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GaN nanowires/Si photocathodes for CO_(2) reduction towards solar fuels and chemicals: advances, challenges, and prospects

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Science China Chemistry 2023年第3期66卷 739-754页

作者： Baowen Zhou Jinglin Li xinyue dong Lin Yao Key Laboratory for Power Machinery and Engineering of Ministry of Education School of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240China China-UK Low Carbon College Shanghai Jiao Tong UniversityShanghai 201306China

Photoelectrocatalytic(PEC)production of fuels and chemicals by using solar energy,water,and CO_(2) paves a promising avenue toward carbon neutrality.Over the past decades,for accelerating this process,a variety of photocathodes have been explored.Among them,the hybrid of GaN nanowires(NWs)and planar silicon has appeared as a disruptive platform for this grand topic,owing to their distinctive structural,optoelectronic,and catalytic properties.This review illustrates the most recent advances in GaN NWs/Si-based photocathodes for CO_(2) reduction reactions powered by simulated sunlight,beginning with a discussion of the critical requirements and fundamental challenges of PEC CO_(2) reduction.The characteristics of GaN NWs/Si are then discussed,showing its great potential in precisely controlling the behavior of photons,charges,and chemical species.As the focus of this review,the progress on the PEC CO_(2) reduction reactions toward different products over GaN NWs/Si-based photocathodes is highlighted.In the end,the challenges and prospects of GaN NWs/Si-based photocathodes for the practical synthesis of solarfuels and chemicals are proposed.

关键词： GaN NWs/Si photocathodes solar fuels and chemicals CO reduction reactions

Active label distribution learning via kernel maximum mean discrepancy

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Frontiers of Computer Science 2023年第4期17卷 69-81页

作者： xinyue dong Tingjin LUO Ruidong FAN Wenzhang ZHUGE Chenping HOU College of Science National University of Defense TechnologyChangsha 410073China

Label distribution learning(LDL)is a new learning paradigm to deal with label ambiguity and many researches have achieved the prominent performances.Compared with traditional supervised learning scenarios,the annotation with label distribution is more expensive.Direct use of existing active learning(AL)approaches,which aim to reduce the annotation cost in traditional learning,may lead to the degradation of their performance.To deal with the problem of high annotation cost in LDL,we propose the active label distribution learning via kernel maximum mean discrepancy(ALDL-kMMD)method to tackle this crucial but rarely studied problem.ALDL-kMMD captures the structural information of both data and label,extracts the most representative instances from the unlabeled ones by incorporating the nonlinear model and marginal probability distribution matching.Besides,it is also able to markedly decrease the amount of queried unlabeled instances.Meanwhile,an effective solution is proposed for the original optimization problem of ALDL-kMMD by constructing auxiliary variables.The effectiveness of our method is validated with experiments on the real-world datasets.

关键词： label distribution learning active learning maximum mean discrepancy auxiliary variable

Efficacy and safety of human umbilical cord-derived mesenchymal stem cells in the treatment of refractory immune thrombocytopenia:a prospective,single arm,phase I trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2250-2259页

作者： Yunfei Chen Yanmei Xu Ying Chi Ting Sun Yuchen Gao Xueqing Dou Zhibo Han Feng Xue Huiyuan Li Wei Liu Xiaofan Liu Huan dong Rongfeng Fu Mankai Ju xinyue Dai Wentian Wang Yueshen Ma Zhen Song Jundong Gu Wei Gong Renchi Yang Lei Zhang State Key Laboratory of Experimental Hematology National Clinical Research Centre for Blood DiseasesHaihe Laboratory of Cell EcosystemTianjin Key Laboratory of Gene Therapy for Blood DiseasesCAMS Key Laboratory of Gene Therapy for Blood DiseasesInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Tianjin Institutes of Health Science Tianjin 301600China National Clinical Research Center for Hematologic Diseases Jiangsu Institute of HematologyThe First Affiliated Hospital of Soochow UniversitySuzhou 215006China National Engineering Research Centre of Cell Products Tianjin Key Laboratory of Engineering Technologies for Cell PharmaceuticalAmCellGene Engineering Co.LtdTianjin 300457China School of Population Medicine and Public Health Chinese Academy of Medical Sciences and Peking Union Medical College100730 BeijingChina

