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Nano Research 2023年第7期16卷 9022-9030页

作者： Jun Qi xinyu zhong Huiyan Zeng Chao Wang zhongfei Liu Jiajun Chen Long Gu Enna Hong Mengxian Li Jiong Li Chunzhen Yang School of Materials Shenzhen Campus of Sun Yat-Sen UniversityShenzhen 518107China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

Understanding the dynamic structural and chemical evolutions at the catalyst-electrolyte interfaces is crucial for the development of active and stable electrocatalysts.In this work,β-Li_(2)IrO_(3)is employed as a model catalyst for the oxygen evolution reaction(OER).Its elastic three-dimensional Ir-O framework enables us to investigate the Li^(+)cation dissolution-induced structure evolutions and the formation mechanism of amorphous IrO_(x)species.Electrochemical measurements by rotating ring disk electrode(RRDE)reveal that up to 60%of the measured OER current can be ascribed to catalyst degradation.A series of in-situ X-ray diffraction spectroscopy(XRD),X-ray absorption spectroscopy(XAS),and Raman spectroscopy are conducted.Structure vibration is observed with oxidation states of Ir being reduced abnormally during OER at high potentials.It’s hypothesized that the reversible proton intercalations are responsible for the Ir turn-over mechanism.Results of this work demonstrate a stable and elastic iridate structure and reveal the initial catalyst degradation behaviors during OER in acid media.

关键词： oxygen evolution reaction structure evolution amorphization acid media catalyst degradation

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侵犯公民个人信息罪的法益界定及其路径

镇江高专学报 2024年第1期37卷 41-45页

作者：钟欣煜武汉大学法学院湖北武汉430072

在法益二元论视域下,侵犯公民个人信息罪的保护法益并不符合集体法益的内涵特征,集体法益说存在一定的逻辑缺陷。侵犯公民个人信息罪的保护法益应当是基于公法法益观的个人法益——个人信息安全,兼顾个人信息的多元价值,回应网络社会保... 详细信息

在法益二元论视域下,侵犯公民个人信息罪的保护法益并不符合集体法益的内涵特征,集体法益说存在一定的逻辑缺陷。侵犯公民个人信息罪的保护法益应当是基于公法法益观的个人法益——个人信息安全,兼顾个人信息的多元价值,回应网络社会保障公民个人信息合理利用之诉求。

关键词：侵犯公民个人信息罪集体法益个人法益个人信息安全

城区与郊区NO_(2)-O_(3)作用的多重分形差异分析

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环境科学与技术 2024年第S1期47卷 79-85页

作者：罗静张娇黄毅钟心宇陈智荣刘春琼史凯吉首大学数学与统计学院湖南吉首416000 西华师范大学环境科学与工程学院四川南充637009

为定量揭示城区和郊区O_(3)前体物对O_(3)生成的差异化影响,文章基于多重分形去趋势互相关分析法和K均值聚类算法,对2016-2022年四川省15个重点城市城区和郊区不同站点NO_(2)-O_(3)互相关性的多尺度特征进行对比分析。结果表明,城区和... 详细信息

为定量揭示城区和郊区O_(3)前体物对O_(3)生成的差异化影响,文章基于多重分形去趋势互相关分析法和K均值聚类算法,对2016-2022年四川省15个重点城市城区和郊区不同站点NO_(2)-O_(3)互相关性的多尺度特征进行对比分析。结果表明,城区和郊区大气NO_(2)-O_(3)互相关性均具有多重分形性及长期持续性特征,且郊区站点多重分形强度显著高于城区。城区和郊区NO_(2)-O_(3)互相关性多重分形强度差异呈现逐年递增规律,且受季节影响较大,其中夏季城区和郊区差异最大,冬季最小,这些差异主要受O_(3)前体物排放特征和热岛效应的影响。研究结果有助于从新的角度理解城区郊区大气污染差异及形成机理,为城郊O_(3)精细化预测模型的完善提供动力参数。

