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AstragalosideⅣplays a role in reducing radiation-induced liver inflammation in mice by inhibiting thioredoxin-interacting protein/nod-like receptor protein 3 signaling pathway

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Journal of Traditional Chinese Medicine 2023年第1期43卷 87-94页

作者： DING Yanping DONG Xiaoqing MA Yifan CHEN lili ZHOU Jie li xinyan SHAO Baoping College of life Science Northwest Normal UniversityLanzhou 730000China College of life Science Lanzhou UniversityLanzhou 730000China

OBJECTIVE:To investigate the efficacy of Astragaloside IV(AS-IV)on radiation-induced liver inflammation in ***:The mice were divided into normal group,dimethyl sulfoxide solvent group,irradiation group(IR),irradiation+AS-IV(20 mg/kg)group(IR+AS-20)and irradiation+AS-IV(40 mg/kg)group(IR+AS-40).One month after intraperitoneal injection of AS-IV,the mice were irradiated with 8Gry Co60γ,the blood was collected for biochemical analysis,and the liver was collected for hematoxylin-eosin staining,immunofluorescence and electron microscopic observation,oxidative stress,and Western blot ***:The AS-IV treatment significantly ameliorated the pathological morphology of liver and reduced the alanine aminotransferase and aspertate aminotransferase levels in serum induced by radiation;AS-IV treatment also significantly reduced the expression of inflammatory factors tumor necrosis factor alpha and interleukin 6 and antagonized malonaldehyde content and superoxide dismutase activity in liver caused by radiation;in addition,AS-IV treatment can significantly inhibited the positive expression of thioredoxin-interacting protein(TXNIP)and nod-like receptor protein 3(NLRP3)inflammasome in liver tissue after radiation;The expression of TXNIP,NLRP3 inflammasome,apoptosisassociated speck-like protein containing a CARD,cysteinyl aspartate-specific proteinase 1 and interleukin 1beta in the AS-IV prevention group decreased significantly compared to the radiation ***:These findings suggested that Co60γradiation can cause structural and functional damage to the liver,which may be related to the NLRP3 mediated inflammatory pathway;AS-IV may play a protective role by inhibiting the TXNIP/NLRP3 inflammasome signaling pathway in the radiation-induced liver injury model.

关键词： radiation,ionizing astragalosideⅣ liver inflammation NLR family,pyrin domain-containing 3 protein thioredoxin-interacting protein

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IRF8靶向铁死亡在急性肺损伤中的作用及机制研究

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医学新知 2024年第4期34卷 363-371页

作者：王佳李忻炎李琳钰张晓晶杨娟折志刚武汉大学人民医院心内科武汉430060 武汉大学基础医学院武汉430071 赣南医科大学赣南创新与转化医学研究院江西赣州341000

目的探讨干扰素调节因子8(interferon regulatory factor 8,IRF8)在急性肺损伤(acute lung injury,Ali)中的作用及其机制。方法采用实时荧光定量逆转录聚合酶链反应(RT-qPCR)和蛋白免疫印迹(WB)检测体内外Ali模型中IRF8 mRNA和蛋白的表... 详细信息

目的探讨干扰素调节因子8(interferon regulatory factor 8,IRF8)在急性肺损伤(acute lung injury,Ali)中的作用及其机制。方法采用实时荧光定量逆转录聚合酶链反应(RT-qPCR)和蛋白免疫印迹(WB)检测体内外Ali模型中IRF8 mRNA和蛋白的表达。体外构建稳定过表达和敲低IRF8的A549细胞系,采用RT-qPCR检测炎症相关基因mRNA的表达;WB检测凋亡相关基因的表达。分别选取12只同窝阴性对照小鼠和12只Irf8敲除品系小鼠,构建Ali模型,收集造模后的小鼠肺组织并称重;收集并检测肺泡灌洗液中总细胞数以及总蛋白含量。采用苏木精-伊红染色及免疫荧光分析肺组织炎症浸润情况;利用RT-qPCR检测Irf8敲除小鼠肺组织炎症相关基因mRNA的表达;TUNEL染色分析肺组织凋亡情况;采用WB分别在体内外Ali模型中检测铁死亡相关信号分子的蛋白表达。结果IRF8在体内体外Ali中表达上调;体外敲低IRF8加剧细胞内炎症以及细胞凋亡,反之,过表达IRF8可在体外Ali模型中发挥保护作用;敲除Irf8加重小鼠肺损伤;进一步机制探索发现IRF8通过调控铁死亡相关信号分子表达从而减轻肺损伤。结论IRF8通过靶向铁死亡在肺损伤中发挥保护作用,为肺损伤的治疗提供潜在靶点。

