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Pupillometry reveals hyper-arousal in response to auditory stimuli in autistic children

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第11期25卷 996-1008页

作者： Ci SONG Runsheng MA Wei NI xinyue peng Xue LI Ruoxi SHI Yuanping ZHANG Li YI School of Psychological and Cognitive Sciences Peking UniversityBeijing100871China Beijing Key Laboratory of Behavior and Mental Health Beijing100871China Peking University Institute of Mental Health Beijing100191China NHC Key Laboratory of Mental Health Peking UniversityBeijing100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing100191China Qingdao Autism Research Institute Qingdao266107China Tianjin YiTong Autism Research Service Center Tianjin300392China IDG/McGovern Institute for Brain Research at PKU Peking UniversityBeijing100871China

Atypical sensory responsivity is widely reported in autistic individuals and is related to elevated functional ***,altered initial responses and/or habituation rates could underlie their atypical averaged responses to repeated sensory *** this study we aimed to measure the arousal level in response to different types of auditory stimuli and the dynamic change of atypical arousal level using pupillometry in autistic *** Experiment 1,43 autistic children and 49 neurotypical(NT)children were asked to passively listen to a mild sound and an aversive sound *** Experiment 2,39 autistic children and 44 NT children who went through Experiment 1 listened to a gradually emerging non-startling sound and a suddenly emerging startling sound in a random *** found that the autistic group showed hyper-arousal in response to the aversive sound and the startling sound as reflected by their larger change in pupil *** comparison,these autistic children demonstrated normal arousal in response to the mild sound and the non-startling ***,the autistic group had a larger peak pupil area change than the NT group in the first trial and a normal habituation rate to the aversive *** summary,our results suggest hyper-arousal to aversive and startling stimuli and the role of larger initial responses in hyper-arousal in *** aversive and startling sensory stimuli or gradually increasing the volume of aversive auditory stimuli to allow autistic children to adapt using the principle of habituation is recommended to reduce the arousal level and problematic behaviors of autistic children.

关键词： Autism spectrum disorder Arousal Habituation Auditory Pupillometry

采用空间和通道激励注意力机制优化ResNet-50的CFRP/TC4叠层材料钻削刀具磨损状态监测

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中国机械工程 2024年第10期35卷 1793-1801页

作者：聂鹏杨程越彭新月于家鹤潘五九沈阳航空航天大学机电工程学院沈阳110136 沈阳飞机工业(集团)有限公司四十六厂沈阳110031

针对碳纤维增强复合材料(CFRP)与钛合金组成的叠层材料在制备装配孔时存在刀具磨损严重的问题,提出了一种空间和通道激励注意力机制(scSE)优化深度残差神经网络(ResNet-50)的刀具磨损监测方法。开展钻削实验,采集钻削过程中的力和温度信... 详细信息

针对碳纤维增强复合材料(CFRP)与钛合金组成的叠层材料在制备装配孔时存在刀具磨损严重的问题,提出了一种空间和通道激励注意力机制(scSE)优化深度残差神经网络(ResNet-50)的刀具磨损监测方法。开展钻削实验,采集钻削过程中的力和温度信号,信号经连续小波变换转换为小波尺度谱。搭建ResNet-50网络结构,从空间和通道双维度对卷积提取的特征图进行权重标定。研究结果表明,scSE可以从空间和通道两个维度做到增强有用特征,抑制无用特征,经scSE优化的网络结构识别准确度达到96.15%。

关键词：刀具磨损连续小波变换空间和通道激励注意力机制深度残差神经网络

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Lung-targeted polyzwitterionic lipid nanoparticles for effective treatment of lung inflammation

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Science China Chemistry 2025年第03期 1107-1116页

作者： Wen Zhang Jiaxin Li Nan Wang Muzi Li Chen peng xinyue Zhang Guanghui Ouyang Yan Li Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological EngineeringUniversity of Science and Technology Beijing CAS Key Laboratory of Colloid Interface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of Sciences