Patients with refractory immune thrombocytopenia(ITP)frequently encounter substantial bleeding risks and demonstrate limited responsiveness to existing therapies.Umbilical cord-derived mesenchymal stem cells(UC-MSCs)present a promising alternative,capitalizing on their low immunogenicity and potent immunomodulatory effects for treating diverse autoimmune disorders.This prospective phase I trial enrolled eighteen eligible patients to explore the safety and efficacy of UC-MSCs in treating refractory ITP.The research design included administering UC-MSCs at escalating doses of 0.5×10^(6)cells/kg,1.0×10^(6)cells/kg,and 2.0×10^(6)cells/kg weekly for four consecutive weeks across three cohorts during the dose-escalation phase,followed by a dose of 2.0×10^(6)cells/kg weekly for the dose-expansion phase.Adverse events,platelet counts,and changes in peripheral blood immunity were monitored and recorded throughout the administration and follow-up period.Ultimately,12(with an addition of three patients in the 2.0×10^(6)cells/kg group due to dose-limiting toxicity)and six patients were enrolled in the dose-escalation and dose-expansion phase,respectively.Thirteen patients(13/18,72.2%)experienced one or more treatment emergent adverse events.Serious adverse events occurred in four patients(4/18,22.2%),including gastrointestinal hemorrhage(2/4),profuse menstruation(1/4),and acute myocardial infarction(1/4).The response rates were 41.7%in the dose-escalation phase(5/12,two received 1.0×10^(6)cells/kg per week,and three received 2.0×10^(6)cells/kg per week)and 50.0%(3/6)in the dose-expansion phase.The overall response rate was 44.4%(8/18)among all enrolled patients.To sum up,UC-MSCs are effective and well tolerated in treating refractory ITP(ClinicalTrials.gov ID:NCT04014166).

关键词： doses immunity treatment

Near room-temperature ferromagnetism in air-stable twodimensional Cr_(1−x)Te grown by chemical vapor deposition

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Nano Research 2022年第4期15卷 3763-3769页

作者： Zhansheng Gao Ming Tang Junwei Huang Jiabiao Chen Wei Ai Linglu Wu xinyue dong Yifei Ma Zheshan Zhang Lei Zhang Yaping Du Huixia Fu Hongtao Yuan Jinxiong Wu Feng Luo Tianjin Key Lab for Rare Earth Materials and Applications Center for Rare Earth and Inorganic Functional MaterialsSchool of Materials Science and EngineeringNankai UniversityTianjin 300350China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing 210093China Center of Quantum Materials and Devices&College of Physics Chongqing UniversityChongqing 401331China Beijing National Laboratory for Molecular Sciences Beijing 100871China

Identifying air-stable two-dimensional(2D)ferromagnetism with high Curie temperature(T_(c))is highly desirable for its potential applications in next-generation spintronics.However,most of the work reported so far mainly focuses on promoting one specific key factor of 2D ferromagnetism(T_(c)or air stability),rather than comprehensive promotion of both of them.Herein,ultrathin Cr_(1-x)Te crystals grown by chemical vapor deposition(CVD)show thickness-dependent T_(c)up to 285 K.The out-of-plane ferromagnetic order is well preserved down to atomically thin limit(2.0 nm),as evidenced by anomalous Hall effect observed in non-encapsulated samples.Besides,the CVD-grown Cr_(1-x)Te nanosheets present excellent ambient stability,with no apparent change in surface roughness or electrical transport properties after exposure to air for months.Our work provides an alternative platform for investigation of intrinsic 2D ferromagnetism and development of innovative spintronic devices.

关键词： Cr1-xTe room-temperature ferromagnetism air stability anomalous Hall effect chemical vapor deposition

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内蒙古伊敏盆地地下水水化学特征及其成因

干旱区研究 2024年第3期41卷 411-420页

作者：王平顺苗新岳燕亚平董生旺董少刚内蒙古大学生态与环境学院内蒙古呼和浩特010021 内蒙古自治区河流与湖泊生态重点实验室内蒙古呼和浩特010021 东北农业大学资源环境学院黑龙江哈尔滨150030 内蒙古生态环境科学研究院有限公司内蒙古呼和浩特010015 内蒙古第一水文地质工程地质勘查有限责任公司内蒙古呼和浩特010020

采矿活动强烈地改变了区域水文循环特征并对地下水化学特征产生明显影响,揭示煤矿开发影响下的地下水系统演变特征,可为煤矿区的生态环境保护和可持续发展提供理论支持。本文以内蒙古伊敏盆地为例,在水文地质调查的基础上结合地下水流... 详细信息

