检索结果-南通市图书馆

Karst trough control of solute transport processes at two karst groundwater flow systems， Western Hubei， Central China

引用

Journal of Earth Science 2022年

作者： Wang Yi'an Zhao Ruichao Ding Lin xiong shuai Li Yin Bu Jianwei Chen Wei Zhou Hong Liu Wei Institute of Geological Survey， China University of Geosciences Geological Environmental Center of Hubei Province School of Environmental Studies， China University of Geosciences State Key Laboratory of Biogeology and Environmental Geology， China University of Geosciences Hubei Key Laboratory of Environmental Water Science in the Yangtze River Basin， China University of Geosciences Hubei Provincial Engineering Research Center of Systematic Water Pollution Control， China University of Geosciences Key Laboratory of Karst Dynamics， MNR & Guangxi， Institute of Karst Geology Key Laboratory of Karst Ecosystem and Treatment of Rocky Desertification， Institute of Karst Geology

To investigate groundwater flow and solute transport characteristics of the karst trough zone in China， tracer experiments were conducted at two adjacent typical karst groundwater flow systems (Yuquandong （YQD） and Migongquan （MGQ）) in Sixi valley， western Hubei， China. High-resolution continuous monitoring was utilized to obtain breakthrough curves （BTCs）， which were then analyzed using the multi-dispersion model （MDM） and the two-region nonequilibrium model （2RNE） with basic parameters calculated by CXTFIT and QTRACER2. Results showed that: （1） YQD flow system had a complex infiltration matrix with overland flow， conduit flow and fracture flow， while the MGQ flow system was dominated by conduit flow with fast flow transport velocity， but also small amount of fracture flow there; （2） they were well fitted based on the MDM (R;=0.928) and 2RNE (R;=0.947) models， indicating that they had strong adaptability in the karst trough zone; （3） conceptual models for YQD and MGQ groundwater systems were generalized. In YQD system， the solute was transported via overland flow during intense rainfall， while some infiltrated down into fissures and conduits. In MGQ system， most were directly transported to spring outlet in the fissure-conduit network.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

综掘工作面气室降尘技术研究

引用

工矿自动化 2024年第1期50卷 80-87页

作者：张京兆苏慧冬闫振国马文杰熊帅张宸毓西安科技大学安全科学与工程学院陕西西安710054

针对掘进巷道中的粉尘控制问题,传统的长压短抽通风降尘技术存在粉尘扩散区域大、风幕降尘技术存在射流孔易堵塞等弊端。以巴拉素煤矿综掘工作面为工程研究背景,建立了掘进作业过程中的粉尘运动数学模型,得出降低综掘工作面粉尘浓度的... 详细信息

针对掘进巷道中的粉尘控制问题,传统的长压短抽通风降尘技术存在粉尘扩散区域大、风幕降尘技术存在射流孔易堵塞等弊端。以巴拉素煤矿综掘工作面为工程研究背景,建立了掘进作业过程中的粉尘运动数学模型,得出降低综掘工作面粉尘浓度的关键因素是控制掘进巷道风流场扰动范围及减小粉尘颗粒运动时间。以上述关键因素为依据,在风幕降尘的基础上开发了气室降尘技术,通过在正压风筒末端加装风袖,与风幕共同作用将粉尘封闭在气室区域内,再由负压风机抽出,以提高降尘效率。采用Fluent软件对长压短抽通风降尘、风幕降尘和气室降尘进行模拟对比分析,并优化了气室降尘技术参数。模拟结果表明:采用气室降尘技术时,综掘工作面人体呼吸带位置的粉尘浓度为350 mg/m^(3),较采用长压短抽通风降尘时的600 mg/m^(3)和风幕降尘时的480 mg/m^(3)大幅降低;气室降尘最优技术参数为正压风筒出风口距综掘工作面14 m、负压风筒末端直径0.6 m。在巴拉素煤矿2号煤2号回风大巷综掘工作面进行现场试验,结果表明采用气室降尘时,掘进巷道最低粉尘浓度为118 mg/m^(3),低于采用长压短抽通风降尘时的184 mg/m^(3)和风幕降尘时的156 mg/m^(3),且降尘效率较长压短抽通风降尘平均提高54.8%。

