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Distributed implantation of a flexible microelectrode array for neural recording

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Microsystems & Nanoengineering 2022年第3期8卷 177-184页

作者： Chunrong Wei Yang Wang Weihua Pei xinyong han Longnian Lin Zhiduo Liu Gege Ming Ruru Chen Pingping Wu Xiaowei Yang Li Zheng Yijun Wang State Key Laboratory of Integrated Optoelectronics Institute ofSemiconductorsChinese Academy of Sciences100083 BeijingChina University of Chinese Academy of Sciences 100049 BeijingChina School of Future Technologies University of Chinese Academy of Sciences100049 BeijingChina School of Microelectronics University of Sciences and Technology of China230000 HefeiChina Institute of Automation ChineseAcademy of Sciences100190 BeijingChina Key Laboratory of Brain Functional Genomics East China Normal University200062 ShanghaiChina Brain Machine Fusion Itelligence Institute 215131 SuzhouChina Technical Institute of Physids and Chemistry Chinese Academy of Sciences100190 BeijingChina Chinese Institute for Brain Research 102206 BeijingChina

Flexible multichannel electrode arrays(fMEAs)with multiple flaments can be flexibly implanted in various *** is necessary to develop a method for implanting the fMEA in different locations and at various depths based on the recording *** study proposed a strategy for reducing the microelectrode volume with integrated *** implantation system was developed specifically for semiautomatic distributed *** feasibility and convenience of the fMEA and implantation platform were verified in *** acute and chronic recording results provied the effectiveness of the packaging and implantation *** methods could provide a novel strategy for developing fMEAs with more flaments and recording sites to measure functional interactions across multiple brain regions.

关键词： implantation recording microelectrode

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多点位监控视频分析在火灾过程重构中的应用

消防科学与技术 2024年第2期43卷 231-236,243页

作者：王晓军苗新勇韩冲王鑫应急管理部天津消防研究所天津300381 工业与公共建筑火灾防控技术应急管理部重点实验室天津300381 天津市消防安全技术重点实验室天津300381 天津大学电气自动化与信息工程学院天津300072 北京市顺义区消防救援支队北京101399 天津大学微电子学院天津300072

以一起大型仓库火灾事故调查为例,介绍了多点位监控视频分析在火灾过程重构中的应用。通过点位初筛筛选出包含有效信息的视频,通过相对时间校准消除了各点位的时间误差,然后根据各点位视频画面综合分析确定了起火时间,根据各点位光影交... 详细信息

以一起大型仓库火灾事故调查为例,介绍了多点位监控视频分析在火灾过程重构中的应用。通过点位初筛筛选出包含有效信息的视频,通过相对时间校准消除了各点位的时间误差,然后根据各点位视频画面综合分析确定了起火时间,根据各点位光影交叉定位和相互印证,确定了起火部位和火势发展情况,从而重构了该起火灾的起火过程。在此基础上,分析了火灾调查工作中提取多点位监控视频的注意事项,总结了多点位监控视频分析中的一些原则和方法。

关键词：多点位视频分析起火时间起火部位火灾过程重构

基于循证体系的针灸学数据挖掘算法构建与应用研究

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中国循证医学杂志 2024年第9期24卷 1070-1078页

作者：王喆陈芊秀董志浩宋庆雨陈新勇韩晶山东中医药大学针灸推拿学院济南250013 山东中医药大学中医学院济南250013 山东中医药大学附属医院针灸科济南250013

在针灸临床研究的腧穴数据挖掘工作中,文献证据质量、样本量、临床疗效等因素对结局质量的影响尚不明确,影响了数据挖掘类研究成果的证据转化与临床应用。本研究提出运用熵权和线性加权法对上述指标进行多指标决策以获得腧穴处方综合权... 详细信息

在针灸临床研究的腧穴数据挖掘工作中,文献证据质量、样本量、临床疗效等因素对结局质量的影响尚不明确,影响了数据挖掘类研究成果的证据转化与临床应用。本研究提出运用熵权和线性加权法对上述指标进行多指标决策以获得腧穴处方综合权重得分,通过加权腧穴处方进行后续数据挖掘工作的新流程。本文以偏头痛研究为例将加权算法与经典算法结果进行对比,结果显示本研究所提出的算法对选穴分散的研究更具意义,在聚类分析中能更好发现潜在的腧穴配伍规律。该算法将循证针灸学体系纳入数据挖掘工作流程,为针灸学数据挖掘相关研究质量的提升提供了新思路,但后续仍需更多的研究加以验证。

关键词：针灸数据挖掘熵权法多指标决策加权关联规则分析加权聚类分析

应用于运动平台光电跟瞄系统的惯性参考单元研究综述

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光学精密工程 2024年第3期32卷 401-421页

作者：李醒飞何梦洁拓卫晓王天宇韩佳欣王信用天津大学精密测试技术及仪器国家重点实验室天津300072 深海技术科学太湖实验室江苏无锡214000

目标的变化和任务的拓展对光电跟瞄系统提出了快速机动的要求,从地基平台到车载、船载、机载、星载等运动平台是光电跟瞄系统的重要发展趋势。基于惯性参考单元(Inertial Reference Unit,IRU)的视轴稳定方式是克服运动平台高频扰动,实... 详细信息

