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Bardet Biedl综合征的诊治进展

临床儿科杂志 2024年第2期42卷 157-163页

作者：林娇徐鑫星王传凯蒋丽琼(综述) 王春林(审校) 浙江大学医学院附属第一医院儿科浙江杭州311100

Bardet Biedl综合征(BBS)是一种罕见的累及多系统的常染色体隐性遗传病,主要特征为视网膜病变、多指(趾)畸形、肥胖、智力低下、性腺发育不良和肾功能异常。迄今已明确26种致病基因,均定位于初级纤毛上,其中BBS1、BBS2和BBS10是最常见... 详细信息

Bardet Biedl综合征(BBS)是一种罕见的累及多系统的常染色体隐性遗传病,主要特征为视网膜病变、多指(趾)畸形、肥胖、智力低下、性腺发育不良和肾功能异常。迄今已明确26种致病基因,均定位于初级纤毛上,其中BBS1、BBS2和BBS10是最常见的变异基因。对于该疾病目前尚无治愈性疗法,主要以对症支持治疗为主。本文从临床特点、诊断标准、致病基因、我国BBS患者现状、治疗等角度对该疾病进行综述,以期为临床对此类疾病的诊治提供参考。

关键词： Bardet Biedl综合征诊断标准致病基因治疗

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蒸制鲟鱼背部肉脂质氧化特性及风味品质评价

食品工业科技 2024年第16期45卷 13-24页

作者：李珂谢伟徐新星刘荔李雪飞白帆汪金林赵元晖中国海洋大学食品科学与工程学院山东青岛266404 中国海洋大学三亚海洋研究院海南三亚572024 衢州鲟龙水产食品科技开发有限公司浙江衢州324002

探究了蒸制时间对鲟鱼背部肉脂质氧化及风味的影响。本文通过测定过氧化值、酸价、丙二醛和共轭烯烃表征了鱼肉蒸制过程中脂质氧化的程度,测定脂肪酸含量变化分析了蒸制对挥发性化合物和营养品质的影响,并通过非靶向脂质组学探究了蒸制... 详细信息

探究了蒸制时间对鲟鱼背部肉脂质氧化及风味的影响。本文通过测定过氧化值、酸价、丙二醛和共轭烯烃表征了鱼肉蒸制过程中脂质氧化的程度,测定脂肪酸含量变化分析了蒸制对挥发性化合物和营养品质的影响,并通过非靶向脂质组学探究了蒸制鲟鱼肉中脂质组成的变化,最后通过热氧化模型验证了磷脂对鲟鱼背部肉风味产生的具体影响。结果表明,蒸制16 min的鲟鱼背部肉脂质氧化程度适中,不饱和脂肪酸含量丰富,营养价值高。脂质适度氧化有利于特征风味的形成,而磷脂是挥发性风味化合物的主要前体物,其中亚油酸(C18:2)、DHA(C22:6)、油酸(C18:1)和花生四烯酸(C20:4)是与磷脂结合的主要不饱和脂肪酸。此外,模拟蒸制条件的结果表明磷脂氧化出现大量的吡嗪和呋喃类化合物,为蒸制鲟鱼背部肉贡献了一定的焙烤香气。综上,脂质的适度氧化有利于提高蒸制鲟鱼背部肉的风味和营养品质,磷脂氧化对蒸制鲟鱼背部肉风味形成具有重要影响,本研究可为鲟鱼肉风味提升提供一定的理论依据。

关键词：鲟鱼蒸制磷脂脂质氧化风味品质

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Performance of GH4169 brazed joint using a new designed nickel-based filler metal via cluster-plus-glue-atom model

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Journal of Materials Science & Technology 2020年第4期39卷 89-98页

作者： Honggang Dong Yueqing Xia xinxing xu Gul Jabeen Naz Xiaohu Hao Peng Li Jun Zhou Chuang Dong School of Materials Science and Engineering Dalian University of TechnologyDalian 116024China Key Laboratory for Materials Modification by Laser Ion and Electron Beam(Dalian University of Technology)Ministry of EducationDalian 116024China Harbin Institute of Welding Mechanical Science Research InstituteHarbin 150028China

A novel Ni-Cr-Si-B filler metal with the cluster formula of[Cr-Ni12]B2Cr+[B-Ni8Cr]BSi Cr based on the cluster-plus-glue-atom model was designed for vacuum brazing GH4169 *** effect of brazing temperature and brazing time on microstructure and shear strength of GH4169 alloy joints was *** brazed seam was mainly composed ofγ-Ni solid solution.(Nb,Ti)-rich phase and(Cr,Nb,Mo)-rich borides distributed in diffusion *** diffusion and aggregation of B,Cr,Nb,and Mo resulted in the variation of phase contrast and morphology of *** precipitations in the joint brazed at1240℃consisted of borides,Laves phase andδ*** shear strength of joints was principally dominated by the brittle precipitations in diffusion zone,and the homogenization of microstructure improved the room-temperature shear strength to 820 MPa with the high-temperature shear strength of 627 MPa for the joint brazed at 1240℃/20 *** joint fractured in diffusion zone and brazed seam,and the existence of borides and Laves phase in diffusion zone provide the potential origin for crack growth.

