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Chinese Chemical Letters 2024年第4期35卷 414-419页

作者： Peide Zhu Yangjia liu Yaoyao Tang Siqi Zhu xinyang liu Lei Yin Quan liu Zhiqiang Yu Quan Xu Dixian Luo Juncheng Wang State Key Laboratory of Heavy Oil Processing China University of Petroleum-BeijingBeijing 102249China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523058China Department of Laboratory Medicine Huazhong University of Science and Technology Union Shenzhen Hospital(Nanshan Hospital)Shenzhen 518052China Institute of Stomatology First Medical CenterChinese PLA General HospitalBeijing 100853China

Liposomes are one of the significant classes of antitumor nanomaterials and the most successful nanomedicine drugs in clinical translation. However, it is difficult to accurately reveal liposome delivery modes and drug release rates at different p H values to assess the biodistribution and drug delivery pathways in vivo. Here, we established a strategy to integrate Bi-doped carbon quantum dots(CQDs)with liposomes to produce fluorescence visualization and therapeutic effects, namely lipo/Bi-doped CQDs.Lipo/Bi-doped CQDs show good water solubility and physicochemical properties, which can be used for in vitro labeling of colon cancer(CT26) cells and in vivo imaging localization tracking tumors for monitoring. Simultaneously, thanks to the excellent p H sensitivity and ion doping characteristic of Bi-doped CQDs, lipo/Bi-doped CQDs can be used to reveal the drug release rate of liposomes at different p H values and exhibit potential effects in vivo antitumor therapy.

关键词： Bi-doped CQDs Lipo/Bi-doped CQDs pH sensitivity In vitro/in vivo imaging Diagnosis and treatment integration

Evaluation of Clinician Training in Autism Screening, Care Management, and Patient Education

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Open Journal of Pediatrics 2024年第3期14卷 488-513页

作者： Belinda O’Hagan Julie White Ilana Hardesty Rachel Amgott Candice Bangham xinyang liu Alyson Codner Amy Ursitti Alana Chandler Sarah Foster Marilyn Augustyn Jacey Greece Division of Developmental and Behavioral Pediatrics Department of Pediatrics Boston Medical Center Boston United States of America Boston University Chobanian & Avedisian School of Medicine Boston United States of America Department of Community Health Sciences Boston University School of Public Health Boston United States of America

Objective: The demand for pediatric developmental evaluations has far exceeded the workforce available to perform them, which creates long significant wait times for services. A year-long clinician training using the Extension for Community Healthcare Outcomes (ECHO®) model with monthly meetings was conducted and evaluated for its impact on primary care clinicians’ self-reported self-efficacy, ability to administer autism screening and counsel families, professional fulfillment, and burnout. Methods: Participants represented six community health centers and a hospital-based practice. Data collection was informed by participant feedback and the Normalization Process Theory via online surveys and focus groups/interviews. Twelve virtual monthly trainings were delivered between November 2020 and October 2021. Results: 30 clinicians participated in data collection. Matched analyses (n = 9) indicated statistically significant increase in self-rated ability to counsel families about autism (Pre-test Mean = 3.00, Post-test Mean = 3.89, p = 0.0313), manage autistic patients’ care (Pre-test Mean = 2.56, Post-test Mean = 4.11, p = 0.0078), empathy toward patients (Pre-test Mean = 2.11, Post-test Mean = 1.22, p = 0.0156) and colleagues (Pre-test Mean = 2.33, Post-test Mean = 1.22, respectively, p = 0.0391). Unmatched analysis revealed increases in participants confident about educating patients about autism (70.59%, post-test n = 12 vs. 3.33%, pre-test n = 1, p = 0.0019). Focus groups found increased confidence in using the term “autism”. Conclusion: Participants reported increases in ability and confidence to care for autistic patients, as well as empathy toward patients and colleagues. Future research should explore long-term outcomes in participants’ knowledge retention, confidence in practice, and improvements to autism evaluations and care.

关键词： Autism Spectrum Disorder Program Evaluation Case-Based Training Provider Burnout Continuing Medical Education

无孔不入与见则治之内镜微创新理念在消化道肿瘤治疗中的应用

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中国肿瘤临床 2024年第1期51卷 9-14页

作者：刘歆阳周平红复旦大学附属中山医院内镜中心上海市200032 上海市内镜微创协同创新中心

消化道肿瘤是严重威胁人类健康的公共问题,内镜微创治疗是实现消化道肿瘤早诊早治的重要途径。本文总结了内镜微创切除治疗消化道早期肿瘤的发展历史及现状,阐释了内镜微创基本要素(elements)、可保可切(reservation-resectio)、医患双... 详细信息

消化道肿瘤是严重威胁人类健康的公共问题,内镜微创治疗是实现消化道肿瘤早诊早治的重要途径。本文总结了内镜微创切除治疗消化道早期肿瘤的发展历史及现状,阐释了内镜微创基本要素(elements)、可保可切(reservation-resectio)、医患双方收益(bilateral-benefit)、指征扩大(expansion)、医工协同(collaboration)的ERBEC新理念在消化道肿瘤治疗中的应用,并提出消化道肿瘤内镜微创切除未来的发展方向。

