别为(1.2±0.1)mmol/L、(119.5±9.4)mL/(min·1.73 m^(2))、(50.6±7.7)μmol/L、(56.6±18.8)U/L、5例(12.5%)】或C组【分别为(1.2±0.1)mmol/L、(125.7±8.7)mL/(min·1.73 m^(2))、(48.9±7.2)μmol/L、(53.9±16.1)U/L、4例(10.0%)】比,均无显著性差异(P>0.05);分娩时,A组孕妇新生儿身高、头围和体质量分别为(50.0±1.1)cm、(333.6±5.1)cm和(3383±319)g,与B组【分别为(49.9±1.2)cm、(333.9±5.1)cm和(3215±327)g】或C组【分别为(50.1±1.1)cm、(332.9±5.7)cm和(3284±328)g】比,均无显著性差异(P>0.05);在分娩不良事件方面,仅C组出现1例新生儿锁骨骨折。结论TDF对HBV感染孕妇肾功能和胎儿生长发育无显著影响,母儿安全性良好。

关键词：乙型肝炎病毒携带者替诺福韦酯孕妇胎儿

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乙型肝炎病毒对妊娠期糖尿病孕妇妊娠结局的影响

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西部医学 2022年第8期34卷 1199-1203,1208页

作者：熊霞鹂朱云霞魏宏赵志强高翔张志红孟君首都医科大学附属北京佑安医院产科北京100069

目的观察乙型肝炎病毒(HBV)对妊娠期糖尿病(GDM)患者妊娠结局的影响。方法纳入2019年10月~2021年4月于我院收治的160例GDM患者为研究对象,开展回顾性分析。按照是否存在HBV感染,将所有患者分为观察组(GDM合并HBV感染,96例)和对照组(单纯... 详细信息

目的观察乙型肝炎病毒(HBV)对妊娠期糖尿病(GDM)患者妊娠结局的影响。方法纳入2019年10月~2021年4月于我院收治的160例GDM患者为研究对象,开展回顾性分析。按照是否存在HBV感染,将所有患者分为观察组(GDM合并HBV感染,96例)和对照组(单纯GDM,64例);观察组根据孕期是否出现肝功能异常分为肝功能异常组(42例)及肝功能正常组(54例)。分别比较观察、对照组以及肝功能异常、肝功能正常组孕妇孕期胰岛素使用率,孕妇在妊娠期高血压疾病(HDCP)、妊娠期肝内胆汁淤积症(ICP)、胎膜早破(PROM)、产后出血(PPH)、早产、剖宫产的发生率;分别比较各组新生儿在分娩时的新生儿窒息、小于胎龄儿(SGA)、巨大儿及新生儿低血糖的发生率。结果观察组孕妇孕期胰岛素使用率,母体并发症如ICP、PPH、早产的发生率均明显高于对照组,差异具有统计学意义(均P0.05)。观察组新生儿并发症如新生儿窒息、SGA的发生率均明显高于对照组,差异具有统计学意义(均P0.05)。肝功能异常组新生儿并发症如新生儿窒息、SGA及新生儿低血糖发生率均明显高于肝功能正常组,差异具有统计学意义(均P<0.05)。结论HBV感染可增加GDM孕妇孕期胰岛素使用率,导致GDM孕妇不良母儿结局增加,且胰岛素使用率及不良母儿结局发生率可能与肝功能相关。

关键词：乙型肝炎病毒感染妊娠期糖尿病妊娠结局

Effect of aerobic exercise on GRP78 and ATF6 expressions in mice with non-alcoholic fatty liver disease

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Sports Medicine and Health Science 2023年第2期5卷 112-119页

作者： Junhan Li Lei Huang Wei xiong Chun Gu Shuling Zhang xiali Xue School of Sports Medicine and Health Chengdu Sport UniversityChengduSichuan ProvinceChina Department of Exercise Rehabilitation Sichuan Provincial Orthopedic HospitalChengduSichuan ProvinceChina Department of Hepatobiliary Surgery Sichuan Provincial People's HospitalChengduSichuan ProvinceChina

Nonalcoholic fatty liver disease(NAFLD)is a prevalent medical condition with an ever-growing *** multiple intracellular mechanisms are involved,endoplasmic reticulum(ER)stress has been demonstrated to play a significant role in the genesis and *** of the research supports the advantages of exercise for ***,little is known about the molecular mechanism(s)that underpin the effectiveness of exercise training in *** study aimed to identify how aerobic exercise affected hepatic ER stress in a mouse NAFLD *** this study,the mice were fed either a standard diet(SD)or a high-fat diet(HFD)for 17 *** mice were trained on a treadmill during the last eight *** animals were tested for serum levels of biochemical assays,protein expression,and gene *** hematoxylin and eosin,Oil red O,and immunohistochemistry staining were also *** results indicated that a high-fat diet generated NAFLD,with serum lipid disruption and hepatic function impairment,and increased GRP78 and ATF6 ***,aerobic training reversed the majority of these *** is concluded that NAFLD appears to be associated with hepatic ER stress response,and aerobic exercise mitigates NAFLD via lowering ER stress proteins GRP78 and ATF6.

