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International Journal of Mining Science and Technology 2024年第2期34卷 137-148页

作者： Chuangbing Zhou Zuyang Ye Chi Yao Xincheng Fan feng xiong School of Infrastructure Engineering Nanchang UniversityNanchang 330031China b School of Resource and Environmental Engineering Wuhan University of Science and TechnologyWuhan 430081China School of Engineering China University of GeosciencesWuhan 430074China

With an extension of the geological entropy concept in porous media,the approach called directional entrogram is applied to link hydraulic behavior to the anisotropy of the 3D fracture networks.A metric called directional entropic scale is used to measure the anisotropy of spatial order in different *** with the traditional connectivity indexes based on the statistics of fracture geometry,the directional entropic scale is capable to quantify the anisotropy of connectivity and hydraulic conductivity in heterogeneous 3D fracture *** to the numerical analysis of directional entrogram and fluid flow in a number of the 3D fracture networks,the hydraulic conductivities and entropic scales in different directions both increase with spatial order(i.e.,trace length decreasing and spacing increasing)and are independent of the dip *** a result,the nonlinear correlation between the hydraulic conductivities and entropic scales from different directions can be unified as quadratic polynomial function,which can shed light on the anisotropic effect of spatial order and global entropy on the heterogeneous hydraulic behaviors.

关键词： 3D fracture network Geological entropy Directional entropic scale Anisotropy Hydraulic conductivity

Algorithmic approach to discrete fracture network flow modeling in consideration of realistic connections in large-scale fracture networks

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3798-3811页

作者： Qihua Zhang Shan Dong Yaoqi Liu Junjie Huang feng xiong Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan430074China SINOPEC Shanghai Engineering Co. Ltd.Shanghai200120China Faculty of Engineering China University of GeosciencesWuhan430074China

Analyzing rock mass seepage using the discrete fracture network(DFN)flow model poses challenges when dealing with complex fracture *** paper presents a novel DFN flow model that incorporates the actual connections of large-scale ***,this model efficiently manages over 20,000 fractures without necessitating adjustments to the DFN *** geometric analyses,such as identifying connected fractures,dividing the two-dimensional domain into closed loops,triangulating arbitrary loops,and refining triangular elements,are fully *** analysis processes are comprehensively introduced,and core algorithms,along with their pseudo-codes,are outlined and explained to assist readers in their programming *** accuracy of geometric analyses is validated through topological graphs representing the connection relationships between *** practical application,the proposed model is employed to assess the water-sealing effectiveness of an underground storage cavern *** analysis results indicate that the existing design scheme can effectively prevent the stored oil from leaking in the presence of both dense and sparse ***,following extensive modification and optimization,the scale and precision of model computation suggest that the proposed model and developed codes can meet the requirements of engineering applications.

关键词： Discrete fracture network(DFN)flow model Geometric algorithm Fracture flow Water-sealing effect

Failure behavior and strength model of blocky rock mass with and without rockbolts

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International Journal of Mining Science and Technology 2024年第6期34卷 747-762页

作者： Chun Zhu Xiansen Xing Manchao He Zhicheng Tang feng xiong Zuyang Ye Chaoshui Xu School of Earth Sciences and Engineering Hohai UniversityNanjing 210024China Key Laboratory of Water Management and Water Security for Yellow River Basin Ministry of Water Resources(under construction)Zhengzhou 450003China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and TechnologyBeijing 10083China Faculty of Engineering China University of GeosciencesWuhan 430074China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China School of Resource and Environmental Engineering Wuhan University of Science and TechnologyWuhan 430081China School of Chemical Engineering Faculty of SciencesEngineering and TechnologyThe University of AdelaideAdeliade 5005Australia

To better understand the failure behaviours and strength of bolt-reinforced blocky rocks,large scale extensive laboratory experiments are carried out on blocky rock-like specimens with and without rockbolt *** results show that both shear failure and tensile failure along joint surfaces are observed but the shear failure is a main controlling factor for the peak strength of the rock mass with and without *** rockbolts are necked and shear deformation simultaneously happens in bolt reinforced rock *** the joint dip angle increases,the joint shear failure becomes more *** number of rockbolts has a significant impact on the peak strain and uniaxial compressive strength(UCS),but little influence on the deformation modulus of the rock *** the Winkler beam model to represent the rockbolt behaviours,an analytical model for the prediction of the strength of boltreinforced blocky rocks is *** agreement between the UCS values predicted by proposed model and obtained from experiments suggest an encouraging performance of the proposed *** addition,the performance of the proposed model is further assessed using published results in the literature,indicating the proposed model can be used effectively in the prediction of UCS of bolt-reinforced blocky rocks.