关键词：消化道肿瘤内镜微创治疗切除技术新理念

System Adaptive AC Filter for a Line Commutated Converter High Voltage DC Transmission System

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CSEE Journal of Power and Energy Systems 2020年第4期6卷 901-910页

作者： xinyang liu Weimin Ma Hongjie Jia Chaoyu Dong School of Electrical and Information Engineering of Tianjin University Tianjin 300072China State Grid Economic and Technological Research Institute Co. LtdBeijing 102209China

This paper proposes a novel AC filter system for a line commutated converter high voltage DC(LCC-HVDC)transmission system.Through the coordination of the hybrid active power filters(APF)and the existing reactive compensation devices,the proposed filter system can not only enhance the suppression performance for LCC-HVDC harmonics,but also optimize the AC yard layout with reduced reactive power subbanks,reducing the cost of HVDC projects.The novel filter system adopts a serial passive resonance topology obtained by careful comparison of different APFs.A proper control scheme is then designed integrating the control strategy of the APF and impedance characteristics of the HVDC system,which is able to realize harmonic suppression and dynamic reactive power support simultaneously.In addition,a novel self-adaption digital low-pass filter algorithm is presented,which is used in the APF harmonic detecting step,enhancing both high precision and fast dynamic response.On the basis of a real HVDC project,the advantages of proposed filter system in harmonic suppression,reactive power regulation,and sub-banks reduction are simulated and demonstrated.

关键词： Active power filter(APF) control system harmonic detecting impedance characteristic line commutated converter high voltage DC(LCC-HVDC) reactive compensation

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面向虚拟人上肢的避障作业姿态规划算法

计算机集成制造系统 2024年第5期30卷 1634-1642页

作者：刘馨阳丰博韩钟剑邵晓东西安电子科技大学机电工程学院陕西西安710071 中国电子科技集团公司第二十研究所高端电子装备工业设计中心陕西西安710068

为了完成虚拟维修仿真环境下的虚拟人维修作业姿态规划问题,提出一种基于改进RRT-Connect算法的虚拟人上肢作业姿态求解方式。在该求解方式中,将人工鱼群算法(AFSA)的觅食行为法则作为导向性策略引入传统RRT-Connect算法,从而使得路径... 详细信息

为了完成虚拟维修仿真环境下的虚拟人维修作业姿态规划问题,提出一种基于改进RRT-Connect算法的虚拟人上肢作业姿态求解方式。在该求解方式中,将人工鱼群算法(AFSA)的觅食行为法则作为导向性策略引入传统RRT-Connect算法,从而使得路径规划任务中初始点与目标点的扩展具有导向性;将路径点作为虚拟人上肢末端关节运动轨迹点。为获得虚拟人维修姿态,利用逆向运动学进行推导,以在每一个路径点中得到符合人体关节自由度的姿态集。另外,为了选择出姿态集中的最优路径,利用快速上肢评估法求取最优的虚拟人上肢维修作业姿态。最后,以无人艇虚拟维修操作仿真为例,验证了该方法在虚拟维修应用中的可行性。

关键词：虚拟人上肢运动路径规划 RRT-Connect算法人机工效学人工鱼群算法

Dendrimers-merging biomimics and photoenergy conversion

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Science China Chemistry 2015年第3期58卷 390-399页

作者： xinyang liu Yi Zeng Xiaohui Zhang Tianjun Yu Jinping Chen Yi Li Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences

Dendrimers are well-defined tree-like macromolecules possessing numerous chain ends emanating from a single core, which makes them attractive candidates for mimicking light-harvesting systems and hydrogenases. Photoinduced electron and energy transfers are main processes involved in light-harvesting and photocatalysis. In this review, the general concepts of design strategies and recent developments of photofunctional dendrimers in biomimics of light-harvesting systems and hydrogenases are discussed. The energy transfer and electron transfer processes in light-harvesting dendrimers and the effect of dendritic structures in photochemical hydrogen production are illustrated.

关键词：树枝状聚合物光能转化电子转移过程合并能量转移树状大分子树枝状结构光系统

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筏板基础大体积混凝土水化热模拟分析

科技资讯 2024年第6期22卷 132-134页

作者：刘新洋深圳地铁集团有限公司广东深圳518026

大体积混凝土硬化过程中会放出大量热量形成温度裂缝,影响结构的安全性和耐久性。依托深圳市皇岗口岸站深基坑筏板工程,通过MIDAS/FEA对大体积混凝土筏板浇筑后的温度变化和热应力情况进行数值分析,对比研究不同浇筑方式对大体积混凝土... 详细信息

大体积混凝土硬化过程中会放出大量热量形成温度裂缝,影响结构的安全性和耐久性。依托深圳市皇岗口岸站深基坑筏板工程,通过MIDAS/FEA对大体积混凝土筏板浇筑后的温度变化和热应力情况进行数值分析,对比研究不同浇筑方式对大体积混凝土水化热的影响。研究结果表明:分段分层斜面浇筑可有效降低大体积混凝土早期温升,控制表面裂缝的产生。