关键词： IRF8 急性肺损伤铁死亡炎症凋亡

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Preparation and characterization of a composite membrane based on the asphaltene component of coal

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Mining Science and Technology 2011年第3期21卷 407-411页

作者： Zhang liying Qin Zhihong li xinyan Chen Juan liu Peng Wang Xiaoyan School of Chemical Engneering and Technology China University of Mining ＆ Technology Xuzhou 221116 China

Asphaltene-ceramic composite membranes were fabricated from ceramic supports and an asphaltene component, which was obtained from the separation of coal to give a kind of new carbonaceous precursor material. Using SEM and thermogravimetric analysis to measure the microstructure and properties of the asphaltene component allowed the porosity, permeability, and retention ratios to be determined. The results show that the asphaltene component can be regarded as a good carbon membrane precursor material because of its high carbon content and strong bonding capacity. When ceramic supports are impregnated with asphaltene colloid the asphaltene easily combines with the support surface and forms a good carbonaceous film after carbonization. little of the asphaltene component permeates into the internal pores of the ceramic support. Although the number of coats applied to the substrate had little affect on the porosity of the asphaltene-ceramic composite membranes the permeability varied depend- ing upon the number of times the substrate was treated. The way bubbles escape from the film, and the phenomenon of coalescence, as affected by different film thicknesses also seem closely related to the number of coats. A composite membrane carbonized at a final temperature of 600℃ is relatively dense and the permeability of Fe（OH）3 colloid through it is very low. A membrane fired at 800℃ is porous and its permeability and retention of Fe（OH）3 colloid are 88 L/（m2 h MPa） and 85.3%, respectively when the trans-membrane pressure is 0.22 MPa.

关键词： Asphaltene Composite membrane Porosity Permeability Fe(OH)3 colloid

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学生结核病患者复学政策对比研究及建议

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中国防痨杂志 2024年第9期46卷 998-1005页

作者：黄弦孟维宇罗涛张伟华李欣妍赖燕芬郭红革邓颖佳赖晓宇李克峰黄明星珠海市第三人民医院珠海519000 中国澳门理工大学应用科学学院人工智能药物发现中心中国澳门特别行政区999078 华中科技大学同济医学院公共卫生学院社会医学与卫生事业管理系武汉430030 中华人民共和国澳门特别行政区卫生局结核病防治中心中国澳门特别行政区999078 广东省结核病控制中心门诊部广州510620

学生是结核病防控的重点人群,患结核病后的复学政策对青少年的身心健康至关重要。目前,各国复学政策存在明显差异,我国现行的休学时间相对较长,可能会对学生学业、社交和心理健康造成不可忽视的影响。基于近年来儿童和青少年结核病诊断... 详细信息

学生是结核病防控的重点人群,患结核病后的复学政策对青少年的身心健康至关重要。目前,各国复学政策存在明显差异,我国现行的休学时间相对较长,可能会对学生学业、社交和心理健康造成不可忽视的影响。基于近年来儿童和青少年结核病诊断和治疗技术的发展,我国已经具备了调整和优化学生药物敏感结核病患者复学政策的现实基础。本文通过对比分析国际上各地的复学政策,结合国内外敏感结核病患者规范服药后传染性评估方面的研究进展和珠海市近10年的实际案例数据,深入探讨规范抗结核治疗后的传染性降低情况,并基于分析结果提出针对儿童和青少年结核病患者新的复学政策建议,以期为我国相关政策的优化与完善提供依据。

关键词：结核学生公共卫生卫生政策传染病控制

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Reversible isomerization of donor-acceptor Stenhouse adduct derivatives in water through dendritic confinement

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Science China Chemistry 2024年第5期67卷 1636-1646页

作者： Jiaxing Zhang Qingyun Zhao xinyan Su Afang Zhang Wen li International Joint Laboratory of Biomimetic and Smart Polymers School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

Modulating reversible isomerization of hydrophobic dyes in aqueous solutions is greatly desired. Here we report on reversible isomerization of solvatochromic donor-acceptor Stenhouse adducts(DASAs) in water through the confinement from dendritic oligoethylene glycols(OEGs). Dendronization of DASAs with dendritic OEGs affords them characteristic thermoresponsiveness. These dendronized DASAs spontaneously isomerize in water from hydrophobic linear state into hydrophilic cyclic state at room temperature due to the strong hydration. However, hydrophobic microenvironment through thermally dehydration and collapse of the dendritic OEGs at elevated temperatures confines hydration of the DASA moieties and mediates their interactions with the collapsed hydrophobic OEG domains, affording their isomerization recovery in water efficiently from the hydrophilic cyclic state into the hydrophobic linear state. The confinement-mediated reversible isomerization of DASA moieties in water can be repeated through alternative photo-irradiation and thermal dehydrations, exhibiting excellent fatigue resistance.