关键词： Blocky rock mass Rockbolt ground support Uniaxial compression test Failure mechanism Uniaxial compressive strength model

Preparation and Analysis of Carbon Fiber-Silicon Carbide Thermally Conductive Asphalt Concrete

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Fluid Dynamics & Materials Processing 2024年第4期20卷 705-723页

作者： Zhiyong Yang Enjie Hu Lei Xi Zhi Chen feng xiong Chuanhai Zhan School of Civil Engineering and Environment Hubei University of TechnologyWuhan430068China

An experimental investigation into the thermal conductivity of CF-SiC two-phase composite asphalt concrete is *** main objective of this study was to verify the possibility of using SiC powder instead of mineral powder as the thermal conductive filler to prepare a new type of asphalt concrete and improve the efficiency of electrothermal snow and ice melting systems *** thermal conductivity of asphalt concrete prepared with different thermally conductive fillers was tested by a transient plane source method,and the related performances were *** the temperature rise rate and surface temperature were studied through field heating ***,the actual ice melting efficiency of the thermally conductive asphalt concrete was evaluated using an effective electrothermal *** shown by the experimental results,the composite made of SiC powder and carbon fiber has a high thermal *** SiC replaces mineral powder,the thermal conductivity of the asphalt mixture increases first and then decreases with the increase of carbon fiber *** the present study,in particular,the thermal conductivity attained a peak when the carbon fiber content was 0.2%of the aggregate mass.

关键词： Carbon fiber silicon carbide thermally conductive asphalt concrete road performance electrothermal snow melting

Alanine aminotransferase as a risk marker for new-onset metabolic dysfunction-associated fatty liver disease

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World Journal of Gastroenterology 2024年第25期30卷 3132-3139页

作者： Di Wang Bing-Yan Zhou Lei Xiang Xu-Yong Chen Jie-xiong feng Department of Pediatric Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

In this editorial,we comment on the article by Chen et *** dysfunction-associated fatty liver disease(MAFLD)is a global public health burden whose incidence has risen concurrently with overweight and *** its detri-mental health impact,early identification of at-risk individuals is *** diagnosis is based on evidence of hepatic steatosis indicated by liver biopsy,imaging,or blood biomarkers,and one of the following conditions:Overweight/obesity,type 2 diabetes mellitus,or metabolic ***,in large-scale epidemiological studies,liver biopsies are not *** application of techniques such as ultrasonography,computed tomography,magnetic resonance imaging,and magnetic resonance spectroscopy is restricted by their limited sensitivity,low effectiveness,high costs,and need for specialized *** biomarkers offer several advantages,particularly in large-scale epidemiological studies or clinical scenarios where traditional imaging techniques are *** of cumulative effects of excess high-normal blood alanine aminotrans-ferase(ALT)levels of blood ALT levels could facilitate identification of at-risk patients who might not be detected through conventional imaging ***,investigating the utility of blood biomarkers in MAFLD should enhance early detection and monitoring,enabling timely inter-vention and management and improving patient outcomes.

关键词： Nonalcoholic fatty liver disease Metabolic dysfunction-associated fatty liver disease Alanine aminotransferase Screening Risk marker

Encoding and display technologies for combinatorial libraries in drug discovery:The coming of age from biology to therapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3362-3384页

作者： Yu Fan Ruibing feng Xinya Zhang Zhen-Liang Wang feng xiong Shuihua Zhang Zhang-feng Zhong Hua Yu Qing-Wen Zhang Zhang Zhang Yitao Wang Guodong Li Macao Centre for Research and Development in Chinese Medicine State Key Laboratory of Quality Research in Chinese MedicineInstitute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development Ministry of Education(MoE)of People’s Republic of ChinaCollege of PharmacyJinan UniversityGuangzhou 510632China Zhuhai UM Science and Technology Research Institute Zhuhai 519031China Department of Pharmacy Guangzhou Red Cross HospitalFaculty of Medical ScienceJinan UniversityGuangzhou 510632China Geriatric Medicine First People’s Hospital of XinXiang and the Fifth Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453100China Shenzhen Innovation Center for Small Molecule Drug Discovery Co. Ltd.Shenzhen 518000China