关键词：臭氧二氧化氮多重分形 K均值聚类热岛效应

Single-Cell Mapping of Brain Myeloid Cell Subsets Reveals Key Transcriptomic Changes Favoring Neuroplasticity after Ischemic Stroke

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Neuroscience Bulletin 2024年第1期40卷 65-78页

作者： Fangxi Liu Xi Cheng Chuansheng Zhao Xiaoqian Zhang Chang Liu Shanshan zhong Zhouyang Liu xinyu Lin Wei Qiu Xiuchun Zhang Department of Neurology.The First Affiliated Hospital of China Medical University Shenyang 110001China Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Stroke Center The First Affiliated Hospital of China Medical UniversityShenyang 110001China

Interactions between brain-resident and periph-eral infiltrated immune cells are thought to contribute to neuroplasticity after cerebral ischemia.However,con-ventional bulk sequencing makes it challenging to depict this complex immune network.Using single-cell RNA sequencing,we mapped compositional and transcriptional features of peri-infarct immune cells.Microglia were the predominant cell type in the peri-infarct region,displaying a more diverse activation pattern than the typical pro-and anti-inflammatory state,with axon tract-associated micro-glia(ATMs)being associated with neuronal regeneration.Trajectory inference suggested that infiltrated monocyte-derived macrophages(MDMs)exhibited a gradual fate trajectory transition to activated MDMs.Inter-cellular crosstalk between MDMs and microglia orchestrated anti-inflammatory and repair-promoting microglia phenotypes and promoted post-stroke neurogenesis,with SOX2 and related Akt/CREB signaling as the underlying mechanisms.This description of the brain's immune landscape and its relationship with neurogenesis provides new insight into promoting neural repair by regulating neuroinflammatory responses.

关键词： Ischemic stroke Monocyte-derived macrophage Microglia Neurogenesis Single-cell sequencing

Subsequent strategies and underlying mechanism of acquired resistance to PD-1 axis inhibitors in advanced non-small cell lung cancer

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中华医学杂志(英文版) 2024年第7期137卷 880-882页

作者： Wang Huilan Cheng xinyu Yang Fan Chen Lu Zhang Anmei zhong Liangzhi Long Haixia Zhu Bo Wang zhongyu Institute of Cancer Xinqiao Hospital Third Military Medical University Chongqing 400037 China

To the Editor:With the widespread application of immune checkpoint inhibitors (ICIs) in clinical practice,acquired resistance (AR) to programmed death-1 (PD-1)/programmed death ligand 1 (PD-L1) axis inhibitors in advanced nonsmall cell lung cancer (NSCLC) develops and limits the durability of immunotherapy.AR is a clinical condition in which a patient initially responds to ICIs but relapses and progresses after a period of time.The rates of AR have not been routinely reported in lung cancer but typically range from 12.9% to 64%.However,studies on subsequent management strategies and the mechanism of AR to PD-1/PD-L1 axis inhibitors in lung cancer are limited.The main exploratory strategies are immunotherapy rechallenge and the combination of ICIs with other therapies,including local therapy,chemotherapy,antiangiogenetic treatment,and cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibitors.The purpose of this study was to characterize the clinical patterns of AR and compare different subsequent therapies and outcomes in NSCLC patients after AR to PD-1/PD-L1 inhibitors.Moreover,we explored the underlying mechanism of AR by analyzing the alterations in next-generation sequencing (NGS) data before and after AR.

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基于便携式近红外光谱仪的土茯苓配方颗粒一致性评价及定量分析方法

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广西医科大学学报 2024年第4期41卷 590-597页

作者：钟欣瑜秦鑫韦锦斌韦红言叶善洋苏志恒梁永红广西医科大学药学院南宁530021 培力南宁药业有限公司南宁530007

目的:建立土茯苓配方颗粒一致性评价及指标成分落新妇苷含量的快速测定方法。方法:基于便携式近红外光谱仪,使用软件OMNIC建立一致性评价模型;结合偏最小二乘法(PLS)、支持向量回归(SVR)建立落新妇苷定量模型。结果:55批土茯苓配方颗粒... 详细信息