目标的变化和任务的拓展对光电跟瞄系统提出了快速机动的要求,从地基平台到车载、船载、机载、星载等运动平台是光电跟瞄系统的重要发展趋势。基于惯性参考单元(Inertial Reference Unit,IRU)的视轴稳定方式是克服运动平台高频扰动,实现光电跟瞄系统微弧度甚至亚微弧度级跟瞄的主要技术手段。针对运动平台光电跟瞄系统精确指向对载体基座扰动抑制的需求,分析和对比了IRU的各种技术方案,特别介绍了利用低噪声、宽频带惯性传感器敏感角扰动,并通过反馈控制实现视轴惯性稳定的系统方案。从此类IRU系统的工作原理出发,阐述了系统的两种工作模式及功能特点,建立了系统数学模型。然后,介绍了IRU的国内外研究进展及发展方向,指出惯性传感、支承结构和控制系统是决定IRU稳定能力的关键因素,梳理了三项关键技术的研究动态。最后,总结了IRU的空间应用情况,并结合目前的应用需求对其未来应用领域进行了探讨。

关键词：惯性参考单元运动平台光电跟瞄系统视轴稳定扰动抑制

智能查重方法在建设项目环评文件技术复核中的应用探讨

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环境影响评价 2021年第6期43卷 28-32页

作者：高爽刘梅屈加豹王苏滨韩鑫勇康运峰吕巍卢力生态环境部环境工程评估中心北京100012 生态环境部国家环境保护环境影响评价数值模拟重点实验室北京100012 中国科学院自动化研究所北京100190 北京中科思瞳信息技术有限公司北京100089

基于大数据和语义识别、深度学习等人工智能技术,创建了一套智能查重方法,用于辅助环评文件的人工技术复核。介绍了智能查重方法的体系、算法和功能,并将该方法应用到环评文件技术复核中,分析了典型环评文件案例存在的问题。本研究创建... 详细信息

基于大数据和语义识别、深度学习等人工智能技术,创建了一套智能查重方法,用于辅助环评文件的人工技术复核。介绍了智能查重方法的体系、算法和功能,并将该方法应用到环评文件技术复核中,分析了典型环评文件案例存在的问题。本研究创建的方法是人工智能技术在环评领域的创新应用尝试,通过聚焦环评文件的抄袭行为,实现对环境影响评价报告书(表)质量的初步筛查,对查处抄袭行为、惩治弄虚作假具有一定现实意义。

关键词：环境影响评价报告书智能查重技术复核环境保护建设项目

Severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) membrane (M) protein inhibits type I and IIIinterferon production by targeting RIG-I/MDA-5 signaling

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Signal Transduction and Targeted Therapy 2021年第1期6卷 171-183页

作者： Yi Zheng Meng-Wei Zhuang Lulu han Jing Zhang Mei-Ling Nan Peng Zhan Dongwei Kang xinyong Liu Chengjiang Gao Pei-Hui Wang Key Laboratory of Infection and Immunity of Shandong Province Department of ImmunologySchool of Basic Medical SciencesCheeloo College of MedicineShandong University250012 JinanChina Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute Cheeloo College of MedicineShandong University250012 JinanChina Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong University44 West Culture Road250012 JinanShandongPR China China–Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province 44 West Culture Road250012 JinanShandongPR China Suzhou Research Institute Shandong UniversityShandong UniversitySuzhouJiangsu 215123China

Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has quickly spread worldwide and has affected more than 10 million individuals.A typical feature of COVID-19 is the suppression of type I and III interferon(IFN)-mediated antiviral ***,the molecular mechanism by which SARS-CoV-2 evades antiviral immunity remains ***,we reported that the SARS-CoV-2 membrane(M)protein inhibits the production of type I and III IFNs induced by the cytosolic dsRNA-sensing pathway mediated by RIG-I/MDA-5–MAVS *** addition,the SARS-CoV-2 M protein suppresses type I and III IFN induction stimulated by SeV infection or poly(I:C)***,the SARS-CoV-2 M protein interacts with RIG-I,MAVS,and TBK1,thus preventing the formation of the multiprotein complex containing RIG-I,MAVS,TRAF3,and TBK1 and subsequently impeding the phosphorylation,nuclear translocation,and activation of ***,ectopic expression of the SARS-CoV-2 M protein facilitates the replication of vesicular stomatitis *** together,these results indicate that the SARS-CoV-2 M protein antagonizes type I and III IFN production by targeting RIG-I/MDA-5 signaling,which subsequently attenuates antiviral immunity and enhances viral *** study provides insight into the interpretation of SARS-CoV-2-induced antiviral immune suppression and illuminates the pathogenic mechanism of COVID-19.

