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Large time behavior of solutions for a class of time-dependent Hamilton-Jacobi equations

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Science China Mathematics 2016年第5期59卷 875-890页

作者： liU QiHuai li xinxiang YAN Jun School of Mathematical Sciences Fudan University School of Mathematics and Computing Sciences Guilin University of Electronic Technology Department of Mathematics Shanghai University

We study the long-time behavior of viscosity solutions for time-dependent Hamilton-Jacobi equations by the dynamical approach based on weak KAM(Kolmogorov-Arnold-Moser) theory due to Fathi. We establish a general conv... 详细信息

关键词： asymptotic behavior viscosity solution weak KAM theory Hamilton-Jacobi equation

Evalution of Thermal Oxidative Degradation of Trimethylol-propane Trioleate by TG/DTA/DSC

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Journal of Wuhan University of Technology(Materials Science) 2021年第2期36卷 280-288页

作者： ZHAN Wen DUAN Haitao li xinxiang li Jian YUAN Chengqing Wuhan Research Institute of Materials Protection China Academy of Machinery Science and TechnologyWuhan 430030China School of Energy and Power Engineering Wuhan University of TechnologyWuhan 430063China

In order to evaluate the thermal oxidation degradation behavior of lubricant with different antioxidants,the thermal kinetics equation based on the anlyses of thermogravimetry(TG),differential thermal analysis(DTA),and differential scanning calorimetry(DSC)was established,respectively,to calculate the activation energy of lubricant thermal-oxidative *** thermal analyses of TG and DTA were employed to determine the thermal decomposition properties of ester oils trimethylolpropane trioleate(TMPTO)with butyl-octyl-diphenylamine/octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate/amine-phenol combination *** activation energy of the lubricating oil adding antioxidant is increased relative to the TMPTO base oil,and the order of activation energy are Ec(93.732 kJ·mol^(-1))>Ed(88.71 kJ·mol^(-1))>Eb(58.41 kJ·mol^(-1))>Ea(46.32 kJ·mol^(-1)).The experimental results show that octadecyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propanoate in TMPTO has favorable resistance to thermal oxidation and *** thermal analysis method of DSC accurately reflects the heat exchange of lubricant thermal-oxidative *** order of activation energy is calculated to ED(144.385 kJ·mol^(-1))>EC(110.05 kJ·mol^(-1))>EB(97.187 kJ·mol^(-1))>EA(66.02 kJ·mol^(-1)).It is illustrated that the amine-phenol combination antioxidant has the best thermal oxidation resistance,which is the same as what the oxidation onset temperature effected.

关键词： thermal oxidative degradation thermal kinetics antioxidants trimethylolpropane oleate

circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer

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Cancer Communications 2023年第1期43卷 100-122页

作者： Yufei Yang Dakui Luo Yang Shao Zezhi Shan Qi liu Junyong Weng Weijing He Ruoxin Zhang Qingguo li Ziliang Wang xinxiang li Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032P.R.China Cancer Institute Fudan University Shanghai Cancer CenterShanghai 200032P.R.China Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese MedicineShanghai 200071P.R.China

Background:Circular RNAs(circRNAs)generated by back-splicing of precursor mRNAs(pre-mRNAs)are often aberrantly expressed in cancer *** evidence has revealed that circRNAs play a critical role in the progression of several cancers,including colorectal cancer(CRC).However,the current understandings of the emerging functions of circRNAs in CRC lipid metabolism and the underlying molecular mechanisms are still ***,we aimed to explore the role of circCAPRIN1 in regulating CRC lipid metabolism and ***:circRNA microarray was performed with three pairs of tumor and non-tumor tissues from CRC *** expression of circRNAs were determined by quantitative PCR(qPCR)and in situ hybridization(ISH).The endogenous levels of circRNAs in CRC cells were manipulated by transfection with lentiviruses overexpressing or silencing *** regulatory roles of circRNAs in the occurrence of CRC were investigated both in vitro and in vivo using gene expression array,RNA pull-down/mass spectrometry,RNA immunoprecipitation assay,luciferase reporter assay,chromatin immunoprecipitation analysis,and fluorescence in situ hybridization(FISH).Results:Among circRNAs,circCAPRIN1 was most significantly upregulated in CRC tissue ***1 expression was positively correlated with the clinical stage and unfavorable prognosis of CRC *** of circCAPRIN1 suppressed proliferation,migration,and epithelial-mesenchymal transition of CRC cells,while circCAPRIN1 overexpression had opposite *** sequencing and gene ontology analysis indicated that circCAPRIN1 upregulated the expressions of genes involved in CRC lipid ***,circCAPRIN1 promoted lipid synthesis by enhancing Acetyl-CoA carboxylase 1(ACC1)*** mechanistic assays demonstrated that circCAPRIN1 directly bound signal transducer and activator of transcription 2(STAT2)to activate ACC1 transcription,thus regulating lipid metabolism and facilit

