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PD-1/L1 inhibitors can improve but not replace chemotherapy for advanced urothelial carcinoma:A systematic review and network meta-analysis

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Cancer Innovation 2023年第3期2卷 191-202页

作者： Longkun Mao Meihua Yang xinxiang fan Wenjie Li Xiaodong Huang Wang He Tianxin Lin Jian Huang Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Medical Research CenterSun Yat-Sen Memorial HospitalSun Yat-Sen(Zhongshan)UniversityGuangzhouChina Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen(Zhongshan)UniversityGuangzhouChina Guangdong Provincial Clinical Research Center for Urological Diseases GuangzhouChina The First Affiliated Hospital of Nanchang University NanchangChina

Background:Programmed cell death-1/ligand 1 inhibitors are a new treatment strategy for advanced urothelial ***,a comparative evaluation of their efficacy and toxicity compared with chemotherapy is ***:We comprehensively searched PubMed,Web of Science,Embase,and Cochrane Library databases and performed a meta-analysis of randomized controlled trials up to July *** considered overall survival as the primary outcome,and progression-free survival,objective response rate,and treatment-related adverse events as secondary ***:Overall,3584 patients from five studies were *** with first-line chemotherapy,programmed cell death-1/ligand 1 inhibitors were significantly associated with worse progression-free survival(p<0.001)and adverse objective response rates(p<0.001).However,the treatments were not significantly different in terms of overall survival(p=0.33).Compared with second-line chemotherapy,programmed cell death-1/ligand 1 inhibitors significantly improved overall survival(p<0.001),and there was no statistically significant difference in progression-free survival(p=0.89)or objective response rate(p=0.34).Compared with chemotherapy,programmed cell death-1/ligand 1 inhibitors were well tolerated(first-line chemotherapy:p<0.001;second-line chemotherapy:p<0.001).Conclusions:The efficacy of programmed cell death-1/ligand 1 inhibitors in patients with advanced urothelial carcinoma is not superior to that of first-line platinum-based chemotherapy but is better than second-line chemotherapy;however,programmed cell death-1/ligand 1 inhibitors are safer than first-and second-line chemotherapy and have a broader prospect for use in combination therapy.

关键词： chemotherapy efficacy immune checkpoint inhibitors safety urinary bladder neoplasms

A nomogram for individualized estimation of survival among adult patients with adrenocortical carcinoma after surgery:a retrospective analysis and multicenter validation study

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Cancer Communications 2019年第1期39卷 683-695页

作者： Jianqiu Kong Junjiong Zheng Jinhua Cai Shaoxu Wu Xiayao Diao Weibin Xie Xiong Chen Chenyi Liao Hao Yu xinxiang fan Chaowen Huang Zhuowei Liu Wei Chen Qiang Lv Haide Qin Jian Huang Tianxin Lin Department of Urology Sun Yat-Sen Memorial HospitalSun Yat-Sen University107 Yan Jiang West RoadGuangzhou 510120GuangdongP.R.China Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120GuangdongP.R.China Department of Neurology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120GuangdongP.R.China Department of Obstetrics and Gynecology Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630GuangdongP.R.China Department of Urology Sun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Urology First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080GuangdongP.R.China Department of Urology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029JiangsuP.R.China State Key Laboratory of Oncology in South China Guangzhou 510120GuangdongP.R.China

Background:Clinical outcome of adrenocortical carcinoma(ACC)varies because of its heterogeneous nature and reliable prognostic prediction model for adult ACC patients is *** objective of this study was to develop and externally validate a nomogram for overall survival(OS)prediction in adult patients with ACC after ***:Based on the data from the Surveillance Epidemiology,and End Results(SEER)database,adults patients diagnosed with ACC between January 1988 and December 2015 were identified and classified into a training set,comprised of 404 patients diagnosed between January 2007 and December 2015,and an internal validation set,com-prised of 318 patients diagnosed between January 1988 and December *** endpoint of this study was *** nomogram was developed using a multivariate Cox proportional hazards regression algorithm in the training set and its performance was evaluated in terms of its discriminative ability,calibration,and clinical *** nomogram was then validated using the internal SEER validation,also externally validated using the Cancer Genome Atlas set(TCGA,82 patients diagnosed between 1998 and 2012)and a Chinese multicenter cohort dataset(82 patients diag-nosed between December 2002 and May 2018),***:Age at diagnosis,T stage,N stage,and M stage were identified as independent predictors for OS.A nomo-gram incorporating these four predictors was constructed using the training set and demonstrated good calibration and discrimination(C-index 95%confidence interval[CI],0.715[0.679-0.751]),which was validated in the internal validation set(C-index[95%CI],0.672[0.637-0.707]),the TCGA set(C-index[95%CI],0.810[0.732-0.888])and the Chi-nese multicenter set(C-index[95%CI],0.726[0.633-0.819]),***,the nomogram was able to successfully distinguished patients with a high-risk of mortality in all enrolled patients and in the subgroup *** curve analysis indicated that the nomogram wa

