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Coupling the Common Land Model to ECHAM5 Atmospheric General Circulation Model

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Journal of Meteorological Research 2019年第2期33卷 251-263页

作者： Yufei XIN Yongjiu DAI Jian LI xinyao RONG Guo ZHANG State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences China Meteorological Administration School of Atmospheric Sciences Sun Yat-Sen University

The ECHAM5 model is coupled with the widely used Common Land Model(CoLM). ECHAM5 is a state-of-theart atmospheric general circulation model incorporated into the integrated weather and climate model of the Chinese Academy of Meteorological Sciences(CAMS-CSM). Land surface schemes in ECHAM5 are simple and do not provide an adequate representation of the vegetation canopy and snow/frozen soil processes. Two AMIP(Atmospheric Model Intercomparison Project)-type experiments using ECHAM5 and ECHAM5-CoLM are run over 30 yr and the results are compared with reanalysis and observational data. It is found that the pattern of land surface temperature simulated by ECHAM5-CoLM is significantly improved relative to ECHAM5. Specifically, the cold bias over Eurasia is removed and the root-mean-square error is reduced in most regions. The seasonal variation in the zonal mean land surface temperature and the in situ soil temperature at 20-and 80-cm depths are both better simulated by ECHAM5-CoLM. ECHAM5-CoLM produces a more reasonable spatial pattern in the soil moisture content, whereas ECHAM5 predicts much drier soils. The seasonal cycle of soil moisture content from ECHAM5-CoLM is a better match to the observational data in six specific regions. ECHAM5-CoLM reproduces the observed spatial patterns of both sensible and latent heat fluxes. The strong positive bias in precipitation over land is reduced in ECHAM5-CoLM, especially over the southern Tibetan Plateau and middle–lower reaches of the Yangtze River during the summer monsoon rainy season.

关键词： atmospheric general circulation models ECHAM5 Common Land Model land-atmosphere coupling

Role of daily anal stimulation for intractable functional constipation in infants

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World Journal of Pediatric Surgery 2020年第2期3卷 29-33页

作者： Tianqi Zhu Xiaoyi sun Dan Zhu Qian You Xiaoting Wan xinyao Meng Jiexiong Feng Department of Pediatric Surgery Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina

Objective Functional constipation is one of the most common problems in pediatric *** aim of the present study was to evaluate the effectiveness of daily anal stimulation in infants with intractable functional constipation(IFC).Our evaluation was based on clinical improvement and on changes in manometric parameters through *** Infants with IFC treated between January 2018 and December 2019 were included in this retrospective *** processing included daily anal stimulation for infants and psychological counseling for *** cases underwent a complete intervention program and were evaluated for improvement in symptoms and for changes in anorectal manometry within 1 year of *** A total of 161 patients were included in this *** response was achieved in all *** of defecation,change in stool form and decrease in the defecatory pain were significantly relieved in all infants after *** anorectal manometry,no significant difference was found in the peristaltic frequency of distal rectum before and after *** was a significant increase in the mean amplitude of peristalsis and improvement in the rhythm after *** the 1 year of follow-up,three patients had recurrence of constipation requiring *** In terms of the high clinical efficacy and limited side effects,daily anal stimulation may be included in the initial part of an intervention program for IFC in infants.

关键词： stimulation constipation clinical

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新型林区土壤温差发电装置性能研究及其仿真

黑龙江大学工程学报(中英俄文) 2024年第3期15卷 63-70页

作者：陈欣瑶张兴丽陈宏远孙壮志刘博文靳炜钰东北林业大学机电工程学院

随着林区无线物联网技术的快速发展，林区特殊环境影响下的供电需求迫在眉睫。基于Seebeck效应设计了一种新型的林区温差发电装置，通过实验和有限元分析相结合的方法，研究了新型林区温差发电装置在不同温差下的发电性能。研究结果表... 详细信息