关键词： circRNA colorectal cancer circCAPRIN1 lipid metabolism STAT2 ACC1

Updates in version 2019 of CSCO guidelines for colorectal cancer from version 2018

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Chinese Journal of Cancer Research 2019年第3期31卷 423-425页

作者： Ying Yuan Xicheng Wang Gong Chen Yi Wang Weiqi Sheng xinxiang li Aiping Zhou Zhen Zhang Guichao li Sanjun Cai Ruihua Xu Jin li Suzhan Zhang Department of Medical Oncology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Medical Oncology Shanghai East HospitalTongji University School of MedicineShanghai 200123China Department of Surgical Oncology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital & InstituteBeijing 100142China Department of Colorectal Surgery Sun Yat-sen University Cancer Center Guangzhou 510060China Department of Radiology Peking University People’s HospitalBeijing 100044China Department of Pathology Fudan University Shanghai Cancer HospitalShanghai 200032China Department of Colorectal Surgery Fudan University Shanghai Cancer HospitalShanghai 200032China Department of Medical Oncology Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Radiation Oncology Fudan University Shanghai Cancer HospitalShanghai 200032 China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China

According to the latest data from cancer registration center, there are estimated to be 3,929,000 individuals newly diagnosed with cancer and 2,338,000 deaths from this disease in China in 2015 (1). Among them, colorectal cancer (CRC) with 388,000 newly diagnosed cases and 187,000 deaths, stands the third place in incidence and the fifth place in mortality. The Chinese Society of Clinical Oncology (CSCO) has organized an expert committee to write and publish the Guideline for Colorectal Cancer in 2017. And its English version has already been published in March 2019 (2). According to the latest progress, the expert committee updated the guideline to the 2019 version in this April, and the summary of the main updates are as following.

关键词： According to the latest individuals newly are as following

Updates in version 2020 of CSCO guidelines for colorectal cancer from version 2019

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Chinese Journal of Cancer Research 2020年第3期32卷 403-407页

作者： Shanshan Weng Ying Yuan Xicheng Wang Gong Chen Yi Wang Weiqi Sheng xinxiang li Aiping Zhou Zhen Zhang Guichao li Sanjun Cai Ruihua Xu Jin li Suzhan Zhang Department of Medical Oncology the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China departm ent of Colorectal Surgery Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Radiology Peking University Peopled HospitalBeijing 100044China departm ent of Pathology Fudan University Shanghai Cancer HospitalShanghai 200032China Department of Colorectal Surgery Fudan University Shanghai Cancer HospitalShanghai 200032China Department of Medical Oncology Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China Depaitment of Radiation Oncology Fudan University Shanghai Cancer HospitalShanghai 200032China departm ent of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Medical Oncology Shanghai East HospitalTongji University School of MedicineShanghai 200123China n Department of Surgical Oncology the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China

According to the latest data released by the National Cancer Center,colorectal cancer(CRC)had the third highest incidence and the fifth highest mortality of all malignancies,with 388,000 new cases and 187,000 cancer deaths in China(1).The Chinese Society of Clinical Oncology(CSCO)originally published the English version of 2018 guideline concerning CRC and updated them in2019(2,3).According to the latest progress,clinical guidelines have been ***,we present the main updates of the 2020 version compared to 2019 version.

关键词： CSCO colorectal mortality

Explicit Representations of Mimmal Immersions of 2-Spheres into S^(2m)

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Acta Mathematica Sinica,English Series 1997年第2期13卷 175-186页

作者： li Xingxiao (Department of Mathematics,Henan Normal University,xinxiang 453002,China)li Anmin (Department of Mathematics,Sichuan University,Chengdu 610064,China)

For all minimal immersions of the 2-sphere S2 into the unit 2m-sphere S2mwith area 2π[m（m+1）+2],we are able to give an explicit representation by some real *** representation is rather important in the study of minimal 2-spheres in S2mbecause the parameters concerned are independent of each *** examples are given and a classification theorem is also obtained.

