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Seroprevalence of neutralizing antibodies against adenovirus type 26 and 35 in healthy populations from Guangdong and Shandong provinces,China

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Virologica Sinica 2022年第5期37卷 716-723页

作者： Haisu Yi Qian Wang Jiankai Deng Hengchun Li Yingkun Zhang Zhilong Chen Tianxin Ji Wenming Liu Xuehua Zheng Qinghua Ma xinxin sun Yudi Zhang Xuegao Yu Mengzhang He Ling Chen Ying Feng State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510120China Department of Laboratory Medicine The First Affiliated HospitalSun Yat-sen UniversityGuangzhou510080China Center for Infection and Immunity Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou510530China Clinical Laboratory Pingyi Hospital of Chinese MedicineLinyi273399China Xiamen Institutes of Respiratory Health Xiamen361013China Department of Respiratory and Critical Care Medicine The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China University of Chinese Academy of Science Beijing100049China Guangzhou Laboratory&Bioland Laboratory Guangzhou510320China

Human adenoviruses type 26(HAdV26)and type 35(HAdV35)have increasingly become the choice of adenovirus vectors for vaccine application.However,the population pre-existing immunity to these two adenoviruses in China,which may reduce vaccine efficacy,remains largely unknown.Here,we established micro-neutralizing(MN)assays to investigate the seroprevalence of neutralizing antibodies(nAbs)against HAdV26 and HAdV35 in the general population of Guangdong and Shandong provinces,China.A total of 1184 serum samples were collected,47.0%and 15.8%of which showed HAdV26 and HAdV35 nAb activity,respectively.HAdV26-seropositive individuals tended to have more moderate nAbs titers(201-1000),while HAdV35-seropositive individuals appeared to have more low nAbs titers(72-200).The seropositive rates of HAdV26 and HAdV35 in individuals younger than 20 years old were very low.The seropositive rates of HAdV26 increased with age before 70 years old and decreased thereafter,while HAdV35 seropositive rates did not show similar characteristics.Notably,the seropositive rates and nAb levels of both HAdV26 and HAdV35 were higher in Guangdong Province than in Shandong Province,but did not exert significant differences between males and females.The seroprevalence between HAdV26 and HAdV35 showed little correlation,and no significant cross-neutralizing activity was detected.These results clarified the characteristics of the herd immunity against HAdV26 and HAdV35,and provided information for the rational development and application of HAdV26 and HAdV35 as vaccine vectors in China.

关键词： Human adenovirus type 26(HAdV 26) Human adenovirus type 35(HAdV 35) Neutralizing antibody(nAb) Seroprevalence Guangdong and shandong provinces

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Whole-process modeling of titanium disc forming for gradient distributions of temperature and deformation

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Chinese Journal of Aeronautics 2020年第12期33卷 3550-3563页

作者： Hongwei LI Bin CHEN Mei ZHAN Jing HE xinxin sun Xin ZHANG State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'an 710072China Shaanxi Key Laboratory of High-Performance Precision Forming Technology and Equipment Northwestern Polytechnical UniversityXi'an 710072China

Gradient distributions of temperature and deformation(GDTD)are crucial for achieving dual-performance discs of titanium alloys which is required by the service environment of aeroengine.However,heating,cooling and deforming sequence in the whole process of the titanium disc forming,which leads to difficulties for achieving GDTD due to a lot of parameters.To solve this problem,a whole-process model of the titanium disc forming for GDTD has been established.In the model,heating and cooling via heat radiation,conduction and convection,and deforming by local loading with mold chilling are all considered.Experiments on heating and cooling as well as deforming were carried out by using a furnace and the Gleeble-3500 machine.The experimental data are used to determine thermal parameters and constitutive relations of the IMI834 titanium alloy,and then to verify the reliability of the model.Then the model was used to simulate the evolution rules of temperature and deformation of the titanium disc.The results show that the heating surface,furnace temperature,billet profile and loading rate play the core role for the control of GDTD,and thus a set of parameters were determined.Therefore,this work provides a base for developing a new forming technology of the dual-performance titanium discs with the approach of local heating and local loading.

关键词： Gradient distributions of temperature and deformation Heat conduction Heat radiation Mold chilling Titanium disc Whole-process modelling

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合法性参与:高职生有效技能形成的现实基础——基于8位高职实习生访谈数据的质性分析

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中国职业技术教育 2024年第10期 58-64,95页

作者：孙欣欣赵宝柱孙芳芳河北科技师范学院

在“合法的边缘性参与”视角下,以华莱士社会研究逻辑模型为研究思路,探讨产教融合背景下高职实习生有效技能形成的初始基点问题。基于8名实习生的访谈数据,发现实习过程中学生被授予了不同的实习身份:被压制的“劳动力”,旁观的“局外... 详细信息