随着林区无线物联网技术的快速发展，林区特殊环境影响下的供电需求迫在眉睫。基于Seebeck效应设计了一种新型的林区温差发电装置，通过实验和有限元分析相结合的方法，研究了新型林区温差发电装置在不同温差下的发电性能。研究结果表明：在室外温差为13℃时，室外温差发电装置产生的最大瞬时电压为2.5mV。对温差发电装置上的温差发电片进行有限元仿真研究，当温差发电片两端温差达到2℃时，一个温差发电片两端产生0.172 mV的电压。分析仿真模拟图显示温差发电片内部温差分布均匀；温差发电片产生的电势在边缘处相差最大。将数值模拟计算结果与实验结果进行比较，两者结论一致。

关键词： Seebeck效应土壤温差森林监测热电转化

Arctic Climate Changes Based on Historical Simulations(1900-2013) with the CAMS-CSM

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Journal of Meteorological Research 2018年第6期32卷 881-895页

作者： Ting WEI Jian LI xinyao RONG Wenjie DONG Bingyi WU Minghu DING State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences School of Atmospheric Sciences Sun Yat-Sen University Zhuhai Joint Innovative Center for Climate–Environment–Ecosystem Future Earth Research InstituteBeijing Normal University Center for Excellence in Tibetan Plateau Earth Sciences Chinese Academy of Sciences Institute of Atmospheric Sciences Fudan University

The Chinese Academy of Meteorological Sciences Climate System Model(CAMS-CSM) is a newly developed global climate model that will participate in the Coupled Model Intercomparison Project phase 6. Based on historical simulations(1900-2013), we evaluate the model performance in simulating the observed characteristics of the Arctic climate system, which includes air temperature, precipitation, the Arctic Oscillation(AO), ocean temperature/salinity,the Atlantic meridional overturning circulation(AMOC), snow cover, and sea ice. The model-data comparisons indicate that the CAMS-CSM reproduces spatial patterns of climatological mean air temperature over the Arctic(60°-90°N) and a rapid warming trend from 1979 to 2013. However, the warming trend is overestimated south of the Arctic Circle, implying a subdued Arctic amplification. The distribution of climatological precipitation in the Arctic is broadly captured in the model, whereas it shows limited skills in depicting the overall increasing trend. The AO can be reproduced by the CAMS-CSM in terms of reasonable patterns and variability. Regarding the ocean simulation, the model underestimates the AMOC and zonally averaged ocean temperatures and salinity above a depth of 500 m, and it fails to reproduce the observed increasing trend in the upper ocean heat content in the Arctic. The largescale distribution of the snow cover extent(SCE) in the Northern Hemisphere and the overall decreasing trend in the spring SCE are captured by the CAMS-CSM, while the biased magnitudes exist. Due to the underestimation of the AMOC and the poor quantification of air–sea interaction, the CAMS-CSM overestimates regional sea ice and underestimates the observed decreasing trend in Arctic sea–ice area in September. Overall, the CAMS-CSM reproduces a climatological distribution of the Arctic climate system and general trends from 1979 to 2013 compared with the observations, but it shows limited skills in modeling local trends and interannual variab

关键词： temperature precipitation Arctic Oscillation Atlantic meridional overturning circulation ocean potential temperature salinity snow cover sea ice

TNFα inhibitor C87 sensitizes EGFRvⅢ transfected glioblastoma cells to gefitinib by a concurrent blockade of TNFα signaling

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Cancer Biology & Medicine 2019年第3期16卷 606-617页

作者： Li Ma Chunhua She Qian Shi Qiang Yin Xinxin Ji Yongrong Wang Yulong Fan xinyao Kong Peng Li Zengfeng sun Xiaohui Zhang Zhen Zhang Jian Wang Tong Wang Yuanfu Xu Wenliang Li Department of Neuro-Oncology and Neurosurgery Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinKey Laboratory of Cancer Immunology and BiotherapyTianjin's Clinical Research Center for CancerTianjin 300060China State Key Laboratory of Experimental Hematology CAMS Key Laboratory for Prevention and Control of Hematological Disease Treatment Related InfectionNational Clinical Research Center for Hematological DisordersInstitute of Hematology and Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin 300020China Department of Immunology Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinKey Laboratory of Cancer Immunology and BiotherapyTianjin’s Clinical Research Center for CancerTianjin 300060China

