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Fenestrated endovascular aortic repair for juxtarenal abdominal aortic aneurysm

Chinese Medical Journal 2013年第3期126卷 409-414页

作者： GUO Wei ZHANG Hong-peng LIU Xiao-ping JIA Xin xiong Jiang ma Xiao-hui Department of Vascular Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China

Background Endovascular stent-graft with fenestration can improve proximal sealing in patients with juxtarenal abdominal aortic aneurysm （JAAA）. The purpose of this study was to describe our primary experience and evaluate the safety and efficacy of fenestrated device for JAAA in high-risk patients. Methods Between march 2011 and may 2012, nine male patients （mean age, （79.6±8.6） years） with asymptomatic JAAAs underwent elective deployment of the Zenith fenestrated stent-grafts at a single institution. All patients were treated in the hybrid operating room under general anesthesia. Follow-up computed tomography angiography （CTA） was routinely performed before discharge, at 3, 6, and 12 months and annually thereafter. Results Procedural success was achieved in all cases. Total sixteen small fenestrations, two large fenestrations and eight scallops were used. Intra-operative complications occurred in four patients, which included one proximal type I endoleak, two type II endoleaks, and one renal artery dissection. The mean hospital stay was （8.9±1.4） days, mean blood loss was （360.5±46.8） ml, and mean iodinated contrast volume was （230.6±58.3） ml. The mean follow-up time was （7.6±4.2） months. The visceral graft patency was 100% until now. One patient had an increase of serum creatinine of more than 30%, but did not require dialysis. No patients died, no stent fractured, and migration were diagnosed during the follow-up. Conclusions The early results of fenestrated device for high-risk patients with complex JAAAs are satisfactory. However, long-term fenestrated graft durability and branch vessel patency remain to be determined.

关键词： abdominal aortic aneurysm juxtarenal aneurysm endovascular aortic repair, fenestrated stent-graft

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Hybrid procedures for thoracoabdominal aortic aneurysms and dissections

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Chinese Medical Journal 2013年第4期126卷 620-625页

作者： ZHANG Hong-peng GUO Wei LIU Xiao-ping JIA Xin xiong Jiang ma Xiao-hui Department of Vascular Surgery Chinese People's Liberation Army General Hospital Beijing 100853 China

Background Hybrid procedures including debranching of visceral and renal arteries followed by endovascular exclusion of the thoracoabdominal aortic aneurysm （TAAA） have recently been proposed as a less invasive alternative to conventional TAAA surgery. This study aimed to evaluate the immediate and long-term outcomes of hybrid procedures for TAAA in high-risk patients. Methods Between September 1998 and may 2012, 32 high-risk TAAA patients （five females, median age 61.5 years） underwent hybrid procedures at a single institution. Simultaneous approach and staged approach were performed on the basis of patients＇ conditions. Follow-up computed tomography angiography （CTA） was routinely performed before discharge and at 6, 12 months and annually thereafter. Results Procedural success was achieved in all cases. The median hospital stay was （21.5＋2.3） days, and the median procedure time was （420＋31） minutes. Blood loss averaged （2100_＋261） ml. A total of 124 visceral artery bypasses was performed. Two patients （6.3%） died within 30 days. One patient exhibited complete paraplegia （3.1%）. The visceral graft patency was 96.1% at 3 years. All-cause survival rates were 93.8%, 87.5%, 81.3% and 53.1% at 1, 2, 3 and 5 years, respectively. No patient died due to aortic events. The freedom rates from aortic events were 96.9%, 93.6%, 87.5%, 68.8% at 1,2, 3 and 5 years, respectively. Conclusions The results of visceral hybrid repair for high-risk patients with complex TAAAs are encouraging. However, the procedure is still a significant physiological insult to patients. Until branched and fenestrated endovascular repair become more common, hybrid procedure will continue to have a role in high-risk patients.