在“合法的边缘性参与”视角下,以华莱士社会研究逻辑模型为研究思路,探讨产教融合背景下高职实习生有效技能形成的初始基点问题。基于8名实习生的访谈数据,发现实习过程中学生被授予了不同的实习身份:被压制的“劳动力”,旁观的“局外人”及“合法的参与者”。分析发现:物理嵌入及“权力”授予是个体获取“合法性”身份的基本条件,是高职生有效技能形成的现实基础之一。探究高职实习生“合法性”身份获取背后的影响机制发现,文凭管治主义对社会的“统治”,技能形塑力量的配比失衡以及校企合作人文关怀的缺失,是造成高职生无法形成有效技能现实基础的重要影响因素。

关键词：合法的边缘性参与校企合作高职学生有效技能

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社会互动理论视角下职业教育社会形象的话语生成逻辑

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江苏高职教育 2024年第1期24卷 34-45页

作者：孙欣欣孙芳芳河北科技师范学院职业教育研究院河北秦皇岛066004

话语作为创造性的社会实践,与社会现实相互构建。探析职业教育社会形象的话语生成逻辑,需要以话语分析为切入点。以社会互动理论为基础,分析发现职业教育形象包括三重话语样态:正面形象下的积极性政策话语、负面形象下的标签化民众话语... 详细信息

话语作为创造性的社会实践,与社会现实相互构建。探析职业教育社会形象的话语生成逻辑,需要以话语分析为切入点。以社会互动理论为基础,分析发现职业教育形象包括三重话语样态:正面形象下的积极性政策话语、负面形象下的标签化民众话语以及双面形象下的冲突性媒体话语。不同话语样态背后存在不同动因,政策话语基于国家战略发展对职业教育进行价值引领,民众话语基于自身利益对职业教育形成价值贬抑,媒体话语作为中介工具对职业教育进行价值复制。为改变职业教育形象的话语空间错位现状,需要以社会互动理论为视角,以职业教育话语主体的自我互动、他我互动及群体互动为基础,探讨职业教育社会形象话语体系的生成逻辑。

关键词：社会互动理论职业教育社会形象话语生成

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煤自燃热失重特征规律及关键官能团研究

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中国安全生产科学技术 2024年第2期20卷 118-124页

作者：李亚清欧霖峰李星孙鑫鑫西安科技大学安全科学与工程学院陕西西安710054 西安科技大学陕西煤炭火灾防治重点实验室陕西西安710054

为了研究煤自燃过程中对失重起重要作用的关键官能团,以3种不同变质程度煤样为研究对象,根据TG热重实验和傅里叶变换红外实验,研究煤自燃热失重过程的特征温度和官能团变化规律,基于频率比模型法和灰色关联度分析煤自燃失重量与官能团... 详细信息

为了研究煤自燃过程中对失重起重要作用的关键官能团,以3种不同变质程度煤样为研究对象,根据TG热重实验和傅里叶变换红外实验,研究煤自燃热失重过程的特征温度和官能团变化规律,基于频率比模型法和灰色关联度分析煤自燃失重量与官能团间的相关性,并探讨不同变质程度煤自燃热失重过程的关键官能团。研究结果表明:随煤变质程度加深,热失重曲线后移,从褐煤到无烟煤,热失重特征温度分别增加22%,37%;随温度增加,官能团含量突变温度点与特征温度相近,羟基在150℃之前呈指数式下降后趋于稳定,脂肪烃、含氧官能团和芳香烃在燃点温度之后线性下降;影响不同变质程度煤自燃热失重的关键官能团不一致,C C是影响褐煤的热失重关键官能团,而甲基是影响烟煤、无烟煤的热失重关键官能团。研究结果可为煤自燃热失重过程关键官能团的确定提供重要参考。

关键词：煤自燃热失重特征相关性关键官能团频率比模型

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基于SOLO分类理论的初中英语写作教学实践探究

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科教导刊 2024年第8期 130-132页

作者：陈雪孙欣欣吉林师范大学外国语学院吉林四平136000

英语写作教学是英语语言教学的重要组成部分,受到广大师生的广泛关注。学生写作的过程也是一个思维锻炼的过程,体现了其思维发展状况。然而,目前我国初中阶段的英语写作教学被教师视为一个考查学生词汇、语法的过程,忽视了对学生思维能... 详细信息

英语写作教学是英语语言教学的重要组成部分,受到广大师生的广泛关注。学生写作的过程也是一个思维锻炼的过程,体现了其思维发展状况。然而,目前我国初中阶段的英语写作教学被教师视为一个考查学生词汇、语法的过程,忽视了对学生思维能力的培养。根据SOLO分类理论的内涵对学生的写作过程进行评价,有助于摆脱当下初中英语写作教学的困境。文章基于SOLO分类理论对初中英语教学进行探究,以期优化初中英语写作教学路径。

关键词： SOLO分类理论初中英语写作教学实践

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Amelioration of imiquimod-induced psoriasis-like dermatitis in mice by DSW therapy inspired hydrogel

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Bioactive Materials 2021年第2期6卷 299-311页

