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MicroRNA-26a inhibits osteosarcoma cell proliferation by targeting IGF-1

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Bone Research 2015年第4期3卷 210-215页

作者： xinyu tan Shicai Fan Wen Wu Yin Zhang Department of Orthopaedics The Third Affiliated Hospital of Southern Medical University

There are still controversies about the roles of microRNA-26a（miR-26a）in human malignancies,as it is a tumor suppressor in breast cancer,gastric cancer,and hepatocellular carcinoma,but is an oncogene in glioma and *** now,the function of miR-26a in osteosarcoma remains largely ***,we found that miR-26a was downregualted in osteosarcoma *** in vitro and in vivo assays,we confirmed that miR-26a could inhibit the abilities of in vitro proliferation and suppress in vivo tumor growth in mouse ***,we identified insulin-like growth factor 1（IGF-1）as a novel and direct target of miR-26a and revealed that miR-26a exerted its tumor-suppressor function,at least in part,by inhibiting *** findings contribute to our understanding of the functions of miR-26a in osteosarcoma.

关键词： osteosarcoma suppressor targeting elusive inhibiting microRNA oncogene cloned nude exerted

Synthesis,properties,and applications of black titanium dioxide nanomaterials

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Science Bulletin 2017年第6期62卷 431-441页

作者： Yan Liu Lihong Tian xinyu tan Xin Li Xiaobo Chen Department of Chemistry University of Missouri-Kansas City MO 64110 USA College of Environment Sichuan Agricultural University Chengdu 611130 China Hubei Collaborative Innovation Center for Advanced Organochemical Materials Ministry of Education Key Laboratory for the Synthesis and Applications of Organic Functional Molecules Hubei University Wuhan 430062 China College of Materials and Chemical Engineering Hubei Provincial Collaborative Innovation Center for New Energy Microgrid China Three Gorges University Yichang 443002 China College of Materials and Energy Key Laboratory of Energy Plants Resource and Utilization Ministry of Agriculture Key Laboratory of Biomass Energy of Guangdong Regular Higher Education Institutions South China Agricultural University Guangzhou 510642 China

Photocatalysis has been regarded as one of best solutions to using the sunlight to produce hydrogen from water and to removing organic pollutants from the environment, and titanium dioxide （TiO2） nanomate- rials have been treated as the primary photocatalyst for these purposes. However. their large band gap has largely limited the activity to the UV region of the solar spectrum. The discovery of black TiO2 in 2011 has triggered world-wide research interests with new hope to overcome this problem. This review briefly summarizes the recent progresses of black TiO2 nanomaterials, including their synthesis, proper- ties and applications, to provide a timely update and to inspire more ideas in the related research.

关键词： TiO2 Black TiO2 Hydrogenation Nanomaterials Photocatalysis

EP-PDMS-PVDF-SiO2超疏水复合涂层的制备与耐摩擦性能

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复合材料学报 2025年第1期42卷 362-373页

作者：姜礼华林一凡孙嘉进龚梦天涂凯陈宇桐肖婷谭新玉三峡大学材料与化工学院无机非金属晶态与能源转换材料重点实验室三峡大学电气与新能源学院

提高超疏水涂层砂纸耐摩擦性能对其应用具有重要意义。因此，以环氧树脂（EP）、聚二甲基硅氧烷（PDMS）和聚偏氟乙烯（PVDF）为粘结剂，以4种纳米级二氧化硅（SiO2）粒子为主要填料和一种微米级SiO2粒子作为增强涂层耐摩擦性能的辅助... 详细信息

提高超疏水涂层砂纸耐摩擦性能对其应用具有重要意义。因此，以环氧树脂（EP）、聚二甲基硅氧烷（PDMS）和聚偏氟乙烯（PVDF）为粘结剂，以4种纳米级二氧化硅（SiO2）粒子为主要填料和一种微米级SiO2粒子作为增强涂层耐摩擦性能的辅助填料制备了一种耐摩擦性能优异的超疏水涂层，并对其砂纸耐摩擦性能进行系统地测试和分析。接触角测试结果表明涂层水滴接触角和滚动角分别保持在156°～165°和2°～4°之间。砂纸摩擦测试表明添加2μm或5μm的SiO2粒子能使涂层耐摩擦周期提高2～3倍。同时，涂层耐摩擦性能还与砂纸粒度相关。涂层被9μm或6.5μm粒度砂纸摩擦失去超疏水性能后，能通过19μm或11μm粒度砂纸的摩擦而恢复其超疏水特性。然而，涂层被38、19或11μm粒度砂纸摩擦后其超疏水性能无法恢复。分析表明，低粒度砂纸更易破坏涂层表面多级微纳粗糙结构，但该结构可通过高粒度砂纸摩擦而被恢复，高粒度砂纸则倾向于使涂层从基材表面剥离。