关键词：综掘工作面掘进巷道粉尘防治气室降尘长压短抽通风降尘风幕降尘风袖正压风筒

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Trace element and Nd isotope analyses of apatite in granitoids and metamorphosed granitoids from the eastern Central Asian Orogenic Belt:Implications for petrogenesis and post-magmatic alteration

引用

Geoscience Frontiers 2023年第2期14卷 71-85页

作者： Xin-Yu Long Jie Tang Wen-Liang Xu Chen-Yang Sun Jin-Peng Luan shuai xiong Xiao-Ming Zhang College of Earth Sciences Jilin UniversityChangchun 130061China Key Laboratory of Mineral Resources Evaluation in Northeast Asia Ministry of Natural Resources of ChinaChangchun 130061China State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi’an 710069China Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110819China State Key Laboratory of Superhard Materials Jilin UniversityChangchun 130012China

We present in situ trace element and Nd isotopic data of apatites from metamorphosed and metasomatized(i.e.,altered)and unaltered granitoids in the Songnen and Jiamusi massifs in the eastern Central Asian Orogenic Belt,with the aim of fingerprinting granitoid petrogenesis,including both the magmatic and post-magmatic evolution processes.Apatites from altered granitoids(AG)and unaltered granitoids(UG)are characterized by distinct textures and geochemical compositions.Apatites from AG have irregular rim overgrowths and complex internal textures,along with low contents of rare earth elements(REEs),suggesting the re-precipitation of apatite during epidote crystallization and/or leaching of REEs from apatite by metasomatic fluids.eNd(t)values of the these apatites are decoupled from zircon eHf(t)values for most samples,which can be attributed to the higher mobility of Nd as compared to Sm in certain fluids.Apatites from UG are of igneous origin based on their homogeneous or concentric zoned textures and coupled Nd-Hf isotopic compositions.Trace element variations in igneous apatite are controlled primarily by the geochemical composition of the parental melt,fractional crystallization of other REEbearing minerals,and changes in partition coefficients.Sr contents and Eu/Eu^(*) values of apatites from UG correlate with whole-rock Sr and SiO2 contents,highlighting the effects of plagioclase fractionation during magma evolution.Apatites from UG can be subdivided into four groups based on REE contents.Group 1 apatites have REE patterns similar to the host granitoids,but are slightly enriched in middle REEs,reflecting the influence of the parental melt composition and REE partitioning.Group 2 apatites exhibit strong light REE depletions,whereas Group 3 apatites are depleted in middle and heavy REEs,indicative of the crystallization of epidote-group minerals and hornblende before and/or during apatite crystallization,respectively.Group 4 apatites are depleted in heavy REEs,but enriched in Sr,which are features of adakites.Som

关键词： Eastern CAOB Granitoid petrogenesis Apatite geochemistry Fluid-induced alteration Nd-Hf isotopic decoupling Crustal assimilation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window

引用

药学学报:英文版 2023年第7期13卷 3008-3026页

作者： shuai xiong Hui Xiao Meng Sun Yunjie Liu Ling Gao Ke Xu Haiying Liang Nan Jiang Yuhui Lin Lei Chang Haiyin Wu Dongya Zhu Chunxia Luo Department of Pharmacology School of PharmacyNanjing Medical UniversityNanjing 211166China Department of Medicinal Chemistry School of PharmacyNanjing Medical UniversityNanjing 211166China Collaborative Innovation Center for Cardiovascular Disease Translational Medicine Nanjing Medical UniversityNanjing 211166China

Many efforts have been made to understand excitotoxicity and develop neuroprotectants for the therapy of ischemic stroke.The narrow treatment time window is still to be solved.Given that the ischemic core expanded over days,treatment with an extended time window is anticipated.Bestrophin1(BEST1)belongs to a bestrophin family of calcium-activated chloride channels.We revealed an increase in neuronal BEST1 expression and function within the peri-infarct from 8 to 48 h after ischemic stroke in mice.Interfering the protein expression or inhibiting the channel function of BEST1 by genetic manipulation displayed neuroprotective effects and improved motor functional deficits.Using electrophysiological recordings,we demonstrated that extrasynaptic glutamate release through BEST1 channel resulted in delayed excitotoxicity.Finally,we confirmed the therapeutic efficacy of pharmacological inhibition of BEST1 during 6—72 h post-ischemia in rodents.This delayed treatment prevented the expansion of infarct volume and the exacerbation of neurological functions.Our study identifies the glutamatereleasing BEST1 channel as a potential therapeutic target against ischemic stroke with a wide time window.

