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C-reactive protein functions as a negative regulator of macrophage activation induced by apoptotic DNA

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Protein & Cell 2011年第8期2卷 672-679页

作者： Weijuan Zhang Yanxing Cai Wei Xu sidong xiong Institute for Immunobiology and Department of Immunology Shanghai Medical CollegeFudan UniversityShanghai 200032China Jiangsu Key Laboratory of Infection and Immunity Institutes of Biology and Medical SciencesSoochow UniversitySuzhou 215123China

C-reactive protein(CRP),an acute-phase protein with an ability to bind to nuclear antigen,has been reported to regulate cytokine secretion and modulate immune *** previously reported that activated syngeneic lymphocyte-derived apoptotic DNA(apopDNA)could induce macrophage activation and contribute to the initiation and progression of lupus *** is reasonable to hypothesize that CRP might regulate apopDNA-induced macrophage ***,CRP was shown to promote macrophage-mediated apopDNA uptake by binding to apopDNA(CRP/apopDNA complex).Notably,CRP/apopDNA treatment inhibited the production of inflammatory cytokines and chemokines by macrophages which could be induced by apopDNA *** coculture and transwell studies revealed that CRP/apopDNA-induced macrophages prohibited apopDNA-induced macrophage activation in an IL-10 dependent *** results provide insight into the potential mechanism of CRP regulatory activity in macrophage activation induced by apopDNA in the context of lupus nephritis and other autoimmune diseases.

关键词： C-reactive protein(CRP) macrophage activation autoimmunity systemic lupus erythematosus(SLE) lupus nephritis

CD4^(+) T cell-released exosomes inhibit CD8^(+) cytotoxic T-lymphocyte responses and antitumor immunity

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Cellular & Molecular Immunology 2011年第1期8卷 23-30页

作者： Haifeng Zhang Yufeng Xie Wei Li Rajni Chibbar sidong xiong Jim Xiang Research Unit Health Research DivisionSaskatchewan Cancer AgencyDepartment of Oncology and ImmunologyUniversity of SaskatchewanSaskatoonSask.Canada Research Unit Health Research DivisionSaskatchewan Cancer AgencyDepartment of PathologyUniversity of SaskatchewanSaskatoonSask.Canada Institute of Biology and Medical Sciences Soochow UniversitySuzhouChina

T cells secrete bioactive exosomes(EXO),but the potential immunoregulatory effect of T-cell EXO is largely *** this study,we generated activated ovalbumin(OVA)-specific CD4^(+) T cells in vitro via coculture of OVA-pulsed dendritic cells(DC_(OVA))with naive CD4^(+) T cells derived from OVA-specific T-cell receptor(TCR)transgenic OTII ***4^(+) T-cell EXO were then purified from the CD4^(+) T-cell culture supernatants by differential ***4^(+) T-cell EXO exhibited the‘saucer’shape that is characteristic of EXO with a diameter between 50 and 100 nm,as assessed by electron microscopy,and contained the EXO-associated proteins LAMP-1,TCR and lymphocyte function associated antigen-1(LFA-1),as determined by western *** cytometric analysis showed that CD4^(+) T-cell EXO expressed CD4^(+) T-cell markers(CD4,TCR,LFA-1,CD25 and Fas ligand),but to a lesser extent than CD4^(+) T *** demonstrated that DC_(OVA) took up CD4^(+) T-cell EXO via peptide/major histocompatibility complex(pMHC)II/TCR and CD54/LFA-1 ***-specific CD4^(+) T-cell EXO from OTII mice,but not ConA-stimulated polyclonal CD4^(+) T-cell EXO from wild-type C57BL/6 mice inhibited DC_(OVA)-stimulated in vitro CD4^(+) T-cell proliferation and in vivo CD81 cytotoxic T lymphocyte(CTL)responses and antitumor immunity against OVA-expressing B16 melanoma BL6-10OVA *** addition,EXO derived from a T-cell hybridoma cell line,MF72.2D9,expressing an OVA-specific CD4^(+) TCR,had a similar inhibitory effect as OTII CD4^(+) T-cell EXO on CTL-mediated antitumor *** together,our data indicate that antigen-specific T-cell EXO may serve as a new type of immunosuppressive reagent for use in transplant rejection and treatment of autoimmune diseases.

关键词： antitumor immunity CTL T-cell exosome

A novel oncolytic virus engineered with PD-L1 scFv effectively inhibits tumor growth in a mouse model

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Cellular & Molecular Immunology 2019年第9期16卷 780-782页

作者： Chuanjian Wu Manman Wu Minglong Liang sidong xiong Chunsheng Dong Jiangsu Key Laboratory of Infection and Immunity The Institutes of Biology and Medical SciencesSoochow University199 Ren-Ai RoadSuzhou 215123 JiangsuChina

The adoptive transfer of engineered chimeric antigen receptor(CAR)T cells has yielded impressive clinical results for targeting hematological cancers.1 However,the advancement of CAR T-cell therapy in solid tumors remains limited,due to the scarcity of tumor antigens that are deemed safe for ***,the requirement of patient-specific autologous T cells for the current standard treatment has also hampered its *** virus(OV)therapy has been classified as another form of novel immunotherapy.

