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J-shaped association between dietary thiamine intake and the risk of cognitive decline in cognitively healthy,older Chinese individuals

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General Psychiatry 2024年第1期37卷 44-52页

作者： Chengzhang Liu Qiguo Meng Yuanxiu Wei xinyue Su Yuanyuan Zhang Panpan He Chun Zhou Mengyi Liu Ziliang ye Xianhui Qin Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefeiAnhuiChina institute of Biomedicine Anhui Medical UniversityHefeiAnhuiChina Division of Nephrology Nanfang HospitalSouthern Medical UniversityNational Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchGuangdong Provincial Institute of NephrologyGuangdong Provincial Key Laboratory of Renal Failure ResearchGuangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhouGuangdongChina

Background The prospective association of dietary thiamine intake with the risk of cognitive decline among the general older adults remains uncertain.Aims To investigate the association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese individuals.Methods The study included a total of 3106 participants capable of completing repeated cognitive function tests.Dietary nutrient intake information was collected through 3-day dietary recalls and using a 3-day food-weighed method to assess cooking oil and condiment consumption.Cognitive decline was defined as the 5-year decline rate in global or composite cognitive scores based on a subset of items from the Telephone Interview for Cognitive Status-modified.Results The median follow-up duration was 5.9 years.There was a J-shaped relationship between dietary thiamine intake and the 5-year decline rate in global and composite cognitive scores,with an inflection point of 0.68 mg/day(95%confidence interval(Cl):0.56 to 0.80)and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.Before the inflection point,thiamine intake was not significantly associated with cognitive decline.Beyond the inflection point,each unit increase in thiamine intake(mg/day)was associated with a significant decrease of 4.24(95%Cl:2.22 to 6.27)points in the global score and 0.49(95%Cl:0.23 to 0.76)standard units in the composite score within 5 years.A stronger positive association between thiamine intake and cognitive decline was observed in those with hypertension,obesity and those who were non-smokers(all p<0.05).Conclusions This study revealed a J-shaped association between dietary thiamine intake and cognitive decline in cognitively healthy,older Chinese individuals,with an inflection point at 0.68 mg/day and a minimal risk at 0.60-1.00 mg/day of dietary thiamine intake.

关键词： intake shaped cognitive

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Role of bitter contributors and bitter taste receptors:a comprehensive review of their sources,functions and future development

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Food Science and Human Wellness 2024年第4期13卷 1806-1824页

作者： xinyue Zhou Han Wang Ming Huang Jin Chen Jianle Chen Huan Cheng Xingqian ye Wenjun Wang Donghong Liu College of Biosystems Engineering and Food Science National-Local Joint Engineering Laboratory of Intelligent Food Technology and EquipmentZhejiang Key Laboratory for Agro-Food ProcessingZhejiang Engineering Laboratory of Food Technology and EquipmentFuli Institute of Food ScienceZhejiang UniversityHangzhou 310058China Innovation Center of Yangtze River Delta Zhejiang UniversityJiashan 314100China Ningbo Research Institute Zhejiang UniversityNingbo 315100China Changshan Aijia Huyou Food Research and Development Center Changshan 324200China The Collaborative Innovation Center for Intelligent Production Equipment of Characteristic Forest Fruits in Hilly and Mountainous Areas of Zhejiang Province Hangzhou 311300China

Bitterness,one of the 5“basic tastes”,is usually undesired by humans.However,abundant literature reported that bitter fruits and vegetables have beneficial health effects due to their bitter contributors.This review provided an updated overview of the main bitter contributors of typical bitter fruits and vegetables and their health benefits.The main bitter contributors,including phenolics,terpenoids,alkaloids,amino acids,nucleosides and purines,were summarized.The bioactivities and wide range of beneficial effects of them on anti-cancers,anti-inflammations,anti-microbes,neuroprotection,inhibiting chronic and acute injury in organs,as well as regulating behavior performance and metabolism were reported.Furthermore,not only did the bitter taste receptors(taste receptor type 2 family,T2Rs)show taste effects,but extra-oral T2Rs could also be activated by binding with bitter components,regulating physiological activities via modulating hormone secretion,immunity,metabolism,and cell proliferation.This review provided a new perspective on exploring and explaining the nutrition of bitter foods,revealing the relationship between the functions of bitter contributors from food and T2Rs.Future trends may focus on revealing the possibility of T2Rs being targets for the treatment of diseases,exploring the mechanism of T2Rs mediating the bioactivities,and making bitter foods more acceptable without getting rid of bitter contributors.