采矿活动强烈地改变了区域水文循环特征并对地下水化学特征产生明显影响,揭示煤矿开发影响下的地下水系统演变特征,可为煤矿区的生态环境保护和可持续发展提供理论支持。本文以内蒙古伊敏盆地为例,在水文地质调查的基础上结合地下水流动系统理论、Piper三线图、Gibbs图、离子比例系数、矿物饱和指数等分析方法探究煤矿开采活动干扰下的地下水化学变化特征。结果表明:研究区水环境整体上呈弱碱性,采矿显著影响区和非影响区内检测指标存在着不同程度的超标情况。盆地内煤矿开采疏排地下水加速了区域水文循环速度,使显著影响区水质向淡化方向演化。露天煤矿的开发使得原本封闭的地下水系统变得开放,含硫煤以及硫铁矿氧化产酸激发的一系列水-岩相互作用是区域地下水化学特征发生变化的主因。盆地地下水的水化学成分受蒸发浓缩作用和水-岩相互作用的影响。沿着地下水的流动方向,显著影响区内水化学类型是从HCO_(3)-Ca·Na型向HCO_(3)-Ca型变化,TDS和Cl-浓度呈现出下降趋势;在非影响区内是从HCO_(3)-Ca·Na型向Cl-Ca·Mg型转变,TDS和Cl-浓度表现为上升趋势。

关键词：地下水水化学特征人类活动影响水-岩相互作用伊敏盆地

Tumor microenvironment-responsive docetaxel-loaded micelle combats metastatic breast cancer

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Science Bulletin 2019年第2期64卷 91-100页

作者： Tianqun Lang xinyue dong Zhong Zheng Yiran Liu Guanru Wang Qi Yin Yaping Li State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences Nano Science and Technology Institute University of Science and Technology of China College of Life Sciences Jilin University School of Pharmacy Yantai University

Efficient tumor-targeting drug delivery systems are urgently needed for treating metastatic breast cancer.In this work, a docetaxel(DTX)-loaded micelle(pDM) as the tumor-microenvironment-responsive delivery platform is developed. The micelle is composed of a pH-sensitive amphiphilic copolymer,poly((1,4-butanediol)-diacrylate-b-N,N-diisopropylethylenediamine)-polyethyleneimine(BD-PEI), and a matrix metalloproteinase(MMP)-responsive polymer, poly((1,4-butanediol)-diacrylate-b-N,N-diisopropy lethylenediamine)-peptide-polyethylene glycol(PEG)(BD-peptide-PEG). The PEG block of BD-peptidePEG will be split by MMPs at the tumor microenvironment, which leads to the change of the surface charge and particle size of the micelle to more positive and smaller one. Owing to this transformation and enhanced permeability and retention(EPR) effect, pDM delivers more DTX into tumor tissues and is internalized more efficiently by tumor cells than the non-MMP-sensitive micelles in the 4 T1 tumorbearing mice model. In addition, DTX is released in acidic endo/lysosomes due to the dissociation of the micelle, triggered by the protonation of the hydrophobic block of BD-PEI. As a result, the DTX-loaded micelle inhibits primary tumor growth and pulmonary metastasis effectively. Thus, this pH/MMP-dual-sensitive drug delivery system, which simultaneously attains three keypoints: prolonged circulation time, directional and efficient uptake into tumor cells, and speedy intracellular drug release, is a promising strategy for metastatic breast cancer therapy.

关键词： Breast cancer Dual-sensitive micelle Metastasis Tumor-targeting

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长白落叶松人工林年轮宽度对气候变化的响应

森林工程 2024年第1期40卷 64-73页

作者：郭新月王文彬董灵波东北林业大学林学院森林生态系统可持续经营教育部重点实验室哈尔滨150040 日照市农业科学研究院山东日照276800

为揭示长白落叶松(Larix olgensis)人工林早材、晚材和全材年轮宽度对气候的响应程度,以东北林业大学帽儿山实验林场27块样地的135株样木树芯为数据源,在建立树木年轮年表的基础上,采用相关性分析量化其早材、晚材和全材年轮宽度与气候... 详细信息

为揭示长白落叶松(Larix olgensis)人工林早材、晚材和全材年轮宽度对气候的响应程度,以东北林业大学帽儿山实验林场27块样地的135株样木树芯为数据源,在建立树木年轮年表的基础上,采用相关性分析量化其早材、晚材和全材年轮宽度与气候要素的关系。结果表明,长白落叶松年轮宽度在时间尺度上可划分为2个明显不同的时间段,其中1974—1985年树木生长主要受春秋两季的温度影响,而1986—2019年则主要受夏季温度的影响。在1974—1985年,冬春季的最高温度和最低温度,特别是上一年和当年的1月和2月以及4月和5月与早材和全材年轮宽度的影响呈负相关的(P<0.05),与晚材年轮宽度的影响呈正相关(P<0.05);上一年和当年春季4、5月的无霜期与早材年轮宽度的影响呈负相关(P<0.05)。在1986—2019年,夏季尤其是上一年和当年6、7月的最高温度以及最低温度与晚材年轮宽度有显著的正相关性(P<0.05);夏季上一年和当年7月的平均温度与晚材年轮宽度的生长有显著的正相关性(P<0.05),但与早材和全材年轮宽度有显著的负相关性(P<0.05)。整体来看,生长季的温度尤其是最低温度和平均温度是限制长白落叶松人工林早材和晚材生长的主要因素,而降水对早材和晚材生长的影响则不显著。