目的:建立土茯苓配方颗粒一致性评价及指标成分落新妇苷含量的快速测定方法。方法:基于便携式近红外光谱仪,使用软件OMNIC建立一致性评价模型;结合偏最小二乘法(PLS)、支持向量回归(SVR)建立落新妇苷定量模型。结果:55批土茯苓配方颗粒指纹图谱特征相似,相似度为0.992 8~0.999 6;落新妇苷PLS和SVR定量模型预测集相关系数(R_(P))分别为0.848 3、0.899 0,预测均方根误差(RMSEP)分别为1.809、1.481。结论:本研究基于便携式近红外光谱仪建立了土茯苓配方颗粒的快速评价方法,所建模型可无损、快速地预测指标成分含量,为土茯苓配方颗粒的质量控制提供一定的参考依据。

关键词：近红外光谱土茯苓配方颗粒落新妇苷一致性评价定量分析

Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

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Journal of Genetics and Genomics 2024年第5期51卷 517-530页

作者： Yuntao Sun Mengge Wang Qiuxia Sun Yan Liu Shuhan Duan Zhiyong Wang Yunyu Zhou Jun zhong Yuguo Huang xinyu Huang Qingxin Yang Xiangping Li Haoran Su Yan Cai Xiucheng Jiang Jing Chen Jiangwei Yan Shengjie Nie Liping Hu Junbao Yang Renkuan Tang Chuan-Chao Wang Chao Liu Xiaohui Deng Libing Yun Guanglin He West China School of Basic Science&Forensic Medicine Sichuan UniversityChengduSichuan 610041China Institute of Rare Diseases West China Hospital of Sichuan UniversitySichuan UniversityChengduSichuan 610000China Center for Archaeological Science Sichuan UniversityChengduSichuan 610000China Faculty of Forensic Medicine Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510275China Guangzhou Forensic Science Institute GuangzhouGuangdong 510055China Department of Forensic Medicine College of Basic MedicineChongqing Medical UniversityChongqing 400331China School of Clinical Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Basic Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Forensic Medicine Kunming Medical UniversityKunmingYunnan 650500China School of Stomatology North Sichuan Medical CollegeNanchongSichuan 637100China Department of Medical Laboratory North Sichuan Medical CollegeNanchongSichuan 637007China School of Life Sciences Xiamen UniversityXiamenFujian 361005China Anti-Drug Technology Center of Guangdong Province GuangzhouGuangdong 510230China School of Forensic Medicine Shanxi Medical UniversityJinzhongShanxi030600China

Tibeto-Burman(TB)people have endeavored to adapt to the hypoxic,cold,and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic period.However,the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people,as well as their interaction mechanism,remain unknown.Here,we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity,admixture history,and differentiated adaptative features of geographically different TB-speaking people.We identify genetic differentiation related to geography and language among TB-speaking people,consistent with their differentiated admixture process with incoming or indigenous ancestral source populations.A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin hypothesis.We finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish speakers.Adaptative signatures associated with the physical pigmentation(EDAR and SLC24A5)and metabolism(ALDH9A1)are identified in Loloish people,which differed from the high-altitude adaptative genetic architecture in Tibetan.TB-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.

关键词： Tibeto-Burman people Geneticprofile Natural selection Geneticdiversity Biological adaptation

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框架语义学视角下中国菜名英译研究

洛阳师范学院学报 2022年第7期41卷 83-86页

作者：钟新宇朱敏燕山大学外国语学院河北秦皇岛066000

从框架语义学视角分析中华食谱的英译,探究中国菜原文和英译文之间的框架关系。研究发现菜名由复杂食材构成时即食材前有限定成分,原文和英译文语义框架间多呈现包含关系;菜名中含有该菜属性或特点时,原文和英译文框架间呈现相交关系;... 详细信息