Objective: More than half of human glioblastomas show EGFR gene amplification and mutation, but EGFR inhibitors have not been effective in treating EGFR-positive glioblastoma *** mechanism behind this type of primary resistance is not well *** aim of this study was to investigate gefitinib resistance in glioblastoma, and explore ways to circumvent this significant clinical ***: MTT method was used to test the cell viability after EGFR-positive glioblastoma cells were treated with indicated drugs;real-time quantitative PCR method was included to detect the TNFα mRNA levels in glioma tissues and cell *** was introduced to measure the TNFα protein levels in cell culture supernatant of glioblastoma cells treated with *** blot was used to detect the activity change of intracellular kinases in drug-treated glioblastoma *** mouse xenograft tumor models were carried out to evaluate the in vivo effects of a combination of EGFR and TNFα ***: We found that glioblastoma resistance to gefitinib may be mediated by an adaptive pro-survival TNFα-JNK-Axl signaling axis, and that high TNFα levels in the glioblastoma microenvironment may further intensify primary resistance.A combination of the TNFα-specific small-molecule inhibitor C87 and gefitinib significantly enhanced the sensitivity of glioblastoma cells to gefitinib in vitro and in ***: Our findings provide a possible explanation for the primary resistance of glioblastoma to EGFR inhibitors and suggest that dual blockade of TNFα and EGFR may be a viable therapeutic strategy for the treatment of patients with chemotherapy-refractory advanced glioblastoma.

关键词： Glioblastoma EGFR TNFα inhibitor drug resistance

Nanodrug enhances post-ablation immunotherapy of hepatocellular carcinoma via promoting dendritic cell maturation and antigen presentation

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Bioactive Materials 2023年第3期21卷 57-68页

作者： Zecong Xiao Tan Li xinyao Zheng Liteng Lin Xiaobin Wang Bo Li Jingjun Huang Yong Wang Xintao Shuai Kangshun Zhu Department of Minimally Invasive Interventional Radiology And Laboratory of Interventional RadiologyThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510630China College of Chemistry and Materials Science Jinan UniversityGuangzhou510632China Department of Dermatology The Nanfang Hospital of Southern Medical UniversityGuangzhouGuangdong510515China

Thermal ablation(TA)as an effective method treating hepatocellular carcinoma(HCC)in clinics is facing great challenges of high recurrence and *** immune-checkpoint blockade(ICB)-based immuno-therapy has shown potential to inhibit recurrence and metastasis,the combination strategy of ICB and thermal ablation has shown little progress in HCC *** tremendous hurdle for combining ICB with thermal ablation lies with the insufficient antigen internalization and immaturity of tumor-infiltrating dendritic cells(TIDCs)which leads to an inferior immune response to distant tumor growth and ***,an antigen-capturing nanoplatform,whose surface was modified with mannose as a targeting ligand,was constructed for co-delivering tumor-associated antigens(TAAs)and m6A demethylases inhibitor(i.e.,fat mass and obesity asso-ciated gene(FTO)inhibitor)into *** vivo results demonstrate that the intratumoral injection of nanodrug followed by HCC thermal ablation promotes dendritic cells(DCs)maturation,improves tumor infiltration of effector T cells and generates immune memory,which synergize with ICB treatment to inhibit the distant tumor growth and lung ***,the antigen-capturing and FTO-inhibiting nanodrug holds potential to boost the ICB-based immunotherapy against HCC after thermal ablation.