关键词：涂层超疏水砂纸耐摩擦性二氧化硅粒子多级微纳粗糙结构

Diabetic ketoacidosis complicated with intussusception: a case report

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World Journal of Emergency Medicine 2024年第5期15卷 419-421页

作者： Qin Huang Xiang Peng Shanshan Hu xinyu tan Xiangmin Li Department of Emergency Medicine Xiangya HospitalCentral South UniversityChangsha 410008China National Clinical Research Center for Geriatric Disorders(Xiangya Hospital) Changsha 410008China

Intussusception is relatively rare in adults but common in children.[1,2]An untreated intussusception often causes intestinal obstruction,intestinal perforation,peritonitis,and shock.[3]Diabetic ketoacidosis(DKA)is the most common acute hyperglycemic emergency in uncontrolled type 1 diabetes(T1DM).[4]More than 60%of DKA patients experience gastrointestinal symptoms such as nausea,vomiting,and abdominal pain,[5,6]which sometimes lead to the neglect of other serious underlying *** delayed gastric emptying,intestinal obstruction,electrolyte imbalance,and metabolic acidosis are associated with DKA,the underlying mechanism has not been fully elucidated.[7]This study aimed to report a DKA patient complicated with intussusception.

关键词： Diabetic obstruction acute

Atomic packing and short-to-medium range order evolution of Zr-Pd metallic glass

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Chinese Science Bulletin 2011年第36期56卷 3908-3911页

作者： QI Li LIU Mei ZHANG ShiLiang ZHANG xinyu tan ChunLin State Key Laboratory of Metastable Materials Science ＆ Technology Yanshan University Qinhuangdao 066004 China

A larger-scale Zr70Pd30 alloy system has been simulated using molecular dynamics (MD) to investigate structure evolution in Zr70Pd30 metallic glass. The simulated pair distribution function of Zr70Pd30 metallic glass agrees well with the experimental results. Voronoi polyhedron analysis indicates that the icosahedra are not randomly distributed in space,but form characteristic intercrossed icosahedral clusters with medium-range order. Intercrossed icosahedral clusters are the dominant local configurations in Zr70Pd30 metallic glass and probably cause the quasicrystalline phase discovered in Zr70Pd30 metallic glass.

关键词：金属玻璃中程 Voronoi 演化包装原子二十面体分子动力学

Microwave absorption of aluminum/hydrogen treated titanium dioxide nanoparticles

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Journal of Materiomics 2019年第1期5卷 133-146页

作者： Michael Green Peng Xiang Zhanqiang Liu James Murowchick xinyu tan Fuqiang Huang Xiaobo Chen Department of Chemistry University of MissourieKansas CityKansas CityMO64110USA College of Materials and Chemical Engineering Hubei Provincial Collaborative Innovation Center for New Energy MicrogridChina Three Gorges UniversityYichang443002China State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Department of Geosciences University of MissourieKansas CityKansas CityMO64110USA State Key Laboratory of Rare Earth Materials Chemistry and Applications College of Chemistry and Molecular EngineeringPeking UniversityBeijing100871China

Interactions between incident electromagnetic energy and matter are of critical importance for numerous civil and military applications such as photocatalysis,solar cells,optics,radar detection,communications,information processing and transport et *** mechanisms for such interactions in the microwave frequency mainly rely on dipole rotations and magnetic domain *** this study,we present the first report of the microwave absorption of Al/H2 treated TiO_(2) nanoparticles,where the A_(l)/H_(2) treatment not only induces structural and optical property changes,but also largely improves the microwave absorption performance of TiO_(2) ***,the frequency of the microwave absorption can be finely controlled with the treatment temperature,and the absorption efficiency can reach optimal values with a careful temperature tuning.A large reflection loss of58.02 dB has been demonstrated with 3.1mm TiO_(2) coating when the treating temperature is 700℃.The high efficiency of microwave absorption is most likely linked to the disordering-induced property changes in the *** with the increased microwave absorption properties are largely increased visiblelight and IR absorptions,and enhanced electrical conductivity and reduced skin-depth,which is likely related to the interfacial defects within the TiO_(2) nanoparticles caused by the Al/H2 treatment.