关键词： Minimal immersion Holomorphic curve Directrix

Single-cell landscape of malignant ascites frompatients with metastatic colorectal cancer

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Cancer Communications 2024年第7期44卷 713-717页

作者： Haiyang Zhou Jiahui Yin Anqi Wang Xiaomao Yin Taojun Jin Kai Xu lin Zhu Jiexuan Wang Wenqiang Wang Wei Zhang xinxiang li Zhiqian Hu Xinxing li Division of Colorectal Surgery Changzheng HospitalNavy Medical UniversityShanghaiP.R.China Institute of Higher Education Tongji UniversityShanghaiP.R.China Department of Gastrointestinal Surgery Tongji HospitalTongji University School of MedicineShanghaiP.R.China Department of Gastroenterology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghaiP.R.China Department of Colorectal Surgery Fudan University Shanghai Cancer CenterShanghaiP.R.China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghaiP.R.China

The presence of malignant ascites in colorectal cancer(CRC)patients is associated with a poor prognosis,a high risk of recurrence,and resistance to chemotherapy and immune therapy[1–3].Understanding the complex interactions among different kinds of cells and the ecosystem of peritoneal metastasized colorectal cancer(pmCRC)ascites may provide insights into effective treatment strategies.

关键词： ascites colorectal patients

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结直肠吻合技术的演变与展望

中华胃肠外科杂志 2018年第4期21卷 470-475页

作者：刘琪李心翔复旦大学附属肿瘤医院大肠外科复旦大学上海医学院肿瘤学系 200032

在世界范围内，结直肠癌位于男性恶性肿瘤发病率的第3位，位于女性恶性肿瘤发病率的第2位。结直肠癌已经成为最常见的恶性肿瘤之一，极大地威胁着人类的健康。虽然放射治疗、化学药物治疗等治疗手段的发展大大地提高了结直肠癌的预后，... 详细信息

在世界范围内，结直肠癌位于男性恶性肿瘤发病率的第3位，位于女性恶性肿瘤发病率的第2位。结直肠癌已经成为最常见的恶性肿瘤之一，极大地威胁着人类的健康。虽然放射治疗、化学药物治疗等治疗手段的发展大大地提高了结直肠癌的预后，但是现阶段，外科治疗即肿瘤的切除。仍然是所有治疗方式中最主要的、决定性的手段。经过一百多年的发展，肿瘤外科已经从单纯地根治性切除肿瘤向保持器官功能、进一步提高生活质量的方向发展，低位保肛手术和腹腔镜结直肠外科的不断发展也正是适应了这种趋势的要求。在结直肠外科手术中，病变（肿瘤）肠段在切除后,通常需要对合肠道断端，施行结直肠吻合术，以恢复消化道的连续性。由此产生了一系列用于结直肠肿瘤切除的结直肠吻合技术，包括手工缝合、吻合器吻合、加压吻合以及如今国内外研究者正在探究的射频焊接肠道吻合技术,其中手工缝合又按不同的方式分为一层吻合和二层吻合，连续缝合和间断缝合，内翻缝合和外翻缝合。本文对主要的几种结直肠吻合技术的发展及演变进行了详细概述，并综合前人研究，评估各吻合技术在肠道吻合的安全性和有效性，对其并发症尤其是吻合口漏、吻合部位狭窄的发生率等方面进行比较，客观阐述了各吻合技术的优缺点，并对未来更为理想的结直肠吻合技术进行了展望。

关键词：结直肠肿瘤吻合演变综述

复合材料波纹板剪切载荷作用下的屈曲试验与分析

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航空学报 2011年第8期32卷 1453-1460页

作者：吴存利段世慧李新祥中国飞机强度研究所陕西西安710065

复合材料波纹板稳定性是飞机机翼结构设计需要考虑的重要方面,是目前飞机结构设计中的一大难点。为了建立波纹板屈曲的数值分析方法,对复合材料波纹板在剪切载荷作用下的屈曲进行试验、工程算法和有限元方法研究。通过试验,探索了3种不... 详细信息

复合材料波纹板稳定性是飞机机翼结构设计需要考虑的重要方面,是目前飞机结构设计中的一大难点。为了建立波纹板屈曲的数值分析方法,对复合材料波纹板在剪切载荷作用下的屈曲进行试验、工程算法和有限元方法研究。通过试验,探索了3种不同波长的复合材料波纹板的屈曲载荷和破坏载荷;采用工程算法和有限元方法计算了8种不同波长的复合材料波纹板屈曲载荷,并与试验结果进行了比较。在试验和分析研究的基础上,初步提出了对复合材料波纹板屈曲载荷计算值进行修正的修正因子。结果表明,波纹板屈曲载荷的工程计算值大于试验值,而有限元计算值小于试验值,且随着波长的增大,两种方法相对于试验结果的计算误差越来越大。计算结果也表明,所提出的计算载荷修正因子可以有效地对有限元计算值和工程计算值进行修正,使修正后的计算值接近于试验值。

关键词：复合材料波纹板剪切载荷有限元模型屈曲