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Delving into the dissimilarities in electrochemical performance and underlying mechanisms for sodium and potassium ion storage in N-doped carbon-encapsulated metallic Cu2Se nanocubes

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Journal of Energy Chemistry 2024年第8期95卷 336-347页

作者： xinyu Wang Yanan Xu Xiaofeng Liu Lei Tan Huaiqiang gu Xin Du Dan Li College of Chemistry Zhengzhou University Green Catalysis Center College of Chemistry Zhengzhou University Institute of Theoretical Physics Lanzhou University School of Nuclear Science and Technology Lanzhou University Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of Chemistry Nankai University State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources College of Chemistry Xinjiang University

The large volumetric variations experienced by metal selenides within conversion reaction result in inferior rate capability and cycling stability,ultimately hindering the achievement of superior electrochemical performance.Herein,metallic Cu2Se encapsulated with N-doped carbon（Cu2Se@NC） was prepared using Cu2O nanocubes as templates through a combination of dopamine polymerization and hightemperature selenization.The unique nanocubic structure and uniform N-doped carbon coating could shorten the ion transport distance,accelerate electron/charge diffusion,and suppress volume variation,ultimately ensuring Cu2Se@NC with excellent electrochemical performance in sodium ion batteries（SIBs） and potassium ion batteries（PIBs）.The composite exhibited excellent rate performance(187.7 mA h g-1at 50 A g-1in SIBs and 179.4 mA h g-1at 5 A g-1in PIBs) and cyclic stability(246,8 mA h g-1at 10 A g-1in SIBs over 2500 cycles).The reaction mechanism of intercalation combined with conversion in both SIBs and PIBs was disclosed by in situ X-ray diffraction（XRD） and ex situ transmission electron microscope（TEM）.In particular,the final products in PIBs of K2Se and K2Se3species were determined after discharging,which is different from that in SIBs with the final species of Na2Se.The density functional theory calculation showed that carbon induces strong coupling and charge interactions with Cu2Se,leading to the introduction of built-in electric field on heterojunction to improve electron mobility.Significantly,the theoretical calculations discovered that the underlying cause for the relatively superior rate capability in SIBs to that in PIBs is the agile Na+diffusion with low energy barrier and moderate adsorption energy.These findings offer theoretical support for in-depth understanding of the performance differences of Cu-based materials in different ion storage systems.

关键词： Cu2Se nanocubes DFT calculations Ion storage mechanism Potassium ion batteries Sodium ion batteries

GM-CSF Promotes the Development of Dysfunctional Vascular Networks in Moyamoya Disease

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Neuroscience Bulletin 2024年第4期40卷 451-465页

作者： Huiqin Li Xiang Cao Xinya gu Mengqi Dong Lili Huang Chenglu Mao Shengnan Xia Haiyan Yang xinyu Bao Yongbo Yang Yun Xu Department of Neurology and Neurosurgery Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower HospitalState Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical DiseasesNanjing UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower Hospital Clinical College of Xuzhou Medical UniversityNanjing210008China Department of Neurology and Neurosurgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Jiangsu Provincial Key Discipline of Neurology Nanjing210008China Nanjing Neurology Medical Center Nanjing210008China

Moyamoya disease(MMD)is a chronic occlusive cerebrovascular disease with the development of a network of abnormal vessels.Immune inflammation is associated with the occurrence and development of MMD.However,the mechanisms underlying the formation of the abnormal vascular network remain unclear.Twenty-eight patients with MMD,26 ischemic stroke patients,and 26 unrelated healthy volunteers were enrolled in this study The data showed that the levels of granulocyte-macrophage colony-stimulating factor(GM-CSF)were higher in MMD patients than in healthy controls(P<0.01),and GM-CSF was mainly from Th1 and Th17 cells in MMD.We found that increased GM-CSF drove monocytes to secrete a series of cytokines associated with angiogenesis,inflammation,and chemotaxis.In summary,our findings demonstrate for the first time the important involvement of GM-CSF in MMD and that GM-CSF is an important factor in the formation of abnormal vascular networks in MMD.

关键词： Moyamoya disease Vascular endothelial cells GM-CSF VEGF

Genetic Algorithm‑Based SOTIF Scenario Construction for Complex Traffic Flow

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Automotive Innovation 2023年第4期6卷 531-546页

作者： Shulian Zhao Jianli Duan Siyu Wu xinyu gu Chuzhao Li Kai Yin Hong Wang The School of Vehicle and Mobility Tsinghua UniversityBeijingChina Yanshan University QinhuangdaoChina China Automotive Engineering Research Institute Co. LtdChongqingChina Beijing Jiaotong University BeijingChina

