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The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi xiong Qin Zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

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消痔灵和强的松龙混合液治疗鼻息肉

第四军医大学学报 2001年第7期22卷 667-668页

作者：朱胜华熊卫红李多洛邹小量湖南省邵阳市中心医院耳鼻咽喉科湖南邵阳422000

0　引言　我科1996/1998分别应用消痔灵与强的松龙混合液、消痔灵液、强的松龙液行鼻息肉内，鼻息肉蒂部注射治疗鼻息肉各50例，并设对照组为鼻腔滴入及口服类固醇激素50例，合计200例，观察并对比其疗效. 1　对象和方法 1．1　对象　男... 详细信息

0　引言　我科1996/1998分别应用消痔灵与强的松龙混合液、消痔灵液、强的松龙液行鼻息肉内，鼻息肉蒂部注射治疗鼻息肉各50例，并设对照组为鼻腔滴入及口服类固醇激素50例，合计200例，观察并对比其疗效. 1　对象和方法 1．1　对象　男128例，女72例，年龄8～78(平均38)岁，病程32 a～45 (平均4.5) a. 其中在本次治疗前做过一次鼻息肉摘除术后复发的27例，做过2次或2次以上手术的12例. 主要症状为鼻塞、流脓涕、头痛及嗅觉减退. 全部病例治疗前均行鼻窦X线拍片，其中上颌窦炎125例、筛窦炎58例、蝶窦炎2例、额窦炎8例. 为描述鼻息肉的大小，在充分收缩下鼻甲粘膜后按下列标准分期:Ⅰ期：息肉限于中鼻道内；Ⅱ期：息肉向前达中鼻甲前部，向下到下鼻甲，但未遮盖下鼻甲；Ⅲ期：除到达中鼻甲前部外，息肉已扩展到中鼻甲的内侧和后部；Ⅳ期：息肉扩展至鼻底，但可以见到一部分鼻甲；Ⅴ期：息肉充满鼻腔，不能窥见鼻甲(表1). 1．2　方法　全部病例均为本院门诊明确诊断为鼻息肉的病例，采用随机抽样法分为A，B，C，D 4组，各组50例，其中A组为消痔灵和强的松龙混合液，B组为单用消痔灵液，C组单用强的松龙混悬液，均在鼻息肉内及蒂部注射，D组（对照组）为鼻腔内滴入0.5 g*L-1可的松滴鼻液，加上口服强的松片剂. A组：患者取端坐位，用强的松龙混悬液等量混合搅匀，用5号细长针头分次注入每个息肉内、息肉蒂部，根据不同分期的息肉采用不同剂量，Ⅰ期，2～3 mL；Ⅱ期3～4 mL；Ⅲ期4～5mL；Ⅳ期5～6 mL；Ⅴ期6～7 mL. 但单侧鼻腔总量不超过8 mL. 注射后鼻粘膜水肿，呈现苍白色.随着水肿消退，息肉渐缩小脱落，5～7 d重复1次，4次为一疗程（在治疗中息肉已脱落，就不须再继续治疗）. B组、C组方法同A组，但为单用一种药物，且单用药物剂量与A组相同，仍为5～7 d重复一次，4次为1疗程（在治疗中息肉已脱落，就不须再继续治疗）. D组（对照组）：给予50 g*L-1可的松滴鼻液滴鼻腔，每日3次，每次3～4滴，同时口服强的松片，第1周每日30 mg，第2周每日20 mg，第3周每日15 mg，第4周每日10 mg，1 mo为1疗程. 以上各组在治疗中不应用其他任何药物，只用1个疗程. 2 a内定期复查随访.

关键词：鼻息肉消痔灵强的松龙治疗疗效

Influence of introducing Zr,Ti,Nb and Ce elements on externally solidified crystals and mechanical properties of high-pressure die-casting Al–Si alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 147-153页

作者： Junjie Li Wenbo Yu Zhenyu Sun Weichen Zheng Liangwei Zhang Yanling Xue Wenning Liu Shoumei xiong Center of Materials Science and Engineering School of Mechanical and Electronic Control EngineeringBeijing Jiaotong UniversityBeijing 100044China Traffic&Transportation Engineering Central South UniversityChangsha 410075China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China

High pressure die casting(HPDC)AlSi10Mn Mg alloy castings are widely used in the automobile *** can optimize the mechanical properties of castings through heat treatment,while the release of thermal stress arouses the deformation of large integrated ***,the development of non-heat treatment Al alloys is becoming the hot *** addition,HPDC contains externally solidified crystals(ESCs),which are detrimental to the mechanical properties of *** achieve high strength and toughness of non-heat treatment die-casting Al-Si alloy,we used AlSi9Mn alloy as matrix with the introduction of Zr,Ti,Nb,and *** influences on ESCs and mechanical properties were systematically investigated through three-dimensional reconstruction and thermodynamic *** results reveal that the addition of Ti increased ESCs'size and porosity,while the introduction of Nb refined ESCs and decreased ***,large-sized Al_3(Zr,Ti)phases formed and degraded the mechanical *** introduction of Ce resulted in the poisoning effect and reduced mechanical properties.

关键词： aluminium alloy high-pressure die-casting externally solidified crystals non-heat treatment

辛伐他汀对糖尿病肾病患者sICAM-1水平的影响

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第四军医大学学报 2005年第16期26卷 1522-1522页

作者：朱慧琪熊燕熊伟华平顶山市煤业集团总医院内分泌科河南平顶山467000 荆州市中心医院肾内科湖北荆州434100

临床资料 2型糖尿病尿白蛋白排泄率（UAER）〉20μg／min住院患者62例，肾功能正常，并排除心、肺、肝疾病及重度感染，最近半年未发生过酮症酸中毒或高渗昏迷，也未应用过肾损害药物和降脂药物等，男49例，女13例，年龄（57．2±9．6... 详细信息

临床资料 2型糖尿病尿白蛋白排泄率（UAER）〉20μg／min住院患者62例，肾功能正常，并排除心、肺、肝疾病及重度感染，最近半年未发生过酮症酸中毒或高渗昏迷，也未应用过肾损害药物和降脂药物等，男49例，女13例，年龄（57．2±9．6）岁，分为辛伐他汀加常规治疗组（辛伐他汀组）30例和常规治疗组（常规组）32例，两组年龄、性别及病情无显著性关异（P>0.05).