关键词： dendrimers donor-acceptor Stenhouse adducts isomerization confinement thermoresponsiveness

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Synergistic effect of Co and Co_(6)Mo_(6)C for electroreduction of nitrate to ammonia on Co-MOF derived Co_(6)Mo_(6)C/Co/NC

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Nano Research 2024年第7期17卷 5807-5816页

作者： xinyan Wang Yue Cao Yan Hai Xiaoman li Min Luo State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering School of Chemistry and Chemical EngineeringNingxia UniversityYinchuan 750021China

Electrocatalytic nitrate reduction reaction(e-NO_(3)RR)offers a promising alternative method for nitrogen cycling and ammonia(NH3)production under ambient ***,the method is still in the dilemma of lowering the reaction overpotential and increasing the reaction *** successfully developed the composition-adjustable Co_(6)Mo_(6)C/Co/N-doped carbon(NC)catalysts by in situ carbonization of Co-based metal-organic framework(MOF)with the constrained phosphomolybdic *** adjusting the ratio of Co0 and Co_(6)Mo_(6)C,Co_(6)Mo_(6)C/Co/NC-3 could satisfy both NO_(3)−conversion at low potential and NH_(x)hydrogenation,and synthesize ammonia efficiently through the synergistic effect of Co0 and Co_(6)Mo_(6)*** achieved an ammonia yield rate as 1233.2μg·h^(−1)·mgcat^(−1)and Faradaic efficiency of NH4+93.6%at−0.33 V *** hydrogen electrode(RHE).Importantly,density functional theory(DFT)calculations and experimental results have demonstrated for the first time the excellent adsorption of nitrite(NO_(2)^(−))by the Mo sites of Co_(6)Mo_(6)C during e-NO_(3)RR,avoiding the undesirable accumulation of NO_(2)^(−).

关键词： synergistic effect nitrate electroreduction Co_(6)Mo_(6)C ammonia synthesis

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基于个案管理模式的渐进性康复护理在发育迟缓患儿中的应用研究

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临床研究 2024年第4期32卷 166-169页

作者：宋辰风范晶晶李新岩张永梅新乡市中心医院新乡医学院第四临床学院小儿康复科河南新乡453000

目的探究基于个案管理模式的渐进性康复护理在发育迟缓患儿中的应用。方法分析2021年10月至2023年10月新乡市中心医院新乡医学院第四临床学院收治的62例发育迟缓患儿临床资料,按照随机数字表法将其分为对照组和观察组,各31例。对照组给... 详细信息

目的探究基于个案管理模式的渐进性康复护理在发育迟缓患儿中的应用。方法分析2021年10月至2023年10月新乡市中心医院新乡医学院第四临床学院收治的62例发育迟缓患儿临床资料,按照随机数字表法将其分为对照组和观察组,各31例。对照组给予常规康复护理,观察组实施个案管理模式的渐进性康复护理。比较两组发育商指标、感觉统合能力、神经缺损功能、精神状态、生活质量及患儿与家属护理满意度。结果护理后观察组粗大运动商(GMQ)、精细运动商(FMQ)和总运动商(TMQ)均值皆高于对照组,差异有统计学意义(P<0.05)。护理后观察组学习能力、体感不良及触觉过分防御评分皆高于对照组,差异有统计学意义(P<0.05)。护理后观察组神经缺损功能评分低于对照组,精神状态评分高于对照组,差异有统计学意义(P<0.05)。护理后观察组生活质量评分高于对照组,差异有统计学意义(P<0.05)。观察组对护理总满意率高于对照组,差异有统计学意义(P<0.05)。结论基于个案管理模式的渐进性康复护理在发育迟缓患儿中应用效果显著,可有效改善患儿的各项指标,提高患儿与家属的护理满意度。

关键词：个案管理模式渐进性康复护理发育迟缓患儿

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NiS_(2)/FeS Heterostructured Nanoflowers for High-Performance Sodium Storage

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Energy Material Advances 2023年第1期4卷 57-66页

作者： Dong Yan Shuhao Xiao xinyan li Jinxia Jiang Qiyuan He Hanchao li Jiaqian Qin Rui Wu Xiaobin Niu Jun Song Chen Institute for Advanced Study Chengdu UniversityChengdu 610106P.R.China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054P.R.China Chongqing Medical and Pharmaceutical College Chongqing 401331P.R.China Department of Materials Science and Engineering City University of Hong KongKowloonHong KongChina Center of Excellence on Advanced Materials for Energy Storage Metallurgy and Materials Science Research InstituteChulalongkorn UniversityBangkok 10330Thailand Shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhenP.R.China