关键词： hybrid procedure thoraeoabdominal aortic aneurysm endovascular aortic repair," dissection," stent-grafi

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航空铝合金系列材料裂纹扩展性能的温度效应

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北京航空航天大学学报 2017年第4期43卷 761-768页

作者：李矿熊峻江马少俊陈勃北京航空航天大学交通科学与工程学院北京100083 北京航空材料研究院北京100095

高低温裂纹扩展性能是航空金属结构损伤容限设计的前提,为此,试验测定了3种系列的6种航空铝合金材料(2024-T351、2397-T8、6061-T651、7050-T7451、7050-T7452和7475-T761)在5种温度环境(-70、-54、25、125和150℃)下的裂纹扩展性能,观... 详细信息

高低温裂纹扩展性能是航空金属结构损伤容限设计的前提,为此,试验测定了3种系列的6种航空铝合金材料(2024-T351、2397-T8、6061-T651、7050-T7451、7050-T7452和7475-T761)在5种温度环境(-70、-54、25、125和150℃)下的裂纹扩展性能,观测了试验现象,并进行了性能对比分析和疲劳断口扫描电子显微镜(SEM)分析,研究了温度对航空铝合金材料裂纹扩展性能的影响机制,获得了具有工程参考价值的结果与结论:与25℃相比,低温下裂纹扩展阻力系数的对数值降低7%~15%,而高温下却增大5%~23%;低温下裂纹扩展指数增大7%~21%,而高温下却减少5%~34%;氢脆效应和高温氧化作用是导致裂纹扩展速率随温度升高而加快的主要原因。

关键词：铝合金裂纹扩展疲劳温度扫描电子显微镜(SEM)

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EZH2 is a prognostic factor associated with tumor stemness and immune infiltration in skull base chordoma

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Genes & Diseases 2024年第5期11卷 85-87页

作者： Qian Liu Mingxuan Li Yujia xiong Yutao Shen Tianshun ma Tianhao Zhang Xiaohong R.Yang Yazhuo Zhang Jiwei Bai Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Division of Cancer Epidemiology and Genetics National Cancer InstituteNIHDHHSBethesdaMD 20892USA

Enhancer of zeste homolog 2(EZH2),an epigenetic regulator that inhibits transcription primarily through trimethylation of Lys-27 in histone 3(H3K27me3),has been reported to play an important role in the regulation of cell cycle,autophagy,and apoptosis,and DNA damage repair.1 EZH2 is highly expressed in a variety of cancers including prostate cancer,breast cancer,and renal clear cell carcinoma,and is associated with adverse prognosis.1 Moreover,it has been reported that EZH2 might increase tumor stemness and metastasis capacity and inhibit antitumor immunity by affecting T cells,NK cells,macrophages,and immune checkpoints.2,3 However,the prognostic value and the mechanism of EZH2 have not been investigated in *** this study,RNA sequencing and whole genome sequencing data based on 48 skull base chordomas as well as immunohistochemistry of paraffin sections were analyzed to elucidate the role of EZH2 in skull base *** found copy number gain mediated high EZH2 expression is associated with tumor stemness,M2 macrophage infiltration,and adverse prognosis in ***,we demonstrated that EZH2 promotes the proliferation,migration,and invasion of chordoma cells in in vitro cell experiments.

关键词： EZH2 immunity invasion

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A methodological systematic review of early versus late stabilization of thoracolumbar spine fractures

A methodological systematic review of early versus late stab...