Drug discovery is a sophisticated process that incorporates scientific innovations and cuttingedge *** to traditional bioactivity-based screening methods,encoding and display technologies for combinatorial libraries have recently advanced from proof-of-principle experiments to promising tools for pharmaceutical hit discovery due to their high screening efficiency,throughput,and resource *** review systematically summarizes the development history,typology,and prospective applications of encoding and displayed technologies,including phage display,ribosomal display,mRNA display,yeast cell display,one-bead one-compound,DNA-encoded,peptide nucleic acidencoded,and new peptide-encoded technologies,and examples of preclinical and clinical *** discuss the progress of novel targeted therapeutic agents,covering a spectrum from small-molecule inhibitors and nonpeptidic macrocycles to linear,monocyclic,and bicyclic peptides,in addition to *** also address the pending challenges and future prospects of drug discovery,including the size of screening libraries,advantages and disadvantages of the technology,clinical translational potential,and market *** review is intended to establish a comprehensive high-throughput drug discovery strategy for scientific researchers and clinical drug developers.

关键词： Drug screening Phage display DNA-encoded chemical libraries Peptide-encoded chemical libraries Clinical drugs

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面向时间触发流量调度的虚拟网络嵌入方法

北京航空航天大学学报 2024年第6期50卷 1982-1990页

作者：熊峰李峭李继冯嘉颖北京航空航天大学电子信息工程学院北京100191

网络虚拟化技术将物理网络中的节点、链路资源进行抽象,通过虚拟网络嵌入(VNE)方法,使多个虚拟网络(VN)共享底层网络(SN)资源。对于应用于航空航天电子领域的时间触发以太网(TTE),提出一种面向时间触发流量调度的虚拟网络嵌入(TT-VNE)方... 详细信息

网络虚拟化技术将物理网络中的节点、链路资源进行抽象,通过虚拟网络嵌入(VNE)方法,使多个虚拟网络(VN)共享底层网络(SN)资源。对于应用于航空航天电子领域的时间触发以太网(TTE),提出一种面向时间触发流量调度的虚拟网络嵌入(TT-VNE)方法,在满足传统虚拟网络嵌入问题的总资源量限制条件的同时,保证时间触发(TT)流量的严格周期性。在求解过程中,根据与虚拟节点相连的链路中TT流量带宽需求及其总带宽资源需求对虚拟节点进行排序,利用广度优先搜索算法嵌入虚拟节点,并在候选最短路径集合中对虚拟链路进行路径规划;如果当前虚拟链路中TT流量不可调度,则进行局部虚拟节点重新嵌入与路径规划的迭代设计。仿真结果表明:TT-VNE方法的请求接受率不低于VNE-DCC、VNE-NTANRC-D、ELECTRE-VNE这3种既有方法,且当星型拓扑中虚拟网络请求数超过30时,其请求接受率比仅考虑网络拓扑属性和资源属性的VNE-NTANRC-D方法提高约14.3%。

关键词：虚拟网络嵌入虚拟化资源分配时间触发以太网时间触发流量

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超越西方现代性的人类文明新形态

世界哲学 2024年第3期 5-15页

作者：李包庚熊峰宁波大学马克思主义学院中国社会科学院大学马克思主义学院江苏省习近平新时代中国特色社会主义思想研究中心南京航空航天大学基地南京航空航天大学马克思主义学院

启蒙运动开启了现代性的序幕,但随着资本主义文明的演化,现代性危机日益凸显。在现代性危机中,资本主义社会愈发迷失自我。为了拯救资本主义文明,西方社会提出了诸多现代性治疗方案。但这些方案具有明显的立场倾向,始终立足于资本主义... 详细信息