关键词：糖尿病肾病 sICAM-1 辛伐他汀

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

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Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei Huang Jiayi Wen Xin xiong Ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

稀土元素Er、Yb和Y掺杂ZrO_(2)的第一性原理研究

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原子与分子物理学报 2025年第1期42卷 156-162页

作者：熊威任浩重庆交通大学航空学院重庆402247 重庆交通大学绿色航空技术研究院重庆401147

氧化锆具有声子能量低,介电常数高和带隙较宽等优良特性,并且立方相的氧化锆(cZrO_(2))透光率高,适合作为上转换发光材料的基质.采用基于密度泛函理论(DFT)的第一性原理平面波赝势法研究了稀土元素Er、Yb和Y掺杂cZrO_(2)的电子结构和光... 详细信息

氧化锆具有声子能量低,介电常数高和带隙较宽等优良特性,并且立方相的氧化锆(cZrO_(2))透光率高,适合作为上转换发光材料的基质.采用基于密度泛函理论(DFT)的第一性原理平面波赝势法研究了稀土元素Er、Yb和Y掺杂cZrO_(2)的电子结构和光学性质.计算结果显示,掺入Y元素后,cZrO_(2)转变为直接带隙材料,继续掺入Er和Yb原子后,费米能级移动到价带内,带隙显著减小.Y和Er混掺后,增强了cZrO_(2)在近红外波段的吸收能力.继续掺入Yb后,cZrO_(2)对近红外波段的吸收能力有了进一步地增加.

关键词：氧化锆第一性原理电子结构光学性质

Ubiquitination in diabetes and its complications:A perspective from bibliometrics

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World Journal of Diabetes 2025年第1期16卷 187-203页

作者： Li-Yuan xiong Wei Zhao Fa-Quan Hu Xue-Mei Zhou Yu-Jiao Zheng College of Traditional Chinese Medicine Anhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

BACKGROUND Diabetes has a substantial impact on public health,highlighting the need for novel ***,an intracellular protein modification process,is emerging as a promising strategy for regulating pathological *** hypothesize that ubiquitination plays a critical role in the development and progression of diabetes and its complications,and that understanding these mechanisms can lead to new therapeutic *** To uncover the research trends and advances in diabetes ubiquitination and its complications,we conducted a bibliometric *** Studies on ubiquitination in diabetes mellitus and its complications were retrieved from the Web of Science Core *** mapping analysis was conducted using the CiteSpace *** We gathered 791 articles published over the past 23 years,focusing on ubiquitination in diabetes and its associated *** articles originated from 54 countries and 386 institutions,with China as the leading *** Jiao Tong University has the highest number of publications in this *** most prominent authors contributing to this research area include Wei-Hua Zhang,with Zhang Y being the most frequently cited ***,The Journal of Biological Chemistry is noted as the most cited in this *** predominant keywords included expression,activation,oxidative stress,phosphorylation,ubiquitination,degradation,and insulin *** The role of ubiquitination in diabetes and its complications,such as diabetic nephropathy and cardiomyopathy,is a key research ***,these areas require further investigations.

关键词： Diabetes mellitus Ubiquitination Bibliometric analysis CiteSpace Research trends

RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao Wang Bang Liu Yang-Pu Jia Zhao-xiong Zhang Xin Liu Dao-Han Wang Yong-Jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

中华民族视觉形象的文化叙事及实践——基于文化形象学的论析

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 112-121页

作者：令小雄苗昕西北师范大学马克思主义学院教育部高校思想政治工作队伍培训研修中心(西北师范大学) 甘肃兰州730070

文本基于多维度理论系统梳理中华民族视觉形象的文化意蕴、内涵质态与构建策略,为铸牢中华民族共同体意识提供理论基础。一是运用文化符号学理论解析中华民族视觉形象的意涵及其历史演变,探赜“和合共生,合谐共美”价值理想承载的多元... 详细信息

文本基于多维度理论系统梳理中华民族视觉形象的文化意蕴、内涵质态与构建策略,为铸牢中华民族共同体意识提供理论基础。一是运用文化符号学理论解析中华民族视觉形象的意涵及其历史演变,探赜“和合共生,合谐共美”价值理想承载的多元一体文化格局,通过提炼核心符号,揭示视觉形象塑造在铸牢中华民族共同体意识中的重要作用。二是采用历史唯物主义方法论考察中华民族视觉形象在不同历史时期的构建与传播路径,通过文化形象考古学和文献学剖析视觉形象文化功能转变与价值重塑过程,探讨其在凝聚民族力量、强化国家认同中的重要意义。三是引入文化哲学、文化心理学视角分析视觉形象在增强社会凝聚力和心理认同中的内在机制,探究视觉符号通过激活集体记忆和情感共鸣、唤起民族自豪感和共同体意识成为社会整合的重要媒介。四是基于文化形象学视角提出构建中华民族视觉形象的策略:从中华文化形象本体论和认识论出发,提炼具有代表性的符号,利用现代数智科技和新媒体创新视觉形象的表达与传播,注重文化形象多样性的辩证统一,发掘整合各民族形象文化元素的共同意识。

关键词：中华民族视觉形象国家形象文化形象认同文化传播