关键词： Microwave absorption Black TiO_(2)nanoparticles Hydrogenation Aluminum reduction

MoS2-Based Photodetectors Powered by Asymmetric Contact Structure with Large Work Function Difference

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Nano-Micro Letters 2019年第2期11卷 217-228页

作者： Zhe Kang Yongfa Cheng Zhi Zheng Feng Cheng Ziyu Chen Luying Li xinyu tan Lun Xiong Tianyou Zhai Yihua Gao Center for Nanoscale Characterization and Devices(CNCD)Wuhan National Laboratory for Optoelectronics(WNLO)and School of Physics and School of Materials Science and Engineering Huazhong University of Science and Technology(HUST)Luoyu Road 1037Wuhan 430074People’s Republic of China College of Materials and Chemical Engineering China Three Gorges UniversityDaxue Road 8Yichang 443002People’s Republic of China Hubei Key Laboratory of Optical Information and Pattern Recognition School of Optical Information and Energy EngineeringSchool of Mathematics and PhysicsWuhan Institute of TechnologyGuanggu 1st Road 206Wuhan 430205People’s Republic of China

Self-powered devices are widely used in the detection and sensing *** metal contacts provide an effective way to obtain self-powered *** two stable metallic electrode materials with large work function differences is the key to obtain highly efficient asymmetric metal contacts ***,common metal electrode materials have similar and high work functions,making it difficult to form an asymmetric contacts structure with a large work function ***,Mo2C crystals with low work function(3.8 eV) was obtained by chemical vapor deposition(CVD) *** large work function difference between Mo2C and Au allowed us to synthesize an efficient Mo2C/MoS2/Au photodetector with asymmetric metal contact structure,which enables light detection without external electric *** believe that this novel device provides a new direcfor the design of miniature self-powered *** results also highlight the great potential of ultrathin Mo2C prepared by CVD in heterojunction device applications.

关键词： Mo2C MoS2 Chemical vapor deposition Asymmetric metal contacts Photodetector

Doped, conductive SiO_(2) nanoparticles for large microwave absorption

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Light(Science & Applications) 2018年第1期7卷 211-219页

作者： Michael Green Zhanqiang Liu Peng Xiang Yan Liu Minjie Zhou xinyu tan Fuqiang Huang Lei Liu Xiaobo Chen Department of Chemistry University of MissouriKansas CityMO 64110USA State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai 200050China College of Materials and Chemical Engineering Hubei Provincial Collaborative Innovation Center for New Energy MicrogridChina Three Gorges UniversityYichang 443002China College of Environment Sichuan Agricultural UniversityChengduSichuan 611130China School of Chemistry and Chemical Engineering Hunan Institute of Science and TechnologyYueyang 414000China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

Although many materials have been studied for the purpose of microwave absorption,SiO_(2) has never been reported as a good *** this study,we present for the first time that doped,microwave conductive SiO_(2) nanoparticles can possess an excellent microwave absorbing performance.A large microwave reflection loss(RL)of−55.09 dB can be *** large microwave absorption originates mainly from electrical relaxation rather than the magnetic relaxation of the incoming microwave *** electrical relaxation is attributed to a large electrical conductivity that is enabled by the incorporation of heterogeneous(N,C and Cl)*** removal of the magnetic susceptibility only results in a negligible influence of the microwave *** contrast,the removal of the heterogeneous atoms leads to a large decrease in the electrical conductivity and microwave absorption ***,the microwave absorption characteristics can be largely adjusted with a change of the thickness,which provides large flexibility for various microwave absorption applications.

关键词： nanoparticles microwave absorption

Global Marine Cold Seep Metagenomes Reveal Diversity of Taxonomy,Metabolic Function,and Natural Products

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 121-134页

作者： Tao Yu Yingfeng Luo xinyu tan Dahe Zhao Xiaochun Bi Chenji Li Yanning Zheng Hua Xiang Songnian Hu State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Cold seeps in the deep sea are closely linked to energy exploration as well as global climate *** alkane-dominated chemical energy-driven model makes cold seeps an oasis of deep-sea life,showcasing an unparalleled reservoir of microbial genetic ***,by analyzing 113 metagenomes collected from 14 global sites across 5 cold seep types,we present a comprehensive Cold Seep Microbiomic Database(CSMD)to archive the genomic and functional diversity of cold seep *** CSMD includes over 49 million non-redundant genes and 3175 metagenome-assembled genomes,which represent 1895 species spanning 105 *** addition,beta diversity analysis indicates that both the sampling site and cold seep type have a substantial impact on the prokaryotic microbiome community *** and anaerobic metabolisms are prevalent in microbial communities,accompanied by considerable mixotrophs and facultative anaerobes,highlighting the versatile metabolic potential in cold ***,secondary metabolic gene cluster analysis indicates that at least 98.81%of the sequences potentially encode novel natural products,with ribosomally synthesized and post-translationally modified peptides being the predominant type widely distributed in archaea and ***,the CSMD represents a valuable resource that would enhance the understanding and utilization of global cold seep microbiomes.

关键词： Global marine cold seep Metagenome Prokaryotic microbiome Metabolic function Natural product