The Safety of The Intended Functionality(SOTIF)challenge represents the triggering condition by elements of a specific scenario and exposes the function limitation of an autonomous vehicle(AV),which leads to hazards.As for operationcontent-related features,the scenario is similar to AVs’SOTIF research and development.Therefore,scenario generation is a significant topic for SOTIF verification and validation procedure,especially in the simulation testing of AVs.Thus,in this paper,a well-designed scenario architecture is first defined,with comprehensive scenario elements,to present SOTIF trigger conditions.Then,considering complex traffic disturbance as trigger conditions,a novel SOTIF scenario generation method is developed.An indicator,also known as Scenario Potential Risk,is defined as the combination of the safety control intensity and the prior collision probability.This indicator helps identify critical scenarios in the proposed method.In addition,the corresponding vehicle motion models are established for general straight roads,curved roads,and safety assessment areas.As for the traffic participants’motion model,it is designed to construct the key dynamic events.To efficiently search for critical scenarios with the trigger of complex traffic flow,this scenario is encoded as genes and it is regenerated through selection,mutation,and crossover iteration processes,known as the Genetic Algorithm(GA).Experimental results show that the GA-based method could efficiently construct diverse and critical traffic scenarios,contributing to the construction of the SOTIF scenario library.

关键词： SOTIF triggers conditions Scenario generation Genetic algorithm Complex traffic disturbance

Emerging new therapeutic antibody derivatives for cancer treatment

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Signal Transduction and Targeted Therapy 2022年第3期7卷 638-665页

作者： Shijie Jin Yanping Sun Xiao Liang xinyu gu Jiangtao Ning Yingchun Xu Shuqing Chen Liqiang Pan Institute of Drug Metabolism and Pharmaceutical Analysis College of Pharmaceutical SciencesZhejiang University310058 HangzhouChina Department of Precision Medicine on Tumor Therapeutics ZJU-Hangzhou Global Scientific and Technological Innovation Center311200 HangzhouChina The First Affiliated Hospital Zhejiang University School of Medicine310003 HangzhouChina Key Laboratory of Pancreatic Disease of Zhejiang Province 310003 HangzhouChina

Monoclonal antibodies constitute a promising class of targeted anticancer agents that enhance natural immune system functions to suppress cancer cell activity and eliminate cancer cells.The successful application of IgG monoclonal antibodies has inspired the development of various types of therapeutic antibodies,such as antibody fragments,bispecific antibodies,and antibody derivatives(e.g.,antibody-drug conjugates and immunocytokines).

关键词： therapeutic cancer antibodies

Evolving cognition of the JAK-STAT signaling pathway:autoimmune disorders and cancer

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2749-2772页

作者： Chen Xue Qinfan Yao xinyu gu Qingmiao Shi Xin Yuan Qingfei Chu Zhengyi Bao Juan Lu Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Kidney Disease Center The First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina

The Janus kinase(JAK)signal transducer and activator of transcription(JAK-STAT)pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment.Various cytokines,interferons,growth factors,and other specific molecules activate JAK-STAT signaling to drive a series of physiological and pathological processes,including proliferation,metabolism,immune response,inflammation,and malignancy.Dysregulated JAK-STAT signaling and related genetic mutations are strongly associated with immune activation and cancer progression.Insights into the structures and functions of the JAK-STAT pathway have led to the development and approval of diverse drugs for the clinical treatment of diseases.Currently,drugs have been developed to mainly target the JAK-STAT pathway and are commonly divided into three subtypes:cytokine or receptor antibodies,JAK inhibitors,and STAT inhibitors.And novel agents also continue to be developed and tested in preclinical and clinical studies.The effectiveness and safety of each kind of drug also warrant further scientific trials before put into being clinical applications.Here,we review the current understanding of the fundamental composition and function of the JAK-STAT signaling pathway.We also discuss advancements in the understanding of JAK-STAT–related pathogenic mechanisms;targeted JAK-STAT therapies for various diseases,especially immune disorders,and cancers;newly developed JAK inhibitors;and current challenges and directions in the field.

关键词： drugs metabolism approval

Intratumoral bacteria interact with metabolites and genetic alterations in hepatocellular carcinoma

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3662-3664页

作者： Chen Xue Junjun Jia xinyu gu Lin Zhou Juan Lu Qiuxian Zheng Yuanshuai Su Shusen Zheng Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina

Dear Editor,Hepatocellular carcinoma(HCC),which ranks globally as the third leading cause of cancer-related deaths,is highly prevalent,and most patients are diagnosed with advanced-stage cancer when treatments are largely ineffective.1 Thus,there is an urgent need for earlier diagnosis to improve HCC patient outcomes.Although many types of tumors have intratumor bacteria,the tumor microbiome is poorly characterized because of limitations in the technology for detection.Recently,Nejman et al.