关键词： therapy clinical engineered

A single dose of recombinant VSV-RABVG vaccine provides full protection against RABV challenge

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Virologica Sinica 2022年第3期37卷 455-458页

作者： Minglong Liang Zongmei Wang Chuanjian Wu sidong xiong Ling Zhao Chunsheng Dong Jiangsu Key Laboratory of Infection and Immunity Institutes of Biology and Medical SciencesSoochow UniversitySuzhou 215123China State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan 430070China Key Laboratory of Preventive Veterinary Medicine of Hubei Province College of Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China

Dear Editor,Rabies virus(RABV)is an enveloped,non-segmented,and singlestranded RNA virus that belongs to the genus Lyssavirus within the Rhabdoviridae family(Douglas et al.,2013).RABV causes rabies,and although vaccines are available,rabies continues to be a global public health concern causing more than 60,000 human deaths each year(WHO,2013).There is a high prevalence especially in developing countries in Asia and Africa(Hampson et al.,2015;Singh et al.,2017).

关键词： al. vaccine Rabies

A Vesicular Stomatitis Virus-Based Vaccine Carrying Zika Virus Capsid Protein Protects Mice from Viral Infection

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Virologica Sinica 2019年第1期34卷 106-110页

作者： Xiaodan Shi Jingping Hu Jing Guo Chuanjian Wu sidong xiong Chunsheng Dong Jiangsu Key Laboratory of Infection and Immunity The Institutes of Biology and Medical SciencesSoochow University

Dear Editor,Zika virus (ZIKV) is a mosquito-borne virus that belongs to the Flavivirus family along with dengue virus (DENV),yellow fever virus, West Nile virus, and Japanese encephalitis virus (Ming et al. 2016). ZIKV is a singlestranded positive-sense RNA virus encoding three structural proteins, including nucleocapsid protein C, prM/M,envelope glycoprotein E, and seven non-structural *** 2015.

关键词： VSV A Vesicular Stomatitis Virus-Based Vaccine Carrying Zika Virus Capsid Protein Protects Mice from Viral Infection

HIV/AIDS患者感染新型冠状病毒发病特征及机制的研究进展

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皮肤病与性病 2024年第4期46卷 248-253页

作者：汤蓓蓓胡琰熊思东宋天章郑永唐苏州大学药学院江苏苏州215021 中国科学院昆明动物研究所中国科学院动物模型与人类疾病机理重点实验室云南昆明650223

新型冠状病毒肺炎疫情已成为21世纪波及范围最广,危害最严重的全球公共卫生事件。免疫功能紊乱是导致新型冠状病毒感染者疾病进展快、多器官功能障碍及死亡的主要原因。作为存在持续免疫损伤的特殊人群,HIV感染者呈现长期免疫活化、免... 详细信息

新型冠状病毒肺炎疫情已成为21世纪波及范围最广,危害最严重的全球公共卫生事件。免疫功能紊乱是导致新型冠状病毒感染者疾病进展快、多器官功能障碍及死亡的主要原因。作为存在持续免疫损伤的特殊人群,HIV感染者呈现长期免疫活化、免疫耗竭、免疫衰老等免疫紊乱特征,其新型冠状病毒感染后的病程及损伤机制可能存在特异性。本文综述了HIV感染者新型冠状病毒感染的流行病学、临床病理学、病毒变异等特征,阐述了针对HIV感染者新冠治疗措施、疫苗有效性及特异性疫苗研发等方面的研究进展。

关键词：人类免疫缺陷病毒新型冠状病毒共感染

Mechanisms of molecular recognition and cellular regulation involved in Self-DNA induced SLE

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Mechanisms of molecular recognition and cellular regulation ...

核酸疫苗技术平台在预防性疫苗开发中的前瞻性观点

第十届全国免疫学学术大会

作者： sidong xiong Institutes of Biology and Medical Sciences (IBMS) Soochow University

Systemic lupus erythematosus(SLE)is the prototype of autoimmune disease and the mechanisms underlying the disease have not yet been *** we reported that a murine model of SLE induced by syngeneic activated lymphocyted...

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中华微生物学和免疫学杂志 2024年第7期44卷 565-572页

作者：汪萱怡王宾熊思东高晓明彭育才金侠朱涛英博寸韡姜春来于继云陈则陈建军莘春林复旦大学生物医学研究院上海市重大传染病和生物安全研究院上海200032 复旦大学基础医学院上海200032 艾棣维欣(苏州)生物制药有限公司苏州215002 苏州大学生物医学研究院苏州215021 珠海丽凡达生物技术有限公司珠海519000 深圳医克生物技术有限公司深圳518000 天津康希诺生物技术有限公司天津300457 苏州艾博生物科技有限公司苏州215123 云南彤宁生物制药技术有限公司昆明650032 长春百克生物科技股份公司长春130103 北京震旦鼎泰生物科技有限公司北京102400 湖南师范大学生命科学学院长沙410006 中国科学院武汉病毒研究所武汉430207

2023年11月,第七届全国核酸疫苗大会召开,会议深入探讨了核酸疫苗的免疫机制、安全风险及优劣势,并回顾了新型冠状病毒核酸疫苗的安全性和有效性。最终形成了会议观点,即在后疫情时代,核酸疫苗技术将在以下几个领域发挥作用:一是应对传... 详细信息

2023年11月,第七届全国核酸疫苗大会召开,会议深入探讨了核酸疫苗的免疫机制、安全风险及优劣势,并回顾了新型冠状病毒核酸疫苗的安全性和有效性。最终形成了会议观点,即在后疫情时代,核酸疫苗技术将在以下几个领域发挥作用:一是应对传统疫苗难以应对的病原体;二是促进传统减毒活疫苗的升级换代;三是助力开发多价与联合疫苗;四是快速响应新发及再现传染病挑战。这些观点为核酸疫苗技术的未来发展指明了方向。

关键词：核酸免疫保护机制安全性预防性疫苗

ER stress aggravates CVB3-induced myocarditis by promoting NF-κB-mediated proinflammatory cytokine production

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ER stress aggravates CVB3-induced myocarditis by promoting N...