Lipid nanoparticles(LNPs) are non-viral nucleic acid delivery systems that show great potential in vaccine development and disease *** LNPs are particularly advantageous for in vivo delivery,the wide application of LNPs is impeded as their systemic delivery of nucleic acid drugs to extrahepatic tissues remains highly *** address this issue,we developed lung-targeted polyzwitterionic LNPs with zwitterionic polymer poly(2-methyacryloyloxyethyl phosphorylcholine)(PMPC) modified 1,2-dimyristoyl-sn-glycerol lipid for the delivery of small interfering RNA(si RNA).Three libraries with 90PMPC-LNPs@siRNA were *** polyzwitterionic PMPC-LNPs had high siRNA encapsulation efficiency of about 90%.The findings revealed that polyzwitterionic PMPC-LNPs@siRNA absorbed protein corona with the main component of Vitronectin,mediating lung-targeted delivery of *** good cellular uptake and endo/lysosomal escape ability,in vitro and in vivo studies demonstrated that polyzwitterionic PMPC-LNPs with siRNA against tumor necrosis factor-α(TNF-α) could significantly down-regulate the TNF-α in mRNA and protein levels,and improved the pathological features of lung *** PMPC-LNPs@siRNA achieved safe and efficient treatment of lung ***,this work offered a promising siRNA therapeutic approach for lung diseases.

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Natural killer cells in obstetric antiphospholipid syndrome

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Chinese Medical Journal 2022年第7期135卷 790-792页

作者： Rongxiu Huo Qianyu Guo Junping Hu Na Li Hechao Liu Zhaoliang Zhang Liangyu Mi xinyue peng Liyun Zhang Ke Xu Department of Rheumatology and Immunology Third Hospital of Shanxi Medical UniversityShanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxl HospitalTaiyuanShanxi 030032China Department of Immunology Shanxi Medical UniversityTaiyuanShanxi 030000China

Antiphospholipid syndrome(APS)is a systemic autoimmune disease characterized by thrombotic or obstetric events caused by persistent antiphospholipid antibodies(aPLs),namely lupus anticoagulant,anticardiolipin antibodies,or anti-β2 glycoprotein I(anti-β2GPI)antibodies.^([1])The main target antigen in APS isβ2GPI,through which aPL binds to the cell membrane and subsequently activates membrane receptors and down-stream signal *** may activate natural killer(NK)cells,leading to obstetric complications.

关键词： killer antibodies glycoprotein

Novel roles of RNA m6A methylation regulators in the occurrence of Alzheimer's Disease and the subtype classification

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Novel roles of RNA m6A methylation regulators in the occurre...

改进YOLOv3模型的GF-2卫星影像车辆检测

中国毒理学会第十次全国毒理学大会

作者： Min Li Wenli Cheng Luyun Zhang Cheng Zhou xinyue peng Susu Yu Wenjuan Zhang Department of Toxicology School of Medicine Jinan University

OBJECTIVE Alzheimer′s disease(AD) is one of the most common forms of dementia,closely related to epigenetic factors. N6-methyladenosine(m6A) related enzymes, combined proteinsand the potential targets were explored to affect the pathogenesis, immunity and development of *** The combined role of 25 common m6A RNA methylation regulators were detected in AD through the integrated bioinformatics approaches. We combined gene expression profiles from the GSE48350 and GSE5281 databases, including 250 normal controls and 176 AD patients, to first explore and validate m6A methylation regulators associated with AD and to identify key genes in AD. In addition, the novel role of m6A regulators,the correlation between m6A regulator expression and the immune infiltrationwere evaluated separatelyin AD and its subtype classification, and the potential targets of m6A regulators were finally explored. RESULTS The 14 m6A regulators related to AD were selected by analyzing differences between AD patients and normal controls. Based on the selected m6A regulators, AD patients could be well classified into two m6A models using consensus *** two clusters of patients had different immune profiles, and m6A regulators were associated with the components of immune cells. Additionally, there were 19 key AD genes obtained by screening differential genes through weighted gene co-expression network and least absolute shrinkage and selection operator regression analysis, which were highly associated with important m6A regulators during the occurrence of AD. More interestingly, NOTCH2 and NME1 could be potential targets for m6A regulation of AD. CONCLUSION The dysregulation of m6A methylation affects the occurrence of AD, which is vital for itssubtype classification and immune infiltration, also offering the possible intervention targets.