关键词： Endoplasmic reticulum stress Exercise GRP78 ATF6 Nonalcoholic fatty liver disease

The MKK3–MPK7 cascade phosphorylates ERF4 and promotes its rapid degradation to release seed dormancy in Arabidopsis

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Molecular Plant 2023年第11期16卷 1743-1758页

作者： Xi Chen Qiujia Li Ling Ding Shengnan Zhang Siyao Shan xiong xiong Wenhui Jiang Bo Zhao Liying Zhang Ying Luo Yiming Lian Xiuqin Kong xiali Ding Jun Zhang Chunli Li Wim J.J.Soppe Yong Xiang Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Center for Crop Science College of AgronomyQingdao Agricultural UniversityQingdao 266109China School of Petrochemical Engineering Lanzhou University of TechnologyLanzhou 730050China Hou Ji Laboratory in Shanxi Province Academy of AgronomyShanxi Agricultural UniversityTaiyuan 030031China State Key Laboratory of Silkworm Genome Biology Southwest UniversityChongqing 400715China Rijk Zwaan 2678 ZG De Lierthe Netherlands

Seeds establish dormancy to delay germination until the arrival of a favorable growing *** this study,we identify a fate switch comprised of the MKK3–MPK7 kinase cascade and the ethylene response factor ERF4 that is responsible for the seed state transition from dormancy to *** show that dormancy-breaking factors activate the MKK3–MPK7 module,which affects the expression of some a-EXPANSIN(EXPA)genes to control seed ***,we identify a direct downstream substrate of this module,ERF4,which suppresses the expression of these EXPAs by directly binding to the GCC boxes in their exon *** activated MKK3–MPK7 module phosphorylates ERF4,leading to its rapid degradation and thereby releasing its inhibitory effect on the expression of these ***,our work identifies a signaling chain consisting of protein phosphorylation,degradation,and gene transcription,by which the germination promoters within the embryo sense and are activated by germination signals from ambient conditions.

关键词： seed dormancy dormancy breaking seed germination MKK3 MPK7 ERF4 phosphorylation protein degradation DNA binding

A Textual Research on Materia Medica of Origin of Orthonym and Synonym of Cuscutae Semen

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Medicinal Plant 2021年第1期12卷 16-19,24页

作者： xiali WU Dongxue BAI Cheng SONG Yaozu xiong Jia LU Yanhui ZHAO School of Pharmacy Liaoning University of Traditional Chinese MedicineDalian 116600China Library of Liaoning University of Traditional Chinese Medicine Shenyang 110032China

A textual research on materia medica of origin of orthonym and synonym of Cuscutae Semen and synonym of Nu Luo was conducted in this study,and the trade name,regional synonym and nickname of Cuscutae Semen were *** records of orthonym and synonym of Cuscutae Semen in the past dynasties,and the first published literature and writing date of orthodox and synonym were *** textual research showed that Nu Luo and Cuscutae Semen were not the same plant,which had positive significance for the identification of the origin and modern application of Cuscutae Semen.

关键词： Semen Cuscutae Nu Luo Orthonym Synonym Textual research on materia medica Review

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一种基于非对称加密的自动信任协商模型

高技术通讯 2022年第9期32卷 922-926页

作者：田夏利熊莹武汉华夏理工学院信息工程学院武汉430223

自动信任协商(ATN)是通过交换数字证书和访问控制策略在陌生人之间建立信任关系的一种重要手段。在协商过程中,可能存在协商模式过于复杂而无法完成协商、用户证书里的敏感信息泄露、因加密算法安全强度不足而遭受攻击等问题。针对这些... 详细信息

自动信任协商(ATN)是通过交换数字证书和访问控制策略在陌生人之间建立信任关系的一种重要手段。在协商过程中,可能存在协商模式过于复杂而无法完成协商、用户证书里的敏感信息泄露、因加密算法安全强度不足而遭受攻击等问题。针对这些不足,本文提出了一种基于非对称加密的自动信任协商模型,该模型采用灵活的证书格式、分步骤的证书交换等手段来满足访问控制策略的要求,采用非对称加密技术对传输消息进行加密,防止信息泄漏。

关键词：自动信任协商(ATN) 数字证书非对称加密信息泄露协商模型