关键词： BEST1 Ischemic stroke Glutamate release Delayed excitotoxicity Infarct expansion Neurological functions Calcium-activated chloride channels

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

热处理制度对K417G铸造高温合金组织和性能的影响

引用

铸造 2024年第2期73卷 150-153页

作者：谢秋峰熊家帅代淑荣王晓慧陈兴福吴剑涛朱小平北京钢研高纳科技股份有限公司北京100081 河北钢研德凯科技有限公司河北保定071000

对K417G合金经过“1080℃/4h,AC+870℃/12h,AC”固溶+时效热处理后的显微组织、性能进行了研究。结果表明,与铸态相比,经“1080℃/4 h,AC”固溶处理后,铸态部分γ′相已经溶解,并且初生γ′相附近聚集着尺寸更小的二次γ′相颗粒;室温... 详细信息

对K417G合金经过“1080℃/4h,AC+870℃/12h,AC”固溶+时效热处理后的显微组织、性能进行了研究。结果表明,与铸态相比,经“1080℃/4 h,AC”固溶处理后,铸态部分γ′相已经溶解,并且初生γ′相附近聚集着尺寸更小的二次γ′相颗粒;室温抗拉强度和塑性提高,而900℃抗拉强度变化不大,塑性指标却明显降低。再经“870℃/12 h,AC”时效处理后,γ′相呈现为规则的立方形,二次γ′相有所长大,尺寸约为20~100 nm;900℃塑性指标有一定提升,其他力学性能与铸态相比变化不明显。

关键词： K417G 热处理显微组织力学性能

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

赤月桃在浦东引种表现及高效“Y”树形栽培技术

引用

农业技术与装备 2024年第2期 128-130页

作者：胡留申熊帅李春曦沈晋楠鲁莹王招程顾志新上海市桃研究所上海浦东201302 上海市浦东新区农业技术推广中心上海浦东201201

在介绍赤月桃在上海浦东的引种表现及品种特性基础上,从苗木准备、建园定植、树形构建、整形修剪、花果管理、病虫害防治等方面,详细总结了赤月桃高效“Y”树形栽培技术,以期为赤月桃品种在上海的快速推广提供借鉴。

关键词：水蜜桃赤月引种表现栽培技术

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progress in processing of porous titanium: a review

引用

Rare Metals 2024年第5期43卷 1932-1955页

作者： Xiao-Li Yang Xian-Feng Du Zhi-Lin Xu Zhong-shuai Liang Li-Long xiong Engineering Research Center of Energy Storage Materials and Devices Ministry of Education School of Chemistry Xi'an Jiaotong University

As a novel structural and functional material,porous titanium and its alloys have been widely used in the aerospace, marine engineering and biomedical fields due to their high corrosion resistance, low density, good biocompatibility and excellent mechanical properties. Therefore, in this paper, a comprehensive review of powder metallurgy(PM)(including additive manufacturing(AM)processes) for fabricating porous titanium is firstly covered in terms of their working principles, capabilities, shortcomings and strengths. Simultaneously, the influencing factors of various methods on final pore structure of porous Ti are involved. Secondly, a summary of the chemical methods(CM) to obtain the porous Ti is also provided,such as dealloying method and reduction method. Finally,the tendency and direction of preparation technology as well as application of porous titanium were prospected.

关键词： Porous titanium Powder metallurgy Chemical method Pore structure Processing process

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

能源服务工程导论课程思政初探索

引用

化工管理 2024年第18期 31-34页

作者：熊帅曾童曹星慧郭勤卫智毅苗鹏杰宋俊丽新疆理工学院能源化工工程学院新疆阿克苏843100

课程思政与课程内容的有机融合,是实现教师对学生的知识传授、价值塑造和能力培养多元统一的有效方式。能源服务工程导论是能源服务工程专业的专业基础课,挖掘适合课程内容的思政元素有利于学生专业知识的培养、学科价值的塑造和素质能... 详细信息