关键词： Bitter contributors Bitter taste receptor Health benefits Fruits Vegetables

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Recent advances and applications of single atom catalysts based electrochemical sensors

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Nano Research 2024年第4期17卷 2994-3013页

作者： Mingyue Wang Mingfu ye Jieyue Wang Yong Xu Zhendong Wang xinyue Tong Xinya Han Kui Zhang Wenhai Wang Konglin Wu Xianwen Wei Institute of Clean Energy and Advanced Nanocatalysis(iClean) School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan 243002China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China Anhui International Research Center of Energy materials green manufacturing and biotechnology School of Chemistry and Chemical EngineeringAnhui University of TechnologyMaanshan 243002China Carbon Cycle and Emission Control Research Center Low-Carbon Research InstituteAnhui University of TechnologyMaanshan 243002China

Single atom catalysts(SACs)have attracted considerable attention due to their unique structures and excellent catalytic performance,especially in the area of catalysis science and energy conversion and storage.In recent years,SACs have emerged as a new type of sensing material for constructing electrochemical sensors(ECSs),presenting excellent sensitivity,selectivity,and stability.Herein,we review the recent advances of SACs in electrochemical sensing and discuss the status quo of current SAC-based ECSs.Specifically,the fundamentals of SAC-based ECSs are outlined,including the involved central metal atoms and various supports of SACs in this field,the detection mechanisms,and improving strategies of SAC-based ECSs.Moreover,the important applications of SAC-based ECSs are listed and classified,covering the detection of reactive oxygen and nitrogen species,environmental pollutants,disease biomarkers,and pharmaceuticals.Last,based on abundant reported cases,the current conundrums of SAC-based ECSs are summarized,and the prediction of their future developing trends is also put forward.

关键词： single atom catalysts(SACs) electrochemical sensors(ECSs) reactive oxygen and nitrogen species environmental pollutants disease biomarkers pharmaceuticals

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Revisiting the gravity laws of inter-city mobility in megacity regions

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Science China Earth Sciences 2023年第2期66卷 271-281页

作者： Pengjun ZHAO Haoyu HU Liangen ZENG Jun CHEN xinyue ye College of Urban and Environmental Sciences Peking UniversityBeijing100871China School of Urban Planning and Design Peking University Shenzhen Graduate SchoolShenzhen518055China Laboratory for Laboratory for Earth Surface System and Human-Earth Relations Ministry of Natural Resources of ChinaPeking University Shenzhen Graduate SchoolShenzhen518055China National Geomatics Center of China Beijing100048China Department of Landscape Architecture and Urban Planning Texas A&M UniversityCollege StationTX77843USA

Inter-city mobility is one of the most important issues in the UN Sustainable Development Goals,as it is essential to access the regional labour market,goods and services,and to constrain the spread of infectious diseases.Although the gravity model has been proved to be an effective model to describe mobility among settlements,knowledge is still insufficient in regions where dozens of megacities interact closely and over 100 million people reside.In addition,the existing knowledge is limited to overall population mobility,while the difference in inter-city travel with different purposes is unexplored on such a large geographic scale.We revisited the gravity laws of inter-city mobility using the 2.12 billion trip chains recorded by 40.48 million mobile phone users’trajectories in the Jing-Jin-Ji Region,which contains China’s capital Beijing.Firstly,unlike previous studies,we found that non-commuting rather than commuting is the dominant type of inter-city mobility(89.3%).Noncommuting travellers have a travel distance 42.3%longer than commuting travellers.Secondly,we developed more accurate gravity models for the spatial distribution of inter-city commuting and non-commuting travel.We also found that inter-city mobility has a hierarchical structure,as the distribution of inter-city travel volume follows Zipf’s law.In particular,the hierarchy of non-commuting travel volume among the cities is more in line with an ideal Zipf distribution than commuting travel.Our findings contribute to new knowledge on basic inter-city mobility laws,and they have significant applications for regional policies on human mobility.