作者： Xiang He Bing Zhu WeiJia Xie Yu He Jian Song Yi Zhang Chi sun Hao Li QiYu Tang xinxin sun Yanni Tan Yong Liu State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China School of Materials Science and Engineering Central South UniversityChangsha410083China Xiangya School of Medicine Central South UniversityChangsha410083China Department of Material and Chemical Engineering Zhengzhou University of Light IndustryZhengzhou450002China Department of Mechanical Engineering Munich School of BioengineeringTechnical University of Munich85748GarchingGermany Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun130022China Center for Medical Genetics Hunan Key Laboratory of Medical GeneticsSchool of Life SciencesCentral South UniversityChangsha410083China A.James Clark School of Engineering University of MarylandCollege Park20742MDUnited States

Psoriasis is a long-lasting and recurrent autoimmune disease which is incurable so far.Dead Sea water(DSW)therapy is an effective approach to help control the symptoms of psoriasis due to the abundant mineral ions in DSW,which inspired the material formulation in this study.Rubidium–Sodium alginate/Polyacrylamide hydrogels(Rb-SA/PAAm gels)composed of sodium alginate and polyacrylamide interpenetrating network structure with different concentrations of rubidium and certain magnesium and zinc content were prepared for the treatment of psoriasis.The obtained results suggest the good mechanical properties of the Rb-SA/PAAm gels including toughness and swelling performance.In terms of in vitro tests,the Rb-SA/PAAm gels not only show nontoxicity to human keratinocyte cell line(Hacats)but also inhibits the activity against inflammatory NF-κβ signaling pathway.Meanwhile,they can release Rb+which enable the Rb-SA/PAAm gels have better antibacterial ability to Streptococcus and Escherichia coli.The results obtained from in vivo tests indicate that these hydrogels could alleviate the symptoms of psoriasis caused by Imiquimod(IMQ)in mice by reducing the inflammatory factor in STAT3 pathway and therefore reduce the immune stimulation of the spleen.In conclusion,the 100Rb-SA/PAAm gel has demonstrated great potential to be a topical wettable dressing for psoriasis treatment.

关键词： DSW therapy Rubidium Hydrogels Imiquimod Psoriasis

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Design and Implementation of a High Precision Frequency Meter based on Multimode

Design and Implementation of a High Precision Frequency Mete...

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作者： Juan Li Fenxian Tian xinxin sun School of Information Science and Engineering Yunnan University

Frequency meter logical resource occupancy is the research object of electronic information field.To solve the precision of the frequency meter and reduce the occupation of logical resources,this paper designs a measurement system based on FPGA,which can switch between high frequency and intermediate frequency modes freely.Firstly,the signal generated by the dualchannel DDS function signal generator is input into the conditioning circuit for corresponding processing,and then the high-frequency mode or mid-frequency mode is selected by the DIP switch and input to the FPGA chip for counting.Finally,the measurement results are displayed on the LCD.The digital frequency meter can execute the corresponding functional test according to the mode selected in advance after testing,and it is found that compared with the modeless high-precision frequency meter,the high frequency has less 103 logical resource occupations in the high-frequency mode,and the mid-frequency has less 242 logic resources in themed-frequency mode.

关键词： Frequency meter Mode High precision

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Design and Implementation of USB3.0 Data Transmission System based on FPGA

Design and Implementation of USB3.0 Data Transmission System...

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作者： Fenxian Tian Juan Li xinxin sun Jun Yang School of Yunnan University

Aiming at the problems of slow transmission speed and high hardware resources in the traditional USB data transmission system,a USB3.0 data transmission system based on FPGA is designed.The system uses FPGA as the core control chip,and EZ-USB FX3 realizes high-speed data transmission of USB3.0 synchronous Slave FIFO mode through GPIF II general programmable interface.The design scheme has high portability and expandability,can be widely applied to different communication projects.System performance analysis and test results show that the average transmission rate of the system can reach 328 MB/S,and the logical resource occupancy rate is less than 1%,realizing high-speed data transmission.

关键词： FPGA USB3.0 DDR3 Data Transmission

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Design of FPGA Hardware based on Genetic Algorithm

Design of FPGA Hardware based on Genetic Algorithm

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作者： xinxin sun Juan Li Fenxian Tian Yanshuang Chen Jun Yang School of Information Science and Engineering Yunnan University

In order to improve the running speed of hardware and the utilization rate of resources,firstly,this paper use genetic algorithm to realize serial and pipeline hardware implementation.Then,the genetic algorithm is improved on the implementation method.In the process of improvement,the pipeline is introduced into the parallel mechanism.Finally,the TSP problem and function extreme value problem are used to verify the resource consumption and running speed of FPGA respectively.The experimental results in this paper show that the two schemes are less expensive in terms of hardware implementation,less expensive in operation and high in efficiency,and the algorithm can also be widely used in the occasions with higher applicability.

关键词： FPGA Genetic algorithm Parallelism Pipeline structure

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