关键词： Thermal ablation Tumor-infiltrating dendritic cells N6-methyladenosine modification Nanoplatform Tumor immunotherapy

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氟铃脲的合成研究

山东化工 2024年第3期53卷 1-3,8页

作者：陈路娟马增欣信文彬谷雨蔺新瑶陈一诺孙在臣田俊杰耿龙龙吕超德州学院别尔哥罗德食品科学学院山东德州253023 德州学院化学与化工学院山东德州253023 德州绿霸精细化工有限公司山东德州253000

以2,6-二氟苯甲酰胺和碳酸二苯酯为原料经过缩合反应得到苯基(2,6-二氟苯甲酰基)氨基甲酸酯,产率达到95.5%;然后将苯基(2,6-二氟苯甲酰基)氨基甲酸酯与3,5-二氯-4-(1,1,2,2-四氟乙氧基)苯胺在甲苯中加热缩合得到氟铃脲(产率达90%),两步... 详细信息

以2,6-二氟苯甲酰胺和碳酸二苯酯为原料经过缩合反应得到苯基(2,6-二氟苯甲酰基)氨基甲酸酯,产率达到95.5%;然后将苯基(2,6-二氟苯甲酰基)氨基甲酸酯与3,5-二氯-4-(1,1,2,2-四氟乙氧基)苯胺在甲苯中加热缩合得到氟铃脲(产率达90%),两步总产率达85.95%,中间体和终产物结构均通过核磁共振氢谱、碳谱、红外光谱和高分辨率质谱确证。本合成路线具有产率高、危废少、能耗低、产物易提纯等优点,具有较大的工业化生产潜力,为今后氟铃脲的合成研究提供借鉴。

关键词：氟铃脲有机合成缩合反应结构确证

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降低次同步谐振风险的大型火电基地经串补线路送出规划和运行方案

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电网技术 2014年第1期38卷 113-119页

作者：李晨孙海顺朱鑫要程时杰强电磁工程与新技术国家重点实验室(华中科技大学) 湖北省武汉市430074

为减小大型火电基地经串补线路送出所面临的次同步谐振(subsynchronous resonance,SSR)风险,采用特征值分析法研究了发电厂侧机组型号、机组运行组合对系统电气谐振特性的影响,并分析了电力网侧关站选址/串补度设置综合方案对系统SSR特... 详细信息

为减小大型火电基地经串补线路送出所面临的次同步谐振(subsynchronous resonance,SSR)风险,采用特征值分析法研究了发电厂侧机组型号、机组运行组合对系统电气谐振特性的影响,并分析了电力网侧关站选址/串补度设置综合方案对系统SSR特性的影响,提出了同电厂采用不同型号机组、优化关站选址/串补度设置来降低系统SSR风险的大型火电基地经串补外送系统的规划方案。针对已经投入运行的系统,提出通过减少运行发电机台数等运行机组组合的调整方案,来降低系统面临的SSR风险。后,通过基于PSCAD/EMTDC的电磁暂态仿真对上述方案的有效性进行了验证。

关键词：次同步谐振风险串补线路特征值分析法规划和运行开关站选址

基于DoDAF的有人/无人机协同作战体系结构建模

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系统工程与电子技术 2020年第10期42卷 2265-2274页

作者：王新尧曹云峰孙厚俊韦彩色陶江南京航空航天大学航天学院江苏南京210016 洛阳电光设备研究所河南洛阳471000

有人/无人机(manned/unmanned aerial vehicle,MAV/UAV)协同作战是未来战场中重要的空中作战模式。由于MAV/UAV协同作战体系系统复杂、涉及作战节点多,需从系统工程的角度对整体作战体系进行顶层设计,并采用统一的结构框架对该体系结构... 详细信息

有人/无人机(manned/unmanned aerial vehicle,MAV/UAV)协同作战是未来战场中重要的空中作战模式。由于MAV/UAV协同作战体系系统复杂、涉及作战节点多,需从系统工程的角度对整体作战体系进行顶层设计,并采用统一的结构框架对该体系结构建模。首先,引入美国国防部体系结构框架(Department of Defense architecture framework,DoDAF),提出一种体系结构快速开发方法,并给出开发步骤。然后,利用视图模型,对MAV/UAV协同作战体系的系统功能、作战任务活动、各作战节点的信息交互及组织关系等建立模型。最后,通过动态仿真对模型进行验证。结果表明,所提作战体系的执行状态与预期的作战流程一致,体系结构设计合理,系统内各作战节点定义及信息体系结构描述具备一致性和协调性。

关键词：美国国防部体系结构框架有人/无人机协同作战体系结构