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第二十届全国中西医结合骨伤科学术研讨会、第二届中国医师协会中西医结合医师分会骨伤科学术年会、第十九届浙江省中西医结合骨伤科专业委员会学术年会

作者： Xin-Long ma Dan Xing Jian-xiong ma Jie Wang Yang Chen Yang Yang Department of Orthopaedics Tianjin Medical University General Hospital Department of Orthopaedics Institute Tianjin Hospital Department of Orthopaedics Tianjin Gongan Hospital

Objective The optimal timing of stabilization in patients with traumatic thoracolumbar fractures remains *** is currently a lack of consensus on the timing of surgical stabilization, which is limited by the reality that a randomized controlled trial to evaluate early versus late stabilization is difficult to ***,the objective of this study was to determine the benefits,safety and costs of early stabilization compared with late stabilization using data available in the current literature. Methods An electronic literature search was performed in Medline,Embase,Cochrane Database of Systematic Reviews,and Cochrane Central Register of Controlled Trials for relevant studies evaluating the timing of surgery in patients with thoracolumbar *** reviewers independently analyzed and selected each study on the basis of the eligibility *** quality of the included studies was assessed using the Grading of Recommendations Assessment,Development,and Evaluation system(GRADE).Any disagreements were resolved by consensus. Results Ten studies involving 2512 subjects were *** studies demonstrated that early stabilization shortened the hospital length of stay,intensive care unit length of stay,ventilator days and reduced morbidity and hospital expenses for patients with thoracic ***,reduced morbidity and hospital expenses were not observed with stabilization of lumbar *** to the very low level of evidence,no conclusion could be made regarding the effect of early stabilization on mortality. Conclusions We adhere to the recommendation that patients with traumatic thoracolumbar fractures should undergo early stabilization,which may reduce the hospital length of stay,intensive care unit length of stay, ventilator days,morbidity and hospital expenses,particularly when the thoracic spine is *** prospective studies are required to confirm whether there are benefits to early stabilization compared

关键词： A methodological systematic review of early versus late stabilization of thoracolumbar spine fractures

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Preparation of BiOCl0.9I0.1/β-Bi2O3 composite for degradation of tetracycline hydrochloride under simulated sunlight

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Chinese Journal of Catalysis 2020年第10期41卷 1535-1543页

作者： xiong ma Kaiyi Chen Bin Niu Yan Li Lei Wang Jingwei Huang Houde She Qizhao Wang School of Environmental Science and Engineering Key Laboratory of Subsurface Hydrology and Ecological Effects in Arid Region of Ministry of EducationChang'an UniversityXi'an 710064ShanxiChina College of Chemistry and Chemical Engineering Northwest Normal UniversityLanzhou 730070GansuChina

A novel and effective BiOCl0.9I0.1/x%β-Bi2O3 composite catalyst was synthesized through a precipitation method. The structure, morphology, and optical properties of the samples were certified by X-ray diffraction, UV-Vis diffuse reflectance, scanning electron microscopy, and X-ray photoelectron spectroscopic characterizations. Photocatalytic experiments demonstrated that the synthesized BiOCl0.9I0.1/x%β-Bi2O3 composite catalyst exhibited excellent photocatalytic performance toward the degradation of tetracycline hydrochloride(TCH) under simulated sunlight. Furthermore, the TCH degradation rate of BiOCl0.9I0.1/15%β-Bi2O3 increased by 27.6% and 61.4% compared with those of the pure BiOCl0.9I0.1 and pure β-Bi2O3, respectively. Due to the multiple vacancies and valence states possessed by BiOCl0.9I0.1/x%β-Bi2O3, namely Bi5+, Bi(3-x)+, Bi5+–O, Bi3+–O, I- and I3-, the charge separation in photocatalysis reactions can be effectively promoted. The Mott-Schottky measurements indicate that the conduction band(CB) level of BiOCl0.9I0.1/15%β-Bi2O3 becomes more negative relative to that of BiOCl0.9I0.1, guaranteeing an advantageous effect on the redox ability of the photocatalyst. This study provides a new bright spot for the construction of high-performance photocatalysts.