关键词：早材晚材全材气候年轮宽度长白落叶松

聚苯乙烯微塑料对杜氏盐藻生长及低分子量有机酸释放的影响研究

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海洋环境科学 2024年第2期43卷 252-261页

作者：董晓丁海兵乔馨越李琪中国海洋大学深海圈层与地球系统前沿科学中心海洋化学理论与工程技术教育部重点实验室和化学化工学院山东青岛266100 崂山实验室海洋生态与环境科学功能实验室山东青岛266235

本文通过系列培养实验,研究了不同粒径(1μm、3μm、10μm)聚苯乙烯(polystyrene,PS)微塑料对杜氏盐藻(Dunaliella salina)的生长过程和低分子量有机酸释放的影响。结果表明,杜氏盐藻在生长过程中能够释放甲酸、乙酸和乳酸3种低分子量... 详细信息

本文通过系列培养实验,研究了不同粒径(1μm、3μm、10μm)聚苯乙烯(polystyrene,PS)微塑料对杜氏盐藻(Dunaliella salina)的生长过程和低分子量有机酸释放的影响。结果表明,杜氏盐藻在生长过程中能够释放甲酸、乙酸和乳酸3种低分子量有机酸。PS微塑料的添加能够延后培养体系乙酸和乳酸的积累,降低培养体系乙酸的积累量,提高乳酸的积累量,并导致培养体系甲酸的明显积累。不同粒径PS微塑料对杜氏盐藻生长和低分子有机酸释放的影响有显著差异。粒径3μm的PS微塑料能在杜氏盐藻生长初期抑制其将海水中的NO3-N转化为NO2-N,对延后并降低培养体系乙酸积累有显著作用。粒径1μm的PS微塑料能够显著延长培养体系乳酸的积累时间。粒径1μm和3μm的PS微塑料均能显著影响杜氏盐藻甲酸的产生与消耗,使培养体系出现明显的甲酸积累。释放甲酸可能是海洋微藻普遍存在的过程。

关键词：杜氏盐藻聚苯乙烯微塑料低分子量有机酸

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中药有效成分结合支架材料促进骨组织再生

中国组织工程研究 2024年第20期28卷 3240-3245页

作者：董心雨董馨月王婉婷范海霞程焕芝济宁医学院口腔医学院山东省济宁市272000

背景:随着淫羊藿苷、黄连素等中药被证实可以促进骨再生,研究者将中药活性成分与骨组织工程相结合,发现其在骨缺损的修复中具有独特优势。目的:从促进成骨的中药有效成分出发,筛选其与不同载药支架材料有效结合的案例,归纳总结有潜力应... 详细信息

背景:随着淫羊藿苷、黄连素等中药被证实可以促进骨再生,研究者将中药活性成分与骨组织工程相结合,发现其在骨缺损的修复中具有独特优势。目的:从促进成骨的中药有效成分出发,筛选其与不同载药支架材料有效结合的案例,归纳总结有潜力应用于骨组织工程的中药有效成分。方法:应用计算机检索中国知网、万方、PubMed、Web of Science等数据库,以“骨组织工程,骨组织工程支架材料,骨缺损,骨修复,骨再生,中医药”为中文检索词,以“bone tissue engineering,bone tissue-engineered scaffold materials,bone defect,bone repair,bone regeneration,traditional Chinese medicine”为英文检索词,检索时限限定为2000-2023年,根据纳入和排除标准进行筛选,最终纳入87篇文献进行综述。结果与结论:促进骨再生的中药有效成分种类繁多,主要包括黄酮类化合物、非黄酮类多酚、生物碱、苷类,有消炎止痛、促进成骨细胞和抑制破骨细胞以及促进血管早期生成的作用。中药有效成分与骨组织工程结合后在抗炎、加速胶原蛋白和骨骼形成、促进成骨基因表达等方面效果显著,为中药在骨组织再生中的应用提供了理论依据,同时为骨缺损修复提供了新的思路。

关键词：中药有效成分骨缺损骨再生骨组织工程支架材料血管生成