关键词： immunity acute MAVS

Contemporary medicinal chemistry strategies for the discovery and optimization of influenza inhibitors targeting vRNP constituent proteins

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1805-1824页

作者： Lingxin Hou Ying Zhang han Ju Srinivasulu Cherukupalli Ruifang Jia Jian Zhang Bing Huang Arianna Loregian xinyong Liu Peng Zhan Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Institute of Poultry Science Shandong Academy of Agricultural SciencesJinan 250100China Department of Molecular Medicine University of PadovaPadova 35121Italy China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province Jinan 250012China Institute of Medical Sciences The Second HospitalCheeloo College of MedicineShandong UniversityJinan 250033China

Influenza is an acute respiratory infectious disease caused by the influenza virus,affecting people globally and causing significant social and economic *** to the inevitable limitations of vaccines and approved drugs,there is an urgent need to discover new anti-influenza drugs with different *** viral ribonucleoprotein complex(vRNP)plays an essential role in the life cycle of influenza viruses,representing an attractive target for drug *** recent years,the functional area of constituent proteins in vRNP are widely used as targets for drug discovery,especially the PA endonuclease active site,the RNA-binding site of PB1,the cap-binding site of PB2 and the nuclear export signal of NP ***,the PA inhibitor baloxavir has been marketed in Japan and the United States,and several drug candidates have also entered clinical trials,such as *** article reviews the compositions and functions of the influenza virus vRNP and the research progress on vRNP inhibitors,and discusses the representative drug discovery and optimization strategies pursued.

关键词： Influenza virus Drug design Influenza polymerase Ribonucleoprotein complex Medicinal-chemistry strategies

SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules

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Signal Transduction and Targeted Therapy 2022年第2期7卷 531-542页

作者： Yi Zheng Jian Deng Lulu han Meng-Wei Zhuang Yanwen Xu Jing Zhang Mei-Ling Nan Yang Xiao Peng Zhan xinyong Liu Chengjiang Gao Pei-Hui Wang Key Laboratory of Infection and Immunity of Shandong Province Department of ImmunologySchool of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory for Experimental Teratology of Ministry of Education and Advanced Medical Research Institute Cheeloo College of MedicineShandong UniversityJinan 250012China Department of Medicinal Chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesCheeloo College of MedicineShandong University44 West Culture Road250012 JinanShandongPR China China-Belgium Collaborative Research Center for Innovative Antiviral Drugs of Shandong Province 44 West Culture Road250012 JinanShandongPR China Suzhou Research Institute Shandong UniversityShandong UniversitySuzhouJiangsu 215123China

As a highly pathogenic human coronavirus,SARS-CoV-2 has to counteract an intricate network of antiviral host responses to establish infection and *** nucleic acid-induced stress response is an essential component of antiviral defense and is closely related to antiviral innate ***,whether SARS-CoV-2 regulates the stress response pathway to achieve immune evasion remains *** this study,SARS-CoV-2 NSP5 and N protein were found to attenuate antiviral stress granule(avSG)***,NSP5 and N suppressed IFN expression induced by infection of Sendai virus or transfection of a synthetic mimic of dsRNA,poly(I:C),inhibiting TBK1 and IRF3 phosphorylation,and restraining the nuclear translocalization of ***,HEK293T cells with ectopic expression of NSP5 or N protein were less resistant to vesicular stomatitis virus ***,NSP5 suppressed avSG formation and disrupted RIG-I–MAVS complex to attenuate the RIG-I–mediated antiviral *** contrast to the multiple targets of NSP5,the N protein specifically targeted cofactors upstream of *** N protein interacted with G3BP1 to prevent avSG formation and to keep the cofactors G3BP1 and PACT from activating ***,the N protein also affected the recognition of dsRNA by *** study revealed the intimate correlation between SARS-CoV-2,the stress response,and innate antiviral immunity,shedding light on the pathogenic mechanism of COVID-19.

关键词： NSP5 immunity stress

基于VMD多尺度散布熵的柴油机故障诊断方法

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汽车工程 2020年第8期42卷 1139-1144页

作者：乔新勇顾程韩立军陆军装甲兵学院车辆工程系北京100072 武警工程大学乌鲁木齐校区乌鲁木齐830049

为从非平稳非线性的缸盖振动信号中提取出柴油机故障特征,本文中提出一种基于变分模态分解(VMD)的多尺度散布熵的柴油机失火故障诊断方法。利用VMD对柴油机缸盖振动信号进行分解,选取散布熵最小的模态分量作为分析信号,计算该信号的多... 详细信息

为从非平稳非线性的缸盖振动信号中提取出柴油机故障特征,本文中提出一种基于变分模态分解(VMD)的多尺度散布熵的柴油机失火故障诊断方法。利用VMD对柴油机缸盖振动信号进行分解,选取散布熵最小的模态分量作为分析信号,计算该信号的多尺度散布熵,并选取前6个尺度散布熵作为故障特征向量,输入粒子群优化的支持向量机(PSO-SVM)中进行失火故障分类判断,并与其他4种常见方法进行对比,结果表明,本文中提出的诊断方法能够有效提取故障特征,准确识别故障类型,优于所对比方法。

关键词：柴油机故障识别变分模态分解多尺度散布熵 PSO-SVM