关键词：大体积混凝土筏板基础水化热分层浇筑仿真模拟

Strategies for Construction of Majors in Universities with Different Characteristic Based on Social Needs

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Journal of Systems Science and Information 2019年第5期10卷 474-485页

作者： Xiuli TAN Zhongquan CHEN xinyang liu Peter DEENEY Zhisong CHEN Business School Yantai Nanshan UniversityYantai 265713China School of Business Administration Northeastern UniversityShenyang 110819China Business School Dublin City UniversityGlasnevin 7008002Ireland Business School Deakin UniversityMelbourneVIC 3125Australia

We used the basic principles of game theory to investigate development strategies for standards of professional competence in universities in the same geographic area,under conditions of non-uniform distribution of social demand preference.The results revealed that,under various conditions in our model,different approaches for differential strategies were selected by university U2 compared with university U1.Specifically,in the competition between U1 and U2,there is a differential strategy compression point of U2 to U1;When U2 universities choose the biggest differentiation strategy,university U1 also have differentiated strategy control points.Arbitrary decision-making of university U1 in relation to university U2 was based on the requirements of professional competence standards,according to the change of the social demand for professional competency standard,universities U2 will adopt the strategy of"no difference","maximum differentiation"and"comprehensive intermediate strategy",respectively.The current results have theoretical implications for the selection of professional development and professional competence development strategies in asymmetric universities operating in the same geographic area.

关键词： heterogeneous preferences specialty construction game analysis

工业机器人自动视觉检测综合实训平台的设计与实践

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实验室研究与探索 2024年第2期43卷 222-225页

作者：刘新洋栗琳张佳明北京科技大学机械工程学院北京100083

为了使学生掌握智能机器人系统设计及集成应用技术,设计了工业机器人自动视觉检测综合实训平台。该平台集成了工业机器人、机器视觉、智能检测、立体仓库等模块,通过工业以太网组建高度集成化的自动化柔性生产线。基于产教融合教学模式... 详细信息

为了使学生掌握智能机器人系统设计及集成应用技术,设计了工业机器人自动视觉检测综合实训平台。该平台集成了工业机器人、机器视觉、智能检测、立体仓库等模块,通过工业以太网组建高度集成化的自动化柔性生产线。基于产教融合教学模式,分层次设计了工业机器人操作实训、自动加工检测生产线PLC程序开发实训、图像识别程序开发实训、工业机器人与自动加工检测生产线综合实训项目。实践表明,该实训平台可以满足机器人工程专业人才培养需求,充分激发学生的自主学习热情,提高学生创新能力与解决工程问题的能力,为学生后续学习打下了坚实的实践基础。

关键词：产教融合实训教学多学科交叉

右美托咪定对原位肝移植受者术中及术后早期并发症的影响

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中华外科杂志 2024年第2期62卷 155-161页

作者：康俊伟张慧陈怡宁郑智滢刘新阳潘熊熊南京医科大学第一附属医院麻醉与围术期医学科南京210029 南京医科大学第一附属医院肝胆中心南京210029

目的探讨右美托咪定对原位肝移植受者术中及术后早期并发症的影响。方法本研究为回顾性队列研究。回顾性收集2016年1月至2020年9月于南京医科大学第一附属医院进行原位肝移植手术的399例受者的临床资料。男性319例,女性80例,年龄(50.9±... 详细信息

目的探讨右美托咪定对原位肝移植受者术中及术后早期并发症的影响。方法本研究为回顾性队列研究。回顾性收集2016年1月至2020年9月于南京医科大学第一附属医院进行原位肝移植手术的399例受者的临床资料。男性319例,女性80例,年龄(50.9±10.2)岁(范围:10~73岁)。根据术中是否持续静脉泵注右美托咪定至手术结束分为对照组(369例)和右美托咪定组(30例)。将两组受者术前和术中各指标作为协变量,采用1∶2倾向性评分匹配法进行匹配,卡钳值为0.2。结局指标包括术中再灌注综合征、术后7 d内急性肾损伤和肺部并发症发生情况、术后总住院时间、术后ICU停留时间、辅助机械通气时间、再次气管插管情况、术后6个月和1年生存情况及无复发生存情况。分别采用独立样本t检验、Mann-WhitneyU检验、χ^(2)检验或Fisher确切概率法对两组受者的资料进行统计分析;采用Kaplan-Meier法绘制总体生存曲线和无复发生存曲线,总体生存率和无复发生存率的比较采用Log-rank检验。结果经倾向性评分匹配后,共纳入78例受者,其中右美托咪定组26例,对照组52例。右美托咪定组受者术后7 d内急性肾损伤发生率为0(0/26),低于对照组的21.2%(11/52)(校正χ^(2)=4.776,P=0.029)。两组受者术中再灌注后综合征发生率、术后7 d内肺部并发症发生率、术后总住院时间、术后ICU停留时间、辅助机械通气时间、再次气管插管率及术后6个月和1年总体生存率及无复发生存率的差异均无统计学意义(P值均>0.05)。结论术中持续静脉泵注右美托咪定可能有利于降低原位肝移植受者术后7 d内急性肾损伤的发生率。

关键词：肝移植麻醉右美托咪定手术中并发症手术后并发症