关键词： alterations diagnosis cancer

Critical review and functional safety of a battery management system for large‑scale lithium‑ion battery pack technologies

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International Journal of Coal Science & Technology 2022年第3期9卷 1-17页

作者： K.W.See guofa Wang Yong Zhang Yunpeng Wang Lingyu Meng xinyu gu Neng Zhang K.C.Lim L.Zhao Bin Xie Azure Mining Technology CCTEG 821 Pacifc HighwaySydneyNSW 2067Australia China Coal Research Institute Beijing 100013China China Mining Products Safety Approval and Certifcation Center Beijing 100013China School of Mechanical Electronic and Information Engineering China University of Mining and TechnologyBeijing 100083China Beijing Tianma Intelligent Control Technology Co. LtdBeijing 101399China Australian Institute for Innovative Materials Institute for Superconducting and Electronic MaterialsUniversity of WollongongInnovation CampusWollongongNSW 2500Australia

The battery management system(BMS)is the main safeguard of a battery system for electric propulsion and machine electrifcation.It is tasked to ensure reliable and safe operation of battery cells connected to provide high currents at high voltage levels.In addition to efectively monitoring all the electrical parameters of a battery pack system,such as the voltage,current,and temperature,the BMS is also used to improve the battery performance with proper safety measures within the system.With growing acceptance of lithium-ion batteries,major industry sectors such as the automotive,renewable energy,manufacturing,construction,and even some in the mining industry have brought forward the mass transition from fossil fuel dependency to electric powered machinery and redefned the world of energy storage.Hence,the functional safety considerations,which are those relating to automatic protection,in battery management for battery pack technologies are particularly important to ensure that the overall electrical system,regardless of whether it is for electric transportation or stationary energy storage,is in accordance with high standards of safety,reliability,and quality.If the system or product fails to meet functional and other safety requirements on account of faulty design or a sequence of failure events,then the environment,people,and property could be endangered.This paper analyzed the details of BMS for electric transportation and large-scale energy storage systems,particularly in areas concerned with hazardous environment.The analysis covers the aspect of functional safety that applies to BMS and is in accordance with the relevant industrial standards.A comprehensive evaluation of the components,architecture,risk reduction techniques,and failure mode analysis applicable to BMS operation was also presented.The article further provided recommendations on safety design and performance optimization in relation to the overall BMS integration.

关键词： Battery management system Functional safety Hazardous area Lithium-ion batteries Failure mode analysis Electric transportation Large-scale energy storage

ALYREF mediates RNA m^(5)C modification to promote hepatocellular carcinoma progression

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1375-1377页

作者： Chen Xue xinyu gu Qiuxian Zheng Qingmiao Shi Xin Yuan Yuanshuai Su Junjun Jia Jianwen Jiang Juan Lu Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina

Dear Editor,The incidence of hepatocellular carcinoma(HCC)is increasing in many countries due to hepatic virus infection and unhealthy diet habits,and the unsatisfactory overall survival rate calls for novel treatments with higher efficacy.1 Recent studies have shown that RNA modifications are likely to participate in the progression of HCC,2 suggesting new methods for tumor growth control.Specifically,5-methylcytosine(m5C)is one of the most interesting RNA modification types,as accumulating evidence suggests its role in the promotion of HCC tumorigenesis.3 The RNA methyltransferase Aly/REF export factor(ALYREF)is considered one type of“reader”protein located in the nucleus that recognizes and binds directly with m5C sites in RNA and facilitates the export of RNA from the nucleus to the cytoplasm.4 Notably,ALYREF is considered a promising target for diagnosis and prognosis prediction.5 However,until now,the low number of related studies has limited the understanding of the mechanism of the HCC-promoting effects of ALYREF.

关键词： hepatocellular diagnosis likely

稻米陈化过程中品质及淀粉精细结构变化研究进展

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浙江大学学报（农业与生命科学版） 2024年第3期50卷 317-328页

作者：谷月李新宇包劲松浙江大学农业与生物技术学院原子核农业科学研究所浙江杭州310058

水稻(Oryza sativa L.)是全球种植最广泛的粮食作物之一,在全球粮食安全中扮演着至关重要的角色。陈化是稻谷储藏过程中发生的一种自然现象,其机制至今未阐明。在储藏过程中,稻米的感官、蒸煮和糊化特性等理化性质以及淀粉结构与功能都... 详细信息

水稻(Oryza sativa L.)是全球种植最广泛的粮食作物之一,在全球粮食安全中扮演着至关重要的角色。陈化是稻谷储藏过程中发生的一种自然现象,其机制至今未阐明。在储藏过程中,稻米的感官、蒸煮和糊化特性等理化性质以及淀粉结构与功能都会发生不同程度的变化。这些变化大多与储藏时间和温度有关,并且对稻米品质的影响是不可逆的。虽然已有许多研究关注稻米陈化过程中相关的理化性质变化,但对稻米储藏后淀粉精细结构的研究还不多。本文综述了稻米人工陈化类型、陈化方法以及陈化对稻米理化性质和淀粉精细结构变化影响的最新研究进展,为进一步阐明稻米陈化机制提供了理论依据。

关键词：稻米陈化理化性质淀粉精细结构