关键词： Mobility Inter-city Travel behaviour Megacity region Zipf’s law China

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Autophagy and cancer treatment: four functional forms of autophagy and their therapeutic applications

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第2期23卷 89-101页

作者： Zhaoshi BAI Yaling PENG xinyue ye Zhixian LIU Yupeng LI Lingman MA Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&the Affiliated Cancer Hospital of Nanjing Medical University Nanjing 210009China School of Life Science and Technology China Pharmaceutical UniversityNanjing 211198China

Cancer is the leading cause of death worldwide. Drugs play a pivotal role in cancer treatment, but the complex biological processes of cancer cells seriously limit the efficacy of various anticancer drugs. Autophagy, a self-degradative system that maintains cellular homeostasis, universally operates under normal and stress conditions in cancer cells. The roles of autophagy in cancer treatment are still controversial because both stimulation and inhibition of autophagy have been reported to enhance the effects of anticancer drugs. Thus, the important question arises as to whether we should try to strengthen or suppress autophagy during cancer therapy. Currently, autophagy can be divided into four main forms according to its different functions during cancer treatment: cytoprotective(cell survival), cytotoxic(cell death), cytostatic(growth arrest), and nonprotective(no contribution to cell death or survival). In addition, various cell death modes, such as apoptosis, necrosis, ferroptosis, senescence, and mitotic catastrophe, all contribute to the anticancer effects of drugs. The interaction between autophagy and these cell death modes is complex and can lead to anticancer drugs having different or even completely opposite effects on treatment. Therefore, it is important to understand the underlying contexts in which autophagy inhibition or activation will be beneficial or detrimental.That is, appropriate therapeutic strategies should be adopted in light of the different functions of autophagy. This review provides an overview of recent insights into the evolving relationship between autophagy and cancer treatment.

关键词： Autophagy Cancer treatment Precision treatment Cell death mode

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Analysis and Characterization of the GABA Transaminase and Succinate Semialdehyde Dehydrogenase Genes in the Microalga Isochrysis zhanjiangensis in Response to Abiotic Stresses

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Journal of Ocean University of China 2024年第3期23卷 775-785页

作者： TIAN Jiaojiao ZHANG Lin LU xinyue ye Lingzhi WU Yuanyuan CHEN Deshui CAO Jiayi JIANG Jiaxin XU Jilin YAN Xiaojun Key Laboratory of Marine Biotechnology of Zhejiang Province School of Marine SciencesNingbo UniversityNingbo 315211China Key Laboratory of Aquacultural Biotechnology Ministry of Education Ningbo UniversityNingbo 315211China Laizhou Bay Marine Technology Co. Ltd.Yantai 261400China Fujian Dalai Seed Science and Technology Co. Ltd.Ningde 352101China