关键词： Cluster-plus-glue-atom model GH4169 alloy Brazing Microstructure Shear strength

Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice

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Food Science and Human Wellness 2023年第6期12卷 2286-2296页

作者： Jing Li Xinyue Yu xinxing xu Peipei Tang Shuang Bi Xiaopu Ren Yong Shi Jihong Wu Fei Lao National Engineering Research Center for Fruit&Vegetable Processing Key Laboratory of Fruit&Vegetable ProcessingMinistry of Agriculture and Rural AffairsBeijing Key Laboratory for Food Non-thermal ProcessingCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Beijing Daily Chemical Products Quality Supervision and Inspection Station Beijing 101111China Department of Food Science and Technology The Ohio State UniversityColumbus 43210USA College of Food Science and Engineering Tarim UniversityAlar 843300China Haoxiangni Health Food Co. Ltd.Xinzheng 451100China

Unfermented jujube pulp(UFJP),fermented jujube pulp(FJP)in high and low doses were fed to constipated ICR *** function,serum gastrointestinal regulatory peptide,fecal short-chain fatty acids(SCFAs)and gut microbial composition were *** showed that high-dose FJP could protect intestinal mucosa tissue,shorten the first black feces defecating time by 17%and increase the number and wet weights of black feces by 72%and 71%,respectively,within 6 ***-dose FJP signifi cantly down-regulated the somatostatin level and up-regulated gastrin level in constipated mice,compared with low-dose FJP and *** high-dose FJP intervention regulated the microbiota profi le,which afterwards restored microbiota,like Bacteroidetes,Bifi dobacterium and Lactobacillus,to a less unhealthy *** study provides convincing in vivo evidence that high-dose FJP supplementation through daily diet could be a promising approach to effectively alleviate constipation and modulate gut health.

关键词： Jujube Lactic acid bacteria fermentation Short-chain fatty acid Probiotics Gut microbiota

Novel CoP/CoMoP_(2) heterojunction with nanoporous structure as an efficient electrocatalyst for hydrogen evolution

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Nano Research 2024年第5期17卷 3693-3699页

作者： Lili Zhang xinxing Shi Aijiao xu Wenwu Zhong Jitang Zhang Shijie Shen Zhejiang Provincial Key Laboratory for Cutting Tools Taizhou UniversityJiaojiang 318000China

The exploration of new heterojunction materials is of great significance in reducing the cost of existing noble metal catalysts and thus realizing the large-scale application of electrocatalytic hydrolysis ***,a novel CoP/CoMoP_(2) heterojunction was synthesized and served as a hydrogen evolution reaction(HER)*** heterojunction has morphology of nanoporous structure,which is conducive to exposing more active sites and facilitating bubbles *** charge distribution is optimized by a strong interface interaction between CoP and CoMoP_(2).The catalyst’s conductivity and the adsorption properties of the intermediates have both been ***/CoMoP_(2) demonstrates excellent HER activity with an overpotential of 93.6 mV at 10 mA∙cm^(-2),which is competitive with the reported performance of analogous *** work provides insights into the development of innovative phosphide-based heterojunction electrocatalysts.

关键词： nanoporous CoP CoMoP_(2) heterojunction hydrogen evolution reaction

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β衰变与同位旋对称性破缺

科学通报 2021年第26期66卷 3405-3411页

作者：徐新星中国科学院近代物理研究所中国科学院高精度核谱学重点实验室兰州730000

研究同位旋对称性破缺对于深入理解核力与核结构有着重要意义.我们在兰州重离子加速器国家实验室放射性束流线终端采用双面硅条与高纯锗组成强大的探测器阵列,精确测量sd壳质子滴线附近原子核β衰变性质,然后与其镜像核的衰变性质进行对... 详细信息

研究同位旋对称性破缺对于深入理解核力与核结构有着重要意义.我们在兰州重离子加速器国家实验室放射性束流线终端采用双面硅条与高纯锗组成强大的探测器阵列,精确测量sd壳质子滴线附近原子核β衰变性质,然后与其镜像核的衰变性质进行对比,系统性研究轻核区同位旋对称性破缺现象.