课程思政与课程内容的有机融合,是实现教师对学生的知识传授、价值塑造和能力培养多元统一的有效方式。能源服务工程导论是能源服务工程专业的专业基础课,挖掘适合课程内容的思政元素有利于学生专业知识的培养、学科价值的塑造和素质能力的提升。文章结合能源服务工程导论课程内容,深入了解学生课程内容兴趣点,挖掘人类命运共同体意识、爱国主义精神、中华民族共同体意识、可持续发展观、创新精神、工匠精神、胡杨精神与边疆奉献精神等思政元素,将这些思政元素教育有机融入教学内容,实现能源服务工程导论对能源服务工程专业学生知识、能力、素质“三位一体”的人才目标培养。

关键词：能源服务工程思政元素教育

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

华北抗日根据地的麻雀战

引用

河北学刊 2023年第2期43卷 216-224页

作者：熊成帅清华大学马克思主义学院北京100084

麻雀战是一种典型的游击战战术。在华北抗日根据地,面对日军的武器优势,根据地军民充分运用麻雀战以阻滞、袭扰和恐吓日军,显示了人民战争的巨大力量。游击战争在敌后抗战中具有的战略属性和抗日根据地阻滞袭扰日军、打击日军小股部队... 详细信息

麻雀战是一种典型的游击战战术。在华北抗日根据地,面对日军的武器优势,根据地军民充分运用麻雀战以阻滞、袭扰和恐吓日军,显示了人民战争的巨大力量。游击战争在敌后抗战中具有的战略属性和抗日根据地阻滞袭扰日军、打击日军小股部队的现实需求,是麻雀战在根据地广泛出现的主要原因。麻雀战通过分散武装不断消耗日军,以多点出击的方式迟滞日军,以军民联合作战的方式恐吓日军,对日军形成了强大的心理威慑。中共领导的武装部队得到了民众的广泛支持,抗日武装对根据地群众进行了常态化的政治教育和军事训练,根据地多种类型的武装实现了有效协同,这些因素为根据地军民广泛开展麻雀战准备了基本条件,促进了麻雀战的广泛开展。麻雀战是人民之战、群众之战,具有保护根据地、捍卫群众利益、鼓舞民心、动员民众的重要意义,值得进一步深入研究。

关键词：抗日战争华北抗日根据地麻雀战游击战

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115

引用

Cellular & Molecular Immunology 2024年第3期21卷 275-291页

作者： Zhi-Dong Zhang Chang-Rui Shi Fang-Xu Li Hu Gan Yanhong Wei Qianhui Zhang Xin shuai Min Chen Yu-Lin Lin Tian-Chen xiong Xiaoqi Chen Bo Zhong Dandan Lin Department of Gastrointestinal Surgery Medical Research InstituteFrontier Science Center of Immunology and MetabolismZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan430071China Department of Virology College of Life SciencesWuhan UniversityWuhan430072China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhan430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan430071China Department of Rheumatology and Immunology Zhongnan Hospital of Wuhan UniversityWuhan430071China Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China

STING(also known as MITA)is an adaptor protein that mediates cytoplasmic DNA-triggered signaling,and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function mutations causes severe inflammation.Here,we show that STING-mediated inflammation and autoimmunity are promoted by RNF115 and alleviated by the RNF115 inhibitor disulfiram(DSF).Knockout of RNF115 or treatment with DSF significantly inhibit systemic inflammation and autoimmune lethality and restore immune cell development in Trex1^(–/–)mice and STING^(N153S/WT) bone marrow chimeric mice.In addition,knockdown or pharmacological inhibition of RNF115 substantially downregulate the expression of IFN-α,IFN-γand proinflammatory cytokines in PBMCs from patients with systemic lupus erythematosus(SLE)who exhibit high concentrations of dsDNA in peripheral blood.Mechanistically,knockout or inhibition of RNF115 impair the oligomerization and Golgi localization of STING in various types of cells transfected with cGAMP and in organs and cells from Trex1^(–/–)mice.Interestingly,knockout of RNF115 inhibits the activation and Golgi localization of STINGN153S as well as the expression of proinflammatory cytokines in myeloid cells but not in endothelial cells or fibroblasts.Taken together,these findings highlight the RNF115-mediated cell type-specific regulation of STING and STINGN153S and provide potential targeted intervention strategies for STING-related autoimmune diseases.

关键词： STING/MITA Disulfiram RNF115 SLE Autoimmunity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：