Transition metal sulfides demonstrate attractive potential for sodium storage owing to their high theoretical specific capacity and high ***,the low conductivity and volume expansion deteriorate their high-rate performance and cycling *** this work,we construct NiS_(2)/FeS heterostructure by growing Ni-based layered double hydroxide nanosheets on Fe-based Prussian Blue nanocrystals followed by gaseous sulfurization,giving rise to flower-like NiS_(2)/FeS *** as-prepared nanocomposite exhibits good rate performance of 156 mAh g^(−1) at 50 A g^(-1) and long cycle life of 606 mAh g^(−1) at 5 A g^(−1) after 1,000 cycles,which are superior to the heterostructure-free counterpart of NiS_(2) and *** functional theory calculation further verifies that the enhanced electrochemical performance of NiS_(2)/FeS is due to the existence of interface derived from the heterostructure.

关键词： flowers attractive cycling

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基于健商理念的健康教育对老年社区获得性肺炎患者自护能力、肺功能及生存质量的影响

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河南医学研究 2024年第10期33卷 1905-1909页

作者：王秋燕徐珍珍李欣彦吴玲玲郑州大学第一附属医院呼吸与重症二科河南郑州450000 郑州大学第一附属医院呼吸内科河南郑州450000 郑州大学第一附属医院呼吸重症科河南郑州450000

目的探究基于健商理念的健康教育对老年社区获得性肺炎(CAP)患者自护能力、肺功能及生存质量的影响。方法选取2021年6月至2022年4月郑州大学第一附属医院102例老年CAP患者,按照随机数字表法分为两组,每组51例。对照组接受常规护理,于... 详细信息

目的探究基于健商理念的健康教育对老年社区获得性肺炎(CAP)患者自护能力、肺功能及生存质量的影响。方法选取2021年6月至2022年4月郑州大学第一附属医院102例老年CAP患者,按照随机数字表法分为两组,每组51例。对照组接受常规护理,于此基础上观察组接受基于健商理念的健康教育。观察两组干预前后肺功能[第1秒用力呼气容积(FEV_(1))、第1秒用力呼气容积与用力肺活量比值(FEV_(1)/FVC)及用力肺活量(FVC)]、健商水平、自护能力[自我护理能力测定表(ESCA)]及随访1 a后CAP再发情况。结果干预后观察组FEV_(1)/FVC、FEV_(1)、FVC均高于对照组(P<0.05);干预后观察组健商水平中精神状态、生活技能、健康知识、自我保健、生活方式均高于对照组(P<0.05);干预后观察组ESCA中自我概念、健康知识水平、自我责任感、自我护理技能均高于对照组(P<0.05);随访1 a观察组CAP再发率低于对照组(P<0.05)。结论在老年CAP患者中应用基于健商理念的健康教育,可有效提升患者健商水平,增强自护能力,从而改善肺功能。

关键词：社区获得性肺炎生活质量健商理念

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Prediction and interpretation of photocatalytic NO removal on g-C_(3)N_(4)-based catalysts using machine learning

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Chinese Chemical Letters 2024年第2期35卷 477-483页

作者： Jing li xinyan liu Hong Wang Yanjuan Sun Fan Dong School of Resources and Environment University of Electronic Science and Technology of ChinaChengdu 611731China Research Center for Carbon-Neutral Environmental & Energy Technology Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China

Predictive modeling of photocatalytic NO removal is highly desirable for efficient air pollution ***,great challenges remain in precisely predicting photocatalytic performance and understanding interactions of diverse features in the catalytic ***,a dataset of g-C_(3) N_(4)-based catalysts with 255 data points was collected from peer-reviewed publications and machine learning(ML)model was proposed to predict the NO removal *** result shows that the Gradient Boosting Decision Tree(GBDT)demonstrated the greatest prediction accuracy with R 2 of 0.999 and 0.907 on the training and test data,*** SHAP value and feature importance analysis revealed that the empirical categories for NO removal rate,in the order of importance,were catalyst characteristics>reaction process>preparation ***,the partial dependence plots broke the ML black box to further quantify the marginal contributions of the input features(e.g.,doping ratio,flow rate,and pore volume)to the model output *** ML approach presents a pure data-driven,interpretable framework,which provides new insights into the influence of catalyst characteristics,reaction process,and preparation conditions on NO removal.

关键词： Machine learning g-C_(3)N_(4)-based catalysts NO removal Interpretability Catalytic informatics

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