关键词： BiOCl0.9I0.1/β-Bi2O3 Degradation Tetracycline hydrochloride Photocatalysis Simulated sunlight

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Dendrobium officinale polysaccharide attenuates type 2 diabetes in mice model by modulating gut microbiota and alleviating intestinal mucosal barrier damage

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Food Science and Human Wellness 2024年

作者： Xiaoxia Chen Chun Chen Changyang ma Wenyi Kang Junlin Wu xiong Fu Guangzhou Wondfo Health Science and Technology Co.， Ltd. National R&D Center for Edible Fungus Processing Technology， Henan University Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety Guangzhou Institute of Modern Industrial Technology 4. Overseas Expertise Introduction Center for Discipline Innovation of Food Nutrition and Human Health (111 Center) SCUT-Zhuhai Institute of Modern Industrial Innovation， School of Food Science and Engineering， South China University of Technology

The purpose of this study was to investigate the hypoglycemic effect and mechanism of Dendrobium officinale polysaccharide (DOP) on type 2 diabetes mellitus (T2DM) mice established by high-fat diet and streptozotocin. The results showed that DOP improved glycolipid metabolism and serum inflammation levels， and inhibited intestinal-derived lipopolysaccharide (LPS) translocation， suggesting that inhibiting LPS-mediated intestinal barrier damage may be a key target for DOP to alleviate T2DM. Interestingly， the study found that DOP reduced intestinal inflammation and oxidative stress levels， significantly up-regulated the mRNA expression of tight junction proteins Claudin-1， Occludin and Zonula occluden-1 (ZO-1)， and ameliorated intestinal epithelial damage. In addition， DOP strongly inhibited the intestinal pathogenic bacteria and LPS-producing bacteria Helicobacter， Enterococcus and Desulfovibrio with a reduction rate of 95%， 73% and 9%， respectively， and promoted the proliferation of anti-inflammatory bacteria Bifidobacterium and Lactobacillus by 139% and 8%， respectively. Taken together， the hypoglycemic effect of DOP was related to the protection of intestinal mucosal barrier， and its underlying mechanism lied in its excellent anti-inflammatory and gut microbiota-modulatory effects， providing a theoretical basis for developing DOP as a novel prebiotic in functional food for diabetes.

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Application of fetoscopy in the management of monochorionic multiple pregnancies

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Chinese Medical Journal 2010年第1期123卷 105-107页

作者： ZHAO Yang-yu xiong Guang-wu ma Cai-hong WEI Yuan WANG Li-na QIAO Jie Department of Obstetrics and Gynecology Peking UniversityThird Hospital Beijing 100191 China

The complications of monochorionic （MC） multiple pregnancies include twin-reversed arterial perfusion（TRAP） and twin-to-twin transfusion syndrome （TTTS）. Currently, the most effective treatment for stages Ⅱ,Ⅲ, and Ⅳ TTTS is generally considered to be fetoscopic laser occlusion of chorioangiopagous vessels （FLOC）.3 MC twins who are severely discordant for growth or demonstrate anomalies may undergo selective reduction by means of a variety of different techniques.4 Radiofrequency ablation （RFA） of an acardiac twin has also proved to be an effective method of improving survival of the pump twin in the TRAP. Therefore, care for these complex pregnancies is ideally a coordinated multidisciplinary effort between perinatology, pediatric/fetal surgery, pediatric neurology, radiology/ ultrasound, genetics, social services, neonatology, and labor and delivery.

关键词： pregnancy reduction, multifetal fetoscopy twin-to-twin transfusion syndrome twins, mono^gotic

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Evidence-based independent risk factors for surgical site infections after spinal surgery:a systematic review

Evidence-based independent risk factors for surgical site in...