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测绘科学 2021年第12期46卷 147-154页

作者：彭新月张吴明钟若飞北京师范大学遥感科学国家重点实验室北京100875 中山大学测绘科学与技术学院广东珠海519082 南方海洋科学与工程广东省实验室(珠海) 广东珠海519080 首都师范大学三维信息获取与应用教育部重点实验室北京100048

针对卫星影像上车辆的漏检问题,该文对深度学习YOLOv3模型进行了网络改进,并用于高分二号卫星影像车辆检测。该方法通过减少原特征提取网络darknet-53的层数来降低网络复杂度,并在原YOLOv3模型3个尺度的基础上进行了尺度扩充以提高对小... 详细信息

针对卫星影像上车辆的漏检问题,该文对深度学习YOLOv3模型进行了网络改进,并用于高分二号卫星影像车辆检测。该方法通过减少原特征提取网络darknet-53的层数来降低网络复杂度,并在原YOLOv3模型3个尺度的基础上进行了尺度扩充以提高对小目标的检测能力。实验结果表明,改进后的YOLOv3模型较好地克服了多数深度学习算法不擅长检测小目标的短板,不仅检测结果比原算法更为精确,而且训练和检测速度也更快,具有一定的优势。

关键词：高分二号卫星遥感图像 YOLOv3 车辆检测深度学习

Modification strategies on nickel-based electrocatalysts for energyefficient anodic reactions

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Nano Research 2025年第1期18卷 50-75页

作者： Jingwen Yu Yunliang Liu Naiyun Liu Yaxi Li Yuanyuan Cheng peng Cao Yixian Liu Xinya Yuan xinyue Zhang Haitao Li Institute for Energy Research School of Chemistry and Chemical EngineeringJiangsu UniversityZhenjiang 212013China

Electrocatalytic chemical oxidation(ECO)is an energy-efficient anodic reaction alternative to the oxygen evolution reaction(OER).ECO lowers the reaction potential and yields higher-value fine chemicals at the *** catalyst material plays a crucial role in influencing and determining ECO *** catalyst performance encompasses aspects such as activity,stability,selectivity and *** electrocatalysts have garnered significant attention for their exceptional performance and widespread use in ECO *** modifying nickel-based electrocatalysts,the formation of NiOOH active centers can be *** such as adjusting size and morphology,doping,introducing defects and constructing heterojunctions are advantageous for enhancing *** the rapid advancements in related research fields,it is imperative to comprehend the mechanisms of nickel-based electrocatalysts in ECO and develop innovative *** article provides an overview of the modification strategies of nickel-based electrocatalysts,as well as their applications and mechanisms in ECO.

关键词： anodic reactions electrocatalytic chemical oxidation nickel-based electrocatalysts NiOOH modification strategies

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刑事合规背景下单位责任人的出罪逻辑与路径

北京警察学院学报 2023年第4期 23-31页

作者：彭欣悦中国政法大学北京100088

刑事合规背景下,存在“严惩责任人”与“放过责任人”之间的内在张力。事实上,基于民营企业尤其是小微企业持续稳定运营的价值分析,单位犯罪归责理论的检视证成以及域外司法实践的有益参考,刑事合规单位责任人出罪具有进一步思考的法理... 详细信息

刑事合规背景下,存在“严惩责任人”与“放过责任人”之间的内在张力。事实上,基于民营企业尤其是小微企业持续稳定运营的价值分析,单位犯罪归责理论的检视证成以及域外司法实践的有益参考,刑事合规单位责任人出罪具有进一步思考的法理逻辑。出罪路径方面,应以再次犯罪危险显著降低为前提,以责任人在合规中的重要作用为依据,并基于类型化思维,对公司治理结构完善的企业,考虑单位责任人的实质作用;对于公司治理结构失范的企业,则充分结合认罪认罚从宽制度、相对不起诉制度等,扩大从宽幅度。

关键词：刑事合规单位犯罪责任人出罪出罪路径

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布朗单增量的Strassen重对数律

数学进展 2021年第2期50卷 267-276页

作者：刘永宏彭心悦桂林电子科技大学数学与计算科学学院广西高校数据分析与计算重点实验室桂林广西541004

利用布朗单与布朗单增量的大偏差,得到了布朗单与布朗单增量的泛函重对数律.

关键词：布朗单增量泛函重对数律