启蒙运动开启了现代性的序幕,但随着资本主义文明的演化,现代性危机日益凸显。在现代性危机中,资本主义社会愈发迷失自我。为了拯救资本主义文明,西方社会提出了诸多现代性治疗方案。但这些方案具有明显的立场倾向,始终立足于资本主义社会形态去医治资本主义的瘤疾,在资本主义的框架内止步不前,难以真正解决现代性问题。马克思通过对现代性方案的辩证分析,揭示了资本现代性的矛盾根源和前途命运,提出构建共产主义社会这一全新的人类文明形态作为超越资本现代性的设想。中国式现代化新道路,以文明的人道性、人民性、协调性、系统性、开放性、包容性、和平性、共生性塑造人类文明新形态,为人类实现现代化提供了新的选择,为世界走出现代性危机,解决现代性难题,提供了全新形态的文明选择。

关键词：现代性西方现代性人类文明新形态中国式现代化

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论中国式现代化蕴含的独特价值观

思想战线 2024年第3期50卷 1-12页

作者：王岩熊峰江苏省习近平新时代中国特色社会主义思想研究中心南京航空航天大学基地南京航空航天大学马克思主义学院

文艺复兴和启蒙运动开启了人类现代化的应然价值诉求，即倡导坚持以人为本，注重人的价值，实现人的自由、平等和幸福。然而，自工业革命以来，以资本逻辑为主导的西方式现代化始终坚持资本至上的价值理念，崇尚理性至上的价值标准，恪... 详细信息

文艺复兴和启蒙运动开启了人类现代化的应然价值诉求，即倡导坚持以人为本，注重人的价值，实现人的自由、平等和幸福。然而，自工业革命以来，以资本逻辑为主导的西方式现代化始终坚持资本至上的价值理念，崇尚理性至上的价值标准，恪守零和博弈的价值取向，逐渐偏离了现代化价值观的应然指向，造成现代化价值观的现实悖论。与西方式现代化不同，中国式现代化蕴含的独特价值观以富强民主文明和谐美丽、社会主义核心价值观和全人类共同价值为核心要义，在价值维度形成了人民至上的价值立场、共同富裕的价值追求、人与自然和谐共生的价值准则、和平发展的价值取向等基本内涵。因此，中国式现代化蕴含的独特价值观具有人民性、连续性、包容性、和平性等主要特性。中国式现代化蕴含的独特价值观对于引领建设中华民族现代文明、深化人类文明的交流与互鉴、绘就人类现代化新世界图景具有重要的时代意义。

关键词：现代化中国式现代化独特价值观

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以全面深化改革赋能新质生产力的塑造

河海大学学报（哲学社会科学版） 2024年第5期26卷 10-20页

作者：熊峰王岩江苏省习近平新时代中国特色社会主义思想研究中心南京航空航天大学基地江苏南京210016

新质生产力以劳动者、劳动资料、劳动对象及其优化组合的跃升为基本内涵,以实现全体人民共同富裕为基本价值追求。以全面深化改革赋能新质生产力,可从劳动者、劳动资料、劳动对象、价值导向4个维度着手:一是以推进教育科技人才体制机制... 详细信息

新质生产力以劳动者、劳动资料、劳动对象及其优化组合的跃升为基本内涵,以实现全体人民共同富裕为基本价值追求。以全面深化改革赋能新质生产力,可从劳动者、劳动资料、劳动对象、价值导向4个维度着手:一是以推进教育科技人才体制机制一体改革提升劳动者的素质,通过深化教育综合改革提升劳动者的思想品德素养、深化科技体制机制改革提升劳动者的创新创造能力、深化人才发展体制机制改革提升劳动者的精益求精精神;二是以健全经济高质量发展体制机制增强劳动资料的技术含量,通过深化科技体制改革、健全新型举国体制和完善现代化产业体系增强劳动资料技术含量的原创性、高端性和前瞻性;三是以构建支持全面创新体制机制拓展劳动对象的范围领域,通过创新企业主导型产学研深度融合体制、创新要素产权制度体系和创新企业组织管理架构健全劳动对象的范围领域;四是以构建高水平社会主义市场经济体制推动实现共同富裕,通过坚持“两个毫不动摇”筑牢实现共同富裕的制度基础、深化分配制度改革完善实现共同富裕的制度保障、健全宏观经济治理体系增强实现共同富裕的制度优势。这是新时代以全面深化改革赋能新质生产力的塑造,推进中国式现代化新发展的应然路径和时代要求。

关键词：全面深化改革新质生产力新型生产关系中国式现代化