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作者： Dan Xing Xin-Long ma Jian-xiong ma Jie Wang Yang Chen Wei-Guo Xu Department of Orthopaedics Tianjin Medical University General Hospital Department of Orthopaedics Tianjin Gongan Hospital Department of Orthopaedics Institute Tianjin Hospital

Objective To identify the independent risk factors for the patients with surgical site infections (SSI) after spinal surgery based on available evidence in the literature. *** site infections(SSI) lead to higher morbidity,mortality and increased healthcare *** risk factors influence the postoperative *** which factors lead to an increased risk of SSI is of importance for the development of prophylactic protocols to counter this ***,these factors have neither been well synthesized or summarised according to methodological quality of studies evaluating risk factors for SSI. Methods Non-interventional studies evaluating the independent risk factors for the patients with SSI following spinal surgery were searched in Medline,Embase,Sciencedirect and *** of included studies were assessed by a modified quality assessment tool,which was previously designed for observational *** effects of studies were combined with the study quality score using a model of best-evidence synthesis. Results 35 observational studies involving 24,774 subjects were *** studies covered a wide range of indications and surgical *** articles published between 1998 to *** to the quality assessment criteria for included studies,14 studies were deemed as high quality studies,5 as moderate quality studies,and 16 as low quality studies.A total of 46 different type of independent factors were evaluated for the risk of *** were strong evidence for 6 factors,including obesity/BMI,longer operation time,diabetes,smoking,history of previous SSI and type of surgery *** also identified 8 moderate evidence,31 limited evidence and one conflicting evidence factors. Conclusion Whilst there is no conclusive evidence for the postoperative SSI,these data provide evidence to guide the clinician to admit patients who will have spinal operation and to choice a optimal prophylactic *** rese

关键词： surgical site infection spinal surgery postoperative infection risk factors systematic review

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Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice

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Zoological Research 2024年第5期45卷 1073-1087页

作者： Jing-Wei Ye Tanveer Abbas Jian-Teng Zhou Jing Chen Meng-Lei Yang xiong-Heng Huang Huan Zhang Hui ma Ao ma Bo Xu Ghulam Murtaza Qing-Hua Shi Bao-Lu Shi Division of Reproduction and Genetics First Affiliated Hospital of University of Science and Technology of ChinaHefei National Laboratory for Physical Sciences at MicroscaleSchool of Basic Medical SciencesDivision of Life Sciences and MedicineBiomedical Sciences and Health Laboratory of Anhui ProvinceInstitute of Health and MedicineHefei Comprehensive National Science CenterUniversity of Science and Technology of ChinaHefeiAnhui 230026China Institute of Andrology Nanjing Drum Tower HospitalAffiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China

Infertility represents a significant health concern,with sperm quantity and quality being crucial determinants of male ***(OAT)is characterized by reduced sperm motility,lower sperm concentration,and morphological abnormalities in sperm heads and *** variants in several genes have been implicated in OAT,its genetic etiologies and pathogenetic mechanisms remain inadequately *** this study,we identified a homozygous nonsense mutation(c.916C>T,***306*)in the coiled-coil domain containing 146(CCDC146)gene in an infertile male patient with *** mutation resulted in the production of a truncated CCDC146 protein(amino acids 1-305),retaining only two out of five coiled-coil *** validate the pathogenicity of the CCDC146 mutation,we generated a mouse model(Ccdc146^(mut/mut))with a similar mutation to that of the ***,the Ccdc146mut/mut mice exhibited infertility,characterized by significantly reduced sperm counts,diminished motility,and multiple defects in sperm heads and ***,the levels of axonemal proteins,including DNAH17,DNAH1,and SPAG6,were significantly reduced in the sperm of Ccdc146^(mut/mut) ***,both human and mouse CCDC146 interacted with intraflagellar transport protein 20(IFT20),but this interaction was lost in the mutated versions,leading to the degradation of *** study identified a novel deleterious homozygous nonsense mutation in CCDC146 that causes male infertility,potentially by disrupting axonemal protein *** findings offer valuable insights for genetic counseling and understanding the mechanisms underlying CCDC146 mutant-associated infertility in human males.

关键词： Oligoasthenoteratozoospermia Human infertility Sperm flagellum CCDC146 Intraflagellar transport IFT20

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