Gamma-aminobutyric acid(GABA),widely existing in different organisms,is rapidly accumulated in plants in response to environmental stresses.The main biosynthesis and degradation pathways of GABA constitute the GABA shunt,which is tied to the tricarboxylic acid(TCA)cycle.GABA transaminase(GABA-T)and succinate semialdehyde dehydrogenase(SSADH)are two essential enzymes for the GABA degradation pathway.While there are abundant studies on GABA shunt in higher plants at the physiological and genetic levels,research on its role in microalgae remains limited.This study aimed at exploring the function of GABA-T and SSADH genes in Isochrysis zhanjiangensis,an important diet microalga,under different stresses.We cloned two GABA-T genes,IzGABA-T1 and IzGABA-T2,and one SSADH gene IzSSADH from Isochrysis zhanjiangensis and conducted heterologous expression experiments.The results showed that the overexpression of IzGABA-T1 or IzGABA-T2 enhanced the survival rates of yeast transformants under heat or NaCl stress,while the overexpression of IzSSADH improved yeast tolerance to NaCl stress but had no obvious effect on heat stress.Additionally,the results of quantitative real-time polymerase chain reaction(qPCR)showed that IzGABA-T1 transcription increased in the HT(salinity 25,35℃)and LS(salinity 15,25℃)groups.At 24 h,the IzGABA-T2 transcriptions increased in the HT,LS,and HS(salinity 35,25℃)groups,but their transcription levels decreased in all groups at 48 h.IzSSADH transcription increased in the LS group.These results suggest that IzGABA-T1,IzGABA-T2,and IzSSADH are associated with temperature and salinity stresses and possess a certain preference for different stresses.

关键词： abiotic stress GABA heterologous expression Isochrysis zhanjiangensis transcription

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Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential ant1ip1 an-coronavirus activity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1186-1198页

作者： Minghui Yang Chunhui Li Guoguo ye Chenguang Shen Huiping Shi Liping Zhong Yuxin Tian Mengyuan Zhao Pengfei Wu Abid Hussain Tian Zhang Haiyin Yang Jun Yang Yuhua Weng xinyue Liu Zhimin Wang Lu Gan Qianyu Zhang Yingxia Liu Ge Yang Yuanyu Huang Yongxiang Zhao School of Life Science Advanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public HealthSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Targeting Oncology National Center for International Research of Biotargeting TheranosticsGuangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China CAMS Key Laboratory of Antiviral Drug Research Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Emerging and recurrent infectious diseases caused by human coronaviruses(HCoVs)continue to pose a significant threat to global public health security.In light of this ongoing threat,the development of a broad-spectrum drug to combat HCoVs is an urgently priority.Herein,we report a series of anti-pan-coronavirus ssDNA aptamers screened using Systematic Evolution of Ligands by Exponential Enrichment(SELEX).These aptamers have nanomolar affinity with the nucleocapsid protein(NP)of Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and also show excellent binding efficiency to the N proteins of both SARS,MERS,HCoV-OC43 and-NL63 with affinity KD values of 1.31 to 135.36 nM.Such aptamer-based therapeutics exhibited potent antiviral activity against both the authentic SARS-CoV-2 prototype strain and the Omicron variant(BA.5)with EC50 values at 2.00 nM and 41.08 nM,respectively.The protein docking analysis also evidenced that these aptamers exhibit strong affinities for N proteins of pan-coronavirus and other HCoVs(−229E and-HKU1).In conclusion,we have identified six aptamers with a high pan-coronavirus antiviral activity,which could potentially serve as an effective strategy for preventing infections by unknown coronaviruses and addressing the ongoing global health threat.

关键词： acute threat conclusion

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Qualitative spatial reasoning on topological relations by combining the semantic web and constraint satisfaction

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Geo-Spatial Information Science 2018年第2期21卷 80-92页

作者： Yandong Wang Mengling Qiao Hui Liu xinyue ye State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhanChina Collaborative Innovation Center of Geospatial Technology Wuhan UniversityWuhanChina Wuhan Land Resource and Planning and Information Center WuhanChina Department of Geography Kent State UniversityKentOHUSA

Qualitative spatial reasoning on topological relations can extract hidden spatial knowledge from qualitatively described topological information,which is of significant importance for decisionmaking and query optimization in spatial analysis.Qualitative reasoning on spatial topological information based on semantic knowledge and reasoning rules is an efficient means of reducing both the known relations and the corresponding rules,which can result in enhanced reasoning performance.This paper proposes a qualitative reasoning method for spatial topological relations based on the semantic description of reasoning rules and constraint set.Combined with knowledge from the Semantic Web,the proposed method can easily extract potential spatial results consistent with both unique and non-unique rules.The Constraint-Satisfactionbased approach,describing constraint set with semantic expressions,is then used together with an improved path consistency algorithm to verify the consistency of the unique-rules-based and non-unique-rules-based reasoning results.The verification can eliminate certain reasoning results to ensure the reliability of the final results.Thus,the task of qualitative spatial reasoning on topological relations is completed.