关键词： β衰变同位旋对称性破缺 sd壳质子滴线硅探测器阵列

3D Printing of Periodic Porous Metamaterials for Tunable Electromagnetic Shielding Across Broad Frequencies

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Nano-Micro Letters 2024年第12期16卷 533-552页

作者： Qinniu Lv Zilin Peng Haoran Pei xinxing Zhang Yinghong Chen Huarong Zhang xu Zhu Shulong Wu State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan UniversityNo.24 South Section 1Yihuan RoadChengdu 610065People’s Republic of China Baosheng Technology Innovation Corporation Limited No.1Suzhong RoadBaoying CountyYangzhou 225800People’s Republic of China

The new-generation electronic components require a balance between electromagnetic interference shielding efficiency and open structure factors such as ventilation and heat *** addition,realizing the tunable shielding of porous shields over a wide range of wavelengths is even more *** this study,the well-prepared thermoplastic polyurethane/carbon nanotubes composites were used to fabricate the novel periodic porous flexible metamaterials using fused deposition modeling 3D ***,the investigation focuses on optimization of pore geometry,size,dislocation configuration and material thickness,thus establishing a clear correlation between structural parameters and shielding *** experimental and simulation results have validated the superior shielding performance of hexagon derived honeycomb structure over other designs,and proposed the failure shielding size(D_(f)≈λ/8-λ/5)and critical inclined angle(θf≈43°-48°),which could be used as new benchmarks for tunable electromagnetic *** addition,the proper regulation of the material thickness could remarkably enhance the maximum shielding capability(85-95 dB)and absorption coefficient A(over 0.83).The final innovative design of the porous shielding box also exhibits good shielding effectiveness across a broad frequency range(over 2.4 GHz),opening up novel pathways for individualized and diversified shielding solutions.

关键词： Polymeric component 3D printing Tunable electromagnetic shielding Periodic porous metamaterials Honeycomb pore structure

LncRNA IDH1-AS1 sponges miR-518c-5p to suppress proliferation of epithelial ovarian cancer cell by targeting RMB47

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The Journal of Biomedical Research 2024年第1期38卷 51-65页

作者： Juan Zhou Yiran xu Luyao Wang Yu Cong Ke Huang xinxing Pan Guangquan Liu Wenqu Li Chenchen Dai Pengfei xu xuemei Jia Department of Gynecology Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China Nanjing Maternity and Child Health Medical Institute Women's Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu 210004China.

Long noncoding RNA(lncRNA)IDH1 antisense RNA 1(IDH1-AS1)is involved in the progression of multiple cancers,but its role in epithelial ovarian cancer(EOC)is ***,we investigated the expression levels of IDH1-AS1 in EOC cells and normal ovarian epithelial cells by quantitative real-time PCR(qPCR).We first evaluated the effects of IDH1-AS1 on the proliferation,migration,and invasion of EOC cells through cell counting kit-8,colony formation,EdU,transwell,wound-healing,and xenograft *** then explored the downstream targets of IDH1-AS1 and verified the results by a dual-luciferase reporter,qPCR,rescue experiments,and Western *** found that the expression levels of IDH1-AS1 were lower in EOC cells than in normal ovarian epithelial *** IDH1-AS1 expression of EOC patients from the Gene Expression Profiling Interactive Analysis database indicated a favorable prognosis,because IDH1-AS1 inhibited cell proliferation and xenograft tumor growth of ***1-AS1 sponged miR-518c-5p whose overexpression promoted EOC cell *** miR-518c-5p mimic also reversed the proliferation-inhibiting effect induced by IDH1-AS1 ***,we found that RNA binding motif protein 47(RBM47)was the downstream target of miR-518c-5p,that upregulation of RBM47 inhibited EOC cell proliferation,and that RBM47 overexpressing plasmid counteracted the proliferation-promoting effect caused by the IDH1-AS1 *** together,IDH1-AS1 may suppress EOC cell proliferation and tumor growth via the miR-518c-5p/RBM47 axis.

关键词： lncRNA IDH1-AS1 epithelial ovarian cancer miR-518c-5p RBM47

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上海市计算机辅助高考英语口试的实践研究

上海教育科研 2005年第10期 52-55页

作者：徐欣幸上海市教育考试院 200235

上海市高考英语口语考试是为高校外语及相关专业招生提供选拔参考而设立的考试.随着人们对语言交际功能重要性认识的不断提高,报名参加高考英语口试的考生人数逐年增加(从1999年的四万多已增至2005年的九万多人).考生规模如此巨大,面试... 详细信息

上海市高考英语口语考试是为高校外语及相关专业招生提供选拔参考而设立的考试.随着人们对语言交际功能重要性认识的不断提高,报名参加高考英语口试的考生人数逐年增加(从1999年的四万多已增至2005年的九万多人).考生规模如此巨大,面试型口试显然无法操作,因此从2000年开始,上海市高考英语口试采用计算机辅助的方式进行.每年在全市40多个考点中,用两天的时间,完成考试.近千名教师用两天时间,在十个评分点完成评分任务.实践证明,计算机辅助英语口试是解决大规模口试的一种有效方法.

关键词：计算机辅助英语口试高考英语上海市实践研究语言交际功能口语考试考生人数 2005年