关键词： Adrenocortical carcinoma Adult patients Overall survival Nomogram Validation Decision curve analysis Surveillance Epidemiology and End Results(SEER) The Cancer Genome Atlas(TCGA) Multicenter

早期精准诊断多学科综合治疗规范随访康复——论膀胱癌全程管理

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中华泌尿外科杂志 2020年第8期41卷 569-572页

作者：黄健范新祥何旺中山大学孙逸仙纪念医院泌尿外科广州510120

膀胱癌容易复发和转移,单纯外科治疗往往难以达到临床治愈的目标。我国在膀胱癌诊治取得了巨大进步的同时,也存在诊治不够规范、治疗手段过于单一和术后随访不足的问题,并且诊治水平在不同机构之间差异也比较大。我们应该大力推行以"早... 详细信息

膀胱癌容易复发和转移,单纯外科治疗往往难以达到临床治愈的目标。我国在膀胱癌诊治取得了巨大进步的同时,也存在诊治不够规范、治疗手段过于单一和术后随访不足的问题,并且诊治水平在不同机构之间差异也比较大。我们应该大力推行以"早期精准诊断、多学科综合治疗和规范随访康复"为核心内容的覆盖全疗程、个性化的精细化管理,既要重视疾病的综合治疗,也要注重满足患者的心理需求和提高患者的生活质量,以达到"医病、医身、医心"的目标。在具体的实施路径方面,我们应该综合运用专业化的个案管理模式,更加重视多学科协作,并充分利用数据库和互联网平台来进行全程管理。

关键词：膀胱癌全程管理多学科治疗精准治疗

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甘肃北山窑洞早铜矿地质特征

甘肃科技 2010年第16期26卷 63-67页

作者：樊新祥甘肃省地质矿产勘查开发局第四地质矿产勘查院甘肃酒泉735000

窑洞早铜矿地处塔里木板块,北山古生代褶皱带,公婆泉加里东褶皱带。铜矿化赋存于敦煌岩群中发育的北东向断裂及其形成的断层蚀变带中,铜矿体形态呈透镜状、脉状,为中高温热液型铜矿床。该铜矿的发现对于甘肃北山地区铜矿的找矿工作具有... 详细信息

窑洞早铜矿地处塔里木板块,北山古生代褶皱带,公婆泉加里东褶皱带。铜矿化赋存于敦煌岩群中发育的北东向断裂及其形成的断层蚀变带中,铜矿体形态呈透镜状、脉状,为中高温热液型铜矿床。该铜矿的发现对于甘肃北山地区铜矿的找矿工作具有十分重要的意义。

关键词：断裂构造蚀变带中高温热液型矿床特征甘肃北山

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泡沫铝三明治板的研究与应用进展

材料导报 2017年第15期31卷 101-107,138页

作者：刘彦强樊建中马自力杨必成聂俊辉魏少华郝心想邓凡北京有色金属研究总院国家有色金属复合材料工程技术研究中心北京100088

泡沫铝三明治板(Aluminum foam sandwich,AFS)是基于泡沫铝材料开发的一类材料-结构一体化的先进多孔复合结构。AFS是交通运输、建筑以及航空航天等装备结构轻量化的重要材料,具有广阔的应用前景。概述了AFS的几类制备技术的基本原理和... 详细信息

泡沫铝三明治板(Aluminum foam sandwich,AFS)是基于泡沫铝材料开发的一类材料-结构一体化的先进多孔复合结构。AFS是交通运输、建筑以及航空航天等装备结构轻量化的重要材料,具有广阔的应用前景。概述了AFS的几类制备技术的基本原理和研究现状,着重分析了复合预制体制备、合金成分、AFS发泡成型工艺等关键环节中存在的理论和技术难点。介绍了AFS作为结构材料和功能材料的典型应用案例;最后总结提出了AFS材料研究和工程化技术开发的关键点与突破途径。