关键词： Qualitative spatial reasoning spatial rules constraint satisfaction topological relations

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不同道德情境下叠音品牌名称对消费者道德反应的影响——心智知觉理论的视角

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心理学报 2024年第5期56卷 650-669页

作者：叶巍岭徐苏周欣悦上海财经大学商学院上海200433 浙江大学管理学院杭州310058

品牌名称是建立品牌-消费者关系的重要连接点,是品牌资产的构成要素。品牌语言学的研究发现,品牌名称的语音特征会影响消费者的认知、情绪与行为,但鲜有研究考察语音特征对消费者的道德反应的影响及其路径。本研究基于心智知觉理论,探... 详细信息

品牌名称是建立品牌-消费者关系的重要连接点,是品牌资产的构成要素。品牌语言学的研究发现,品牌名称的语音特征会影响消费者的认知、情绪与行为,但鲜有研究考察语音特征对消费者的道德反应的影响及其路径。本研究基于心智知觉理论,探究了品牌分别作为道德主体和道德受害者两种不同的角色时,叠音品牌名称影响消费者道德反应的非对称性路径。具体而言:品牌作为道德主体违规的情境下,相较于非叠音,叠音品牌名称能通过降低消费者感知的品牌心智的“思考”维度(而非“感受”维度),来缓解消费者对品牌的消极道德反应(愤怒、厌恶、谴责、惩罚行为意图);而当品牌作为道德受害者受害的情境下,叠音品牌名称则通过提升消费者感知的品牌心智的“感受”维度(而非“思考”维度),来增强消费者对品牌的积极道德反应(同情、怜悯、遗憾、购买支持行为意图)。本研究通过7个实验证明了假设,从理论上创新性地探索了语音特征与道德反应的因果关系,揭示了品牌心智的两个维度作为不对称中介存在的机制,为实践中品牌道德事件公关和公益营销传播工作提供了借鉴。

关键词：叠音道德反应心智知觉理论道德主体道德受害者

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Modelling impacts of high-speed rail on urban interaction with social media in China’s mainland

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Geo-Spatial Information Science 2021年第4期24卷 638-653页

作者： Junfang Gong Shengwen Li xinyue ye Qiong Peng Sonali Kudva School of Geography and Information Engineering China University of GeosciencesWuhanChina National Engineering Research Center for Geographic Information System China University of GeosciencesWuhanChina Department of Landscape Architecture and Urban Planning&Department of Geography Urban Data Science LabTexas A&m UniversityCollege StationTXUSA Department of Urban Studies and Planning National Center for Smart GrowthUniversity of MarylandCollege ParkMDUSA Department of Communication University of TampaTampaFLUSA

High-Speed Rail(HSR)has increasingly become an important mode of inter-city transportation between large cities.Inter-city interaction facilitated by HSR tends to play a more prominent role in promoting urban and regional economic integration and development.Quantifying the impact of HSR’s interaction on cities and people is therefore crucial for long-term urban and regional development planning and policy making.We develop an evaluation framework using toponym information from social media as a proxy to estimate the dynamics of such impact.This paper adopts two types of spatial information:toponyms from social media posts,and the geographical location information embedded in social media posts.The framework highlights the asymmetric nature of social interaction among cities,and proposes a series of metrics to quantify such impact from multiple perspectives-including interaction strength,spatial decay,and channel effect.The results show that HSRs not only greatly expand the uneven distribution of inter-city connections,but also significantly reshape the interactions that occur along HSR routes through the channel effect.

关键词： High-Speed Rail social media asymmetric spatial relatedness channel effect China

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