从框架语义学视角分析中华食谱的英译,探究中国菜原文和英译文之间的框架关系。研究发现菜名由复杂食材构成时即食材前有限定成分,原文和英译文语义框架间多呈现包含关系;菜名中含有该菜属性或特点时,原文和英译文框架间呈现相交关系;当菜名中含有引申义或历史文化典故时,原文和英译文框架间呈独立关系。因此,翻译时应灵活调整扩大或缩小英译文的框架范畴,剔除英译文中多余因素或补充缺少因素,替换英译文整体框架。

关键词：框架语义学框架中国菜名翻译翻译策略

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基于动态电阻串联的高阻接地故障精确建模

电工技术学报 2024年第7期39卷 2046-2059页

作者：钟逸涵邓丰史鸿飞徐帆李鑫瑜长沙理工大学电气与信息工程学院长沙410114 国网湖南省电力有限公司湘潭供电公司湘潭411100

现有各类高阻接地故障模型缺乏对故障发展全过程的物理解释,难以准确模拟故障的非线性特征。该文根据现场录波数据,深入研究高阻接地故障的物理过程,归纳可知故障电流波形的非线性畸变来源于两个方面:空气间隙击穿引起的非线性与接地介... 详细信息

现有各类高阻接地故障模型缺乏对故障发展全过程的物理解释,难以准确模拟故障的非线性特征。该文根据现场录波数据,深入研究高阻接地故障的物理过程,归纳可知故障电流波形的非线性畸变来源于两个方面:空气间隙击穿引起的非线性与接地介质本身的非线性。据此提出高阻接地故障的故障电阻由电弧电阻和接地电阻串联组成,进而建立基于动态电阻串联的高阻接地故障新模型。首先,利用汤逊原理分析空气介质击穿过程中动态电弧的产生,建立了故障点指数电弧模型;然后,研究故障电流在土壤中的流散过程,结合土壤电阻率变化规律,求解接地电阻随故障电流变化的表达式,建立接地电阻模型;最后,在PSCAD中将二者串联,搭建高阻接地故障新模型,结合现场故障数据并与其他模型对比,验证了该文所提模型能更准确地表征不同接地介质下高阻接地故障的非线性特征,为后续研究高阻接地故障辨识提供更精确的数据支撑。

关键词：配电网高阻接地故障电弧电阻接地电阻非线性特征

基于复合跨模态交互网络的时序多模态情感分析

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计算机科学与探索 2024年第5期18卷 1318-1327页

作者：杨力钟俊弘张赟宋欣渝西南石油大学计算机与软件学院成都610500

针对多模态情感分析中存在的不同模态间语义特征差异性导致模态融合不充分、交互性弱等问题,通过研究分析不同模态之间存在的潜在关联性,搭建一种基于复合跨模态交互网络的时序多模态情感分析(CCIN-SA)模型。该模型首先使用双向门控循... 详细信息

针对多模态情感分析中存在的不同模态间语义特征差异性导致模态融合不充分、交互性弱等问题,通过研究分析不同模态之间存在的潜在关联性,搭建一种基于复合跨模态交互网络的时序多模态情感分析(CCIN-SA)模型。该模型首先使用双向门控循环单元和多头注意力机制提取具有上下文语义信息的文本、视觉和语音模态时序特征;然后,设计跨模态注意力交互层,利用辅助模态的低阶信号不断强化目标模态,使得目标模态学习到辅助模态的信息,捕获模态间的潜在适应性;再将增强后的特征输入到复合特征融合层,通过条件向量进一步捕获不同模态间的相似性,增强重要特征的关联程度,挖掘模态间更深层次的交互性;最后,利用多头注意力机制将复合跨模态强化后的特征与低阶信号做拼接融合,提高模态内部重要特征的权重,保留初始模态独有的特征信息,将得到的多模态融合特征进行最终的情感分类任务。在CMU-MOSI和CMUMOSEI数据集上进行模型评估,结果表明,CCIN-SA模型相比其他现有模型在准确率和F1指标上均有提高,能够有效挖掘不同模态间的关联性,做出更加准确的情感判断。

关键词：跨模态交互注意力机制特征融合复合融合层多模态情感分析