关键词：泡沫铝三明治复合板粉末冶金熔体发泡

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甘肃省漳县马路里地区发现大型红柱石矿床

中国地质 2024年第2期51卷 701-702页

作者：王鹏杨博樊新祥叶红刚罗官文甘肃省地质矿产勘查开发局第四地质矿产勘查院甘肃酒泉735000 甘肃省自然资源厅甘肃兰州730000

1研究目的(Objective)红柱石(andalusite)属岛状结构的硅酸盐矿物,具有在高温下一次性膨胀转化为莫来石后不再收缩的特性,是优质的耐火原料,主要应用于航空航天、高级耐火材料、涂料、焊接材料、宝石及工艺品等方面。但红柱石矿床在西... 详细信息

1研究目的(Objective)红柱石(andalusite)属岛状结构的硅酸盐矿物,具有在高温下一次性膨胀转化为莫来石后不再收缩的特性,是优质的耐火原料,主要应用于航空航天、高级耐火材料、涂料、焊接材料、宝石及工艺品等方面。但红柱石矿床在西北地区发现相对较少,难以满足新发展阶段的需要,为落实党的二十大“确保能源资源、重要产业链供应链安全”有关要求,本次在甘肃省漳县马路里地区开展了红柱石矿的勘查工作。

关键词：新发展阶段供应链安全高级耐火材料耐火原料硅酸盐矿物能源资源航空航天红柱石

函子范畴的incidence代数的两个例子

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福建工程学院学报 2018年第4期16卷 372-375页

作者：范馨香薛蓉华福建师范大学协和学院信息技术系福建福州350117 福建工程学院数理学院福建福州350118

以箭图Q_1,Q_2,Q_3为例,构造有限偏序k范畴Γ_1,Γ_2,考虑Γ_1,Γ_2及函子范畴Γ_1^(Γ_2)诱导的incidence代数的两个例子。

关键词：函子范畴 Incidence代数同构

智慧网络环境下“网络工程设计与综合布线”课程分析

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无线互联科技 2018年第13期15卷 37-38页

作者：王明芬范馨香福建师范大学协和学院信息技术系福建福州350017

网络工程设计与综合布线是物联智慧网络的基础设施以及强有力的支撑,智慧网络给网络设计与布线系统带来了技术的革新,将由传统技术向智能技术转变。文章针对新时代的应用背景下"网络工程设计与综合布线"课程建设的新需求,对教学资源调... 详细信息

网络工程设计与综合布线是物联智慧网络的基础设施以及强有力的支撑,智慧网络给网络设计与布线系统带来了技术的革新,将由传统技术向智能技术转变。文章针对新时代的应用背景下"网络工程设计与综合布线"课程建设的新需求,对教学资源调整、教学模式和考核方式多方面探索课程改革的新举措,完善实践性课程改革。

关键词：智慧网络工程设计综合布线

北祁连造山带西段车路沟岩体U-Pb年代学、地球化学特征及岩石成因

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中国地质 2020年第3期47卷 755-766页

作者：樊新祥孔维琼杨镇熙赵吉昌李昱星甘肃省地质矿产勘查开发局第四地质矿产勘查院甘肃酒泉735000 兰州新区自然资源局甘肃兰州730000

车路沟岩体位于北祁连造山带最西端,岩石类型以英云闪长玢岩和闪长玢岩为主。本次对英云闪长玢岩进行U-Pb年代学研究,获得加权平均年龄为(462.1±3.8)Ma,表明岩体形成于中奥陶世。岩石地球化学分析结果显示,英云闪长玢岩中SiO2含量60.37... 详细信息

车路沟岩体位于北祁连造山带最西端,岩石类型以英云闪长玢岩和闪长玢岩为主。本次对英云闪长玢岩进行U-Pb年代学研究,获得加权平均年龄为(462.1±3.8)Ma,表明岩体形成于中奥陶世。岩石地球化学分析结果显示,英云闪长玢岩中SiO2含量60.37%~66.73%,Al2O3含量15.65%~16.45%,Na2O/K2O值7.47~9.96,A/CNK为0.90~1.00,属中酸性岩系列,显示相对富钠、低钾的特征, A/CNK=0.90~1.00,属于准铝质低钾钙碱性系列;稀土总量较低(33.40×10-6~39.27×10-6),LREE/HREE值为3.95~6.51,在稀土元素配分图解上呈现出右倾特征;δEu值1.23~1.49之间,呈现Eu呈正异常特征;在微量元素原始地幔标准化图解上,显示富集Ba、Sr,亏损Nb、Ti、Yb高场强元素的特征。对车路沟岩体地质、地球化学特征与产出背景的全面分析,认为其为奥陶纪祁连洋持续向华北板块俯冲,诱使俯冲洋壳部分熔融形成的埃达克岩。

关键词：车路沟岩体锆石U-Pb 洋壳俯冲北祁连造山带埃达克岩